Narrative and procedural discourse in temporal lobe epilepsy

2003 ◽  
Vol 9 (5) ◽  
pp. 733-739 ◽  
Author(s):  
BRIAN BELL ◽  
CHRISTIAN DOW ◽  
E. RYANN WATSON ◽  
AUSTIN WOODARD ◽  
BRUCE HERMANN ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Early Onset ◽  
Narrative Discourse ◽  
Cognitive Domain ◽  
Control Group ◽  
Individual Level ◽  
Procedural Discourse ◽  
Language Measures ◽  
The Individual

It is well established that some individuals with temporal lobe epilepsy (TLE) demonstrate language deficits at the single word level. However, discourse production rarely has been examined quantitatively within this group. This study compared adult TLE patients with an early seizure onset (≤ age 14 years, n = 27) to a control group (n = 28) on narrative and procedural discourse tasks. As a group, the TLE patients performed normally on the procedural discourse task, but differed significantly from the controls on several narrative discourse variables. At the individual level, 30% of the TLE patients versus 4% of the controls demonstrated impaired discourse ability (p < .01). Within this early onset TLE group, discourse performance was not associated with demographic or seizure history variables. Considering the cognitive domain, discourse performance correlated significantly with working memory. In summary, mild discourse dysfunction was present in a significant minority of early onset TLE patients, but this deficit was not closely associated with other language measures. Discourse ability and its neuropsychological, neuroanatomical and conversational speech correlates deserve further study in TLE patients. (JINS, 2003, 9, 733–739.)

scholarly journals Synaptic Reshaping and Neuronal Outcomes in the Temporal Lobe Epilepsy

2021 ◽  
Vol 22 (8) ◽  
pp. 3860
Author(s):  
Elisa Ren ◽  
Giulia Curia
Keyword(s):  
Animal Models ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Current Knowledge ◽  
Focal Epilepsy ◽  
Ex Vivo ◽  
Hippocampal Sclerosis ◽  
Control Group ◽  
Epileptogenic Zone ◽  
Epileptiform Discharges

Temporal lobe epilepsy (TLE) is one of the most common types of focal epilepsy, characterized by recurrent spontaneous seizures originating in the temporal lobe(s), with mesial TLE (mTLE) as the worst form of TLE, often associated with hippocampal sclerosis. Abnormal epileptiform discharges are the result, among others, of altered cell-to-cell communication in both chemical and electrical transmissions. Current knowledge about the neurobiology of TLE in human patients emerges from pathological studies of biopsy specimens isolated from the epileptogenic zone or, in a few more recent investigations, from living subjects using positron emission tomography (PET). To overcome limitations related to the use of human tissue, animal models are of great help as they allow the selection of homogeneous samples still presenting a more various scenario of the epileptic syndrome, the presence of a comparable control group, and the availability of a greater amount of tissue for in vitro/ex vivo investigations. This review provides an overview of the structural and functional alterations of synaptic connections in the brain of TLE/mTLE patients and animal models.

Neurodevelopmental disruption in early-onset temporal lobe epilepsy: Evidence from a voxel-based morphometry study

2011 ◽  
Vol 20 (4) ◽  
pp. 694-699 ◽  
Author(s):  
Sabine Kaaden ◽  
Carlos M. Quesada ◽  
Horst Urbach ◽  
Roy Koenig ◽  
Bernd Weber ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Early Onset ◽  
Voxel Based Morphometry

Stereoelectroencephalographic language mapping of the basal temporal cortex predicts postoperative naming outcome

2021 ◽  
pp. 1-11
Author(s):  
Chifaou Abdallah ◽  
Hélène Brissart ◽  
Sophie Colnat-Coulbois ◽  
Ludovic Pierson ◽  
Olivier Aron ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Verbal Fluency ◽  
Temporal Cortex ◽  
Visual Object ◽  
Drug Resistant ◽  
Language Mapping ◽  
Individual Level ◽  
Language Outcome ◽  
Temporal Lobe Resection ◽  
The Individual

OBJECTIVEIn drug-resistant temporal lobe epilepsy (TLE) patients, the authors evaluated early and late outcomes for decline in visual object naming after dominant temporal lobe resection (TLR) according to the resection status of the basal temporal language area (BTLA) identified by cortical stimulation during stereoelectroencephalography (SEEG).METHODSTwenty patients who underwent SEEG for drug-resistant TLE met the inclusion criteria. During language mapping, a site was considered positive when stimulation of two contiguous contacts elicited at least one naming impairment during two remote sessions. After TLR ipsilateral to their BTLA, patients were classified as BTLA+ when at least one positive language site was resected and as BTLA− when all positive language sites were preserved. Outcomes in naming and verbal fluency tests were assessed using pre- and postoperative (means of 7 and 25 months after surgery) scores at the group level and reliable change indices (RCIs) for clinically meaningful changes at the individual level.RESULTSBTLA+ patients (n = 7) had significantly worse naming scores than BTLA− patients (n = 13) within 1 year after surgery but not at the long-term evaluation. No difference in verbal fluency tests was observed. When RCIs were used, 5 of 18 patients (28%) had naming decline within 1 year postoperatively (corresponding to 57% of BTLA+ and 9% of BTLA− patients). A significant correlation was found between BTLA resection and naming decline.CONCLUSIONSBTLA resection is associated with a specific and early naming decline. Even if this decline is transient, naming scores in BTLA+ patients tend to remain lower compared to their baseline. SEEG mapping helps to predict postoperative language outcome after dominant TLR.

Parameters of autonomic regulation in patients with focal frontal and temporal epilepsy

2021 ◽  
Vol 29 (1) ◽  
pp. 45-53
Author(s):  
Julia I. Medvedeva ◽  
Roman A. Zorin ◽  
Vladimir A. Zhadnov ◽  
Michael M. Lapkin
Keyword(s):  
Regression Analysis ◽  
Temporal Lobe Epilepsy ◽  
Evoked Potentials ◽  
Temporal Lobe ◽  
Focal Epilepsy ◽  
Autonomic Regulation ◽  
Control Group ◽  
Temporal Epilepsy ◽  
Logit Regression ◽  
Autonomic Support

Aim. This study aimed to investigate the mechanisms of autonomic regulation and autonomic support in focal frontal and temporal lobe epilepsy. Materials and Methods. Thirty-six individuals were examined (19 men and 17 women; mean age 33.71.4 years) in the control group (without history of epileptic seizures) and 68 patients (32 men and 36 women, 34.11.5 years) with focal epilepsy (36 patients with frontal lobe epilepsy, of which 32 had temporal lobe epilepsy). Physiological parameters of heart rate variability and of skin sympathetic evoked potentials were evaluated. Results. Predomination of sympathetic influences in both groups of patients was found. According to the analysis of skin sympathetic evoked potentials, a high activity of the suprasegmental autonomic centers was determined in patients with epilepsy. Based on the results of the correlation analysis, the initial state in patients with temporal lobe epilepsy was characterized by greater intrasystemic tension that reflects the high level of physiological costs. The logit regression analysis model makes it possible to distribute patients with focal epilepsy into groups with different disease courses on the basis of the parameters of the autonomic support of the activity. Conclusion. In patients with focal epilepsy, predomination of sympathetic influences was observed, as well as greater activity of the suprasegmental centers of the autonomic regulation. Intrasystemic ratios of autonomic regulation parameters demonstrate an increase in the intrasystemic tension and a limitation of functional reserves in patients with temporal lobe epilepsy. A complex of parameters of autonomic support allows, based on the logit regression analysis, to distribute patients into groups with different courses of focal epilepsy.

Reorganization of Verbal Memory Function in Early Onset Left Temporal Lobe Epilepsy

1997 ◽  
Vol 35 (1) ◽  
pp. 132-148 ◽  
Author(s):  
Michael Seidenberg ◽  
Bruce P. Hermann ◽  
Jen Schoenfeld ◽  
Keith Davies ◽  
Allen Wyler ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Verbal Memory ◽  
Early Onset ◽  
Memory Function ◽  
Left Temporal Lobe

scholarly journals Manganese-enhanced magnetic resonance imaging in the acute phase of the pilocarpine-induced model of epilepsy

2012 ◽  
Vol 10 (2) ◽  
pp. 247-252 ◽  
Author(s):  
Jackeline Moraes Malheiros ◽  
Beatriz Monteiro Longo ◽  
Alberto Tannús ◽  
Luciene Covolan
Keyword(s):  
Status Epilepticus ◽  
Magnetic Resonance ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Acute Phase ◽  
Cell Activation ◽  
Experimental Models ◽  
Magnetic Resonance Images ◽  
Control Group ◽  
Experimental Conditions

Magnetic resonance images are useful in the study of experimental models of temporal lobe epilepsy. The manganese-enhanced MRI (MEMRI) technique is of interest since it combines the effects caused by manganese on the increased contrast in activated cell populations, when competing with calcium in synaptic transmission. Thus, the purpose of this study was to investigate the temporal evolution of the contrast related to manganese in the acute phase of temporal lobe epilepsy induced by systemic pilocarpine and compare it to the expression of the c-Fos protein. During this phase, the intensity of the MEMRI signal was analyzed at three different time points (5, 15 or 30 minutes) after the onset of status epilepticus (SE). The group that was maintained in status epilepticus for 30 minutes showed a decrease in intensity of the signal in CA1 and the dentate gyrus (DG). There were no differences between the control group and the other groups treated with pilocarpine. The expression of the protein, c-Fos, in the same animals showed that even in the short-duration status epilepticus (5 minutes), there was already maximal cellular activation in subregions of the hippocampus (DG, CA1 and CA3). Under the experimental conditions tested, our data suggest that the MEMRI signal was not sensitive for the identification of detectable variations of cell activation in the acute phase of the pilocarpine model. Our findings are not consistent with the idea that manganese contrast reflects primarily alterations in cellular activity during SE when other signal-modifying elements can act.

Individual patient prediction of seizure lateralization in temporal lobe epilepsy: A comparison between neuropsychological memory measures and the Intracarotid Amobarbital Procedure

1997 ◽  
Vol 3 (2) ◽  
pp. 159-168 ◽  
Author(s):  
ANTHONY C. KNEEBONE ◽  
GORDON J. CHELUNE ◽  
HANS O. LÜDERS
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Visual Memory ◽  
Clinical Analysis ◽  
Neuropsychological Measures ◽  
Wechsler Memory Scale ◽  
Warrington Recognition Memory Test ◽  
The Individual ◽  
Free Status ◽  
Intracarotid Amobarbital Procedure

Neuropsychological assessment has been extensively used in the presurgical evaluation of temporal lobe epilepsy (TLE) patients to assist in determining lateralization of seizure onset. Very few studies have examined the accuracy with which commonly used neuropsychological instruments provide this information in the individual patient. In 81 patients (49 right-, 32 left-TLE) without space-occupying lesions in whom correct seizure lateralization was inferred on the basis of postsurgical seizure-free status, we compared the frequency with which discrepancies between the Wechsler Memory Scale–Revised (WMS–R; Wechsler, 1987) Verbal and Visual Memory Indices, Warrington Recognition Memory Test (WRMT; Warrington, 1984) Words and Faces scaled scores, and Intracarotid Amobarbital Procedure (IAP) hemispheric memory scores correctly predicted seizure lateralization in the individual patient. Using both clinical analysis and discriminant function analyses (DFA), the IAP was found to be a clearly superior predictor of seizure laterality to the neuropsychological measures, whether used individually or in combination with one another. Using clinical analysis the WRMT was found to be a superior predictor to the WMS–R, which frequently gave false lateralizing information. Using all 3 measures in combination with one another, 87.1% of patients were correctly lateralized using DFA. Correctly lateralized patients were older and had longer durations of seizure disorder. (JINS, 1997, 3, 159–168.)

scholarly journals Voluntary Language Switching in the Context of Bilingual Aphasia

2020 ◽  
Vol 10 (9) ◽  
pp. 141
Author(s):  
Nicholas Grunden ◽  
Giorgio Piazza ◽  
Carmen García-Sánchez ◽  
Marco Calabria
Keyword(s):  
Group Performance ◽  
Ecological Validity ◽  
Control Group ◽  
Control Mechanisms ◽  
Reactive Control ◽  
Language Switching ◽  
Individual Level ◽  
Language Control ◽  
Bilingual Aphasia ◽  
The Individual

As studies of bilingual language control (BLC) seek to explore the underpinnings of bilinguals’ abilities to juggle two languages, different types of language switching tasks have been used to uncover switching and mixing effects and thereby reveal what proactive and reactive control mechanisms are involved in language switching. Voluntary language switching tasks, where a bilingual participant can switch freely between their languages while naming, are being utilized more often due to their greater ecological validity compared to cued switching paradigms. Because this type of task had not yet been applied to language switching in bilingual patients, our study sought to explore voluntary switching in bilinguals with aphasia (BWAs) as well as in healthy bilinguals. In Experiment 1, we replicated previously reported results of switch costs and mixing benefits within our own bilingual population of Catalan-Spanish bilinguals. With Experiment 2, we compared both the performances of BWAs as a group and as individuals against control group performance. Results illustrated a complex picture of language control abilities, indicating varying degrees of association and dissociation between factors of BLC. Given the diversity of impairments in BWAs’ language control mechanisms, we highlight the need to examine BLC at the individual level and through the lens of theoretical cognitive control frameworks in order to further parse out how bilinguals regulate their language switching.

Definiteness in written Swedish by Finnish-speaking immersion pupils at the end of immersion

2018 ◽  
Vol 6 (1) ◽  
pp. 57-84
Author(s):  
Eeva-Liisa Nyqvist
Keyword(s):  
Control Group ◽  
Group Level ◽  
Individual Level ◽  
Definite Form ◽  
Spontaneous Writing ◽  
Acquisition Order ◽  
The Individual ◽  
The Right ◽  
Better Than

Abstract There are two primary goals for this study – first, to analyse definiteness and article use in spontaneous writing in Swedish by 15-year-old Finnish immersion students (n = 162) and secondly, to compare their performance with that of non-immersion students at the same age (n = 67). Analyses at the group level show that immersion students usually perform significantly better than the control group, but they also reveal similar problems to what L2-Swedish non-immersion students have demonstrated in previous studies, such as omission of indefinite articles and difficulty in choosing the right definite form of the noun. Still, these inaccuracies occurred less often in the data from the immersion students. The studied constructions also show at the group level an acquisition order similar to that reported in previous studies, explainable by different aspects of complexity and cross-linguistic influence. Analyses on the individual level, however, show different acquisition orders depending on the criteria being used.

Psychiatric Manifestations in Temporal Lobe Epilepsy: A Controlled Study

1979 ◽  
Vol 135 (5) ◽  
pp. 411-417 ◽  
Author(s):  
G. D. Shukla ◽  
O. N. Srivastava ◽  
B. C. Katiyar ◽  
V. Joshi ◽  
P. K. Mohan
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Economic Status ◽  
Relevant Literature ◽  
Emotional Disturbances ◽  
Controlled Study ◽  
Control Group ◽  
Study Group ◽  
Premorbid Personality ◽  
Grand Mal

SummaryPsychiatric disorder was studied in 62 patients with temporal lobe epilepsy (study group) and 70 patients with grand mal epilepsy (control group), both diagnosed electroencephalographically. The two groups were similar as regards age, sex, socio-economic status, duration and frequency of fits, family history and premorbid personality.A significantly greater number of temporal lobe epileptics had emotional disturbances in childhood and psychiatric abnormalities at the time of study. Neuroses, schizophrenia and behaviour disorder occurred more commonly in the study group, while epileptic personality and confusional psychosis were seen more frequently in the controls.The findings of the study are discussed in the light of relevant literature.

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