The role of calcium and cellular membrane dysfunction in experimental trauma and subarachnoid hemorrhage
1985 ◽
Vol 62
(5)
◽
pp. 698-703
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Keyword(s):
A Chain
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✓ Acute subarachnoid hemorrhage (SAH) and intraparenchymal hematoma (IPH) in cats are accompanied by massive cellular depolarization. This depolarization, characterized by potassium (K+) efflux and calcium (Ca++) influx, results in membrane destabilization, osmotic imbalance, and a decrease in electrical conduction. The Ca++ influx appears to initiate a chain reaction that, in some instances, may result in delayed cell destruction. The ionic dysequilibrium probably contributes to both brain engorgement and spasm in large vessels. The cellular depolarization and calcium-induced cell membrane injury at the moment of impact may play a greater role in the pathophysiology of head trauma than previously thought.
2021 ◽
Vol ahead-of-print
(ahead-of-print)
◽
Keyword(s):
1985 ◽
Vol 63
(5)
◽
pp. 691-692
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1998 ◽
Vol 89
(4)
◽
pp. 559-567
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1987 ◽
Vol 66
(5)
◽
pp. 775-778
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1982 ◽
Vol 57
(2)
◽
pp. 233-239
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1992 ◽
Vol 77
(3)
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pp. 417-423
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1997 ◽
Vol 87
(2)
◽
pp. 275-280
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2021 ◽
pp. neurintsurg-2021-017670
1984 ◽
Vol 61
(6)
◽
pp. 1120-1128
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