Radiation-induced meningioma with a 63-year latency period

✓ Meningiomas are known to be induced by low-, moderate-, and high-dose radiation therapy, with an average time interval to tumor appearance of 35, 26, and 19 to 24 years, respectively. An inverse relationship is suggested between the dose of radiation given and the time to tumor formation. The authors report a case of a 68-year-old woman who received orthovoltage radiotherapy at 5 years of age for a presumed (nonbiopsy confirmed) right cerebellar tumor and developed multiple meningiomas in the radiation portals 63 years later. Like many radiation-induced meningiomas, the tumor was histologically atypical and multiple in its presentation. This case suggests that previous radiotherapy may confer a low, but life-long, risk for meningioma occurrence.

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Radiation-Induced Primary Brain Lymphoma: A Case Report

Tumori Journal ◽

10.1177/030089169508100311 ◽

1995 ◽

Vol 81 (3) ◽

pp. 204-207 ◽

Cited By ~ 2

Author(s):

Moshe E. Stein ◽

Nissim Haim ◽

Menachem Ben-Shachar ◽

Dorith Goldsher ◽

Zvi Bernstein ◽

...

Keyword(s):

Latency Period ◽

High Dose ◽

Low Grade ◽

Whole Brain Irradiation ◽

Brain Lymphoma ◽

Brain Irradiation ◽

Long Latency ◽

Primary Brain Lymphoma ◽

Radiation Induced ◽

Acquired Immunodeficiency

A patient who developed primary brain lymphoma 6 years following whole brain irradiation due to a low-grade glioma is described. The patient had no evidence of congenital or acquired immunodeficiency state and achieved a good and prompt response to aggressive chemotherapy, including high-dose methotrexate. The previous radiation therapy is implicated in the etiology of the lymphoma because of the geometric coincidence, the relatively long latency period and the different histology. A brief review of current literature is reported.

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Meningiomas: genetics, malignancy, and the role of radiation in induction and treatment

Journal of Neurosurgery ◽

10.3171/jns.1994.81.5.0666 ◽

1994 ◽

Vol 81 (5) ◽

pp. 666-675 ◽

Cited By ~ 108

Author(s):

Charles B. Wilson

Keyword(s):

San Francisco ◽

Early Recognition ◽

Neurological Injury ◽

High Dose ◽

Content Type ◽

Parasellar Region ◽

Patients At Risk ◽

Radiation Induced ◽

Malignant Lesions ◽

The University

✓ The author reviews the molecular genetics, pathology, and cell kinetics of meningiomas and the role that regional multiplicity in the dura mater may play in their recurrence. Malignant and radiation-induced meningiomas are discussed, with summaries of series of 60 patients with frankly malignant lesions treated over a period of 22 years at the University of California, San Francisco, and of 10 patients with meningiomas induced by high-dose radiation therapy. Reviewing a 23-year series of 140 patients with subtotally removed meningiomas who were treated postoperatively with radiation, the author recommends that, with meticulous technique, irradiation is effective in preventing the regrowth of subtotally removed benign meningiomas and of all malignant meningiomas. Adoption of both the microscopical cytological grading system proposed by Jääskeläinen's group in Helsinki and the classification of operations proposed by Donald Simpson is also recommended. Wide removal of dura adjacent to meningioma reduces the risk of recurrence, and determination of the bromodeoxyuridine labeling index provides a valid basis for planning treatment and follow-up evaluations. Increased awareness is necessary for early recognition of radiation-induced meningiomas in patients at risk for developing such tumors. For meningiomas in such sites as the parasellar region and the posterior fossa, conservative removal of tumor followed by irradiation is advocated in preference to a radical operation that may cause neurological injury without being curative.

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High dose radiation induced meningioma

British Journal of Neurosurgery ◽

10.1080/02688690400022789 ◽

2004 ◽

Vol 18 (6) ◽

pp. 617-621 ◽

Cited By ~ 12

Author(s):

SN Shenoy ◽

KG Munish ◽

A Raja

Keyword(s):

High Dose ◽

Radiation Induced ◽

Dose Radiation

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Taurine-EVA copolymer-paraffin rods dosimeters for EPR high-dose radiation dosimetry

Nukleonika ◽

10.2478/nuka-2014-0005 ◽

2014 ◽

Vol 59 (1) ◽

pp. 9-13

Author(s):

Ahmed M. Maghraby ◽

A. Mansour ◽

A. A. Abdel-Fattah

Keyword(s):

Ethylene Vinyl Acetate ◽

High Dose ◽

Radiation Doses ◽

Modulation Amplitude ◽

Molten Mixture ◽

Radiation Induced ◽

Epr Signal ◽

High Doses ◽

Dose Radiation ◽

Eva Copolymer

Abstract Taurine/EPR rods (3 × 10 mm) have been prepared by a simple technique in the laboratory where taurine powder was mixed with a molten mixture of paraffin wax and an ethylene vinyl acetate (EVA) copolymer. The binding mixture EVA/Paraffin does not present interference or noise in the EPR signal before or after irradiation. The rods show good mechanical properties for safe and multi-use handling. An EPR investigation of radiation induced radicals in taurine rods revealed that there are two types of radicals produced after exposure to gamma radiation (60Co). EPR spectra were recorded and analyzed - also the microwave power saturation and modulation amplitude were studied and optimized. Response of taurine to different radiation doses (1.5-100 kGy) was studied and found to follow a linear relationship up to 100 kGy. Radiation induced radicals in taurine persists and showed a noticeable stability over 94 days following irradiation. Uncertainities associated with the evaluation of radiation doses using taurine dosimeters were discussed and tabulated. It was found that taurine possesses good dosimetric properties using EPR spectroscopy in high doses in addition to its simple spectrum.

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Radiation-induced vertebral compression fracture following spine stereotactic radiosurgery: clinicopathological correlation

Journal of Neurosurgery Spine ◽

10.3171/2013.2.spine12739 ◽

2013 ◽

Vol 18 (5) ◽

pp. 430-435 ◽

Cited By ~ 56

Author(s):

Ameen Al-Omair ◽

Roger Smith ◽

Tim-Rasmus Kiehl ◽

Louis Lao ◽

Eugene Yu ◽

...

Keyword(s):

Tumor Progression ◽

Stereotactic Radiosurgery ◽

Vertebral Compression Fracture ◽

Compression Fracture ◽

Spinal Tumors ◽

High Dose ◽

Diagnostic Challenge ◽

New Era ◽

Radiation Induced ◽

Dose Radiation

Spine stereotactic radiosurgery (SRS) is increasingly being used to treat metastatic spinal tumors. As the experience matures, high rates of vertebral compression fracture (VCF) are being observed. What is unknown is the mechanism of action; it has been postulated but not confirmed that radiation itself is a contributing factor. This case report describes 2 patients who were treated with spine SRS who subsequently developed signal changes on MRI consistent with tumor progression and VCF; however, biopsy confirmed a diagnosis of radiation-induced necrosis in 1 patient and fibrosis in the other. Radionecrosis is a rare and serious side effect of high-dose radiation therapy and represents a diagnostic challenge, as the authors have learned from years of experience with brain SRS. These cases highlight the issues in the new era of spine SRS with respect to relying on imaging alone as a means of determining true tumor progression. In those scenarios in which it is unclear based on imaging if true tumor progression has occurred, the authors recommend biopsy to rule out radiation-induced effects within the bone prior to initiating salvage therapies.

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Radiation-induced meningiomas: clinical, pathological, cytokinetic, and cytogenetic characteristics

Journal of Neurosurgery ◽

10.3171/jns.2004.100.6.1002 ◽

2004 ◽

Vol 100 (6) ◽

pp. 1002-1013 ◽

Cited By ~ 122

Author(s):

Ossama Al-Mefty ◽

Cahide Topsakal ◽

Svetlana Pravdenkova ◽

Jeffrey R. Sawyer ◽

Michael J. Harrison

Keyword(s):

Progesterone Receptors ◽

Latency Period ◽

Content Type ◽

Chromosome 1P ◽

Proliferation Indices ◽

Cytogenetic Aberrations ◽

Additional Chromosome ◽

Radiation Induced ◽

The Mean ◽

Fine Print

Object. Radiation-induced meningiomas are known to occur after high- and low-dose cranial radiation therapy. The goal of this study was to discern the distinguishing findings and characteristics of radiation-induced meningiomas. Methods. The records of 16 patients (seven men and nine women) who fulfilled the criteria for radiation-induced meningiomas were retrospectively reviewed. Clinical, histopathological, cytokinetic, and cytogenetic findings as well as the patients' outcome were analyzed. The mean age of the patients was 38.8 years and the mean tumor latency was 26.5 years. Five patients had multiple meningiomas in the irradiated field. The recurrence rate was 100% after the initial resection; 62% of patients had a second recurrence and 17% had a third recurrence. Thirty-eight percent of patients had atypical or malignant histopathological findings. The presence of progesterone receptors and low proliferation indices in these patients did not correlate with benign tumor behavior. Cytogenetic analysis showed multiple clonal aberrations in all tumors studied. The most frequent aberrations were found on chromosomes 1p, 6q, and 22. Derivative, lost, or additional chromosome 1p was found in 89% of cases and loss or deletion on chromosome 6 was found in 67%. Conclusions. The age of patients at presentation with meningioma and the latency period of radiation-induced meningiomas are dose related. These tumors are more aggressive and are certain to recur, have a higher histopathological grade, and are associated with complex cytogenetic aberrations particularly involving 1p and 6q.

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Optical evaluation of dithizone solution as a new radiochromic dosimeter

Pigment & Resin Technology ◽

10.1108/prt-10-2019-0091 ◽

2020 ◽

Vol 49 (4) ◽

pp. 249-253 ◽

Cited By ~ 1

Author(s):

Khalid Rabaeh ◽

Ahmed Basfar

Keyword(s):

Free Radicals ◽

Region Of Interest ◽

Food Irradiation ◽

Optical Measurements ◽

High Dose ◽

Radiation Processing ◽

Content Type ◽

Radiochromic Dosimeter ◽

Practical Implications ◽

Dose Radiation

Purpose The purpose of this paper is to propose a new dithizone solution dosimeter for high radiation applications such as polymers applications and food irradiation. Design/methodology/approach Gamma-rays cell of Co-60 source with 8.4 kGy/h dose rate was used to irradiate the dithizone solutions at different irradiation temperatures. The optical measurements of unirradiated and irradiated dithizone dye solution dosimeters were performed using a UV/VIS spectrophotometer at absorption peaks of 421 and 515 nm. Findings The new dosimeter improved significantly with the increase of dithizone dye concentrations from 0.025 to 0.1 mM. The dosimeter shows a perfect pre- and post-irradiation stability after irradiation for five days. Because of irradiation temperature dependence, the dithizone solution dosimeter should be corrected under actual processing conditions. Practical implications Dosimetry is a key point in quality control of radiation processing to assure that uniform and correct radiation doses are delivered to a region of interest. Therefore, this study introduces a dithizone solution dosimeter for high-dose radiation applications such as food irradiation, polymers applications and agriculture. Originality/value Ionizing radiation interacted with the ethanol solvent, resulting in the formation of free radicals, then these free radicals interacted with the dithizone molecule and changed the dye color from yellow to orange.

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Radiation therapy in the management of low-grade supratentorial astrocytomas

Journal of Neurosurgery ◽

10.3171/jns.1989.70.6.0853 ◽

1989 ◽

Vol 70 (6) ◽

pp. 853-861 ◽

Cited By ~ 235

Author(s):

Edward G. Shaw ◽

Catherine Daumas-Duport ◽

Bernd W. Scheithauer ◽

David T. Gilbertson ◽

Judith R. O'Fallon ◽

...

Keyword(s):

Low Dose ◽

Survival Rates ◽

High Dose ◽

Survival Times ◽

Low Dose Radiation ◽

Tumor Removal ◽

Content Type ◽

Pilocytic Astrocytomas ◽

Dose Radiation ◽

Fine Print

✓ The records of 167 patients with grade 1 or 2 supratentorial pilocytic astrocytomas (41 patients), ordinary astrocytomas (91 patients), or mixed oligoastrocytomas (35 patients) diagnosed between 1960 and 1982 are retrospectively reviewed. The extent of surgical tumor removal was gross total or radical subtotal in 33 patients (20%) and subtotal or biopsy only in the remaining 134 patients (80%). Postoperative radiation therapy was given to 139 (83%) of the 167 patients, with a median dose of 5000 cGy (range 600 to 6500 cGy). Multivariate analysis revealed that a pilocytic histology was the most significant prognostic variable associated with a good survival. The 5- and 10-year survival rates were, respectively, 85% and 79% for the 41 patients with pilocytic astrocytomas compared to 51% and 23% for the 126 patients with ordinary astrocytomas or mixed oligoastrocytomas. Postoperative irradiation did not appear to be associated with improved survival times in the patients with pilocytic astrocytomas; however, in the 126 patients with ordinary astrocytomas or mixed oligoastrocytomas, those who received “high-dose” radiation (≥ 5300 cGy) had significantly better survival times than those who received “low-dose” radiation (< 5300 cGy) or surgery alone. The 5- and 10-year survival rates were, respectively, 68% and 39% for the 35 patients receiving high-dose radiation, 47% and 21% for the 67 receiving low-dose radiation, and 32% and 11% for the 19 treated with surgery alone. The survival rate was poor for the 23 patients with ordinary astrocytomas and oligoastrocytomas who underwent gross total or radical subtotal tumor removal (14 of whom were also irradiated): 52% at 5 years and 21% at 10 years, with 19 of 23 patients developing tumor progression and dying 1 to 12 years postoperatively. In contrast, all 10 patients with pilocytic astrocytomas who had gross total or radical subtotal tumor removal alone were long-term survivors, with follow-up periods of about 4 to 25 years.

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Radiation-induced meningioma: a descriptive study of 253 cases

Journal of Neurosurgery ◽

10.3171/jns.2002.97.5.1078 ◽

2002 ◽

Vol 97 (5) ◽

pp. 1078-1082 ◽

Cited By ~ 146

Author(s):

Siegal Sadetzki ◽

Pazit Flint-Richter ◽

Tehila Ben-Tal ◽

Dvora Nass

Keyword(s):

Ionizing Radiation ◽

Present Report ◽

Previous History ◽

Latency Period ◽

Content Type ◽

Established Risk Factor ◽

History Of ◽

Radiation Induced ◽

The Mean ◽

Fine Print

Object. Ionizing radiation is the only established risk factor recognized today in the causation of meningioma. The aim of the present report is to describe the demographic and clinical characteristics of a large series of 253 patients with radiation-induced meningiomas (RIMs). These parameters were compared with those of 41 patients with meningiomas in whom there was no previous history of irradiation (non-RIM group) and with other series of patients presented in the literature. Methods. The cases of RIM were recruited from a cohort of appproximately 11,000 individuals who had been treated with ionizing radiation during childhood for tinea capitis and from a group of individuals who, as adults, applied for compensation because of that treatment. The non-RIM group was identified through the Israeli Cancer Registry. Exposure to radiation was carefully validated among all cases of RIM and absence of previous irradiation was verified for all patients in the non-RIM group. Significantly, a lower patient age at diagnosis, higher prevalence of calvarial tumors, higher proportion of multiple meningiomas, and a nonsignificant higher recurrence rate were observed among patients with RIM compared with the non-RIM group. The mean latency period from date of radiation exposure to development of a meningioma among the RIM group was approximately 36 years. Conclusions. The findings of this study agree with those of other studies indicating the demographic, clinical, and even genetic variability between RIM and non-RIM cases. The existence of two different subtypes of meningiomas may have profound implications for screening, early diagnosis, and therapy of meningiomas.

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