Brain metastasis from germinal tumors of the testis

1998 ◽  
Vol 88 (4) ◽  
pp. 761-763 ◽  
Author(s):  
Seiichi Yoshida ◽  
Ken Morii
Keyword(s):  
Brain Metastasis ◽  
Testicular Tumor ◽  
Lung Tumors ◽  
Surgical Removal ◽  
Cerebellar Tumor ◽  
Content Type ◽  
Left Testicle ◽  
Nonseminomatous Germ Cell Tumor ◽  
Large Brain ◽  
The Brain

✓ Brain metastasis in patients with disseminated nonseminomatous germ cell tumor (NSGCT) has been considered to occur rarely. The authors present the case of a 43-year-old man with an enlarged left testicle, a palpable inguinal tumor, multiple lung tumors, and a large cerebellar tumor. In separate operations, performed 1 month apart, the large cerebellar tumor and the testicular tumor were excised. Elements of teratocarcinoma, embryonal carcinoma, and choriocarcinoma were present in both the brain and testicular tumors. After chemotherapy in which bleomycin, etoposide, and cisplatin were used, the lung tumors and also the surrounding metastasis disappeared; the patient now leads a useful life and remains free from cancer in all organs. The authors suggest that surgical removal of tumor before initiating radiotherapy and chemotherapy for large brain metastasis from NSGCT will produce better results than using the nonsurgical treatments alone.

Brain Metastasis from Nonseminomatous Germ Cell Tumors of the Testis: Case Report and Review of the Role of Surgery

Neurosurgery ◽  
1989 ◽  
Vol 25 (5) ◽  
pp. 814-819 ◽  
Author(s):  
Richard K. Jelsma ◽  
Michael Carroll
Keyword(s):  
Radiation Therapy ◽  
Brain Metastasis ◽  
Germ Cell ◽  
Cell Tumor ◽  
Nonseminomatous Germ Cell Tumor ◽  
Whole Brain Radiation ◽  
Large Brain ◽  
Surgical Debulking ◽  
Brain Radiation ◽  
The Brain

Abstract The prognosis for patients with nonseminomatous germ cell tumor of the testis is good, even when extensive metastatic disease is present, because this tumor is very sensitive to chemotherapy with cisplatin, vinblastine, and bleomycin (PVB). If a metastasis occurs in the brain, however, the prognosis is poor because the blood-brain barrier limits the entrance of these drugs into the brain and creates a sanctuary for tumor. The current treatment for a brain metastasis is either standard PVB chemotherapy plus whole brain radiation therapy or a rigorous chemotheraputic regimen that penetrates the blood-brain barrier better than PVB. Surgery is seldom used for brain metastasis, largely because of the poor results with surgical debulking in noncentral nervous system disease. This is the report of a patient with disseminated nonseminomatous germ cell tumor and multiple large brain metastases, who was treated with surgery, PVB, and whole brain radiation therapy and cured. Evidence is presented to support a role for surgical debulking in patients with large brain metastasis.

Choriocarcinoma brain metastasis in a patient with viable intrauterine pregnancy

2002 ◽  
Vol 97 (2) ◽  
pp. 477-481 ◽  
Author(s):  
Adam N. Mamelak ◽  
Gregory J. Withers ◽  
Xuedong Wang
Keyword(s):  
Brain Metastasis ◽  
Multidisciplinary Treatment ◽  
Metastatic Tumor ◽  
Mass Effect ◽  
Surgical Removal ◽  
High Dose ◽  
Intrauterine Pregnancy ◽  
Content Type ◽  
Large Brain ◽  
Dose Corticosteroid

✓ The authors report the case of a woman who presented during her 30th week of pregnancy with a large brain metastasis from a previously undetected metastatic choriocarcinoma. The metastasis caused significant neurological deficit due to mass effect, necessitating rapid intervention. Medical management included a regimen of high-dose corticosteroid medications for 36 hours, followed by cesarean delivery of the fetus and craniotomy to remove the metastatic tumor; chemotherapy and radiation therapy were begun within 1 week postsurgery. Both the baby and mother survived, and as of the 1-year follow-up examination, there was no evidence of disease in the mother. This is only the second report of a metastatic choriocarcinoma associated with a simultaneous viable intrauterine pregnancy, and the only case in which surgical removal of a brain metastasis was required. Coordinated multidisciplinary treatment of mother and fetus by members of the neurosurgery, medical oncology, neonatology, and obstetrics services facilitated a good outcome in this case.

Vascular malformations of the brain stem

1989 ◽  
Vol 70 (6) ◽  
pp. 847-852 ◽  
Author(s):  
Douglas Chyatte
Keyword(s):  
Brain Stem ◽  
Vascular Malformation ◽  
Vascular Malformations ◽  
Surgical Removal ◽  
Content Type ◽  
Appropriate Treatment ◽  
Complete Obliteration ◽  
Time Of Presentation ◽  
The Brain ◽  
Fine Print

✓ Vascular malformations of the brain stem are unusual lesions that may pose a diagnostic and therapeutic challenge. Seven patients with vascular malformations involving the brain stem were evaluated; six were treated surgically, with complete obliteration of the lesion in five patients. In five patients symptoms developed only after a hemorrhage had occurred, and three of these suffered a rebleed before appropriate treatment was given. Angiography failed to demonstrate lesions in three cases, which did not appear to protect from repeat hemorrhage since two of the three rebled. There were no operative deaths, and no patients were made permanently worse after surgery. Useful recovery occurred commonly after appropriate treatment and appeared to be possible even in patients who had suffered a catastrophic neurological deficit at the time of presentation. These data indicate that surgical removal of the lesion may be warranted in some patients with symptomatic brain-stem vascular malformation.

Monitoring of 57Co-bleomycin delivery to brain metastases and their tumors of origin

1987 ◽  
Vol 67 (4) ◽  
pp. 506-510 ◽  
Author(s):  
Dov Front ◽  
Einat Even-Sapir ◽  
Galina Iosilevsky ◽  
Ora Israel ◽  
Alex Frenkel ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Lung Tumor ◽  
Single Photon ◽  
Photon Emission ◽  
Lung Tumors ◽  
Drug Uptake ◽  
Content Type ◽  
Significant Difference ◽  
The Difference ◽  
The Brain

✓ The concentration of cobalt-57 (57Co)-labeled bleomycin delivered to three brain metastases and to their tumors of origin in the lungs was measured using a single-photon emission computerized tomography technique. In two brain metastases the 57Co-bleomycin concentration measured at different times after the intravenous injection was significantly lower than that in the originating lung tumors (p < 0.01 and p < 0.001). In these two patients, the tumor cumulative concentration (TCC) of drug in the brain neoplasm compared to the lung carcinoma was 12.92 versus 15.12 and 10.30 versus 19.74 µg/cc/min. In the third patient there was no significant difference in drug concentration between the tumor in the brain and in the lung (TCC 16.02 vs. 15.09 µg/cc/min). There was a significant difference in the drug TCC between the three brain metastases: the difference between the lowest and highest concentrations was more than 50% (10.3 vs. 16.02 µg/cc/min). When the concentration in the tumor over time (CT(t)) of the 57Co-bleomycin was compared in the brain and lung tumors, a good correlation was found in each of the three cases (r = 0.93, 0.99, and 0.97). This suggests that the difference in drug uptake between brain metastases and their originating lung tumor is a quantitative rather than a qualitative phenomenon. The results show that the amount of drug to which brain metastases are exposed varies and may be very low in some tumors; therefore, effectiveness of drug delivery may play a role in the nonresponsiveness of brain metastases to treatment.

Nasal glioma

1977 ◽  
Vol 46 (1) ◽  
pp. 85-91 ◽  
Author(s):  
Leonard F. Hirsh ◽  
Sylvan E. Stool ◽  
Thomas W. Langfitt ◽  
Luis Schut
Keyword(s):  
Surgical Approach ◽  
Clinical Characteristics ◽  
Neural Tissue ◽  
Surgical Removal ◽  
Content Type ◽  
Nasal Tumors ◽  
Mass Lesions ◽  
The Brain ◽  
Selection Of ◽  
Fine Print

✓ Six cases of nasal gliomas, which are rare ectopic rests of neural tissue found at the root of the nose, are presented. It is important to distinguish nasal tumors from basofrontal encephaloceles to avoid inadvertent exposure of the brain during the surgical removal of mass lesions. Because of their related embryologic origins, the distinction between nasal gliomas and basofrontal encephaloceles may not be clear clinically. Nasal gliomas may be treated by several surgical specialties, and only a proper awareness of their relationship to encephaloceles can assure the selection of a flexible and adequate surgical approach. This paper emphasizes the salient clinical characteristics of nasal gliomas, their clinical distinction from and embryologic relationship to encephaloceles, and the options for treatment.

Brain metastasis from malignant pancreatic somatostatinoma

1996 ◽  
Vol 85 (4) ◽  
pp. 681-684 ◽  
Author(s):  
Takumi Abe ◽  
Kinya Oshida ◽  
Kiyoshi Matsumoto ◽  
Masataka Iida ◽  
Naoko Sanno
Keyword(s):  
Brain Metastasis ◽  
Lymph Nodes ◽  
Primary Tumor ◽  
Tumor Recurrence ◽  
Brain Lesions ◽  
Endocrine Tumors ◽  
Content Type ◽  
Pancreatic Tail ◽  
The Brain ◽  
Fine Print

✓ Somatostatinomas are rare endocrine tumors that are located primarily in the pancreas. Metastases are seen most frequently in the liver and lymph nodes. The authors present the case of a 63-year-old man who had a malignant somatostatinoma of pancreatic tail origin that metastasized to the brain 10 years after diagnosis of the primary tumor. The metastatic brain lesions were totally removed and the patient is alive without tumor recurrence 12.3 years after the initial diagnosis. To our knowledge, this case represents the first documentation of brain metastasis from a malignant somatostatinoma, as well as the longest survival time of a patient with a somatostatinoma.

Extrasellar extension of a pituitary adenoma in a patient with a normal-sized sella turcica and impaired vision from an atheromatous carotid artery

1973 ◽  
Vol 39 (3) ◽  
pp. 398-401 ◽  
Author(s):  
John R. Clifford ◽  
Dean H. Echols
Keyword(s):  
Carotid Artery ◽  
Surgical Intervention ◽  
Sella Turcica ◽  
Complete Recovery ◽  
The Other ◽  
Surgical Removal ◽  
Impaired Vision ◽  
Content Type ◽  
The Brain ◽  
Fine Print

✓ Chromophobe adenomas rarely invade the brain without causing enlargement of the sella turcica and without compressing the optic nerves or chiasm. Such a case is reported, in which the patient made a complete recovery after surgical removal of the tumor. Five years later impaired vision in the other eye suggested recurrence of the adenoma. This time surgical intervention disclosed compression of the optic nerve by an atheromatous carotid artery.

Intracranial metastasis from a sacrococcygeal chordoma

2005 ◽  
Vol 102 (4) ◽  
pp. 730-732 ◽  
Author(s):  
Mahmoud Hamdy Kamel ◽  
Chris Lim ◽  
Michael Kelleher ◽  
Kristian Aquilina ◽  
Catherine Keohane ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
English Literature ◽  
Metastatic Potential ◽  
Intracranial Metastasis ◽  
Content Type ◽  
Invasive Tumor ◽  
Extraneural Metastases ◽  
The Brain ◽  
Fine Print

✓ Chordoma is a locally invasive tumor of low metastatic potential. Only six cases of chordoma that metastasized to the brain are found in the English literature. Most of these lesions were clinically silent and all were associated with extraneural metastases. The authors report a case of symptomatic brain metastasis from a sacrococcygeal chordoma in the absence of other metastases. The incidence, sites, and factors predictive of chordoma metastasis are discussed.

Surgical treatment of vascular lesions in the brain stem

1975 ◽  
Vol 42 (1) ◽  
pp. 23-31 ◽  
Author(s):  
Shelley N. Chou ◽  
Donald L. Erickson ◽  
Humberto J. Ortiz-Suarez
Keyword(s):  
Surgical Treatment ◽  
Brain Stem ◽  
Arteriovenous Malformations ◽  
Vascular Lesions ◽  
Surgical Removal ◽  
Content Type ◽  
The Brain ◽  
Fine Print

✓ The authors report the total surgical removal of five vascular lesions of the brain stem, three hemangioblastomas and two arteriovenous malformations. One patient died; among the others, the quality of survival is excellent. Factors favoring surgical removal of such lesions are discussed.

Surgical removal of arteriovenous malformations from the brain stem and cerebellopontine angle

1975 ◽  
Vol 43 (6) ◽  
pp. 661-670 ◽  
Author(s):  
Charles G. Drake
Keyword(s):  
Arteriovenous Malformation ◽  
Brain Stem ◽  
Arteriovenous Malformations ◽  
Cerebellopontine Angle ◽  
Neurological Deficits ◽  
Surgical Removal ◽  
Surgical Experience ◽  
Content Type ◽  
The Brain ◽  
Fine Print

✓ The author reports his surgical experience with five cases of arteriovenous malformation of the brain stem and cerebellopontine angle causing multiple hemorrhages and severe neurological deficits. Surgical removal of the lesions had good results in four cases; there was one death.

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