Primary paraspinal leiomyosarcoma invading the cervical spinal canal successfully treated with surgery, radiotherapy, and chemotherapy

✓A primary paraspinal leiomyosarcoma invading the spine is an exceedingly rare neoplasm that may clinically mimic a schwannoma. The authors report a case involving a 45-year-old man with a primary leiomyosarcoma of the cervical paraspinal musculature that invaded the spinal canal at C1–2 and subsequently metastasized to the lungs and pancreas. Aggressive treatment consisting of resection of the primary tumor, adjunctive radiation therapy and chemotherapy, and surgical debulking of metastatic disease resulted in local tumor control at the primary site and long-term survival of the patient.

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Local Tumor Control and Long-Term Overall Survival in 51 Patients with Anterior Skull Base Tumors Treated with Intraoperative Radiation Therapy

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2020.07.355 ◽

2020 ◽

Vol 108 (3) ◽

pp. e830

Author(s):

M. Kopp

Keyword(s):

Overall Survival ◽

Radiation Therapy ◽

Local Tumor Control ◽

Anterior Skull Base ◽

Intraoperative Radiation Therapy ◽

Tumor Control ◽

Local Tumor ◽

Skull Base Tumors ◽

Intraoperative Radiation

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Local Tumor Control and Long-Term Overall Survival in 47 Patients with Anterior Skull Base Tumors Treated with Intraoperative Radiation Therapy

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2018.07.889 ◽

2018 ◽

Vol 102 (3) ◽

pp. e276

Author(s):

M. Kopp ◽

G. Fastner ◽

M. Dejaco ◽

G. Moser ◽

P. Kopp ◽

...

Keyword(s):

Overall Survival ◽

Radiation Therapy ◽

Local Tumor Control ◽

Anterior Skull Base ◽

Intraoperative Radiation Therapy ◽

Tumor Control ◽

Local Tumor ◽

Skull Base Tumors ◽

Intraoperative Radiation

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Response to Neoadjuvant Chemotherapy Combined With Regional Hyperthermia Predicts Long-Term Survival for Adult Patients With Retroperitoneal and Visceral High-Risk Soft Tissue Sarcomas

Journal of Clinical Oncology ◽

10.1200/jco.2002.07.146 ◽

2002 ◽

Vol 20 (14) ◽

pp. 3156-3164 ◽

Cited By ~ 72

Author(s):

Clemens-M. Wendtner ◽

Sultan Abdel-Rahman ◽

Matthäus Krych ◽

Jens Baumert ◽

Lars H. Lindner ◽

...

Keyword(s):

Neoadjuvant Chemotherapy ◽

Response Rate ◽

Soft Tissue Sarcomas ◽

Local Tumor Control ◽

Tumor Control ◽

Local Tumor ◽

Regional Hyperthermia ◽

Term Survival ◽

Free Survival

PURPOSE: To determine the efficacy of neoadjuvant chemotherapy combined with regional hyperthermia (RHT) for local tumor control and overall survival (OS) in adult patients with retroperitoneal or visceral (RP/V) high-risk soft tissue sarcomas (HR-STS). PATIENTS AND METHODS: From 1991 to 1997, 58 patients with HR-STS at RP/V sites were prospectively treated with four cycles of etoposide, ifosfamide, and doxorubicin combined with RHT followed by surgery, adjuvant chemotherapy, and radiation. RESULTS: Objective response rate assessable in 40 patients was 13% (five partial responses). Including minor responses (n = 8), the radiographic response rate was 33%. The pathologic response rate assessable in 26 patients after surgical resection was 42%. Median OS was 31 months. At a median observation time of 74 months, 5-year probability of local failure-free survival (LFFS), distant metastasis-free survival, event-free survival, and OS were 25%, 51%, 20%, and 32%, respectively. Averaged minimum temperatures (Tmin) and time-averaged temperatures achieved in 50% (T50) and 90% (T90) of all measured tumor sites differed significantly between responders and nonresponders (Tmin, 39.3°C v 38.0°C; P = .002; T50, 40.9°C v 40.3°C; P = .038; T90, 40.1°C v 39.3°C; P = .017). At 5-year follow-up, probability of LFFS (59% v 0%; P < .001) and OS (60% v 10%; P < .001) was significantly in favor of patients responding to neoadjuvant thermochemotherapy. CONCLUSION: Response to neoadjuvant chemotherapy combined with RHT is predictive for an improved local tumor control resulting in a long-term survival benefit for patients with HR-STS at unfavorable RP/V sites; however, the impact of RHT has to be defined in a randomized phase III trial.

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Petroclival meningiomas: long-term outcomes of multimodal treatments and management strategies based on 30 years of experience at a single institution

Journal of Neurosurgery ◽

10.3171/2019.2.jns182604 ◽

2020 ◽

Vol 132 (6) ◽

pp. 1675-1682 ◽

Cited By ~ 5

Author(s):

Jin Wook Kim ◽

Hee-Won Jung ◽

Yong Hwy Kim ◽

Chul-Kee Park ◽

Hyun-Tai Chung ◽

...

Keyword(s):

Adjuvant Treatment ◽

Management Strategies ◽

Local Tumor Control ◽

Tumor Control ◽

Years Of Experience ◽

Local Tumor ◽

Long Term Outcomes ◽

Single Institution ◽

Petroclival Meningiomas

OBJECTIVEA thorough investigation of the long-term outcomes and chronological changes of multimodal treatments for petroclival meningiomas is required to establish optimal management strategies. The authors retrospectively reviewed the long-term clinical outcomes of patients with petroclival meningioma according to various treatments, including various surgical approaches, and they suggest treatment strategies based on 30 years of experience at a single institution.METHODSNinety-two patients with petroclival meningiomas were treated surgically at the authors’ institution from 1986 to 2015. Patient demographics, overall survival, local tumor control rates, and functional outcomes according to multimodal treatments, as well as chronological change in management strategies, were evaluated. The mean clinical and radiological follow-up periods were 121 months (range 1–368 months) and 105 months (range 1–348 months), respectively.RESULTSA posterior transpetrosal approach was most frequently selected and was followed in 44 patients (48%); a simple retrosigmoid approach, undertaken in 30 patients, was the second most common. The initial extent of resection and following adjuvant treatment modality were classified into 3 subgroups: gross-total resection (GTR) only in 13 patients; non-GTR treatment followed by adjuvant radiosurgery or radiation therapy (non-GTR+RS/RT) in 56 patients; and non-GTR without adjuvant treatment (non-GTR only) in 23 patients. The overall progression-free survival rate was 85.8% at 5 years and 81.2% at 10 years. Progression or recurrence rates according to each subgroup were 7.7%, 12.5%, and 30.4%, respectively.CONCLUSIONSThe authors’ preferred multimodal treatment strategy, that of planned incomplete resection and subsequent adjuvant radiosurgery, is a feasible option for the management of patients with large petroclival meningiomas, considering both local tumor control and postoperative quality of life.

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Thermal Ablation of Bone Metastases

Seminars in Interventional Radiology ◽

10.1055/s-0038-1673422 ◽

2018 ◽

Vol 35 (04) ◽

pp. 299-308 ◽

Cited By ~ 7

Author(s):

A. Kurup ◽

Matthew Callstrom ◽

Michael Moynagh

Keyword(s):

Radiation Therapy ◽

Bone Metastases ◽

Thermal Ablation ◽

Local Tumor Control ◽

Tumor Control ◽

Pain Palliation ◽

Local Tumor ◽

Image Guided ◽

Skeletal Related Events ◽

Percutaneous Thermal Ablation

AbstractImage-guided, minimally invasive, percutaneous thermal ablation of bone metastases has unique advantages compared with surgery or radiation therapy. Thermal ablation of osseous metastases may result in significant pain palliation, prevention of skeletal-related events, and durable local tumor control. This article will describe current thermal ablation techniques utilized to treat bone metastases, summarize contemporary evidence supporting such thermal ablation treatments, and outline an approach to percutaneous ablative treatment.

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