scholarly journals Coexistence of Cardiomyopathy and Chronic Liver Disease in Non-Moderate Drinkers

2013 ◽  
Vol 52 (189) ◽  
pp. 217-223 ◽  
Author(s):  
Mani Prasad Gautam ◽  
Usha Ghimire ◽  
Gangapatnam Subramanyam ◽  
Sogunuru Guruprasad
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Heart Muscle ◽  
Systolic Function ◽  
Chronic Liver ◽  
Muscle Disease ◽  
Moderate Drinking ◽  
Echo Features ◽  
Lv Systolic Function ◽  
The Relationship

Introduction: The dose-response relationship suggests a toxic effect of alcohol on heart and liver and the possibility of a correlation between alcohol-induced liver and heart disease. The present study was aimed to look into the relationship between chronic liver and heart muscle disease among the non-moderate drinkers in our context.Methods: An observational study on non-moderate chronic drinkers was carried out. Clinical evaluation along with detail sonographic study of heart and liver was conducted.Results: Fifty-eight percent had echocardiographic features consistent with heart muscle disease, either as a dilated cardiomyopathy, categorized by the presence of echo features of impaired LV systolic function and dilated left ventricle or as a possible cardiomyopathy categorized by the presence of any of these two echo features. Similarly, 56 of the total recruits showed ultrasonographic evidence of chronic liver disease as cirrhosis or early cirrhosis. Approximately, 86% of these 56 non-moderate drinkers with chronic liver disease also had echocardiographic features of heart muscle disease and 83% of the 58 non-moderate drinkers showing echo features of heart muscle disease had ultrasonographic features of chronic liver disease.Conclusions:Our study showed a strongly positive relationship on the coexistence of chronic liver disease and cardiomyopathy among the non-moderate drinkers. Non-moderate drinkers with chronic liver disease have a high likelihood of having a concurrent clinical or sub-clinical heart muscle disease and vice versa.Keywords: alcohol; chronic liver disease; heart muscle disease; non-moderate drinking.

scholarly journals The Relationship between Trace Elements and Depression among Older Patients with Chronic Liver Disease

2020 ◽  
Vol 17 (5) ◽  
pp. em224
Author(s):  
Rania Mohammed Abou-Hashem ◽  
Maram Magdy Shaat ◽  
Sarah Ahmed Hamza ◽  
Nermine Helmy Mahmoud ◽  
Suzan Mounir Ali
Keyword(s):  
Trace Elements ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Older Patients ◽  
Chronic Liver ◽  
The Relationship

scholarly journals The relationship between amino acid-nitrogen metabolism and plasma zinc in patients with chronic liver disease.

Kanzo ◽  
2001 ◽  
Vol 42 (3) ◽  
pp. 120-125 ◽  
Author(s):  
Kazuhiro KATAYAMA ◽  
Yuko OOKA ◽  
Sumi KIKKAWA ◽  
Akio UEMURA ◽  
Shinichiro SHINZAKI ◽  
...  
Keyword(s):  
Liver Disease ◽  
Amino Acid ◽  
Chronic Liver Disease ◽  
Nitrogen Metabolism ◽  
Chronic Liver ◽  
Plasma Zinc ◽  
Amino Acid Nitrogen ◽  
The Relationship

scholarly journals The relationship between cardiac and liver iron evaluated by MR imaging in haematological malignancies and chronic liver disease

2012 ◽  
Vol 2 (1) ◽  
pp. e49-e49 ◽  
Author(s):  
J M Virtanen ◽  
K J Remes ◽  
M A Itälä-Remes ◽  
J P Saunavaara ◽  
M E Komu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Mr Imaging ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Haematological Malignancies ◽  
Liver Iron ◽  
The Relationship

scholarly journals The Relationship between Hepatic Myeloid-Derived Suppressor Cells and Clinicopathological Parameters in Patients with Chronic Liver Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Zhijia Zhou ◽  
Penghua Lai ◽  
Shaoliang Zhang ◽  
Yujie Wang ◽  
Ning Qu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Clinical Characteristics ◽  
Suppressor Cells ◽  
Chronic Liver ◽  
Clinicopathological Parameters ◽  
Myeloid Derived Suppressor Cells ◽  
Liver Inflammation ◽  
The Difference ◽  
The Relationship

Myeloid-derived suppressor cells (MDSCs) have attracted attention due to their important role in inflammation. Several studies have investigated the involvement of MDSCs in chronic liver disease. However, due to the difference of MDSC phenotypes, patient types, and sample sources among the studies, the results are inconsistent and controversial. We took advantage of a large well-defined cohort of 98 (24 patients with CHB, 18 with NAFLD, 13 with HCC, 16 with PBC, and 27 with AIH) patients with liver inflammation and 12 healthy controls to investigate the expression of MDSCs, and the relationships between the expression of hepatic MDSCs and the clinical characteristics were analyzed. We found that the expression of CD11b+CD33+ MDSCs is closely related to chronic liver disease and positively correlated with clinical parameters such as ALT, AST, and globulin. Ultimately, the present study suggests that hepatic CD11b+CD33+ MDSCs are increased in HCC and AIH and positively correlate with the liver stages of hepatitis activity and liver fibrosis stage.

scholarly journals Digital Pathology Enables Automated and Quantitative Assessment of Inflammatory Activity in Patients with Chronic Liver Disease

Biomolecules ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1808
Author(s):  
David Marti-Aguado ◽  
Matías Fernández-Patón ◽  
Clara Alfaro-Cervello ◽  
Claudia Mestre-Alagarda ◽  
Mónica Bauza ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Digital Pathology ◽  
Scoring Systems ◽  
Chronic Liver ◽  
Research Network ◽  
Histological Evaluation ◽  
Nonalcoholic Fatty Liver ◽  
Metavir Score ◽  
The Relationship

Traditional histological evaluation for grading liver disease severity is based on subjective and semi-quantitative scores. We examined the relationship between digital pathology analysis and corresponding scoring systems for the assessment of hepatic necroinflammatory activity. A prospective, multicenter study including 156 patients with chronic liver disease (74% nonalcoholic fatty liver disease-NAFLD, 26% chronic hepatitis-CH etiologies) was performed. Inflammation was graded according to the Nonalcoholic Steatohepatitis (NASH) Clinical Research Network system and METAVIR score. Whole-slide digital image analysis based on quantitative (I-score: inflammation ratio) and morphometric (C-score: proportionate area of staining intensities clusters) measurements were independently performed. Our data show that I-scores and C-scores increase with inflammation grades (p < 0.001). High correlation was seen for CH (ρ = 0.85–0.88), but only moderate for NAFLD (ρ = 0.5–0.53). I-score (p = 0.008) and C-score (p = 0.002) were higher for CH than NAFLD. Our MATLAB algorithm performed better than QuPath software for the diagnosis of low-moderate inflammation (p < 0.05). C-score AUC for classifying NASH was 0.75 (95%CI, 0.65–0.84) and for moderate/severe CH was 0.99 (95%CI, 0.97–1.00). Digital pathology measurements increased with fibrosis stages (p < 0.001). In conclusion, quantitative and morphometric metrics of inflammatory burden obtained by digital pathology correlate well with pathologists’ scores, showing a higher accuracy for the evaluation of CH than NAFLD.

scholarly journals Diastolic versus systolic dysfunction in patients with chronic liver disease – A single center study in South-South, Nigeria

2021 ◽  
Vol 5 ◽  
pp. 1-7
Author(s):  
Uchenna Njideofor ◽  
Uchenna Okonkwo ◽  
Victor O Ansa ◽  
Clement O Odigwe
Keyword(s):  
Liver Disease ◽  
Diastolic Dysfunction ◽  
Chronic Liver Disease ◽  
Left Atrial ◽  
Systolic Function ◽  
Systolic Dysfunction ◽  
Left Ventricular ◽  
Chronic Liver ◽  
Cirrhotic Cardiomyopathy ◽  
Female Ratio

Objectives: The term cirrhotic cardiomyopathy (CCM) has been used to describe the constellation of cardiovascular abnormalities including diastolic and systolic dysfunctions in patients with chronic liver disease (CLD). CCM contributes to morbidity and mortality associated with CLD. The aim of the study was to evaluate the left atrial and ventricular geometry, systolic and diastolic functions in patients with CLD. Material and Methods: This was a cross-sectional analytical study that involved 80 patients with CLD seen at University of Calabar Teaching Hospital, Calabar, Nigeria, and 80 apparently healthy controls matched for age/ gender. The participants were interviewed, examined and had resting transthoracic echocardiography. The data were analyzed using IBM SPSS version 20.0. Results: A total of 160 subjects were recruited into the study with a male to female ratio of 2.8:1. There was no difference in the mean age of cases and controls (P = 0.115). Systolic function of the left ventricle was similar in the two arms. However, left ventricular diastolic dysfunction, left atrial enlargement, and increased left ventricular mass index (LVMI) were more prevalent among the patients with CLD compared to controls (P < 0.05). Conclusion: The study demonstrated increased left atrial diameter, increased LVMI associated with diastolic dysfunction, and preserved systolic function at rest among CLD patients.

scholarly journals Chronic Kidney Disease – Chronic Liver Disease. An Immunologic Cross-talk

2015 ◽  
Vol 53 (1) ◽  
pp. 3-12
Author(s):  
Gh. Gluhovschi ◽  
Ligia Petrica ◽  
I. Sporea ◽  
Manuela Curescu ◽  
Silvia Velciov ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Immune System ◽  
Liver Disease ◽  
Kidney Disease ◽  
Chronic Liver Disease ◽  
Liver Diseases ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Immune Mechanisms ◽  
The Relationship

Abstract The relationship between the kidney and other organs is notable. The bestknown is the relation with the cardiovascular system. Relationships with other organs are less studied, although their involvement sometimes dominates the clinical picture and the outcome of disease. The paper analyzes the kidney-liver relationship, namely chronic kidney disease and chronic liver disease from an immune viewpoint. The immune system operates as a unitary whole. There is an interdependence between the immune system of the liver, considered a lymphoid organ, and the kidney, whose participation in immune processes is well-known. The most important chronic liver diseases are viral hepatitis B and C. Infection with these viruses can lead to renal involvement, producing mainly glomerular disease. At the same time, secondary glomerulonephritis can cause an unfavorable outcome of the primary disease. The relationship between chronic liver disease and chronic kidney disease during chronic B and C hepatitis occurs via circulating immune complexes or complexes formed in situ. Cell-mediated immunity is also involved. The antiviral treatment of B and C hepatitis is also aimed at secondary glomerular disease. The participation of immune mechanisms raises the question of administering immunomodulating medication, a type of medication that influences viral replication - this is why it is associated with antiviral medication. Other two chronic liver diseases, namely liver cirrhosis, in which the main mechanism is a toxic one, and non-alcoholic steatohepatitis can produce via immune mechanisms glomerular involvement. In its turn, chronic kidney disease in advanced stages causes lipid metabolism disturbances with hypertriglyceridemia, which can influence fatty loading of the liver in the above-mentioned liver diseases. One can speak about a cross-talk between the liver and the kidney, in which immune mechanisms play an important role.

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