Morphometric Analysis of Second Cervical Vertebrae and Its Clinical Implications - A Cross Sectional Study

2009 ◽  
Vol 33 (9) ◽  
pp. 336-340
Author(s):  
John Dunn ◽  
Michael Haskew ◽  
Anshuman Pant

Aims and MethodTo investigate non-adherence to substitute opioid treatment, using a cross-sectional study design, with 630 patients from three London community drug services. Adherence was measured as the number of doses collected from the pharmacy as a proportion of the total number of doses stipulated on the prescription during a 28-day period and was further investigated through laboratory urine drug screens.ResultsOverall, 30.5% (n= 191) of individuals failed to pick up at least one dose of medication from the pharmacy over 1 month, but only 1.6% (n= 10) missed 50% or more of their doses. Non-adherence was associated with supervised consumption, more frequent pick-up, shorter duration of treatment, younger age, a lower dose of methadone and a recent urinalysis result positive for opiates.Clinical ImplicationsTreatment services need to monitor levels of adherence to treatment and develop strategies to improve it so that treatment can be optimised effectively.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yuji Shimizu ◽  
Shin-Ya Kawashiri ◽  
Yuko Noguchi ◽  
Yasuhiro Nagata ◽  
Takahiro Maeda ◽  
...  

AbstractOur recent studies indicate that thyroid cysts have clinical implications. Thyroid cysts could have a positive effect on the supply of thyroid hormones. Both hyperthyroidism and hypothyroidism cause hypertension. Hypothyroidism, but not hyperthyroidism, is a risk factor for atherosclerosis. Therefore, thyroid cysts could be associated with hypertension, and atherosclerosis might influence the association between thyroid cysts and hypertension. To evaluate the clinical significance of thyroid cysts, a cross-sectional study was conducted with 1801 Japanese aged 40–74 years. Thyroid cysts were significantly positively associated with hypertension in participants without atherosclerosis. However, there was a significant inverse association in those with atherosclerosis. The potential confounding factor adjusted odd ratios and 95% confidence intervals (95% CIs) were 1.49 (95% CI 1.17–1.90) for participants without atherosclerosis and 0.49 (95% CI 0.24–0.98) for those with atherosclerosis. The present study demonstrates that thyroid cysts have clinical implications because thyroid cysts support thyroid hormone activity. Our findings provide sufficient evidence to develop a risk assessment for hypertension for the general population, even though further research is required.


2016 ◽  
Vol 2 (4) ◽  
pp. 213
Author(s):  
JayasankarPurushothaman Pillai ◽  
Riddhi Patel ◽  
Alka Banker ◽  
J Rajarajeswari ◽  
Sukhdev Mishra

2015 ◽  
Vol 18 ◽  
Author(s):  
María de Gracia León-Palacios ◽  
Juan Úbeda-Gómez ◽  
Silvia Escudero-Pérez ◽  
María Dolores Barros-Albarán ◽  
Ana María López-Jiménez ◽  
...  

AbstractThis study was designed to find out whether a person’s relationship with his voices and the negative affect he suffers from are mediated by beliefs about the voices. Research done to date shows contradictory results (Sorrell, Hayward, & Meddings, 2010, Vaughan & Fowler, 2004). A cross-sectional study was done to study the associations among variables, and a multiple mediation model (Preacher & Hayes, 2008) in which the beliefs about voices were the mediating variables was tested. Sixty subjects who heard voices participated. The VAY (Hayward, Denney, Vaughan, & Fowler, 2008), BAVQ (Chadwick & Birchwood, 1995), BAI (Beck & Steer, 1993) and BDI-II (Beck, Steer & Brown, 1996) were given. We found a significant positive correlation between perception of voices as dominant and intrusive and maintaining a position of distance from them on one hand, and negative affect [anxiety (r = .57, p < .001; r = .40, p < .001; r = .34, p < .01 respectively) and depression (r = .58, p < .001; r = .37, p < .01; r = .38, p < .001 respectively)] on the other. We also found that beliefs of malevolence and omnipotence mediated between relating style and negative affect (anxiety and depression). The theoretical implications of the results and clinical implications of the mediating relationships found are discussed.


2013 ◽  
Vol 23 (1) ◽  
pp. 19-20 ◽  
Author(s):  
M. Nosè ◽  
C. Barbui

According to a recent cross-sectional study, some antidepressants, including amitriptyline, citalopram and escitalopram, are associated with QTc prolongation. However, the magnitude of this association is relatively small, and the clinical implications uncertain. In this article, the main strengths and weaknesses of this cross-sectional study are briefly analysed alongside recent warnings issued by regulatory authorities. Implications for research and practice are discussed.


2015 ◽  
Vol 28 (6) ◽  
pp. 726 ◽  
Author(s):  
Maria Joana Santos ◽  
Vera Fernandes ◽  
Fernando Mota Garcia

<strong>Introduction:</strong> Although vitamin D deficiency is increasingly recognized around the world, there are few studies on the Portuguese reality. This study aims to analyse vitamin D levels in the assays performed in our hospital and their relationship with age, genre, requesting specialty and moment of sample collection.<br /><strong>Material and Methods:</strong> Cross-sectional study of measurements of 25(HO)D performed in our Hospital between June 2012 and November 2014. Included variables: gender, age, requesting specialty, month of sample collection. Vitamin D status classified as: ‘Deficiency’ (≤ 20 ng/mL), ‘Insufficiency’ (21 - 29 ng/ml) and ‘Sufficiency’ (≥ 30 ng/mL).<br /><strong>Results:</strong> We included 5 439 assays; 55.0% from women; the median age was 64.0 years. Sixty per cent had ‘Deficiency’, 20.7% ‘Insufficiency’ and 18.9% ‘Sufficiency’. We found a negative correlation between age and vitamin D level (p &lt; 0.001). We didn’t find differences in vitamin D levels between genres. Nine specialties requested 98% of the assays, namely Nephrology (56.2%). We found differences between specialties based on age and vitamin D level (p &lt; 0.001). Vitamin D levels changed throughout the year, with higher levels in the summer, followed by autumn, spring and winter (p &lt; 0.001). Despite this seasonal fluctuation, vitamin D sufficiency was only present in a minority of assays (27.8% in summer and 9.2% in winter).<br /><strong>Discussion:</strong> Vitamin D deficiency is prevalent in this population, affects individuals of all ages and is not offset by the seasonal variation of sunlight.<br /><strong>Conclusion:</strong> Vitamin D deficiency is a real and prevalent problem in our population that needs further attention and action, given its clinical implications.


2021 ◽  
Vol 67 (3) ◽  
pp. 186-192
Author(s):  
Elena Galan ◽  
◽  
Andreea Raluca Hlatcu ◽  
Angelica Bencze ◽  
Elina Teodorescu ◽  
...  

In order to verify the concordance of the bone development indices (SMI) estimated on the hand and fist radiograph by the method of Fishman (1982) and the indices of development of the cervical vertebrae (CVMS), estimated on the profile teleradiography by the method of Baccetti (2002), was conducted a cross-sectional study on a group of 150 subjects (89 girls and 61 boys), aged 8-18 years. Based on the existing data in the literature and taking into account the average ages at which the SMI and CVMS stages were reached in the research group, a hypothesis of correspondence between SMI and CVMS stages in the pubertal stages was issued and this hypothesis was statistically verified using the coefficient Cohen k. The obtained results (k = 0.82 for the girls 'group and k = 0.67 for the boys' group) confirm the concordance of the SMI and CVMS indices within the researched group and validate the correspondence hypothesis issued.


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