Formulation and Evaluation of Fast Disintegrating Tablet of Paclitaxel by Hydrotropy Technique

2020 ◽  
Vol 13 (01) ◽  
Keyword(s):  
Fast Disintegrating Tablet

A novel fast disintegrating tablet fabricated by three‐dimensional printing

2009 ◽  
Vol 00 (00) ◽  
pp. 090730035508060-7
Author(s):  
Deng-Guang Yu ◽  
Chris Branford-White ◽  
Yi-Cheng Yang ◽  
Li-Min Zhu ◽  
Edward William Welbeck ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Three Dimensional Printing ◽  
Fast Disintegrating Tablet ◽  
Dimensional Printing

scholarly journals FORMULATION AND EVALUATION OF ORAL FAST DISINTEGRATING TABLET OF IBUPROFEN USING TWO SUPER DISINTEGRANTS

2017 ◽  
Vol 9 (4) ◽  
pp. 92
Author(s):  
Hrishav Das Purkayastha ◽  
Bipul Nath
Keyword(s):  
Drug Release ◽  
Magnesium Stearate ◽  
Direct Compression ◽  
Compression Method ◽  
Disintegration Time ◽  
Orally Disintegrating Tablet ◽  
Rapid Release ◽  
Weight Variation ◽  
Fast Disintegrating Tablet

Objective: The aim of the present investigation was to design and evaluate orally disintegrating tablet (ODT) of Ibuprofen, a NSAID drug used for the treatment of arthritis with a view to improve its oral bioavailability. The focus of the current study was to develop ODT of Ibuprofen using super disintegrants for ease of administration and its physicochemical characterization.Methods: Tablets were made from blends by direct compression method. All the ingredients were passed through mesh no. 80. All the ingredients were co-ground in a pestle motor. The resulting blend was lubricated with magnesium stearate and compressed into tablets using the Cadmach single punch (round shaped, 8 mm thick) machine.Results: Physicals parameters of the prepared tablets like Hardness, Weight variation, Friability, thickness, drug content etc. found within the limits. The disintegration time of prepared ODTs was in the range of 45 to 55 seconds. In vitro dispersion time was found to be 22 to 52 seconds which may be attributed to faster uptake of water due to the porous structure formed by super disintegrants. Short disintegration and faster release of ibuprofen were observed with Cross carmellose sodium as compared to sodium starch glycollate.Conclusion: It is concluded that F3 offered the relatively rapid release of Ibuprofen when compared with other formulations. The increase in the concentrations of super disintegrants may lead to increase in the drug release. The formulation prepared with cross carmellose sodium was offered the relatively rapid release of Ibuprofen when compared with other concentrations of both the super disintegrant. 

scholarly journals Formulation Study for Lansoprazole Fast-disintegrating Tablet. I. Effect of Compression on Dissolution Behavior

2003 ◽  
Vol 51 (8) ◽  
pp. 942-947 ◽  
Author(s):  
Toshihiro Shimizu ◽  
Yoshinori Nakano ◽  
Shuji Morimoto ◽  
Tetsuro Tabata ◽  
Naoru Hamaguchi ◽  
...  
Keyword(s):  
Dissolution Behavior ◽  
Fast Disintegrating Tablet

scholarly journals Formulasi Fast Disintegrating Tablet Ekstrak Etanol Daun Salam dengan Kombinasi Crospovidone dan Croscarmellose Sodium sebagai Superdisintegrants

2021 ◽  
Vol 8 (3) ◽  
pp. 285
Author(s):  
Widyasari Putranti ◽  
Citra Ariani Edityaningrum ◽  
Endah Prastyaningrum ◽  
Lina Widiyastuti
Keyword(s):  
Program Design ◽  
T Test ◽  
Design Expert ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Fast Disintegrating Tablet ◽  
Croscarmellose Sodium ◽  
Simplex Lattice

Pengembangan formulasi ekstrak daun Salam (Syzygium polyanthum W.) sebagai antihiperlipidemia yang mampu hancur cepat setelah diletakkan di atas lidah sangat diperlukan untuk mempercepat onset obat dan memberikan kenyamanan terutama pada pasien hiperlipidemia usia lanjut yang sulit menelan obat. Tujuan dari penelitian ini untuk mengetahui komposisi perbandingan superdisintegrants crospovidone dan croscarmellose sodium yang mampu menghasilkan sifat fisik Fast Disintegrating Tablet (FDT) yang optimum. Pembuatan FDT menggunakan metode granulasi basah dengan variasi konsentrasi crospovidone dan croscarmellose sodium dalam rentang 2%-5%. Hasil uji sifat fisik FDT dianalisis menggunakan metode Simplex Lattice Design (SLD) program Design Expert 10.1.). Kombinasi kedua superdisintegrants dapat mempengaruhi respon sifat fisik yaitu mampu menurunkan kekerasan, waktu disintegrasi, waktu pembasahan dan meningkatkan kerapuhan FDT ekstrak daun salam. Formula optimum didapat pada kombinasi crospovidone dan croscarmellose sodium dengan perbandingan 25 mg : 10 mg dalam setiap 500 mg tablet. Formula optimum tersebut memiliki kekerasan 4,21 kg, kerapuhan 0,52%, waktu pembasahan 106,65 detik, dan waktu hancur 55,73 detik. Hasil analisis dengan one sample t-test menunjukkan persamaan SLD valid digunakan untuk menyusun formula yang memberikan parameter-parameter optimum FDT.

scholarly journals Pharmacokinetic and bioavailability study of lercanidipine hydrochloride fast disintegrating tablets in rabbits by high-performance liquid chromatography

2020 ◽  
Vol 11 (4) ◽  
pp. 7289-7292
Author(s):  
Seema Saini ◽  
Rajeev Garg
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Plasma Concentration ◽  
High Performance ◽  
Pharmacokinetic Parameters ◽  
Pharmacokinetic Data ◽  
Blood Samples ◽  
Fast Disintegrating Tablet ◽  
Fast Disintegrating Tablets ◽  
Lercanidipine Hydrochloride

In the present study, fast disintegrating tablets of Lercanidipine Hydrochloride (LFDT) were tested in vivo in the buccal cavity of the rabbits. Various pharmacokinetic parameters were analysed in the study, including maximum measured plasma concentration (Cmax), time of maximum measured plasma concentration (tmax) and area under the plasma concentration vs time curve (AUC). Also, the comparative study of the Lercanidipine Hydrochloride fast disintegrating tablets (LFDT) was performed with the marketed conventional tablets of the drug (LMKT). The technique selected for the bioanalytical analysis of the blood samples of the rabbits for pharmacokinetic data computation was High-Performance Liquid Chromatography. An already well-established and validated method was used to analyse the blood samples of the rabbits. The results revealed that the rate of absorption was improved for fast disintegrating tablets of Lercanidipine Hydrochloride (LFDT) as compared to the marketed conventional tablets of the drug (LMKT). This indicated that drug was rapidly absorbed from the fast disintegrating tablet and attained elevated plasma concentration in a short interval after dosing than the marketed formulation. However, the value of tmax was drastically shorter for LFDT than the LMKT. The average peak plasma concentration also designated a rise in the extent of absorption (AUC). From the present study, it was concluded that the fast disintegrating tablet batch (LFDT) had much more improved pharmacokinetic parameters as compared to its conventional marketed counterpart (LMKT).

scholarly journals Formulation and Evaluation of Sustained Release Preparation of Ibuprofen Fast-Disintegrating Tablet (FDT)

2011 ◽  
Vol 41 (1) ◽  
pp. 51-57
Author(s):  
Kwang-Hyeon Kim ◽  
Jun-Bom Park ◽  
Joo-Hyung Kang ◽  
Kun-Hee Lee ◽  
Chin-Yang Kang
Keyword(s):  
Sustained Release ◽  
Sustained Release Preparation ◽  
Release Preparation ◽  
Fast Disintegrating Tablet

Formulation Development and Evaluation of Fast Disintegrating Sustained Release Pellets Containing Verapamil Hydrochloride Tablets by Fluidized Bed Processor

2021 ◽  
pp. 261-266
Author(s):  
Jagruti J. Pansare ◽  
Rajendra K. Surawase
Keyword(s):  
Sustained Release ◽  
Fluidized Bed ◽  
Extended Period ◽  
Coating Film ◽  
Formulation Development ◽  
Eudragit Rs 30D ◽  
Fast Disintegrating Tablet ◽  
Model Drug ◽  
Verapamil Hcl ◽  
Tablet Hardness

This study aimed to developed novel fast disintegrating sustained release pellets containing tablet by using Fluidized Bed processor. Verapamil HCl used as a model drug for the formulation. Fluidized bed processor was used for coating of drug and polymer on the sugar spheres. To overcome the problem of swallowing for paediatric, geriatric, psychiatric, bedridden patients, uncooperative patients or for active patients who are busy and travelling and may not access to we aim to formulate the fast-disintegrating tablet. The superdisintigrant are commonly use like cross povidone, sodium starch glycolate which disintegrate tablet rapidly. It is assumed that, after the disintegration of tablets, pellets within tablets which are reside in GIT for several hours and gradually released a drug in controlled way. Eudragit RS 30D and ethyl cellulose were used as a sustained release polymer. Coating of spheres with sustained release film is achieved by bottom spray processor of FBP. Proper pellets coating film thickness, and concentration of polymers’, ensure obtaining desirable VH release profile for extended period of time, was defined. X composition of tablet with pellets were examined in order to obtained formulation, from which VH release would mostly appropriate pellets before compressing. Compression of pellets into tablet, being a modern technological process than enclosing them into hard gelatine capsule. The optimized batch evaluated by studied the effect of compression force, tablet hardness and friability and drug release from the pellets by sustained release manner.

Sign in / Sign up

Export Citation Format

Share Document