Synthesis and Antimicrobial Activity of Bisphosphonates

2009 ◽  
Vol 2009 (4) ◽  
pp. 258-260 ◽  
Author(s):  
M. Veera Narayana Reddy ◽  
K.R. Kishore Kumar Reddy ◽  
C. Bhupendra Reddy ◽  
B. Siva Kumar ◽  
C. Suresh Reddy ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Data ◽  
Mass Spectral Data ◽  
Step Process ◽  
Mass Spectral

Dimethyl [(substitutedphenyl)(6-oxo6λ5dibenzo[ d,f][1,3,2]dioxaphophepin-6-yl)methyl]phosphonates (5a-j) were synthesised through a three step process involving preparation of dimethyl hydroxy(substitutedphenyl)methyl-phosphonates (4a-j) and their reaction with 6-bromodibenzo[ d,f][1,3,2]dioxaphosphepine (2) in dry toluene in the presence of triethylamine at 50–60°C. Tetramethylguanidine (TMG) as a catalyst was found to increase the yields and purity of the products. These compounds were characterised by IR, 1H, 13C, 31P NMR and mass spectral data found to possess higher antimicrobial activity then the standards.

scholarly journals Green Synthetic Protocol for (E)-1-Aryl-3-(2-morpholinoquinolin- 3-yl)prop-2-en-1-ones and Their Antimicrobial Activity

2019 ◽  
Vol 31 (9) ◽  
pp. 1895-1898
Author(s):  
Relangi Siva Subrahmanyam ◽  
Venkateswara Rao Anna
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Data ◽  
1H Nmr ◽  
13C Nmr ◽  
Mass Spectral Data ◽  
In Vitro Antimicrobial Activity ◽  
Mass Spectral ◽  
Fungal Organisms

We report here an easy, efficient and green synthetic protocol for the (E)-1-aryl-3-(2-morpholinoquinolin-3-yl)prop-2-en-1-ones by the Claisen-Schmidt condensation of 2-morpholinoquinoline-3-carbaldehyde and different substituted acetophenones by using 1-butyl-3-methylimidazolium tetrafluoroborate (Bmim)BF4. The compounds were characterized by using 1H NMR, 13C NMR and mass spectral data and screened there in vitro antimicrobial activity against different bacterial and fungal organisms.

scholarly journals Synthesis and Antimicrobial Activity ofSome New 2-Substituted Benzothiazole Derivatives

2009 ◽  
Vol 6 (3) ◽  
pp. 775-779 ◽  
Author(s):  
B. Rajeeva ◽  
N. Srinivasulu ◽  
S. M. Shantakumar
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Data ◽  
Diffusion Method ◽  
Disc Diffusion ◽  
Phosphoryl Chloride ◽  
Mass Spectral Data ◽  
Disc Diffusion Method ◽  
Mass Spectral ◽  
Benzothiazole Derivatives ◽  
H Nmr

Some new 2-(5-substituted-1,3,4-oxadiazole-2-yl)-1,3- benzothiazole(3a-j)were synthesized by refluxing benzothiazolyl carboxyhydrazide with different aryl acids in phosphoryl chloride. Structures of the synthesized compounds were established on the basis of1H NMR and Mass spectral data. The anti microbial activity of the synthesized compounds was evaluated by disc diffusion method.

scholarly journals Synthesis and Antimicrobial Activity of 2-(4-Phenyl-2H-chromen-3-yl)-1H-benzo[d]imidazole

2021 ◽  
Vol 33 (8) ◽  
pp. 1723-1728
Author(s):  
Ramachandraiah Dasari ◽  
Gangadhar Thalari ◽  
Jayaprakash Rao Yerrabelly ◽  
Prasad Rao Chitneni
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Data ◽  
Column Chromatography ◽  
13C Nmr ◽  
Mass Spectral Data ◽  
Mass Spectral

A new series of 4-phenyl-2H-chromene-3-benzimidazoles (8a-o) were synthesized by the condensation of 4-phenyl-2H-chromene-3-carbaldehyde with o-phenylene diamines. The products were purified through column chromatography and structures of these compounds were characterized by IR, 1H & 13C NMR and mass spectral data. All the final compounds were screened for their antimicrobial activity and their efficacy were matched with ciprofloxacin. Five compounds (8b, 8d, 8i, 8l and 8o) were found to be most effective compounds of this series and with activities improved than ciprofloxacin under the tested conditions

scholarly journals Synthesis and Antimicrobial Activity of (2-Methoxy/2-Amino)-6-{4'-[(4'''-Chlorophenyl) (Phenyl) Methyl Amino] Phenyl}-4-Aryl Nicotinonitrile

2015 ◽  
Vol 49 ◽  
pp. 99-103
Author(s):  
J.V. Guna ◽  
V.N. Bhadani ◽  
H.D. Purohit ◽  
Dipak M. Purohit
Keyword(s):  
Antimicrobial Activity ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Spectral Data ◽  
Elemental Analysis ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Bacteria And Fungi ◽  
Layer Chromatography

2- Methoxy – 6 - {4' - [(4'''- Chlorophenyl) (phenyl) methyl amino] phenyl} - 4 - aryl nicotinonitrile (3a-3l) and 2-Amino-6-{4'-[(4'''-Chlorophenyl)(phenyl)methyl amino]phenyl}-4-aryl nicotinonitrile (4a-4l) have been synthesized. The products have been assayed for their antimicrobial activity against Gram +ve, Gram -ve bacteria and fungi. The structure of the products has been elucidated by IR, 1H-NMR, mass spectral data, elemental analysis and thin layer chromatography.

scholarly journals Synthesis and Biological Evaluation of Some Novel 1, 3, 5-Trisubstituted Pyrazolines

2010 ◽  
Vol 7 (1) ◽  
pp. 295-298 ◽  
Author(s):  
B. C. Revanasiddappa ◽  
R. Nagendra Rao ◽  
E. V. S. Subrahmanyam ◽  
D. Satyanarayana
Keyword(s):  
Antimicrobial Activity ◽  
Acetic Acid ◽  
Spectral Data ◽  
Glacial Acetic Acid ◽  
Biological Evaluation ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Synthesis And Biological Evaluation

A new series of chalcones (3a-j) were synthesized by condensation of simple aldehydes with substituted acetophenones in presence of alkali. The resulted chalcones upon cyclization in presence of glacial acetic acid with isoniazid (INH) will yields the title compounds (4a-j). The newly synthesized compounds were assigned on the basis of IR,1H NMR, and Mass spectral data. All the final compounds were evaluated for theirin vitroantimicrobial activity.

scholarly journals Synthesis, Characterization, and Biological Evaluation of Some New Functionalized Terphenyl Derivatives

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Seranthimata Samshuddin ◽  
Badiadka Narayana ◽  
Balladka Kunhanna Sarojini ◽  
Divya N. Shetty ◽  
Nalilu Suchetha Kumari
Keyword(s):  
Antimicrobial Activity ◽  
Antioxidant Activity ◽  
Spectral Data ◽  
Antioxidant Properties ◽  
Biological Evaluation ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr

New functionalized terphenyl derivatives incorporating various heterocyclic rings are prepared by using 4,4′′-difluoro-5′-hydroxy-1,1′:3′,1′′-terphenyl-4′-carbohydrazide as a key intermediate derived from 4,4′-difluoro chalcone, a versatile synthone. All the derivatives are characterized by 1H NMR, IR, and mass spectral data. All the synthesized products are screened for their in vitro antimicrobial and antioxidant properties. The majority of the tested compounds exhibited significant antioxidant activity and some of them showed good antimicrobial activity.

scholarly journals Synthesis and Antimicrobial Screening 6-Aryl-2-(Amino/Methoxy)-4-[(4′-Difluoro Methoxy) (3′-Hydroxy) Phenyl] Nicotinonitrile

2015 ◽  
Vol 50 ◽  
pp. 35-42 ◽  
Author(s):  
Vijay N. Bhadani ◽  
Piyush A. Patel ◽  
Heta D. Purohit ◽  
Dipak M. Purohit
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Data ◽  
1H Nmr ◽  
Elemental Analysis ◽  
Sodium Methoxide ◽  
Ammonium Acetate ◽  
Mass Spectral Data ◽  
Antimicrobial Screening ◽  
Mass Spectral ◽  
Efficient Route

A series of an easy and efficient route for the synthesis of some new 2-amino-3-cyanopyridine (4a-4i) and 2-methoxy-3-cyanopyridine (5a-5i) derivatives were synthesized through the reaction of various chalcone (3a-3i) with malononitrile in presence of ammonium acetate and sodium methoxide, respectively. The constitutions of the all synthesized compounds have been established by the IR, 1H-NMR, Mass spectral data and Elemental analysis. Furthermore, all the synthesized products were screened for their antimicrobial activity.

Synthesis and study of some new N-substituted imide derivatives as potential antibacterial agents

2010 ◽  
Vol 64 (5) ◽  
Author(s):  
Abd Khalil ◽  
Moged Berghot ◽  
Moustafa Gouda
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Data ◽  
13C Nmr ◽  
Antibacterial Agents ◽  
Mass Spectral Data ◽  
1H And 13C Nmr ◽  
Mass Spectral ◽  
Starting Compound

AbstractDibenzobarrelene (I) was used as a starting compound for the synthesis of some new 3a,4,9,9a-tetrahydro-4,9-[1,2]benzeno-1H-benzo[f]isoindole-1,3(2H)-diones, N-substituted with: 4-toluenesulfonyloxy, III; butoxy, IV; 3-bromopropoxy, V; 3-(4-phenylpiperazin-1-yl)propoxy, VI; 3-chloro-3-oxopropyl, VIII; 3-(4-phenylpiperazin-1-yl)-3-oxopropyl, IXa; 3-(4-methylpiperazin-1-yl)-3-oxopropyl, IXb; 3-oxo-3-(piperidin-1-yl)propyl, X; 3-morpholino-3-oxopropyl, XI; 3-phenylamino-3-oxopropyl, XII; 2-acetylaminoethyl, XIV; 2-aminoethyl, XV, and 2-acetoxyethyl, XVI. Newly synthesized compounds were characterized by IR, 1H and 13C NMR, and mass spectral data. Selected products were tested for antimicrobial activity.

scholarly journals Synthesis and Antimicrobial Activity of Some Novel Substituted Piperazinyl-quinazolin-3(4H)-ones

2008 ◽  
Vol 5 (1) ◽  
pp. 23-33 ◽  
Author(s):  
N. M. Raghavendra ◽  
P. P. Thampi ◽  
P. M. Gurubasavarajaswamy
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Data ◽  
Elemental Analysis ◽  
Single Step ◽  
Mass Spectral Data ◽  
Antifungal Activities ◽  
Mass Spectral ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
Single Step Reaction

Several substituted-quinazolin-3(4H)-ones were synthesized by condensation of 2-chloro-N-(4-oxo-substituted-quinazolin-3(4H)-yl)-acetamides with various substituted piperazines through single step reaction. Elemental analysis, IR,1HNMR and mass spectral data confirmed the structure of the newly synthesized compounds. Synthesized quinazolin-4-one derivatives were investigated for their antibacterial and antifungal activities.

scholarly journals Antimicrobial Activity of some Pyrimidine Derivatives in DMF and DMSO

2015 ◽  
Vol 56 ◽  
pp. 131-141
Author(s):  
Shipra Baluja ◽  
Sumitra Chanda ◽  
Kajal Nandha
Keyword(s):  
Antimicrobial Activity ◽  
Dimethyl Sulfoxide ◽  
Spectral Data ◽  
Dimethyl Formamide ◽  
Mass Spectral Data ◽  
Pyrimidine Derivatives ◽  
Gram Negative ◽  
Mass Spectral ◽  
H Nmr

A series of pyrimidine derivatives have been synthesized and their structures were confirmed by IR, 1H NMR and mass spectral data. All these synthesized compounds were tested in vitro for their antimicrobial potential against Gram positive, Gram negative strains of bacteria as well as fungal strains in N, N-dimethyl formamide and dimethyl sulfoxide.

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