An Efficient One-Pot Method for a Highly Stereoselective Base-Catalysed Synthesis of Novel Trans-Spirocyclopropane-Indanedione Derivatives
2017 ◽
Vol 41
(10)
◽
pp. 611-613
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A one-pot, efficient, synthesis of six novel trans-spirocyclopropane-indanedione derivatives with high stereoselectivity has been achieved via the reaction of acetopyridinium chloride with 1,3-indandione and an araldehyde in the presence of triethylamine in acetonitrile under reflux conditions. The attractive features of the method are excellent yields and high purity, short reaction times, and easy work-up.