Synthesis of Novel Derivatives of (Benz)Imidazo[2,1-b]Pyrimido[4,5-d][1,3]Thiazine

2017 ◽  
Vol 41 (12) ◽  
pp. 730-733 ◽  
Author(s):  
Marzieh Akbarzadeh ◽  
Mehdi Bakavoli ◽  
Hossein Eshghi ◽  
Ali Shiri
Keyword(s):  
Secondary Amines ◽  
The Novel ◽  
One Pot ◽  
The One ◽  
Derivatives Of

Several derivatives of the novel heterocyclic systems 2-substituted-imidazo- and benzimidazo-[2,1- b]pyrimido[4,5- d][1,3]thiazine have been synthesised through the one-pot cyclocondensation of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine with imidazolidine-2-thione and 1 H-benzimidazole-2(3 H)-thione and subsequently substituted by various secondary amines in moderately good yields.

scholarly journals Facile Synthesis of COF-Supported Reduced Pd-Based Catalyst for One-Pot Reductive Amination of Aldehydes

Catalysts ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 287
Author(s):  
Jianguo Liu ◽  
Mingyue Zhang ◽  
Longlong Ma
Keyword(s):  
Heterogeneous Catalysts ◽  
Reductive Amination ◽  
Secondary Amines ◽  
Metallic State ◽  
One Pot ◽  
Effective Synthesis ◽  
Pharmaceutical Industries ◽  
The One ◽  
Heterocyclic Aldehydes ◽  
Supported Pd

Dibenzylamine motifs are an important class of crucial organic compounds and are widely used in fine chemical and pharmaceutical industries. The development of the efficient, economical, and environmentally friendly synthesis of amines using transition metal-based heterogeneous catalysts remains both desirable and challenging. Herein, we prepared the covalent organic framework (COF)-supported heterogeneous reduced COF-supported Pd-based catalyst and used it for the one-pot reductive amination of aldehydes. There are both Pd metallic state and oxidated Pdσ+ in the catalysts. Furthermore, in the presence of the reduced COF-supported Pd-based catalyst, many aromatic, aliphatic, and heterocyclic aldehydes with various functional groups substituted were converted to their corresponding amines products in good to excellent selectivity (up to 91%) under mild reaction conditions (70 °C, 2 h, NH3, 20 bar H2). This work expands the covalent organic frameworks for the material family and its support catalyst, opening up new catalytic applications in the economical, practical, and effective synthesis of secondary amines.

One-pot synthesis of 3-aminofurans using a simple and efficient recyclable CuI/[bmim]PF6 system

2021 ◽  
Author(s):  
Guguloth Veeranna ◽  
Ramesh Balaboina ◽  
Narasimha Swamy Thirukovela ◽  
Ravindhar Vadde
Keyword(s):  
Secondary Amines ◽  
Terminal Alkynes ◽  
One Pot ◽  
One Pot Synthesis ◽  
System P ◽  
Three Component Reaction ◽  
The One

The one-pot three-component reaction of several 2-ketoaldehdyes, secondary amines and terminal alkynes to access 3-aminofurans was proceeded well in [bmim][PF6] using a simple and cheap CuI catalyst. The resulted 3-aminofuran...

Intermetallic Ni2Si/SiCN as a highly efficient catalyst for the one-pot tandem synthesis of imines and secondary amines

2020 ◽  
Vol 7 (1) ◽  
pp. 82-90 ◽  
Author(s):  
Xiao Chen ◽  
Shuhua Han ◽  
Dongdong Yin ◽  
Changhai Liang
Keyword(s):  
High Activity ◽  
Aromatic Amine ◽  
Reductive Amination ◽  
High Selectivity ◽  
Secondary Amines ◽  
One Pot ◽  
Efficient Catalyst ◽  
Highly Efficient ◽  
The One ◽  
Tandem Synthesis

For the one-pot reductive amination of benzaldehyde with nitrobenzene, intermetallic Ni2Si/SiCN from the decomposition of a nickel-modified polysilazane precursor exhibited high activity (>99%) and high selectivity (92% to aromatic amine).

One-pot, chemoselective synthesis of secondary amines from aryl nitriles using a PdPt–Fe3O4 nanoparticle catalyst

2020 ◽  
Vol 10 (13) ◽  
pp. 4201-4209
Author(s):  
Jin Hee Cho ◽  
Sangmoon Byun ◽  
Ahra Cho ◽  
B. Moon Kim
Keyword(s):  
Reductive Amination ◽  
Secondary Amines ◽  
Fe3o4 Nanoparticle ◽  
Catalytic Method ◽  
One Pot ◽  
Chemoselective Synthesis ◽  
Aryl Nitriles ◽  
The One ◽  
Nanoparticle Catalyst

We have developed a new catalytic method for the one-pot, cascade synthesis of unsymmetrical secondary amines via the reductive amination of aryl nitriles with nitroalkanes using a PdPt–Fe3O4 nanoparticle (NP) catalyst.

scholarly journals Water-Soluble O-, S- and Se-Functionalized Cyclic Acetyl-triaza-phosphines. Synthesis, Characterization and Application in Catalytic Azide-alkyne Cycloaddition

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5479
Author(s):  
Abdallah Mahmoud ◽  
Piotr Smoleński ◽  
M. Guedes da Silva ◽  
Armando Pombeiro
Keyword(s):  
Cycloaddition Reaction ◽  
Structural Features ◽  
Water Soluble ◽  
31P Nmr Spectroscopy ◽  
The Novel ◽  
X Ray Diffraction ◽  
One Pot ◽  
Hirshfeld Surfaces ◽  
The One ◽  
High Yields

The 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA) derivatives, viz. the already reported 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane 5-oxide (DAPTA=O, 1), the novel 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane-5-sulfide (DAPTA=S, 2), and 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane-5-selenide (DAPTA=Se, 3), have been synthesized under mild conditions. They are soluble in water and most common organic solvents and have been characterized using 1H and 31P NMR spectroscopy and, for 2 and 3, also by single crystal X-ray diffraction. The effect of O, S, or Se at the phosphorus atom on the structural features of the compounds has been investigated, also through the analyses of Hirshfeld surfaces. The presence of 1–3 enhances the activity of copper for the catalytic azide-alkyne cycloaddition reaction in an aqueous medium. The combination of cheaply available copper (II) acetate and compound 1 has been used as a catalyst for the one-pot and 1,4-regioselective procedure to obtain 1,2,3-triazoles with high yields and according to ‘click rules’.

Reaktive E=C(p-p)π-Systeme, XXVIII / Reactive E=C(p-p)π-Systems, XXVIII

1991 ◽  
Vol 46 (8) ◽  
pp. 978-984 ◽  
Author(s):  
Joseph Grobe ◽  
Duc Le Van ◽  
Thomas Großpietsch
Keyword(s):  
Room Temperature ◽  
The Other ◽  
Molar Ratio ◽  
Primary Amines ◽  
Addition Reactions ◽  
The Novel ◽  
One Pot ◽  
Cycloaddition Product ◽  
Tert Butylamine ◽  
The One

The reaction of perfluoro-2-phosphapropene F3CP=CF2 (1) with tert-butylamine or isopropylamine in a 1:3 molar ratio leads to the novel iminomethylene phosphanes F3CP=C=N(tBu) [(2), 30% yield] and F3CP=C=N(iPr) [(3), 5%], respectively. 2 slowly decomposes at room temperature giving tert-butylisonitrile and the cyclophosphanes (F3CP)n (n = 3, 4, 5). 3 is found to be less stable than 2 and for example is attacked by primary amines. The reaction of 2 with 2,3-dimethyl-1,3-butadiene or trimethylphosphane yields, on the one hand, the cycloaddition product of bis(trifluormethyl)diphosphene (4), and on the other hand, the phosphorus ylid Me3P=PCF3 (5) together with (tBu)NC.2 and 3, respectively, are not obtained from (F3C)2PH and the corresponding primary amines in a series of HF elimination and H2NR addition reactions. The main products formed from a 1:4 molar mixture of (F3C)2PH and H2N(iPr) in a one-pot procedure were shown to be the chiral phosphanes F3CP[NH(iPr)]C[=N(iPr)]H (6), F3CP[NH(iPr)]CHF2 (7) and F3CP[NH(iPr)]CH2F (8) (60:35:5). The corresponding reaction of (F3C)2PH with H2N(tBu) mainly yields the compound F3CP[NH(tBu)]CH2F (10).

A Photoredox-Catalyzed Four Component Reaction for the Atom-Efficient Synthesis of Complex Secondary Amines

2020 ◽  
Author(s):  
Lisa Marie Kammer ◽  
Matthias Krumb ◽  
Benjamin Spitzbarth ◽  
Benjamin Lipp ◽  
Jonas Kühlborn ◽  
...  
Keyword(s):  
Secondary Amines ◽  
Efficient Synthesis ◽  
One Pot ◽  
Simultaneous Formation ◽  
Mild Conditions ◽  
Simple Protocol ◽  
Reaction Proceeds ◽  
Styrene Derivatives ◽  
The One ◽  
Single Bonds

The one-pot sulfonylation/aminoalkylation of styrene derivatives furnishing highly substituted gamma-sulfonylamines was accomplished through a photoredox-catalyzed four-component reaction. Apart from one molecule of water and the sodium counterion of the sulfinate, all atoms of the starting materials are transferred to the final product, rendering this process highly atom-efficient. The operationally simple protocol allows for the simultaneous formation of three new single bonds (C–S, C–N, and C–C) and therefore grants rapid access to structurally diverse products. The reaction proceeds under mild conditions in aqueous acetonitrile and shows a broad scope, including natural products and drug-like molecules.

A Photoredox-Catalyzed Four Component Reaction for the Atom-Efficient Synthesis of Complex Secondary Amines

2020 ◽  
Author(s):  
Lisa Marie Kammer ◽  
Matthias Krumb ◽  
Benjamin Spitzbarth ◽  
Benjamin Lipp ◽  
Jonas Kühlborn ◽  
...  
Keyword(s):  
Secondary Amines ◽  
Efficient Synthesis ◽  
One Pot ◽  
Simultaneous Formation ◽  
Mild Conditions ◽  
Simple Protocol ◽  
Reaction Proceeds ◽  
Styrene Derivatives ◽  
The One ◽  
Single Bonds

The one-pot sulfonylation/aminoalkylation of styrene derivatives furnishing highly substituted gamma-sulfonylamines was accomplished through a photoredox-catalyzed four-component reaction. Apart from one molecule of water and the sodium counterion of the sulfinate, all atoms of the starting materials are transferred to the final product, rendering this process highly atom-efficient. The operationally simple protocol allows for the simultaneous formation of three new single bonds (C–S, C–N, and C–C) and therefore grants rapid access to structurally diverse products. The reaction proceeds under mild conditions in aqueous acetonitrile and shows a broad scope, including natural products and drug-like molecules.

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