scholarly journals MERS-CoV in Upper Respiratory Tract and Lungs of Dromedary Camels, Saudi Arabia, 2013–2014

2015 ◽  
Vol 21 (7) ◽  
pp. 1153-1158 ◽  
Author(s):  
Abdelmalik I. Khalafalla ◽  
Xiaoyan Lu ◽  
Abdullah I.A. Al-Mubarak ◽  
Abdul Hafeed S. Dalab ◽  
Khalid A.S. Al-Busadah ◽  
...  
2016 ◽  
Vol 90 (9) ◽  
pp. 4838-4842 ◽  
Author(s):  
W. Widagdo ◽  
V. Stalin Raj ◽  
Debby Schipper ◽  
Kimberley Kolijn ◽  
Geert J. L. H. van Leenders ◽  
...  

Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor—dipeptidyl peptidase 4 (DPP4)—is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.


2021 ◽  
Author(s):  
Bradley Fevrier

The current SARS-CoV-2 (coronavirus) outbreak has reached pandemic proportions with a large global imprint. In December 2019, COVID-19 was first reported in Wuhan, Hubei Province, China and has continued largely unabated. The SARS-CoV-2 (coronavirus) is much talked about currently; however, it is worth noting that there are several different coronaviruses known to man, with most of them being responsible for causing illness in animals. Seven (7) types of coronaviruses are identified as causing illnesses in humans. Of the seven human coronavirus infections, four involve mild upper respiratory tract complaints that produce slight symptoms of the common cold. Conversely, the other three human coronavirus infections present more severe consequences as recently demonstrated by the SARS-CoV-2. These deadly outbreaks of pneumonia can have consequences that are far-reaching and are global in nature. SARS-CoV was the first new viral pandemic of the 21st century. It had its beginnings in southern China during November 2002 having started mysteriously; It was contained in 2004 after having spread to five continents and thirty-three countries, infecting approximately 8000 people. MERS-CoV the virus that the causes Middle East respiratory syndrome (MERS) was first identified in 2012 in Saudi Arabia and Jordan and has since registered roughly 2,220 confirmed cases and 790 deaths.


Author(s):  
Prihatini Prihatini

Upper respiratory tract infection usually has been presence on hajj pilgrims after they spent at the holy Mecca. They are known by long duration cough until they were come home. The pilgrims have been given health education how to live in Mecca and Medina before they go to Saudi Arabia and had meningitis vaccination as well. The purpose of this study is to know what the cause of the upper respiratory tract infection. If the pathogens have been found, before departure the infected pilgrims have been given antibiotics to prevent the pilgrimage ceremony to be disturbed.. Regarding the infection problems this study will be done, to give information whether the pathogenic that cause URI is from Indonesia or Saudi Arabia. About 118 people partially from Surabaya’s pilgrims were divided into 1st and 2nd groups (53 and 65 persons). Each group have been examined their pharyngeal swab before the departure to Mecca and after arrival in Surabaya. The samples were kept in transport media, than sent to the Clinical Pathologic Laboratory at Dr Soetomo Hospital. The swab samples were isolated and identificated after the cultivation in the incubator at the laboratory. From the118 pilgrims, only 95 persons completed the laboratory examination before the departure to Mekah and after they arrived in Surabaya. It is found before departure 5 person (5%) contaminated by pathogenic microorganism, four from K. pneumoniae and one A betahemolytic Streptococcus group. After their arrival about 97% have normal flora, but two of them contaminated by Gamma Streptococcus regarding to these results it is concluded that URI may cause by the environment, difference of weather or viral infection origin Because in the town at Saudi Arabia the pilgrim lived together with other peoples which came from various countries of the world.


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