Using Varying Diagnostic Criteria to Examine Mild Cognitive Impairment Prevalence and Predict Dementia Incidence in a Community-Based Sample

Background: Mild cognitive impairment (MCI) induced the majority number of dementia patients. The prevalence of MCI in China varied across studies with different screening tools and diagnostic criteria. Objective: A systematic review and meta-analysis was conducted to estimate the pooled MCI prevalence among the population aged 55 years and older in China. Methods: PubMed, EMBASE, CNKI, Wanfang, CQVIP, and CBMdisc were searched for studies on prevalence of MCI among Chinese elderly between January 1, 1980, and February 10, 2020. The quality assessment was conducted via external validity, internal validity, and informativity, the pooled prevalence was calculated through the random-effect model, and the homogeneity was evaluated by Cochran’s Q test and I2. Results: Fifty-three studies with 123,766 subjects were included. The pooled prevalence of MCI among Chinese elderly was 15.4% (95% CI: 13.5–17.4%). Subgroup analyses indicated that the prevalence calculated with different screening tools was 20.2% (95% CI: 15.1–25.9%) for Montreal Cognitive Assessment (MoCA) and 13.0% (95% CI: 10.7–15.5%) for Mini-Mental State Examination (MMSE). According to different diagnostic criteria, the prevalence was 14.8% (95% CI: 12.2–17.6%) for Petersen criteria, 15.0% (95% CI: 12.7–17.5%) for DSM-IV, and 21.2% (95% CI: 17.5–25.2%) for Chinese Expert Consensus on Cognitive Impairment (CECCI). Besides, women, older adults, illiterate people, rural residents, and those who lived with unhealthy lifestyles and morbidity showed higher prevalence. Conclusions: The prevalence of MCI in China was 15.4%, which varied by demographics, lifestyles, morbidity, screening tools, and diagnostic criteria. In further studies, screening tools and diagnosis criteria should be considered when estimating MCI prevalence.

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P3-161: Antithrombotic medication use and dementia incidence among people with mild cognitive impairment and atrial fibrillation

Alzheimer s & Dementia ◽

10.1016/j.jalz.2013.05.1233 ◽

2013 ◽

Vol 9 ◽

pp. P612-P612 ◽

Cited By ~ 3

Author(s):

Dana Meranus ◽

Walter Kukull

Keyword(s):

Atrial Fibrillation ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Medication Use ◽

Dementia Incidence ◽

Antithrombotic Medication

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Operationalizing the Diagnostic Criteria for Mild Cognitive Impairment: The Salience of Objective Measures in Predicting Incident Dementia

American Journal of Geriatric Psychiatry ◽

10.1016/j.jagp.2016.12.012 ◽

2017 ◽

Vol 25 (5) ◽

pp. 485-497 ◽

Cited By ~ 13

Author(s):

Henry Brodaty ◽

Liesbeth Aerts ◽

John D. Crawford ◽

Megan Heffernan ◽

Nicole A. Kochan ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Diagnostic Criteria ◽

Objective Measures ◽

Incident Dementia

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Using Fractional Anisotropy Imaging to Detect Mild Cognitive Impairment and Alzheimer’s Disease among Mexican Americans and Non-Hispanic Whites: A HABLE Study

Dementia and Geriatric Cognitive Disorders ◽

10.1159/000518102 ◽

2021 ◽

pp. 1-8

Author(s):

James R. Hall ◽

Leigh A. Johnson ◽

Fan Zhang ◽

Melissa Petersen ◽

Arthur W. Toga ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Fractional Anisotropy ◽

Mexican Americans ◽

Diffusion Tensor ◽

Characteristic Curve ◽

Aging Brain ◽

Community Based

Introduction: Alzheimer’s disease (AD) is the most frequently occurring neurodegenerative disease; however, little work has been conducted examining biomarkers of AD among Mexican Americans. Here, we examined diffusion tensor MRI marker profiles for detecting mild cognitive impairment (MCI) and dementia in a multi-ethnic cohort. Methods: 3T MRI measures of fractional anisotropy (FA) were examined among 1,636 participants of the ongoing community-based Health & Aging Brain among Latino Elders (HABLE) community-based study (Mexican American n = 851; non-Hispanic white n = 785). Results: The FA profile was highly accurate in detecting both MCI (area under the receiver operating characteristic curve [AUC] = 0.99) and dementia (AUC = 0.98). However, the FA profile varied significantly not only between diagnostic groups but also between Mexican Americans and non-Hispanic whites. Conclusion: Findings suggest that diffusion tensor imaging markers may have a role in the neurodiagnostic process for detecting MCI and dementia among diverse populations.

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Mild cognitive impairment: prevalence and incidence according to different diagnostic criteria

The British Journal of Psychiatry ◽

10.1192/bjp.182.5.449 ◽

2003 ◽

Vol 182 (5) ◽

pp. 449-454 ◽

Cited By ~ 142

Author(s):

Anja Busse ◽

Jeannette Bischkopf ◽

Steffi G. Riedel-Heller ◽

Matthias C. Angermeyer

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Longitudinal Study ◽

Diagnostic Criteria ◽

Community Sample ◽

Neuropsychological Testing ◽

Incidence Rates ◽

Prevalence Rates ◽

Case Definitions ◽

Increased Risk

BackgroundAlthough mild cognitive impairment is associated with an increased risk of developing dementia, there has been little work on its incidence and prevalence.AimsTo report age-specific prevalence, incidence and predictive validities for four diagnostic concepts of mild cognitive impairment.MethodA community sample of 1045 dementia-free individuals aged 75 years and over was examined by neuropsychological testing in a three-wave longitudinal study.ResultsPrevalence rates ranged from 3% to 20%, depending on the concept applied. The annual incidence rates applying different case definitions varied from 8 to 77 per 1000 person-years. Rates of conversion to dementia over 2.6 years ranged from 23% to 47%.ConclusionsMild cognitive impairment is frequent in older people. Prevalence, incidence and predictive validities are highly dependent on the diagnostic criteria applied.

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Utility of a Computerised Cognitive Screen in MCI and Depression in an Older Population

Australian Journal of Rehabilitation Counselling ◽

10.1375/jrc.16.1.14 ◽

2010 ◽

Vol 16 (1) ◽

pp. 14-26 ◽

Cited By ~ 6

Author(s):

Rachell Kingsbury ◽

Nancy A. Pachana ◽

Michael Humphreys ◽

Gerry Tehan ◽

Gerard J.A. Byrne

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Operating Characteristic ◽

Memory Loss ◽

Partial Support ◽

Community Based ◽

Symptoms Of Depression ◽

Clinically Significant ◽

Cognitive Screen

AbstractThe current study investigated the ability of CogniScreen to differentiate older adults with mild cognitive impairment (MCI) from those reporting symptoms of depression. Participants included 140 community-based adults (30 MCI, 15 self-rated depressed, and 95 typical older adults) aged 50–89 years. Intergroup comparisons performed using receiver operating characteristic (ROC) analyses suggest tasks within CogniScreen are sensitive to clinically significant memory loss. Data provided partial support for some CogniScreen tasks to also differentiate individuals with MCI from those who are depressed. Results suggest CogniScreen may be potentially useful in screening older adults for early cognitive decline.

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P1-058 Vienna transdanube aging (VITA): subtypes of mild cognitive impairment and prediction of dementia in a community-based age-cohort

Neurobiology of Aging ◽

10.1016/s0197-4580(04)80372-5 ◽

2004 ◽

Vol 25 ◽

pp. S111

Author(s):

Susanne Jungwirth ◽

Silvia Weissgram ◽

Karl Heinz Tragl ◽

Peter Fischer

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Community Based ◽

Age Cohort

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Mild cognitive impairment with Lewy bodies: neuropsychiatric supportive symptoms and cognitive profile

Psychological Medicine ◽

10.1017/s0033291720002901 ◽

2020 ◽

pp. 1-9

Author(s):

Paul C Donaghy ◽

Joanna Ciafone ◽

Rory Durcan ◽

Calum A Hamilton ◽

Sally Barker ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Diagnostic Criteria ◽

Likelihood Ratio ◽

Neuropsychiatric Symptoms ◽

Lewy Bodies ◽

Cognitive Profile ◽

Anxiety And Depression ◽

Delayed Recall ◽

Independent Cohort

Abstract Background Recently published diagnostic criteria for mild cognitive impairment with Lewy bodies (MCI-LB) include five neuropsychiatric supportive features (non-visual hallucinations, systematised delusions, apathy, anxiety and depression). We have previously demonstrated that the presence of two or more of these symptoms differentiates MCI-LB from MCI due to Alzheimer's disease (MCI-AD) with a likelihood ratio >4. The aim of this study was to replicate the findings in an independent cohort. Methods Participants ⩾60 years old with MCI were recruited. Each participant had a detailed clinical, cognitive and imaging assessment including FP-CIT SPECT and cardiac MIBG. The presence of neuropsychiatric supportive symptoms was determined using the Neuropsychiatric Inventory (NPI). Participants were classified as MCI-AD, possible MCI-LB and probable MCI-LB based on current diagnostic criteria. Participants with possible MCI-LB were excluded from further analysis. Results Probable MCI-LB (n = 28) had higher NPI total and distress scores than MCI-AD (n = 30). In total, 59% of MCI-LB had two or more neuropsychiatric supportive symptoms compared with 9% of MCI-AD (likelihood ratio 6.5, p < 0.001). MCI-LB participants also had a significantly greater delayed recall and a lower Trails A:Trails B ratio than MCI-AD. Conclusions MCI-LB is associated with significantly greater neuropsychiatric symptoms than MCI-AD. The presence of two or more neuropsychiatric supportive symptoms as defined by MCI-LB diagnostic criteria is highly specific and moderately sensitive for a diagnosis of MCI-LB. The cognitive profile of MCI-LB differs from MCI-AD, with greater executive and lesser memory impairment, but these differences are not sufficient to differentiate MCI-LB from MCI-AD.

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