scholarly journals Four Common Late-Life Cognitive Trajectories Patterns Associate with Replicable Underlying Neuropathologies

2021 ◽  
pp. 1-13
Author(s):  
Shama D. Karanth ◽  
Frederick A. Schmitt ◽  
Peter T. Nelson ◽  
Yuriko Katsumata ◽  
Richard J. Kryscio ◽  
...  
Keyword(s):  
Random Forest ◽  
Cerebral Atrophy ◽  
Late Life ◽  
Community Based ◽  
University Of Kentucky ◽  
Total N ◽  
Single Measure ◽  
Multinomial Models ◽  
Treatment And Prevention ◽  
The University

Background: Late-life cognitive function is heterogeneous, ranging from no decline to severe dementia. Prior studies of cognitive trajectories have tended to focus on a single measure of global cognition or individual tests scores, rather than considering longitudinal performance on multiple tests simultaneously. Objective: The current study aimed to examine cognitive trajectories from two independent datasets to assess whether similar patterns might describe longitudinal cognition in the decade preceding death, as well as what participant characteristics were associated with trajectory membership. Methods: Data were drawn from autopsied longitudinally followed participants of two cohorts (total N = 1,346), community-based cohort at the University of Kentucky Alzheimer’s Disease Research Center (n = 365) and National Alzheimer’s Coordinating Center (n = 981). We used group-based multi-trajectory models (GBMTM) to identify cognitive trajectories over the decade before death using Mini-Mental State Exam, Logical Memory-Immediate, and Animal Naming performance. Multinomial logistic and Random Forest analyses assessed characteristics associated with trajectory groups. Results: GBMTM identified four similar cognitive trajectories in each dataset. In multinomial models, death age, Braak neurofibrillary tangles (NFT) stage, TDP-43, and α-synuclein were associated with declining trajectories. Random Forest results suggested the most important trajectory predictors were Braak NFT stage, cerebral atrophy, death age, and brain weight. Multiple pathologies were most common in trajectories with moderate or accelerated decline. Conclusion: Cognitive trajectories associated strongly with neuropathology, particularly Braak NFT stage. High frequency of multiple pathologies in trajectories with cognitive decline suggests dementia treatment and prevention efforts must consider multiple diseases simultaneously.

LATE Neuropathologic Changes with Little or No Alzheimer Disease is Common and is Associated with Cognitive Impairment but Not Frontotemporal Dementia

2021 ◽  
Author(s):  
Peter T Nelson
Keyword(s):  
Cognitive Impairment ◽  
Alzheimer Disease ◽  
Frontotemporal Dementia ◽  
Clinical Syndrome ◽  
Community Based ◽  
University Of Kentucky ◽  
Full Spectrum ◽  
Disease Research ◽  
Age Related ◽  
The University

Abstract Limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC) often occur in aged brains that also contain appreciable Alzheimer disease neuropathologic changes (ADNC). Question has arisen as to whether LATE-NC can occur independently of ADNC. We evaluated data from the University of Kentucky Alzheimer’s Disease Research Center autopsy cohort (383 included subjects) to address 2 questions: (i) Is LATE-NC seen in the absence of ADNC, outside of persons who had the frontotemporal dementia (FTD) clinical syndrome? and (ii) is LATE-NC associated with cognitive impairment across the full spectrum of ADNC severity? In the present study, the pathologic combination of LATE-NC (Stage >1) and low/no ADNC was common: 8.9% (34/383) of all subjects (including demented and non-demented individuals) showed this combination. There were no FTLD-TDP cases to be included from the community-based cohort. Across a broad range of ADNC severity, the presence of LATE-NC was associated with impaired cognition but was never associated with a FTD clinical syndrome.

Lesbians, Bisexual Women, and Perceptions of Risk in the Bluegrass

1993 ◽  
Vol 15 (4) ◽  
pp. 48-51
Author(s):  
Angela Martin ◽  
Dorothee Seifen ◽  
Mary Maloney
Keyword(s):  
Bisexual Women ◽  
Community Based ◽  
University Of Kentucky ◽  
Perceptions Of Risk ◽  
Present Information ◽  
Aids Risk ◽  
And Bisexual ◽  
The University ◽  
The Impact ◽  
Hiv Aids

In September 1992, we embarked upon a research project designed to investigate lesbian attitudes towards HIV/AIDS risk and the impact on these attitudes of a safer sex workshop for lesbians and bisexual women. This project was part of a graduate seminar aimed at familiarizing students in the Anthropology Department at the University of Kentucky with techniques involved in community-based ethnographic research. As anthropologists, we were interested in collecting data on individual behaviors and perceptions of risk. We then wanted to contrast our findings with institutionally recognized risk categories and behaviors, such as those of the Centers for Disease Control (CDC). Over the course of three months, teenagers, minorities, and so on. A pamphlet aimed at teens will often employ the language teens use. Similarly, materials geared toward gay men will not present information on vaginal intercourse. If one examines a range of such materials, one finds that lesbians are nowhere represented or targeted. (See Rebecca Cole and Sally Cooper, "Lesbian Exclusion from HIV/AIDS Education," SEICUS Report, December 1990/January 1991.)

Water as the Context for Community-Based Science Projects

2017 ◽  
Author(s):  
Carol Hanley ◽  
Kelly Taylor
Keyword(s):  
Young People ◽  
Real Life ◽  
Project Based Learning ◽  
Science Careers ◽  
College Of Agriculture ◽  
Community Based ◽  
University Of Kentucky ◽  
Science Projects ◽  
K 12 ◽  
The University

This chapter explores the educational practices employed to motivate young people to become interested and study science careers. Educators of the University of Kentucky (UK), College of Agriculture, Food and Environment’s (CAFE) Environmental and Natural Resources Initiative consider their use of real-life situations and projects to teach science to Kentucky’s K-12 students. The educators demonstrate how they use project-based learning in conjunction with community-based issues to interest students in science topics and careers. Multiple examples of community-based science programs are described along with reflections from students and teachers. Recommendations for future projects methodologies are included.

A Place-Based University?: The Land-Grant Mission in the 21st Century

2001 ◽  
Vol 23 (2) ◽  
pp. 24-28 ◽  
Author(s):  
Betsy Taylor
Keyword(s):  
Higher Education ◽  
21St Century ◽  
Academic Research ◽  
Organizational Models ◽  
Community Based ◽  
University Of Kentucky ◽  
Global Movement ◽  
Training And Research ◽  
The University ◽  
University Training

The Project for the Civic and Environmental Commons is a cluster of initiatives, started by the Appalachian Center, University of Kentucky, in 1999, to support academic/ citizen partnerships in action research for equity and sustainability in the Appalachian region. It tries to serve as a bridge between movements within and outside academe. First, it attempts to link the university with the global movement for community-based development. A ferment of creativity in the nongovernmental sector in the last two decades has generated a rich variety of research methods (especially in participatory and place-based techniques for community assessment) and new organizational models for decentralized and democratic planning. The Project attempts to channel new techniques and models from this grassroots experimentation into university training and research, and to provide whatever support academics can give to citizen-led, community-based development. Second, the Project for the Civic and Environmental Commons tries to join this community-based work with reform movements within higher education that argue that institutional change is necessary for higher education to adequately respond to emerging problems of the 21st century. Those who call for a "New Academy" and for "public scholars" argue that much of academic research needs to be more targeted to meeting public needs and problems, and that the professionalization process needs to do a better job of producing scholars who are intellectually and emotionally able to engage in community-based work.

Adapting a matrix organizational structure to the College of Dentistry at the University of Kentucky

1989 ◽  
Vol 53 (4) ◽  
pp. 246-252
Author(s):  
DA Nash ◽  
EP Hicks ◽  
HR Laswell ◽  
GP Lewis ◽  
TT Lillich ◽  
...  
Keyword(s):  
Organizational Structure ◽  
University Of Kentucky ◽  
The University

From Volunteering to Academic Programming: A Case Example

2016 ◽  
Vol 1 (17) ◽  
pp. 7-11 ◽  
Author(s):  
Cindy Gill ◽  
Sneha Bharadwaj ◽  
Nancy Quick ◽  
Sarah Wainscott ◽  
Paula Chance
Keyword(s):  
Special Needs ◽  
Cultural Relevance ◽  
Master's Program ◽  
Speech Language Pathology ◽  
Community Based ◽  
Charitable Organization ◽  
Language Pathology ◽  
The University

A speech-language pathology master's program that grew out of a partnership between the University of Zambia and a U.S.-based charitable organization, Connective Link Among Special needs Programs (CLASP) International, has just been completed in Zambia. The review of this program is outlined according to the suggested principles for community-based partnerships, a framework which may help evaluate cultural relevance and sustainability in long-term volunteer efforts (Israel, Schulz, Parker, & Becker, 1998).

Sustaining University-Community Partnerships in Indigenous Communities: Five Lessons from Papakōlea

2019 ◽  
Vol 16 (1-2) ◽  
pp. 35-63
Author(s):  
Robert Agres ◽  
Adrienne Dillard ◽  
Kamuela Joseph Nui Enos ◽  
Brent Kakesako ◽  
B. Puni Kekauoha ◽  
...  
Keyword(s):  
Learning Community ◽  
Ways Of Knowing ◽  
Indigenous Communities ◽  
Community Based ◽  
Urban And Regional Planning ◽  
Culture Of Learning ◽  
Community Values ◽  
University Of Hawai'i ◽  
The University

This resource paper draws lessons from a twenty-year partnership between the Native Hawaiian community of Papakōlea, the Hawai‘i Alliance for Community-Based Economic Development, and the Department of Urban and Regional Planning at the University of Hawai‘i. Key players and co-authors describe five principles for sustained partnerships: (1) building partnerships based upon community values with potential for long-term commitments; (2) privileging indigenous ways of knowing; (3) creating a culture of learning together as a co-learning community; (4) fostering reciprocity and compassion in nurturing relationships; and (5) utilizing empowering methodologies and capacity-building strategies.

scholarly journals Academic relationships between Hungarian professors and the Second Vienna Medical School

2021 ◽  
Author(s):  
Béla Szende ◽  
Attila Zalatnai
Keyword(s):  
Medical Education ◽  
Medical School ◽  
Medical Doctors ◽  
Surgical Department ◽  
Treatment And Prevention ◽  
Obstetrics And Gynaecology ◽  
Practice Of Medicine ◽  
Vienna Medical School ◽  
The University ◽  
The Impact

SummaryThis article discusses the impact of the ‘second’ Vienna Medical School, hallmarked by Karl Rokitansky, Joseph Skoda and Ferdinand Hebra, on the study and practice of medicine in Hungary. Six medical doctors’ lives and achievements are outlined, who formed a bridge between Vienna and Budapest through their studies and work. Four of them returned to Hungary and promoted the cause of medicine and medical education there. Lajos Arányi (1812–1877) founded in 1844 the Institute of Pathology at the University of Pest. János Balassa (1814–1868) took the Chair of the Surgical Department. Ignaz Philip Semmelweis (1818–1865), the ‘Saviour of Mothers’, received a position at the Department of Obstetrics and Gynaecology in Vienna in 1846. Gustav Scheuthauer (1832–1894) became Arányi’s successor. Each of them continued to keep contact with their tutors in Vienna, especially with Karl Rokitansky, and followed the clinicopathological conception pioneered by the Vienna Medical School regarding diagnostics, treatment and prevention of diseases. Two physicians remained in Vienna: Mór Kaposi (1837–1902), who became known worldwide posthumously due to the connection between Kaposi’s sarcoma and AIDS, was the director of the Department of Dermatology of the Vienna University in 1878. Salomon Stricker (1837–1898) undertook the leadership of the Department of General and Experimental Pathology in 1872.

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