PRATEEK: Integration of Multimodal Neuroimaging Data to Facilitate Advanced Brain Research

Background: In vivo neuroimaging modalities such as magnetic resonance imaging (MRI), functional MRI (fMRI), magnetoencephalography (MEG), magnetic resonance spectroscopy (MRS), and quantitative susceptibility mapping (QSM) are useful techniques to understand brain anatomical structure, functional activity, source localization, neurochemical profiling, and tissue susceptibility respectively. Integrating unique and distinct information from these neuroimaging modalities will further help to enhance the understanding of complex neurological disease. Objective: To develop a processing scheme for multimodal data integration in seamless manner on healthy young population, thus establishing a generalized framework for various clinical conditions (e.g., Alzheimer’s disease). Methods: A multimodal data integration scheme has been developed to integrate the outcomes from multiple neuroimaging data (fMRI, MEG, MRS, and QSM) spatially. Furthermore, the entire scheme has been incorporated into a user-friendly toolbox- “PRATEEK”. Results: The proposed methodology and toolbox has been tested for viability among fourteen healthy young participants for bilateral occipital cortices as the region of interest. This scheme can also be extended to other anatomical regions of interest. Overlap percentage from each combination of two modalities (fMRI-MRS, MEG-MRS, fMRI-QSM, and fMRI-MEG) has been computed and also been qualitatively assessed for combinations of the three (MEG-MRS-QSM) and four (fMRI-MEG-MRS-QSM) modalities. Conclusion: This user-friendly toolbox minimizes the need of an expertise in handling different neuroimaging tools for processing and analyzing multimodal data. The proposed scheme will be beneficial for clinical studies where geometric information plays a crucial role in advance brain research.

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Spectroscopic imaging of human disease

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100166889 ◽

1996 ◽

Vol 54 ◽

pp. 884-885

Author(s):

D.J. Meyerhoff

Keyword(s):

Magnetic Field ◽

Magnetic Resonance ◽

Field Gradient ◽

Human Disease ◽

Morphological Changes ◽

Magnetic Field Gradient ◽

Spectroscopic Imaging ◽

Resonance Spectroscopy ◽

Tissue Water

Magnetic Resonance Imaging (MRI) observes tissue water in the presence of a magnetic field gradient to study morphological changes such as tissue volume loss and signal hyperintensities in human disease. These changes are mostly non-specific and do not appear to be correlated with the range of severity of a certain disease. In contrast, Magnetic Resonance Spectroscopy (MRS), which measures many different chemicals and tissue metabolites in the millimolar concentration range in the absence of a magnetic field gradient, has been shown to reveal characteristic metabolite patterns which are often correlated with the severity of a disease. In-vivo MRS studies are performed on widely available MRI scanners without any “sample preparation” or invasive procedures and are therefore widely used in clinical research. Hydrogen (H) MRS and MR Spectroscopic Imaging (MRSI, conceptionally a combination of MRI and MRS) measure N-acetylaspartate (a putative marker of neurons), creatine-containing metabolites (involved in energy processes in the cell), choline-containing metabolites (involved in membrane metabolism and, possibly, inflammatory processes),

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In Vivo 31P Magnetic Resonance Spectroscopy in Liver Cirrhosis: Assessment of Phosphorus Metabolites accordingto Hepatic Dysfunction

Journal of the Korean Radiological Society ◽

10.3348/jkrs.1998.39.6.1171 ◽

1998 ◽

Vol 39 (6) ◽

pp. 1171 ◽

Cited By ~ 1

Author(s):

Kwon Ha Yoon ◽

Moon Gyu Lee ◽

Jung Hee Lee ◽

Chang Guhn Kim ◽

Yong Ho Auh

Keyword(s):

Liver Cirrhosis ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Hepatic Dysfunction ◽

Resonance Spectroscopy ◽

31P Magnetic Resonance Spectroscopy ◽

Phosphorus Metabolites

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In-Vivo Magnetic Resonance Spectroscopy III: In-Vivo MR Spectroscopy: Potential and Limitations

10.1007/978-3-642-77218-4 ◽

1992 ◽

Cited By ~ 2

Keyword(s):

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Mr Spectroscopy ◽

Resonance Spectroscopy

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Rapid Catalyst Capture Enables Metal-Free Parahydrogen-Based Hyperpolarized Contrast Agents

10.26434/chemrxiv.6076175.v1 ◽

2018 ◽

Author(s):

Danila Barskiy ◽

Lucia Ke ◽

Xingyang Li ◽

Vincent Stevenson ◽

Nevin Widarman ◽

...

Keyword(s):

Magnetic Resonance ◽

Contrast Agents ◽

Inductively Coupled Plasma ◽

Organometallic Compounds ◽

Atomic Emission ◽

Platinum Group Metals ◽

Resonance Spectroscopy ◽

Plasma Atomic Emission ◽

Inductively Coupled

Hyperpolarization techniques based on the use of parahydrogen provide orders of magnitude signal enhancement for magnetic resonance spectroscopy and imaging. The main drawback limiting widespread applicability of parahydrogen-based techniques in biomedicine is the presence of organometallic compounds (the polarization transfer catalysts) in solution with hyperpolarized contrast agents. These catalysts are typically complexes of platinum-group metals and their administration in vivo should be avoided. Herein, we show how extraction of a hyperpolarized compound from an organic phase to an aqueous phase combined with a rapid (less than 10 seconds) Ir-based catalyst capture by metal scavenging agents can produce pure parahydrogen-based hyperpolarized contrast agents as demonstrated by high-resolution nuclear magnetic resonance (NMR) spectroscopy and inductively coupled plasma atomic emission spectroscopy (ICP-AES). The presented methodology enables fast and efficient means of producing pure hyperpolarized aqueous solutions for biomedical and other uses.

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Rapid Catalyst Capture Enables Metal-Free Parahydrogen-Based Hyperpolarized Contrast Agents

10.26434/chemrxiv.6076175 ◽

2018 ◽

Author(s):

Danila Barskiy ◽

Lucia Ke ◽

Xingyang Li ◽

Vincent Stevenson ◽

Nevin Widarman ◽

...

Keyword(s):

Magnetic Resonance ◽

Contrast Agents ◽

Inductively Coupled Plasma ◽

Organometallic Compounds ◽

Atomic Emission ◽

Platinum Group Metals ◽

Resonance Spectroscopy ◽

Plasma Atomic Emission ◽

Inductively Coupled

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Biological NMR Spectroscopy

10.1093/oso/9780195094688.001.0001 ◽

1997 ◽

Keyword(s):

Nuclear Magnetic Resonance ◽

Nmr Spectroscopy ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

State Of The Art ◽

Critical Assessment ◽

Resonance Spectroscopy ◽

History Of ◽

Structure Of Proteins

This book presents a critical assessment of progress on the use of nuclear magnetic resonance spectroscopy to determine the structure of proteins, including brief reviews of the history of the field along with coverage of current clinical and in vivo applications. The book, in honor of Oleg Jardetsky, one of the pioneers of the field, is edited by two of the most highly respected investigators using NMR, and features contributions by most of the leading workers in the field. It will be valued as a landmark publication that presents the state-of-the-art perspectives regarding one of today's most important technologies.

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Editorial for “In Vivo Magnetic Resonance Spectroscopy of Hyperpolarized [1‐13C]Pyruvate in a Guinea Pig Model of Life‐Long Western Diet Consumption and Non‐Alcoholic Fatty Liver Disease Development”

Journal of Magnetic Resonance Imaging ◽

10.1002/jmri.27757 ◽

2021 ◽

Author(s):

Theresa A. Tuthill ◽

Trent T. Ross

Keyword(s):

Liver Disease ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Fatty Liver Disease ◽

Resonance Spectroscopy ◽

Disease Development ◽

Alcoholic Fatty Liver ◽

Guinea Pig Model ◽

Alcoholic Fatty Liver Disease

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In Vivo Measurement of Neurochemical Abnormalities in the Hippocampus in a Rat Model of Cuprizone-Induced Demyelination

Diagnostics ◽

10.3390/diagnostics11010045 ◽

2020 ◽

Vol 11 (1) ◽

pp. 45

Author(s):

Do-Wan Lee ◽

Jae-Im Kwon ◽

Chul-Woong Woo ◽

Hwon Heo ◽

Kyung Won Kim ◽

...

Keyword(s):

Magnetic Resonance ◽

Rat Model ◽

Resonance Spectroscopy ◽

Chow Diet ◽

Gamma Aminobutyric Acid ◽

Sprague Dawley ◽

In Vivo Measurement ◽

Hippocampal Lesions ◽

Total Creatine

This study quantitatively measured the changes in metabolites in the hippocampal lesions of a rat model of cuprizone-induced demyelination as detected using in vivo 7 T proton magnetic resonance spectroscopy. Nineteen Sprague Dawley rats were randomly divided into two groups and fed a normal chow diet or cuprizone (0.2%, w/w) for 7 weeks. Demyelinated hippocampal lesions were quantitatively measured using a 7 T magnetic resonance imaging scanner. All proton spectra were quantified for metabolite concentrations and relative ratios. Compared to those in the controls, the cuprizone-induced rats had significantly higher concentrations of glutamate (p = 0.001), gamma-aminobutyric acid (p = 0.019), and glutamate + glutamine (p = 0.001); however, creatine + phosphocreatine (p = 0.006) and myo-inositol (p = 0.001) concentrations were lower. In addition, we found that the glutamine and glutamate complex/total creatine (p < 0.001), glutamate/total creatine (p < 0.001), and GABA/total creatine (p = 0.002) ratios were significantly higher in cuprizone-treated rats than in control rats. Our results showed that cuprizone-induced neuronal demyelination may influence the severe abnormal metabolism in hippocampal lesions, and these responses could be caused by microglial activation, mitochondrial dysfunction, and astrocytic necrosis.

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