Classification and grading of diabetic retinopathy images using mixture of ensemble classifiers

2021 ◽  
pp. 1-13
Author(s):  
R. Bhuvaneswari ◽  
S. Ganesh Vaidyanathan
Keyword(s):  
Neural Network ◽  
Diabetic Retinopathy ◽  
Convolutional Neural Network ◽  
Blood Vessels ◽  
Support Vector ◽  
Network Architectures ◽  
Ensemble Classifiers ◽  
Feature Maps ◽  
Class Labels ◽  
Hierarchical Features

Diabetic Retinopathy (DR) is one of the most common diabetic diseases that affect the retina’s blood vessels. Too much of the glucose level in blood leads to blockage of blood vessels in the retina, weakening and damaging the retina. Automatic classification of diabetic retinopathy is a challenging task in medical research. This work proposes a Mixture of Ensemble Classifiers (MEC) to classify and grade diabetic retinopathy images using hierarchical features. We use an ensemble of classifiers such as support vector machine, random forest, and Adaboost classifiers that use the hierarchical feature maps obtained at every pooling layer of a convolutional neural network (CNN) for training. The feature maps are generated by applying the filters to the output of the previous layer. Lastly, we predict the class label or the grade for the given test diabetic retinopathy image by considering the class labels of all the ensembled classifiers. We have tested our approaches on the E-ophtha dataset for the classification task and the Messidor dataset for the grading task. We achieved an accuracy of 95.8% and 96.2% for the E-ophtha and Messidor datasets, respectively. A comparison among prominent convolutional neural network architectures and the proposed approach is provided.

scholarly journals Permutation Entropy-Based Interpretability of Convolutional Neural Network Models for Interictal EEG Discrimination of Subjects with Epileptic Seizures vs. Psychogenic Non-Epileptic Seizures

Entropy ◽  
2022 ◽  
Vol 24 (1) ◽  
pp. 102
Author(s):  
Michele Lo Giudice ◽  
Giuseppe Varone ◽  
Cosimo Ieracitano ◽  
Nadia Mammone ◽  
Giovanbattista Gaspare Tripodi ◽  
...  
Keyword(s):  
Neural Network ◽  
Discriminant Analysis ◽  
Convolutional Neural Network ◽  
Epileptic Seizures ◽  
Permutation Entropy ◽  
Diagnostic Tools ◽  
Support Vector ◽  
Feature Maps ◽  
Time Frequency ◽  
Interictal Eeg

The differential diagnosis of epileptic seizures (ES) and psychogenic non-epileptic seizures (PNES) may be difficult, due to the lack of distinctive clinical features. The interictal electroencephalographic (EEG) signal may also be normal in patients with ES. Innovative diagnostic tools that exploit non-linear EEG analysis and deep learning (DL) could provide important support to physicians for clinical diagnosis. In this work, 18 patients with new-onset ES (12 males, 6 females) and 18 patients with video-recorded PNES (2 males, 16 females) with normal interictal EEG at visual inspection were enrolled. None of them was taking psychotropic drugs. A convolutional neural network (CNN) scheme using DL classification was designed to classify the two categories of subjects (ES vs. PNES). The proposed architecture performs an EEG time-frequency transformation and a classification step with a CNN. The CNN was able to classify the EEG recordings of subjects with ES vs. subjects with PNES with 94.4% accuracy. CNN provided high performance in the assigned binary classification when compared to standard learning algorithms (multi-layer perceptron, support vector machine, linear discriminant analysis and quadratic discriminant analysis). In order to interpret how the CNN achieved this performance, information theoretical analysis was carried out. Specifically, the permutation entropy (PE) of the feature maps was evaluated and compared in the two classes. The achieved results, although preliminary, encourage the use of these innovative techniques to support neurologists in early diagnoses.

scholarly journals Prediction of protein function using a deep convolutional neural network ensemble

2017 ◽  
Author(s):  
Evangelia I Zacharaki
Keyword(s):  
Neural Network ◽  
Amino Acid ◽  
Convolutional Neural Network ◽  
Protein Function ◽  
Protein Structures ◽  
Function Prediction ◽  
Deep Convolutional Neural Network ◽  
Supervised Machine Learning ◽  
Support Vector ◽  
Feature Maps

Background. The availability of large databases containing high resolution three-dimensional (3D) models of proteins in conjunction with functional annotation allows the exploitation of advanced supervised machine learning techniques for automatic protein function prediction. Methods. In this work, novel shape features are extracted representing protein structure in the form of local (per amino acid) distribution of angles and amino acid distances, respectively. Each of the multi-channel feature maps is introduced into a deep convolutional neural network (CNN) for function prediction and the outputs are fused through Support Vector Machines (SVM) or a correlation-based k-nearest neighbor classifier. Two different architectures are investigated employing either one CNN per multi-channel feature set, or one CNN per image channel. Results. Cross validation experiments on enzymes (n = 44,661) from the PDB database achieved 90.1% correct classification demonstrating the effectiveness of the proposed method for automatic function annotation of protein structures. Discussion. The automatic prediction of protein function can provide quick annotations on extensive datasets opening the path for relevant applications, such as pharmacological target identification.

scholarly journals Computer-Assisted Diagnosis for Diabetic Retinopathy Based on Fundus Images Using Deep Convolutional Neural Network

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
Yung-Hui Li ◽  
Nai-Ning Yeh ◽  
Shih-Jen Chen ◽  
Yu-Chien Chung
Keyword(s):  
Neural Network ◽  
Diabetic Retinopathy ◽  
Convolutional Neural Network ◽  
Recognition Rate ◽  
Deep Convolutional Neural Network ◽  
Support Vector ◽  
Svm Classifier ◽  
Computer Assisted ◽  
Fundus Images ◽  
Max Pooling

Diabetic retinopathy (DR) is a complication of long-standing diabetes, which is hard to detect in its early stage because it only shows a few symptoms. Nowadays, the diagnosis of DR usually requires taking digital fundus images, as well as images using optical coherence tomography (OCT). Since OCT equipment is very expensive, it will benefit both the patients and the ophthalmologists if an accurate diagnosis can be made, based solely on reading digital fundus images. In the paper, we present a novel algorithm based on deep convolutional neural network (DCNN). Unlike the traditional DCNN approach, we replace the commonly used max-pooling layers with fractional max-pooling. Two of these DCNNs with a different number of layers are trained to derive more discriminative features for classification. After combining features from metadata of the image and DCNNs, we train a support vector machine (SVM) classifier to learn the underlying boundary of distributions of each class. For the experiments, we used the publicly available DR detection database provided by Kaggle. We used 34,124 training images and 1,000 validation images to build our model and tested with 53,572 testing images. The proposed DR classifier classifies the stages of DR into five categories, labeled with an integer ranging between zero and four. The experimental results show that the proposed method can achieve a recognition rate up to 86.17%, which is higher than previously reported in the literature. In addition to designing a machine learning algorithm, we also develop an app called “Deep Retina.” Equipped with a handheld ophthalmoscope, the average person can take fundus images by themselves and obtain an immediate result, calculated by our algorithm. It is beneficial for home care, remote medical care, and self-examination.

scholarly journals Prediction of protein function using a deep convolutional neural network ensemble

2017 ◽  
Author(s):  
Evangelia I Zacharaki
Keyword(s):  
Neural Network ◽  
Amino Acid ◽  
Convolutional Neural Network ◽  
Protein Function ◽  
Protein Structures ◽  
Function Prediction ◽  
Deep Convolutional Neural Network ◽  
Supervised Machine Learning ◽  
Support Vector ◽  
Feature Maps

Background. The availability of large databases containing high resolution three-dimensional (3D) models of proteins in conjunction with functional annotation allows the exploitation of advanced supervised machine learning techniques for automatic protein function prediction. Methods. In this work, novel shape features are extracted representing protein structure in the form of local (per amino acid) distribution of angles and amino acid distances, respectively. Each of the multi-channel feature maps is introduced into a deep convolutional neural network (CNN) for function prediction and the outputs are fused through Support Vector Machines (SVM) or a correlation-based k-nearest neighbor classifier. Two different architectures are investigated employing either one CNN per multi-channel feature set, or one CNN per image channel. Results. Cross validation experiments on enzymes (n = 44,661) from the PDB database achieved 90.1% correct classification demonstrating the effectiveness of the proposed method for automatic function annotation of protein structures. Discussion. The automatic prediction of protein function can provide quick annotations on extensive datasets opening the path for relevant applications, such as pharmacological target identification.

Single Channel EEG signal for Automatic Detection of Absence Seizure using Convolutional Neural Network

2019 ◽  
Vol 13 ◽  
Author(s):  
Niha Kamal Basha ◽  
Aisha Banu Wahab
Keyword(s):  
Neural Network ◽  
Support Vector Machine ◽  
Convolutional Neural Network ◽  
Monitoring System ◽  
Single Channel ◽  
Confusion Matrix ◽  
Sudden Change ◽  
Automatic Detection ◽  
Support Vector ◽  
Absence Seizure

: Absence seizure is a type of brain disorder in which subject get into sudden lapses in attention. Which means sudden change in brain stimulation. Most of this type of disorder is widely found in children’s (5-18 years). These Electroencephalogram (EEG) signals are captured with long term monitoring system and are analyzed individually. In this paper, a Convolutional Neural Network to extract single channel EEG seizure features like Power, log sum of wavelet transform, cross correlation, and mean phase variance of each frame in a windows are extracted after pre-processing and classify them into normal or absence seizure class, is proposed as an empowerment of monitoring system by automatic detection of absence seizure. The training data is collected from the normal and absence seizure subjects in the form of Electroencephalogram. The objective is to perform automatic detection of absence seizure using single channel electroencephalogram signal as input. Here the data is used to train the proposed Convolutional Neural Network to extract and classify absence seizure. The Convolutional Neural Network consist of three layers 1] convolutional layer – which extract the features in the form of vector 2] Pooling layer – the dimensionality of output from convolutional layer is reduced and 3] Fully connected layer–the activation function called soft-max is used to find the probability distribution of output class. This paper goes through the automatic detection of absence seizure in detail and provide the comparative analysis of classification between Support Vector Machine and Convolutional Neural Network. The proposed approach outperforms the performance of Support Vector Machine by 80% in automatic detection of absence seizure and validated using confusion matrix.

A visual terrain classification method for mobile robots’ navigation based on convolutional neural network and support vector machine

2021 ◽  
pp. 014233122098791
Author(s):  
Wanli Wang ◽  
Botao Zhang ◽  
Kaiqi Wu ◽  
Sergey A Chepinskiy ◽  
Anton A Zhilenkov ◽  
...  
Keyword(s):  
Neural Network ◽  
Support Vector Machine ◽  
Mobile Robots ◽  
Convolutional Neural Network ◽  
Hybrid Method ◽  
Classification Accuracy ◽  
Support Vector ◽  
High Classification Accuracy ◽  
Enhance Efficiency ◽  
Multi Class Classification

In this paper, a hybrid method based on deep learning is proposed to visually classify terrains encountered by mobile robots. Considering the limited computing resource on mobile robots and the requirement for high classification accuracy, the proposed hybrid method combines a convolutional neural network with a support vector machine to keep a high classification accuracy while improve work efficiency. The key idea is that the convolutional neural network is used to finish a multi-class classification and simultaneously the support vector machine is used to make a two-class classification. The two-class classification performed by the support vector machine is aimed at one kind of terrain that users are mostly concerned with. Results of the two classifications will be consolidated to get the final classification result. The convolutional neural network used in this method is modified for the on-board usage of mobile robots. In order to enhance efficiency, the convolutional neural network has a simple architecture. The convolutional neural network and the support vector machine are trained and tested by using RGB images of six kinds of common terrains. Experimental results demonstrate that this method can help robots classify terrains accurately and efficiently. Therefore, the proposed method has a significant potential for being applied to the on-board usage of mobile robots.

scholarly journals Methods for Preventing Visual Attacks in Convolutional Neural Networks Based on Data Discard and Dimensionality Reduction

2021 ◽  
Vol 11 (11) ◽  
pp. 5235
Author(s):  
Nikita Andriyanov
Keyword(s):  
Neural Network ◽  
Convolutional Neural Network ◽  
Network Inference ◽  
Recognition Accuracy ◽  
Network Architectures ◽  
Reduced Dimensions ◽  
Different Types ◽  
Rectangular Area ◽  
Noise Impulse ◽  
Selection Of

The article is devoted to the study of convolutional neural network inference in the task of image processing under the influence of visual attacks. Attacks of four different types were considered: simple, involving the addition of white Gaussian noise, impulse action on one pixel of an image, and attacks that change brightness values within a rectangular area. MNIST and Kaggle dogs vs. cats datasets were chosen. Recognition characteristics were obtained for the accuracy, depending on the number of images subjected to attacks and the types of attacks used in the training. The study was based on well-known convolutional neural network architectures used in pattern recognition tasks, such as VGG-16 and Inception_v3. The dependencies of the recognition accuracy on the parameters of visual attacks were obtained. Original methods were proposed to prevent visual attacks. Such methods are based on the selection of “incomprehensible” classes for the recognizer, and their subsequent correction based on neural network inference with reduced image sizes. As a result of applying these methods, gains in the accuracy metric by a factor of 1.3 were obtained after iteration by discarding incomprehensible images, and reducing the amount of uncertainty by 4–5% after iteration by applying the integration of the results of image analyses in reduced dimensions.

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