Knowledge about adverse drug reactions reporting among healthcare professionals in Nepal

Abstract Aim: Our objective was to explore the processes and determinants leading physicians to integrate estimated glomerular filtration rate (eGFR) in their drug prescriptions Background: Access to patients’ eGFR would allow primary care pharmacists to optimise their role in the procedure of safe prescribing. Some rare physicians actively integrate eGFR in their prescriptions, in a sporadically and uncoordinated manner. Methods: Qualitative study using semi-directed interviews conducted among 12 French physicians who integrated eGFR in their drug prescriptions, (February 2016–April 2017). These voluntary participants were recruited through different means: Twitter®, forums, direct contact and snowball sampling. Data analysis was based on the grounded theory approach, underpinned by a comprehensive perspective of interactionist orientation. Findings: Residency and training, professional experience – including experiences of adverse drug reactions – and the membership in various communities of professionals were key drivers for the integration of eGFR in prescriptions. The theoretical aim was above all safe prescribing in order to reduce adverse drug reactions, with the control by a dispensing pharmacist and/or other healthcare professionals. Nevertheless, none of the physicians had received any feedback from any healthcare professionals. Despite their disappointment, the physicians remained convinced of the interest of integrating eGFR in their prescriptions and would continue to do so. Characteristics associated with integration of eGFR in drug prescriptions belong partly to Roger’s theory of innovations. If a widespread diffusion of this habit takes place, it will be necessary to evaluate its adoption by both physicians and pharmacists.

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A Multi-Agent System for Reporting Suspected Adverse Drug Reactions

Online Journal of Public Health Informatics ◽

10.5210/ojphi.v6i3.5579 ◽

2014 ◽

Vol 6 (3) ◽

Author(s):

Yanqing Ji ◽

Fangyang Shen ◽

See-Yan Lau ◽

John Tran

Keyword(s):

Adverse Drug Reactions ◽

Healthcare Professionals ◽

Public Health Problem ◽

Reporting Rate ◽

Drug Reactions ◽

Data Mining Approach ◽

Spontaneous Reports ◽

Post Marketing ◽

Multi Agent ◽

Suspected Adverse Drug Reactions

Adverse drug reactions (ADRs) represent a serious worldwide public health problem. Current post-marketing ADR detection approaches largely rely on spontaneous reports filed by various healthcare professionals such as physicians, pharmacists et.al.. Underreporting is a serious deficiency of these methods - the actually reported adverse events represent less than 10% of all cases. Studies show that two important reasons that cause the underreporting are: 1) healthcare professionals are unaware of encountered ADRs, especially for those unusual ADRs; 2) they are too busy to voluntarily report ADRs since it takes a lot of time to fill out the reporting forms. This paper addresses these two issues by developing a multi-agent ADR reporting system. The system 1) helps healthcare professionals detect the potential causal relationship between a drug and an ADR by analyzing patients’ electronic records via both case-based analysis and statistical data mining approach; 2) allows healthcare professionals to add new rules to signal potential ADRs based on their medical expertise; 3) makes the reporting much easier by automatically linking the patients’ electronic data with the reporting form. A functioning prototype of the system has been developed. The proposed data analysis approaches as well as the performance of the system have been tested. The results indicate that this system has a great potential to improve the spontaneous reporting rate of suspected adverse drug reactions.

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STUDY TO EVALUATE SEVERE ADRS IN A TERTIARY CARE TEACHING HOSPITAL

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2017v9i5.22137 ◽

2017 ◽

pp. 55-58

Author(s):

A. R. Malahat ◽

C. Deepa Latha ◽

Sudhakar K. ◽

Deepika Baloju ◽

G. Vijayalakshmi

Keyword(s):

Adverse Drug Reactions ◽

Teaching Hospital ◽

Prospective Observational Study ◽

Healthcare Professionals ◽

Tertiary Care ◽

Care Centre ◽

Drug Reactions ◽

Tertiary Care Centre ◽

Tertiary Care Teaching Hospital ◽

Care Teaching

Objective: This study attempts to analyze the severe ADRs in a tertiary care centre and assess their seriousness, outcome, causality and severity. We emphasize on the need for reporting of ADRs by all healthcare professionals as it will reduce the burden of morbidity due to drugs and ensure better and more efficient healthcare. To analyse and evaluate the severe ADVERSE DRUG REACTIONs reported from various departments in a Tertiary care Teaching hospital.Methods: It is a prospective observational study that was carried out over a period of 6 mo (from July 2016 to December 2016) to assess the percentage of severe adverse drug reactions reported to the Pharmacovigilance cell of a tertiary care teaching hospital. The data collected included patientâ€™s demographic details, presenting complaints, clinical diagnosis and details of the drug(s) prescribed. The data was analysed for causality (as per the WHO-UMC scale) and severity (as per Hartwig and Siegel scale).Results: Out of 64 ADRs reported, 17 were serious. The majority of serious ADRs were categorized as probable (82.35%), whilst 1(5.8%) was categorized as possible and 2(11.76%) as certain in nature. The criteria for the majority of serious ADRs were hospitalization (%) followed by intervention to prevent permanent impairment or damage (%).Conclusion: The highest percentage of severe cases was reported with Antitubercular therapy (23.5%) followed by analgesics (23%) and anti epileptic agents (17.6%).

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The Role of Pharmacovigilance Center in Sudan in Reporting Adverse Drug Reactions

Pharmacoinformatics and Drug Discovery Technologies - Advances in Bioinformatics and Biomedical Engineering ◽

10.4018/978-1-4666-0309-7.ch021 ◽

2012 ◽

pp. 344-354

Author(s):

Abdalla Omer Elkhawad

Keyword(s):

Adverse Drug Reactions ◽

International Organizations ◽

Healthcare Professionals ◽

Drug Reactions ◽

Different Types ◽

Large Populations ◽

Pharmacovigilance Center

Pharmacovigilance is an active discipline, which is the study of structured mechanisms of the safety of medicines being used in clinical situations in large populations. In this chapter, the authors attempt to characterize the different types of Adverse Drug Reactions (ADRs) and related problems and mechanisms by which they cause harm to patients. They investigate the methods of detection of ADRs and various pharmacovigilance methods. The role and contributions of international organizations will be presented. The authors present the importance and need for education of healthcare professionals about pharmacovigilance and the proper reporting of ADRs for the purpose of efficient and safe use of medicines. The establishment of the Sudan pharmacovigilance center and how the system works will be discussed. Sources of data and actions taken since its inception are presented. The authors conclude by highlighting the problems and weaknesses of the system and ways to strengthen it.

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Evaluation of the knowledge, attitude and practices on adverse drug reactions and pharmacovigilance among healthcare professionals in a Nepalese hospital: a preliminary study

The Internet Journal of Pharmacology ◽

10.5580/271a ◽

2008 ◽

Vol 6 (1) ◽

Cited By ~ 1

Keyword(s):

Adverse Drug Reactions ◽

Healthcare Professionals ◽

Drug Reactions ◽

Preliminary Study

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Rare, Serious, and Comprehensively Described Suspected Adverse Drug Reactions Reported by Surveyed Healthcare Professionals in Uganda

PLoS ONE ◽

10.1371/journal.pone.0123974 ◽

2015 ◽

Vol 10 (4) ◽

pp. e0123974 ◽

Cited By ~ 3

Author(s):

Ronald Kiguba ◽

Charles Karamagi ◽

Paul Waako ◽

Helen B. Ndagije ◽

Sheila M. Bird

Keyword(s):

Adverse Drug Reactions ◽

Healthcare Professionals ◽

Drug Reactions ◽

Suspected Adverse Drug Reactions

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A comparative study of adverse drug reactions reported by healthcare professionals and patients in a tertiary care teaching hospital

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20171499 ◽

2017 ◽

Vol 6 (5) ◽

pp. 1078 ◽

Cited By ~ 1

Author(s):

Harsha Ramakrishnaiah ◽

Sushma Naidu ◽

Jyothsnya S.

Keyword(s):

Adverse Drug Reactions ◽

Healthcare Professionals ◽

Spontaneous Reporting ◽

Health Concern ◽

Selective Reporting ◽

Patient Reporting ◽

Drug Reactions ◽

Patient Reports ◽

The Impact

Background: Adverse drug reactions (ADRs) are one of major health concern affecting population of all ages causing significant morbidity mortality and hospitalization of the patients increasing the economic burden on the society. Monitoring of ADRs is of paramount importance for the continued effective and safe use of medicines. Though they are unavoidable accompaniments of pharmacotherapy, the reporting of ADR is poor and inadequate. Substantial under-reporting and selective reporting of ADRs are the major drawbacks of the commonly followed method of spontaneous reporting by healthcare professionals (HCP). Patient direct reporting of ADR has been incorporated into the pharmacivigilance (PV) system in several countries like USA, Canada, Australia, New Zealand, Denmark, Sweden and the Netherlands. Patient direct reporting of ADR was qualitatively similar to HCP ADR report. Patient reports often had richer narratives than those of HCPs. Patient reports often contained detailed information about the impact of the suspected ADR on the patient’s quality of life. The quality of ADR reported by the patients was similar to the reports by HCP in terms of description of ADRs and its severity. So, present study was taken to evaluate the process of spontaneous reporting of suspected ADR by the patient and compare the quality of ADR reported by Health care professional and Patients.Methods: This study was a prospective observational study conducted in 111 consecutive patients who experienced ADRs in the department of medicine Comparison between spontaneous reporting by healthcare professionals and patient direct reporting of adverse drug reactions was assessed in terms of response rate, pattern of ADR reported, causality by Naranjo s scale, severity by modified Hartwig scale and preventability by using Schumock and Thornton scale. Social, emotional, occupational impact due to ADR and narrative elaboration scores were also compared.Results: Majority of the ADRs were from HCP as compared to patient reporting, indicating that better awareness among HCP about pharmacovigilance Majority of the reactions reported by patient were mild in severity, in contrast majority of ADR reported by HCP were moderate. Comparisons between HCP reporting and patient direct reporting also revealed that majority of ADR in both groups were probably preventable. Qualitative analysis reported ADR showed that majority of ADR reported by HCP had no narration or had scant narration, in contrast to patient direct reporting had very elaborate narration of ADR. Patient who did direct reporting of ADR highlighted more about emotional impact, occupational impact and social impact of ADR occurred to them, when compared to ADRs reported by HCP.Conclusions: Patients were clearly willing to report any adverse drug reactions occurring to them. The evidence indicates that patient reporting of suspected ADRs has more Potential benefits than drawbacks. The results indicate that patient perceptions of potential ADRs are relevant and should be an integral part of ADR reporting system.

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Assessment of Knowledge, Attitude and Practices of Healthcare Professionals Towards Adverse Drug Reactions Monitoring and Reporting: A Cross-Sectional Study in Lahore, Pakistan

Modern Care Journal ◽

10.5812/modernc.104827 ◽

2020 ◽

Vol 17 (3) ◽

Author(s):

Furqan Hashmi ◽

Sara Mustafa Khan ◽

Sulman Qureshi ◽

Usman Rashid Malik ◽

Naveel Atif ◽

...

Keyword(s):

Health Care ◽

Adverse Drug Reactions ◽

Health Care Professionals ◽

Healthcare Professionals ◽

Cross Sectional Study ◽

Categorical Variables ◽

Sectional Study ◽

Drug Reactions ◽

Cross Sectional ◽

History Of

Background: Adverse drug reactions (ADRs) are one of the leading causes of mortality and morbidity. Avoiding adverse reactions requires comprehensive knowledge about how they can be monitored, controlled, and reported. Objectives: The current study aimed to evaluate the knowledge, attitude, practices, and perceptions of the health care professionals concerning the adverse drug reactions monitoring and reporting in Lahore, Pakistan. Methods: A prospective cross-sectional study was conducted in Lahore, Pakistan, from October 2018 to December 2018. Descriptive statistics were obtained and the Pearson chi-square test was used to analyze the association between categorical variables. Results: In total, 150 pharmacists, physicians, and nurses were approached, that 40, 39, and 46 of them responded, respectively. Almost 95% pharmacists, 17.3% of nurses, and 58.9% of physicians correctly defined the “pharmacovigilance”, while 70, 10, and 30.5%, respectively, defined ADRs correctly. The current study revealed that 87% of pharmacists, 82.5% of physicians, and 82.6% of nurses had a history of identifying ADR in patients. Out of which only 52, 41, and 19% of pharmacists, physicians, and nurses had a history of reporting adverse drug reactions, respectively. Conclusions: This study revealed inadequate knowledge of health care professionals. Most healthcare professionals were motivated to report identified ADRs. However, the responsibility lies with the governing authorities to provide them with a suitably efficient platform to practice proper ADR reporting and monitoring. Educational campaigns and training, financial incentives, and simplification of the reporting process might change the levels of knowledge and attitude.

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