scholarly journals Best Research Practice Implementation: The Experience of the N.N. Burdenko National Medical Research Center of Neurosurgery

2021 ◽  
Author(s):  
Gleb Danilov ◽  
Michael Shifrin ◽  
Yulia Strunina ◽  
Timur Ishankulov ◽  
Timur Zagidullin ◽  
...  
Keyword(s):  
Clinical Research ◽  
Medical Research ◽  
Russian Federation ◽  
Research Center ◽  
Scientific Journals ◽  
Research Practice ◽  
Level Of Evidence ◽  
National Medical ◽  
Practice Implementation ◽  
Important Shift

Implementing the best research principles initiates an important shift in clinical research culture, improving efficiency and the level of evidence obtained. In this article, we share our own view on the best research practice and our experience introducing it into the scientific activities of the N.N. Burdenko National Medical Research Center of Neurosurgery (Moscow, Russian Federation). While being adherent to the principles described in the article, the percentage of publications in the international scientific journals in our Center has increased from 7% to 27%, with an overall gain in the number of articles by 2 times since 2014. We believe it is important that medical informatics professionals equally to medical experts involved in clinical research are familiar with the best research principles.

scholarly journals A new indolocarbazole derivative in melanoma and carcinoma lung in vivo treatment

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Anna Lantsova ◽  
Irina Golubeva ◽  
Larisa Borisova ◽  
Lyudmila Nikolaeva ◽  
Lydia Ektova ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Medical Research ◽  
Russian Federation ◽  
Research Center ◽  
Maximum Effect ◽  
Drug Form ◽  
Ministry Of Health ◽  
F1 Hybrid ◽  
National Medical ◽  
Experimental Drug

Abstract Objective The current scientific research direction is development of drugs with a targeted effect on malignant tumors. One of the promising groups is indolocarbazoles and their derivatives, which can initiate various tumor cell death pathways. Russian scientists from N. N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russian Federation has developed a new experimental drug form of the original compound LCS 1269 with cytotoxic and antiangiogenic properties, blocking vasculogenic mimicry in tumor. The study aim is the experimental drug form LCS 1269 antitumor activity on models of transplantable mouse tumors B-16 melanoma and Lewis epidermoid lung carcinoma (LLC) with different routes and modes of administration. Material and methods Female F1 hybrid mice (C57Bl/6 x DBA/2) and male and female linear mice C57BL/6 were used for management of tumor strains. Mice were obtained from N. N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russian Federation vivarium. The antitumor effect was assessed by tumor growth inhibition (TGI) and increase of treated animal’s life span (ILS) compared to the control. Results The experimental drug form showed high antitumor activity when administered intravenously once at doses of 100 and 120 mg/kg (TGI = 98–82% and TGI = 95–77%, respectively, ILS = 24%, p < 0.05) on melanoma B-16 mice. On LLC mice, the experimental drug form showed that the intravenous administration route was effective in the range of doses from 60 to 80 mg/kg with a 5 day administration regimen with an interval of 24 h. A dose of 70 mg/kg had maximum effect at the level of TGI = 96–77% (p < 0.05) with its retention for 20 days after the end of treatment. Conclusion The studies have shown that the new compound LCS 1269 in the original drug form, has a pronounced antitumor activity and significantly reduces the volume of tumor mass both on melanoma B-16 and on LLC. It allows us to recommend continue the search for sensitivity of animal transplantable tumors to LCS 1269.

scholarly journals The development of pediatric oncology-hematology in the Russian Federation: the experience of collaboration between the National Society of Pediatric Hematologists and Oncologists and the National Medical Research Center

2019 ◽  
Vol 6 (3) ◽  
pp. 12-25 ◽  
Author(s):  
K. I. Kirgizov ◽  
S. A. Kogan ◽  
Ya. A. Erdomaeva ◽  
G. M. Muftakhova ◽  
T. G. Shlyakhtina ◽  
...  
Keyword(s):  
Medical Research ◽  
Russian Federation ◽  
Pediatric Oncology ◽  
Development Program ◽  
Research Center ◽  
Healthcare Sector ◽  
National Society ◽  
Pediatric Hematology ◽  
National Medical ◽  
The Russian Federation

The basis for constructing a vertically integrated management system in the healthcare sector in the Russian Federation is the model of functioning of national centers. One of the key components in achieving success is the interaction of the national center with a leading national society. The aim of the article is to present the experience of joint work of the National Society of Pediatric Hematologists and Oncologists (NSPHO) with the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology in the field of development of pediatric oncology-hematology in the Russian Federation. In order to accomplish the task of building a system for organizing medical care for children in pediatric oncology-hematology, a comprehensive development program was implemented, which included collecting data on the structure of the service through questionnaires in the regions, obtaining expert opinion and the subsequent creation of a service passport using data visualization. In addition, the experience of creating professional standards and the concept of a unified approach in the field of training in the specialties “Pediatric Oncology” and “Hematology” using the technology of continuing medical education are reflected. The result of the work was the formation of a single plan for the organization of the service of pediatric oncology-hematology, developed by the NSPHO in conjunction with the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology with the support of the National Medical House and under the leadership of the Ministry of Health of Russia.

scholarly journals Experience in Using Simulation Equipment in Teaching Transthoracic Echocardiography Skills

2021 ◽  
Vol 1 (3) ◽  
pp. 132-133
Author(s):  
Kh. A. Tengizov ◽  
S. V. Shahidzhanova ◽  
M. A. Saidova
Keyword(s):  
Medical Research ◽  
Russian Federation ◽  
Transthoracic Echocardiography ◽  
Research Center ◽  
Federal State ◽  
Ministry Of Health ◽  
National Medical ◽  
The Russian Federation

This paper describes the experience of teaching transthoracic echocardiography (TTE) skills on simulation equipment, accumulated over 2 years of training of residents in the direction of "Cardiology" at the Federal State Budgetary Institution "National Medical Research Center of Cardiology" of the Ministry of Health of the Russian Federation (Cardiocenter).

scholarly journals Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study. Ten years later

2021 ◽  
Vol 20 (5) ◽  
pp. 3007
Author(s):  
S. A. Boytsov ◽  
O. M. Drapkina ◽  
E. V. Shlyakhto ◽  
A. O. Konradi ◽  
Yu. A. Balanova ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Medical Research ◽  
Epidemiological Study ◽  
Russian Federation ◽  
Research Center ◽  
Noncommunicable Diseases ◽  
Russian Regions ◽  
National Medical ◽  
Epidemiological Characteristics

The growing weight of noncommunicable diseases, primarily cardiovascular diseases (CVDs), is a great threat to the health of population worldwide, worsening the quality of life and reducing life expectancy. Realization of this threat led to initiation of epidemiological study by the Russian Ministry of Health to investigate the prevalence of CVDs and their risk factors, since it is CVDs that specify the high allcause mortality in Russia. In the modern history of epidemiology of non-infectious disease, the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study occupies a special place. This is the largest epidemiological study, which is considered as a continuation of preventive activity in order to obtain unbiased information on epidemiological characteristics of population in Russian regions. To conduct the study, the Research Organizing Committee of ESSE-RF study was created and a protocol was developed. All interested scientists and experts from following three centers took part in the work: National Medical Research Center for Therapy and Preventive Medicine, Almazov National Medical Research Center, National Medical Research Center of Cardiology. The Russian regions were justified and selected for participation. In 2012-2014 ESSE-RF study, 13 following Russian regions took part: Volgograd, Vologda, Voronezh, Ivanovo, Kemerovo, Tyumen Oblasts; Krasnoyarsk and Primorsky Krai; the Republic of North Ossetia (Alania); cities of Orenburg, Samara, St. Petersburg and Tomsk. All participated regions used a single study protocol, while biochemical parameters were determined in Federal centers using the same equipment and reagent kits. The paper presents some of the most interesting results that indicate a change in Russian epidemiological situation over the past few years. After the end of cross-sectional study, a field of priority research areas was formed in each center.Conclusion. Epidemiological studies are the most important scientific tool for assessing the prevalence of diseases, their risk factors, as well as predicting adverse events. Based on the results obtained, healthcare system and medical community determine priorities and develop related strategies (population-based and high-risk strategies). For their implementation, a regulatory and legal framework is being created.

scholarly journals State of Specialized Outpatient Trauma and Orthopedic Care in the Russian Federation. Development Perspectives

2017 ◽  
pp. 5-10 ◽  
Author(s):  
N. A. Es’kin ◽  
T. M. Andreeva
Keyword(s):  
Medical Research ◽  
Musculoskeletal Disorders ◽  
Russian Federation ◽  
Outpatient Care ◽  
The State ◽  
Research Center ◽  
National Medical ◽  
Orthopedic Care ◽  
The Russian Federation ◽  
Injured Patients

N.N. Priorov National Medical Research Center of Traumatology and Orthopaedics, Moscow, Russia Injuries and musculoskeletal disorders are the most widely spread diseases. It is shown that the majority of injured patients and patients with orthopedic pathology require an outpatient care. The state of specialized outpatient care is analyzed and the ways of its perfection are proposed. 

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