SYSTEM APPROACH TO INFORMATIONAL SUPPORT OF PHARMACEUTICAL DEVELOPMENT OF FINISHED MEDICINAL PRODUCTS

The article considers the application of the system approach for constructing informational support for the life cycle of the production of medicinal products. The principal difficulties of creating a single informational system of the entire life cycle are considered in this article. A brief analysis of the information and computer support of individual links in the life cycle is given. Particular attention is paid to the use of a systematic approach to the creation of information support for the pharmaceutical development of medicines. The principle of QbD - “Quality planned for development” - was taken as a basis. For the implementation the QbD principle on the basis of the system approach, it is proposed to use the Shewhart-Deming iteration cycle to create an information support for a sustainable search for the optimal version (the program) of the conducted studies. The possibility of combining the PDCA cycle and the methodology of the system approach is shown. On its basis, system-theoretic multiple models of nformation support for pharmaceutical development in the graphic-analytical nomination were constructed. The method of applying the criterial approach for the formation of global and local criteria for managing research and the construction of system management models in the Melentiev’s brackets nomination are presented. The information modeling of the stage of pharmaceutical development has been carried out. Functional models have been constructed in the IDEF0 nomination.

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INFORMATION-ALGORITHMIC SUPPORT FOR DEVELOPMENT OF SOLID PHARMACEUTICAL FORM

Тонкие химические технологии ◽

10.32362/2410-6593-2018-13-5-73-81 ◽

2018 ◽

Vol 13 (5) ◽

pp. 73-81 ◽

Cited By ~ 2

Author(s):

V. F. Kornushk ◽

I. V. Bogunova ◽

A. A. Flid ◽

O. M. Nikolaeva ◽

A. A. Grebenshchikov

Keyword(s):

System Approach ◽

Dosage Form ◽

Dosage Forms ◽

Information Modeling ◽

Relational Model ◽

Information Support ◽

Solid Dosage Forms ◽

Pharmaceutical Development ◽

Solid Dosage Form ◽

Solid Dosage

The article deals with the application of the system approach for constructing informationalgorithmic support for the pharmaceutical development of solid dosage forms. Information modeling of the life cycle of pharmaceutical drug development has been carried out starting from the stage of studying the active pharmaceutical substance and ending with the utilization of the drug. These models are built in the IDEF0 nomination. A generalized block diagram is presented that reflects, in its most general form, the iterative process of developing a ready-made dosage form as applied to the further transfer of technology. The basis of the system approach is QbD - "Quality planned in the development". To implement the QbD principle on the basis of the system approach, systemic set-theoretic models of information support of pharmaceutical development in the nomenclature of Melentiev have been constructed. A model for controlling the pressing process is also provided, which takes into account all the technological stages in the development of a solid dosage form. Functional models in the IDEF0 nomenclature of the technological process are constructed from the preparation of premises, personnel and components of the dosage form to the stage of packing and packaging of the finished dosage form. The construction of an informational intellectual control system for pharmaceutical development has been considered in detail with particular attention paid to the construction of a database of medicinal and auxiliary substances using the example of solid dosage forms. In Melentiev's bracket notation, the database of auxiliary substances necessary for the design of a solid dosage form is filled. The "Entity-relationship" model and the relational model for the database of medicinal and auxiliary substances have been constructe

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Pass-through information support of order industrial production of furniture

Forestry Engineering Journal ◽

10.12737/1761 ◽

2013 ◽

Vol 3 (3) ◽

pp. 76-81 ◽

Cited By ~ 1

Author(s):

Стариков ◽

Aleksandr Starikov ◽

Брыкин ◽

Aleksey Brykin

Keyword(s):

Life Cycle ◽

Industrial Production ◽

Product Life Cycle ◽

Information Support ◽

Informational Support ◽

Automated Systems ◽

Product Life ◽

Cad System ◽

Pass Through

The advantages of using light CAD system in the production of furniture are investigated. They allow providing rapid product develop-ment, as well as carrying out all necessary engineering calculations. In addition, it is possible efficiently and as quickly as possible to prepare the product for production. The basic stages of informational support through the product life cycle with reference to automated systems are described. There are the advantages of the use of transparent information to support the product in the conditions of order manufacturing.

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Effectiveness Of Life Cycle Management Of Projects Using Information Modeling

Promyshlennoe i Grazhdanskoe Stroitel stvo ◽

10.33622/0869-7019.2019.09.24-29 ◽

2019 ◽

pp. 24-29 ◽

Cited By ~ 1

Keyword(s):

Life Cycle ◽

Construction Projects ◽

Life Cycle Management ◽

Information Modeling ◽

Engineering Systems ◽

Basic Principles ◽

Complex Engineering ◽

Domestic Practices ◽

Capital Construction ◽

Complex Engineering Systems

Improving the efficiency of life cycle management of capital construction projects using information modeling technologies is one of the important tasks of the construction industry. The paper presents an analysis of accumulated domestic practices, including the legal and regulatory framework, assessing the effectiveness of managing the implementation of investment construction projects and of complex and serial capital construction projects, as well as the life cycle management of especially dangerous technically complex and unique capital construction projects using information modeling technologies, especially capital construction projects, as well as their supporting and using systems, primarily in the nuclear and transport sectors. A review of modern approaches to assessing the effectiveness of life cycle management systems of complex engineering systems in relation to capital construction projects is carried out. The presented material will make it possible to formulate the basic principles and prospects of applying approaches to assessing the effectiveness of the life cycle management system of a capital construction project using information modeling technologies.

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Life Cycle of Construction Objects at Information Simulation of Buildings and Structures

Promyshlennoe i Grazhdanskoe Stroitel stvo ◽

10.33622/0869-7019.2019.01.65-72 ◽

2019 ◽

pp. 65-72 ◽

Cited By ~ 2

Keyword(s):

Life Cycle ◽

Construction Projects ◽

Life Cycle Management ◽

Information Modeling ◽

Sources Of Information ◽

Logical Scheme ◽

Modeling Technology ◽

Information Models ◽

Building Information ◽

The Russian Federation

The variants of the division of the life cycle of a construction object at the stages adopted in the territory of the Russian Federation, as well as in other countries are considered. Particular attention is paid to the exemplary work plan – "RIBA plan of work", used in England. A feature of this document is its applicability in the information modeling of construction projects (Building information Modeling – BIM). The article presents a structural and logical scheme of the life cycle of a building object and a list of works that are performed using information modeling technology at various stages of the life cycle of the building. The place of information models in the process of determining the service life of the building is shown. On the basis of the considered sources of information, promising directions for the development of the life cycle management system of the construction object (Life Cycle Management) and the development of the regulatory framework in order to improve the use of information modeling in construction are given.

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Integrated Information Support System (IISS). Volume 5. Common Data Model Subsystem. Part 4. Information Modeling Manual - IDEF1 Extended Development Specification for the CDM Subsystem

10.21236/ada252449 ◽

1990 ◽

Author(s):

J. L. Althoff ◽

M. L. Apicella ◽

S. Singh

Keyword(s):

Support System ◽

Data Model ◽

Information Modeling ◽

Information Support ◽

Common Data Model ◽

Information Support System ◽

Integrated Information

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Integration of Emergy Analysis with Building Information Modeling

Sustainability ◽

10.3390/su13147990 ◽

2021 ◽

Vol 13 (14) ◽

pp. 7990

Author(s):

Suman Paneru ◽

Forough Foroutan Jahromi ◽

Mohsen Hatami ◽

Wilfred Roudebush ◽

Idris Jeelani

Keyword(s):

Life Cycle ◽

Building Materials ◽

Building Information Modeling ◽

Energy Analysis ◽

Information Modeling ◽

Environmental Cost ◽

Emergy Analysis ◽

Modeling Tools ◽

Building Information

Traditional energy analysis in Building Information Modeling (BIM) only accounts for the energy requirements of building operations during a portion of the occupancy phase of the building’s life cycle and as such is unable to quantify the true impact of buildings on the environment. Specifically, the typical energy analysis in BIM does not account for the energy associated with resource formation, recycling, and demolition. Therefore, a comprehensive method is required to analyze the true environmental impact of buildings. Emergy analysis can offer a holistic approach to account for the environmental cost of activities involved in building construction and operation in all its life cycle phases from resource formation to demolition. As such, the integration of emergy analysis with BIM can result in the development of a holistic sustainability performance tool. Therefore, this study aimed at developing a comprehensive framework for the integration of emergy analysis with existing Building Information Modeling tools. The proposed framework was validated using a case study involving a test building element of 8’ × 8’ composite wall. The case study demonstrated the successful integration of emergy analysis with Revit®2021 using the inbuilt features of Revit and external tools such as MS Excel. The framework developed in this study will help in accurately determining the environmental cost of the buildings, which will help in selecting environment-friendly building materials and systems. In addition, the integration of emergy into BIM will allow a comparison of various built environment alternatives enabling designers to make sustainable decisions during the design phase.

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