Supraglottic Cancer Pathologic Primary Tumor TNM Finding v7

Whole-body scintigraphy with both 99mTc-phosphonate and 67Ga was performed on 92 patients suspected of primary bone tumors. In 46 patients with primary malignant bone tumors, scintigraphy with 99mTc-phosphonate disclosed the primary tumor in 44 cases and skeletal metastases in 11, and 67Ga scintigraphy detected the primary tumor in 43 cases, skeletal metastases in 6 cases and soft-tissue metastases in 8 cases. In 25 patients with secondary malignant bone tumors, bone scintigraphy visualized a single lesion in 10 cases and several lesions in 15 cases, and 67Ga scintigraphy detected the primary tumor in 17 cases, skeletal metastases in 17 cases and soft-tissue metastases in 9 cases. In 21 patients with benign bone disease positive uptake of 99mTc-phosphonate was recognized in 19 cases and uptake of 67Ga in 17 cases. It is concluded that bone scintigraphy should be used in patients suspected of primary bone tumors. If malignancy is suspected, 67Ga scintigraphy should be performed in addition.

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Heterogenous PSMA expression in primary tumor of prostate cancer as a reason for negative 68 Ga-PSMA PET/CT scan? Immunohistochemical validation of 40 patients undergoing radical prostatectomy

10.1055/s-0040-1708334 ◽

2020 ◽

Author(s):

W Cytawa ◽

S Kircher ◽

C Lapa ◽

AK Buck ◽

B Brockhuis ◽

...

Keyword(s):

Prostate Cancer ◽

Radical Prostatectomy ◽

Ct Scan ◽

Primary Tumor ◽

Psma Pet ◽

Pet Ct ◽

Pet Ct Scan ◽

Psma Expression

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Clinical Outcome of Salvage Treatment for Recurrent Supraglottic Cancer

Korean Journal of Otolaryngology - Head and Neck Surgery ◽

10.3342/kjorl-hns.2009.52.5.419 ◽

2009 ◽

Vol 52 (5) ◽

pp. 419

Author(s):

Ji Heui Kim ◽

Yoon Se Lee ◽

Min Su Kwon ◽

Jong-Lyel Roh ◽

Seung-Ho Choi ◽

...

Keyword(s):

Clinical Outcome ◽

Salvage Treatment ◽

Supraglottic Cancer

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The Role of Wireless Capsule Endoscopy (WCE) in the Detection of Occult Primary Neuroendocrine Tumors

Journal of Gastrointestinal and Liver Diseases ◽

10.15403/jgld.2014.1121.262.wce ◽

2017 ◽

Vol 26 (2) ◽

pp. 151-156

Author(s):

Manuele Furnari ◽

Andrea Buda ◽

Gabriele Delconte ◽

Davide Citterio ◽

Theodor Voiosu ◽

...

Keyword(s):

Neuroendocrine Tumor ◽

Neuroendocrine Tumors ◽

Capsule Endoscopy ◽

Primary Tumor ◽

Diagnostic Yield ◽

Somatostatin Receptor ◽

Tertiary Care ◽

Wireless Capsule Endoscopy ◽

First Line ◽

Wireless Capsule

Background & Aims: Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms with unclear etiology that may show functioning or non-functioning features. Primary tumor localization often requires integrated imaging. The European Neuroendocrine Tumors Society (ENETS) guidelines proposed wireless-capsule endoscopy (WCE) as a possible diagnostic tool for NETs, if intestinal origin is suspected. However, its impact on therapeutic management is debated. We aimed to evaluate the yield of WCE in detecting intestinal primary tumor in patients showing liver NET metastases when first-line investigations are inconclusive.Method: Twenty-four patients with histological diagnosis of metastatic NET from liver biopsy and no evidence of primary lesions at first-line investigations were prospectively studied in an ENETS-certified tertiary care center. Wireless-capsule endoscopy was requested before explorative laparotomy and intra-operative ultrasound. The diagnostic yield of WCE was compared to the surgical exploration.Results: Sixteen subjects underwent surgery; 11/16 had positive WCE identifying 16 bulging lesions. Mini-laparotomy found 13 NETs in 11/16 patients (9 small bowel, 3 pancreas, 1 bile ducts). Agreement between WCE and laparotomy was recorded in 9 patients (Sensitivity=75%; Specificity=37.5%; PPV=55%; NPV=60%). Correspondence assessed per-lesions produced similar results (Sensitivity=70%; Specificity=25%; PPV=44%; NPV=50%). No capsule retentions were recorded.Conclusions: Wireless-capsule endoscopy is not indicated as second-line investigation for patients with gastro-entero-pancreatic NETs. In the setting of a referral center, it might provide additional information when conventional investigations are inconclusive about the primary site.Abbreviations: DBE: double balloon enteroscopy; GEP-NET: gastro-entero-pancreatic neuroendocrine tumor; GI: gastrointestinal; ENETS: European Neuroendocrine Tumor Society; NET: neuroendocrine tumor; SSRS: somatostatin receptor scintigraphy; WCE: wireless capsule endoscopy.

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