Atypical Endometriosis

Abstract Background In recent years, the endometriosis has overcome a noteworthy renaissance in the recognition of its potential. In certain patients, a demonstrable malignant progression of ectopic foci leading to development of ovarian cancer is seen. The knowledge of endometriosis overthrow background into endometriosis associated ovarian cancer is of paramount importance for selection of patients at risk. The goal of the presented study was to review a malignant potential of the endometriosis and to specify predictive factors of endometriosis progression into ovarian cancer. Altogether 189 patients were included in the study. Conventional cytogenetics as well as measurement of transcriptional activity of CTNNB1 (β-catenin) and HIF1A (HIF1-α) genes were prospectively studied in 60 endometriosis patients and 50 control group patients. The retrospective histopathological analysis was performed in 19 endometriosis associated ovarian cancer patients and 60 patients with histologically confirmed endometriosis. Results Five endometriosis patients showed a deviation from normal cytogenetics finding without affecting of their phenotype. In 6 cases of endometriosis associated ovarian cancer ectopic endometrium was not confirmed. The remaining 13 cases demonstrated either benign or atypical endometriosis or even structures of borderline carcinoma. Atypical endometriosis was histologically confirmed in 20% of 60 endometriosis patients. Determination of gene expression (CTNNB1, HIF1A) formed two subgroups. Transcriptionally incipient endometriosis subgroup with insignificant genes expression compared to control group. In transcriptionally evident endometriosis subgroup were genes expressions significantly higher compared to control group (p < 0.01) as well as transcriptionally incipient endometriosis subgroup (p < 0.05). Conclusions Significant structural abnormalities of chromosomes are not included in genetic rigging of endometriosis patients. Atypical endometriosis represents a histopathologically detectable intermediate of endometriosis progression. Determination of genes expression CTNNB1 and HIF1A helps to allocate risk patients with endometriosis where more precise management is needed.

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Evaluation of PTEN and Ki67 Expression in Typical and Atypical Endometriosis and Endometriosis Associated Ovarian Cancer

Shiraz E-Medical Journal ◽

10.5812/semj.99291 ◽

2020 ◽

Vol 21 (11) ◽

Author(s):

Mojgan Akbarzadeh-Jahromi ◽

Zahra Zare ◽

Fatemeh Sari Aslani ◽

Simin Torabinezhad

Keyword(s):

Ovarian Cancer ◽

Precancerous Lesion ◽

Early Event ◽

P Value ◽

Ovarian Endometriosis ◽

Ki 67 ◽

Pten Loss ◽

Epithelial Component ◽

Increased Risk ◽

Atypical Endometriosis

Background: Several studies reported that endometriosis is associated with an increased risk of ovarian cancer. Atypical endometriosis is common in patients with endometriosis-associated ovarian, which might be considered as a precancerous lesion. Objectives: This study aimed to assess ki67 and PTEN expression in endometriosis associated ovarian cancer (EAOC), atypical endometriosis, and typical endometriosis. Methods: In this study, all H & E slides of 260 ovarian endometriosis cases were reviewed. And 25 cases were diagnosed with atypical endometriosis. Forty-one typical endometrioses and 24 ovarian cancers with endometriosis were included. We assessed PTEN and Ki67 immunoexpression in epithelial and stromal cells. Results: The prevalence of atypical endometriosis was about 9%. PTEN loss was found in 12 (out of 24 or 50%) of EAOC, 2 (out of 25; 8%) of atypical endometriosis, and none of the typical endometriosis. In all 12 PTEN loss cases, the PTEN loss pattern in endometriosis adjacent to ovarian cancer was similar to that of ovarian cancer. A total of 7.3% of typical endometriosis and 8% atypical endometriosis and 33.3% of EAOC had Ki67 staining in more than 50% of the epithelial component. Both typical and atypical endometriosis showed similar PTEN loss and Ki 67 staining (in more than 50% of the epithelial component) (P value > 0.05), and both of them were different from EAOC (P value < 0.05). Conclusions: The PTEN loss pattern in endometriosis adjacent to ovarian cancer was similar to that of ovarian cancer. The result indicated that PTEN loss could be an early event in the tumor development pathway from endometriosis to ovarian cancer.

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Cancer-associated protein Tetraspanin1 increases cell growth through AMPK in atypical endometriosis

Gynecologic Oncology ◽

10.1016/j.ygyno.2020.05.197 ◽

2020 ◽

Vol 159 ◽

pp. 145

Author(s):

H. Shin ◽

D.B. Chay ◽

W. Yang ◽

H. Cho ◽

S. Jeon ◽

...

Keyword(s):

Cell Growth ◽

Atypical Endometriosis

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Carcinosarcoma arising from atypical endometriosis in a cesarean section scar

International Journal of Gynecological Cancer ◽

10.1111/j.1525-1438.2006.00199.x ◽

2006 ◽

Vol 16 (1) ◽

pp. 432-435 ◽

Cited By ~ 40

Author(s):

J. LENG ◽

J. LANG ◽

L. GUO ◽

H. LI ◽

Z. LIU

Keyword(s):

Cesarean Section ◽

Atypical Endometriosis

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Atypical Endometriosis of the Urinary Bladder: Review of the Literature and a Clinical Case

Doctor Ru ◽

10.31550/1727-2378-2018-150-6-61-66 ◽

2018 ◽

pp. 61-66 ◽

Cited By ~ 2

Author(s):

N. N. Bairamova ◽

◽

A. E. Protasova ◽

G. A. Raskin ◽

Kh. N. Bairamov ◽

...

Keyword(s):

Urinary Bladder ◽

Clinical Case ◽

Review Of The Literature ◽

Atypical Endometriosis

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Association between atypical endometriosis and ovarian malignancies in the real world

Journal of Ovarian Research ◽

10.1186/s13048-021-00865-2 ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Kyeong A So ◽

Sung Ran Hong ◽

Nae Ri Kim ◽

Eun Jung Yang ◽

Seung-Hyuk Shim ◽

...

Keyword(s):

Ovarian Tumor ◽

Clinical Characteristics ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Borderline Tumor ◽

Endometrioid Adenocarcinoma ◽

Ovarian Malignancy ◽

Histopathological Results ◽

Endometriosis Surgery ◽

Atypical Endometriosis

Abstract Background To evaluate the clinical outcome of atypical endometriosis and its association with ovarian malignancy. Methods This retrospective study included patients diagnosed with atypical endometriosis between January 2001 and December 2017. All patients had received surgical treatment for ovarian tumor. The clinical characteristics and histopathological results of all patients were reviewed. Results Atypical endometriosis was diagnosed in 101 patients. We analyzed 98 patients with a mean age of 34.8 years (range: 16–58 years). Ten patients (10.2%) had previously undergone endometriosis surgery more than once. In total, 12 (12.2%) patients had atypical endometriosis-associated ovarian malignancy—nine had carcinomas and three had borderline tumor. The tumors were pathologically classified as follows: five, clear cell carcinomas; two, endometrioid adenocarcinomas; one, mixed clear cell and endometrioid adenocarcinoma; one, seromucinous carcinoma; two, mucinous borderline tumors; and one, seromucinous borderline tumor. Conclusion Atypical endometriosis is most frequently associated with clear cell carcinoma and endometrioid adenocarcinoma. To identify the risk of ovarian malignancy and manage patients with endometriosis, diagnosing atypical endometriosis and recognizing its precancerous potential are important.

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Long-Term Follow-Up after Surgical Management for Atypical Endometriosis: A Series of Nine Cases

Case Reports in Oncology ◽

10.1159/000496178 ◽

2019 ◽

Vol 12 (1) ◽

pp. 76-83 ◽

Cited By ~ 1

Author(s):

Yasuhito Tanase ◽

Ryuji Kawaguchi ◽

Tomoko Uchiyama ◽

Hiroshi Kobayashi

Keyword(s):

Ovarian Cancer ◽

Clinical Characteristics ◽

Median Overall Survival ◽

Case Series ◽

Endometrioid Carcinoma ◽

Long Term Follow Up ◽

Laparoscopic Cystectomy ◽

Atypical Endometriosis

Background and Objective: Atypical endometriosis is reported to possess a precancerous potential attributed to premalignant changes characterized by cytological atypia and architecture proliferation. Although the coexistence of atypical endometriosis and neoplasms has been reported, cases of atypical endometriosis transformation to carcinoma are rarely reported. The purpose of this case series was to evaluate the prognosis of atypical endometriosis. Subjects and Methods: Data from nine women who underwent surgical treatment including cystectomy and salpingo-oophorectomy with or without hysterectomy and diagnosed with atypical endometriosis was analyzed. Between January 2006 and January 2018, the clinical characteristics and prognosis of atypical endometriosis were evaluated. Results: During the follow-up period, eight of nine patients with atypical endometriosis did not develop malignant epithelial tumors, although one patient developed endometrioid carcinoma, grade 1, 48 months after her right laparoscopic cystectomy. The median overall survival period for all patients was 68 (range 13–131) months. Conclusion: When we encounter the cases of atypical endometriosis, it is necessary to consider the possibility of ovarian cancer and carefully follow those cases for long periods.

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Umbilical Nodule with Cyclical Bleeding: A Case Report and Literature Review of Atypical Endometriosis

Case Reports in Obstetrics and Gynecology ◽

10.1155/2016/7401409 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6

Author(s):

Marlene Teixeira Andrade ◽

Cláudia V. Marques de Freitas ◽

Sara Filipa Camacho Câmara ◽

José Joaquim Nunes Vieira

Keyword(s):

Case Report ◽

Laparoscopic Surgery ◽

Literature Review ◽

Medical History ◽

Surgical Resection ◽

Diagnostic Tests ◽

Reproductive Age ◽

Women Of Reproductive Age ◽

Atypical Endometriosis ◽

Umbilical Endometriosis

Endometriosis is defined as the presence of endometrial glands and stroma outside the uterus. It affects 3 to 10 percent of women of reproductive age. Umbilical endometriosis is rare, with an estimated incidence of 0.5–1.0% among all cases of endometriosis, and is usually secondary to prior laparoscopic surgery involving the umbilicus. In this report, we described a case of umbilical endometriosis treated with surgical resection and highlight the great importance of medical history compared to complementary diagnostic tests that can be sometimes inconclusive.

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