scholarly journals Sodium Phenylacetate

2020 ◽  
Author(s):  
Keyword(s):  
Sodium Phenylacetate

scholarly journals Lovastatin and sodium phenylacetate normalize the levels of very long chain fatty acids in skin fibroblasts of X- adrenoleukodystrophy

FEBS Letters ◽  
1998 ◽  
Vol 426 (3) ◽  
pp. 342-346 ◽  
Author(s):  
Inderjit Singh ◽  
Kalipada Pahan ◽  
Mushfiquddin Khan
Keyword(s):  
Fatty Acids ◽  
Skin Fibroblasts ◽  
Long Chain Fatty Acids ◽  
Sodium Phenylacetate ◽  
Long Chain ◽  
Chain Fatty Acids

Synergistic inhibition of human rhabdomyosarcoma cells by sodium phenylacetate and tretinoin

1993 ◽  
Vol 29 (3) ◽  
pp. 189-191 ◽  
Author(s):  
Grzegorz K. Górski ◽  
Milton H. Donaldson ◽  
Lydia E. McMorrow
Keyword(s):  
Synergistic Inhibition ◽  
Sodium Phenylacetate

Ionic conductance of sodium phenylacetate

2016 ◽  
pp. 1430-1430
Author(s):  
Rudolf Holze
Keyword(s):  
Ionic Conductance ◽  
Sodium Phenylacetate

scholarly journals Clinical and biochemical findings in 7 patients with X-linked adrenoleukodystrophy treated with Lorenzo's Oil

2000 ◽  
Vol 23 (4) ◽  
pp. 697-701 ◽  
Author(s):  
Carmen R. Vargas ◽  
Alethéa G. Barschak ◽  
Daniella M. Coelho ◽  
Vivian Furlanetto ◽  
Carolina F.M. de Souza ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Biological Fluids ◽  
Long Chain Fatty Acids ◽  
Restricted Diet ◽  
Male Patients ◽  
Sodium Phenylacetate ◽  
Tetracosanoic Acid ◽  
Lorenzo’S Oil ◽  
Recommended Therapy ◽  
Long Chain

X-Linked adrenoleukodystrophy (X-ALD) is a hereditary disorder of the peroxisomal metabolism biochemically characterized by the accumulation of very long chain fatty acids (VLCFA) in tissues and biological fluids. The major accumulated acids are hexacosanoic acid (C26:0) and tetracosanoic acid (C24:0). The disorder is characterized clinically by central and peripheral demyelination and adrenal insufficiency closely related to the accumulation of fatty acids. The incidence of X-ALD is estimated to be 1:25,000 males. At least six phenotypes can be distinguished. The most common phenotypes are childhood cerebral ALD and adrenomyeloneuropathy (AMN). The recommended therapy consists of the use of the glyceroltrioleate/glyceroltrierucate (GTO/GTE) mixture, known as Lorenzo's Oil, combined with a VLCFA-poor diet. There are alternative treatments such as bone marrow transplantation and immunosuppression, as well as the use of lovastatin and sodium phenylacetate. In the present study we report the clinical and biochemical course of 7 male patients with X-ALD treated with Lorenzo's Oil and a VLCFA-restricted diet. Treatment produced 50% reduction in C26:0 and 42.8% reduction in the C26:0/C22:0 ratio. Most patients remained clinically well, although approximately 30% of them presented a rapid clinical deterioration. The results showed a poor biochemical-clinical correlation for treatment, indicating that new therapies for X-ALD are needed in order to obtain a better prognosis for patients.

Extinction coefficient and recombination rate of benzyl radicals. I. Photolysis of sodium phenylacetate

1972 ◽  
Vol 94 (23) ◽  
pp. 7981-7986 ◽  
Author(s):  
Theodore O. Meiggs ◽  
Leonard I. Grossweiner ◽  
Sidney I. Miller
Keyword(s):  
Extinction Coefficient ◽  
Recombination Rate ◽  
Benzyl Radicals ◽  
Sodium Phenylacetate

scholarly journals A novel sodium phenylacetate-dextran derivative ester inhibits the growth and angiogenesis of MCF-7ras breast cancer xenografts

2001 ◽  
Vol 3 (S1) ◽  
Author(s):  
M Di Benedetto ◽  
D Briane ◽  
O Oudar ◽  
O Sainte Catherine ◽  
J Jozefonvicz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Sodium Phenylacetate ◽  
Breast Cancer Xenografts

scholarly journals Sodium phenylacetate enhances the inhibitory effect of dextran derivative on breast cancer cell growth in vitro and in nude mice

2001 ◽  
Vol 85 (6) ◽  
pp. 917-923 ◽  
Author(s):  
M Di Benedetto ◽  
Y Kourbali ◽  
A Starzec ◽  
R Vassy ◽  
J Jozefonvicz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Nude Mice ◽  
Inhibitory Effect ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Sodium Phenylacetate

Three cases of intravenous sodium benzoate and sodium phenylacetate toxicity occurring in the treatment of acute hyperammonaemia

2000 ◽  
Vol 23 (2) ◽  
pp. 129-136 ◽  
Author(s):  
V. Praphanproj ◽  
S. A. Boyadjiev ◽  
L. J. Waber ◽  
S. W. Brusilow ◽  
M. T. Geraghty
Keyword(s):  
Sodium Benzoate ◽  
Sodium Phenylacetate ◽  
Intravenous Sodium
Sign in / Sign up

Export Citation Format

Share Document