Synergistic inhibition of human rhabdomyosarcoma cells by sodium phenylacetate and tretinoin

1993 ◽  
Vol 29 (3) ◽  
pp. 189-191 ◽  
Author(s):  
Grzegorz K. Górski ◽  
Milton H. Donaldson ◽  
Lydia E. McMorrow
Keyword(s):  
Synergistic Inhibition ◽  
Sodium Phenylacetate

Synergistic Inhibition Between Polyvinylpyrollidone and Iodide Ions on Corrosion of Aluminium in HCl~!2008-10-03~!2008-11-08~!2009-01-06~!

2009 ◽  
Vol 2 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Saviour A. Umoren ◽  
Ime B. Obot ◽  
Isaac O. Igwe
Keyword(s):  
Iodide Ions ◽  
Synergistic Inhibition

scholarly journals Mechanism of pyruvate inhibition of kidney pyruvate dehydrogenasea kinase and synergistic inhibition by pyruvate and ADP.

1979 ◽  
Vol 254 (15) ◽  
pp. 7191-7196 ◽  
Author(s):  
M L Pratt ◽  
T E Roche
Keyword(s):  
Synergistic Inhibition

Trapping of Acrolein by Curcumin and the Synergistic Inhibition Effect of Curcumin Combined with Quercetin

2020 ◽  
Author(s):  
Xiaoyun Jiang ◽  
Huifang Lv ◽  
Yang Lu ◽  
Yongling Lu ◽  
Lishuang Lv
Keyword(s):  
Inhibition Effect ◽  
Synergistic Inhibition ◽  
Synergistic Inhibition Effect

scholarly journals Enhanced anti-melanoma efficacy through a combination of the armed oncolytic adenovirus ZD55-IL-24 and immune checkpoint blockade in B16-bearing immunocompetent mouse model

2021 ◽  
Author(s):  
Hai-Jun Hu ◽  
Xiu Liang ◽  
Hai-Lang Li ◽  
Huai-Yuan Wang ◽  
Jin-Fa Gu ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Mouse Model ◽  
Immune Checkpoint Blockade ◽  
Oncolytic Adenovirus ◽  
Immunocompetent Mouse ◽  
Combination Strategy ◽  
Obvious Effect ◽  
Immune Infiltration ◽  
Synergistic Inhibition ◽  
Recent Treatment

AbstractAlthough the recent treatment in melanoma through the use of anti-PD-1 immunotherapy is successful, the efficacy of this approach remains to be improved. Here, we explore the feasibility of combination strategy with the armed oncolytic adenovirus ZD55-IL-24 and PD-1 blockade. We find that combination therapy with localized ZD55-IL-24 and systemic PD-1 blockade leads to synergistic inhibition of both local and distant established tumors in B16-bearing immunocompetent mouse model. Our further mechanism investigation reveals that synergistic therapeutic effect is associated with marked promotion of tumor immune infiltration and recognition in both local and distant tumors as well as spleens. PD-1 blockade has no obvious effect on promotion of tumor immune infiltration and recognition. Localized therapy with ZD55-IL-24, however, can help PD-1 blockade to overcome the limitation of relatively low tumor immune infiltration and recognition. This study provides a rationale for investigation of such combination therapy in the clinic.

scholarly journals Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2061
Author(s):  
Cecilia Pozzi ◽  
Matteo Santucci ◽  
Gaetano Marverti ◽  
Domenico D’Arca ◽  
Lorenzo Tagliazucchi ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Thymidylate Synthase ◽  
Ovarian Cancer Cell ◽  
Ovarian Cancer Cells ◽  
Preclinical Research ◽  
Cancer Cell Growth ◽  
X Ray ◽  
Synergistic Inhibition

Combining drugs represent an approach to efficiently prevent and overcome drug resistance and to reduce toxicity; yet it is a highly challenging task, particularly if combinations of inhibitors of the same enzyme target are considered. To show that crystallographic and inhibition kinetic information can provide indicators of cancer cell growth inhibition by combinations of two anti-human thymidylate synthase (hTS) drugs, we obtained the X-ray crystal structure of the hTS:raltitrexed:5-fluorodeoxyuridine monophosphate (FdUMP) complex. Its analysis showed a ternary complex with both molecules strongly bound inside the enzyme catalytic cavity. The synergistic inhibition of hTS and its mechanistic rationale were consistent with the structural analysis. When administered in combination to A2780 and A2780/CP ovarian cancer cells, the two drugs inhibited ovarian cancer cell growth additively/synergistically. Together, these results support the idea that X-ray crystallography can provide structural indicators for designing combinations of hTS (or any other target)-directed drugs to accelerate preclinical research for therapeutic application.

Synergistic inhibition behavior between indigo carmine and cetyl trimethyl ammonium bromide on carbon steel corroded in a 0.5 M HCl solution

2015 ◽  
Vol 357 ◽  
pp. 845-855 ◽  
Author(s):  
Zhe Zhang ◽  
Ningchen Tian ◽  
Xiuying Li ◽  
Lingzhi Zhang ◽  
Ling Wu ◽  
...  
Keyword(s):  
Carbon Steel ◽  
Cetyl Trimethyl Ammonium Bromide ◽  
Indigo Carmine ◽  
Ammonium Bromide ◽  
Synergistic Inhibition ◽  
Cetyl Trimethyl Ammonium ◽  
Hcl Solution
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