scholarly journals Chronic efffects of bisphenol an exposure on zebrafish (Danio rerio) at juvenile state

2019 ◽  
Vol 3 (1) ◽  
pp. 37-45
Author(s):  
Mai Thi Ngo ◽  
Phuong Thao Thi Doan ◽  
Ngoc Diem Thi Vo ◽  
Cong Thanh Nguyen ◽  
Nga Phi Le
Keyword(s):  
Natural Waters ◽  
Growth Period ◽  
The Other ◽  
Food Storage ◽  
Endocrine Disrupting Chemical ◽  
Hepatic Cells ◽  
Endocrine Disrupting ◽  
Plastic Toys ◽  
Plastic Containers ◽  
Nuclear Enlargement

Introduction: Bisphenol A (BPA) is an endocrine disrupting chemical, therefore some countries have banned the use of it in plastic containers for food storage and plastic toys for children. BPA can be found in natural waters with measured concentrations varying from ng/l to mg/l. However, in fact that the chronic ecotoxicology data obtained from aquatic animals for BPA exposure at these levels are quite few. Methods: In this study zebrafish at 30 days of age were exposed to four variants 0, 1, 10 and 100 μg/l BPA along 60 days, which is the fasted growth period in zebrafish (Juvenile stage). At the end of the experiments, all fish weight and length were measured and their fresh livers were used for histological assessment. Results: The results showed that weight and length of fish in 100 mg/l BPA group increased significantly as compared with that in the other experimental groups. Also only in this group, changes in hepatic morphology such as vacuolar number and size increasement, cytoplasmicand/or nuclear enlargement, glycogen reduction, lipid enhancement, were observed, but especially no significant inflammation. Fish in the other groups exposed to BPA concentrations <100mg/l had no change in all targeted endpoints as compared with that of the control. Conclusion: Chronic exposure of 100mg/L BPA to zebrafish along the fast-growth period (Juvenile) caused increasement of weight and length, and altered morphology of hepatic cells, that may harm to liver functions.  

scholarly journals Bioremediation of Benzophenone by Glycosylation with Immobilized Marine Microalga Chrysocampanulla spinifera and Amphidinium crassum

2011 ◽  
Vol 4 ◽  
pp. BCI.S8212
Author(s):  
Kei Shimoda ◽  
Yushi Uchimura ◽  
Hiroya Imai ◽  
Megumi Kitagawa ◽  
Hirotaka Hirano ◽  
...  
Keyword(s):  
Catharanthus Roseus ◽  
Plant Cells ◽  
The Other ◽  
Endocrine Disrupting Chemical ◽  
Marine Microalga ◽  
Other Hand ◽  
Endocrine Disrupting ◽  
One Step ◽  
Immobilized Plant Cells

Reduction and glycosylation of benzophenone, which is an endocrine disrupting chemical, were investigated using immobilized marine microalga and plant cells from the viewpoint of bioremediation of benzophenone. Immobilized marine microalga of Chrysocampanulla spinifera reduced benzophenone to diphenylmethanol. Immobilized marine microalga of Amphidinium crassum glucosylated diphenylmethanol to the corresponding glucoside. The sequential biotransformation with C. spinifera and A. crassum effectively converted benzophenone into diphenylmethyl glucoside. On the other hand, immobilized plant cells of Catharanthus roseus transformed benzophenone to diphenylmethanol, diphenylmethyl glucoside, and diphenylmethyl primeveroside, which was a new compound, by one-step biotransformation.

scholarly journals Endocrine disrupting chemical-associated hair product use during pregnancy and gestational age at delivery: a pilot study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Emma V. Preston ◽  
Victoria Fruh ◽  
Marlee R. Quinn ◽  
Michele R. Hacker ◽  
Blair J. Wylie ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Black Women ◽  
Pilot Study ◽  
Gestational Age ◽  
Endocrine Disrupting Chemical ◽  
Product Use ◽  
Frequent Use ◽  
Increased Risk ◽  
Endocrine Disrupting ◽  
Gestational Age At Delivery

Abstract Background Prenatal endocrine disrupting chemical (EDC) exposure has been associated with increased risk of preterm birth. Non-Hispanic Black women have higher incidence of preterm birth compared to other racial/ethnic groups and may be disproportionately exposed to EDCs through EDC-containing hair products. However, research on the use of EDC-associated hair products during pregnancy and risk of preterm birth is lacking. Therefore, the objective of this pilot study was to estimate associations of prenatal hair product use with gestational age at delivery in a Boston, Massachusetts area pregnancy cohort. Methods The study population consisted of a subset of participants enrolled in the Environmental Reproductive and Glucose Outcomes (ERGO) Study between 2018 and 2020. We collected self-reported data on demographics and hair product use using a previously validated questionnaire at four prenatal visits (median: 12, 19, 26, 36 weeks’ gestation) and abstracted gestational age at delivery from medical records. We compared gestational age and hair product use by race/ethnicity and used linear regression to estimate covariate-adjusted associations of product use and frequency of use at each study visit with gestational age at delivery. Primary models were adjusted for maternal age at enrollment and delivery method. Results Of the 154 study participants, 7% delivered preterm. Non-Hispanic Black participants had lower mean gestational age at delivery compared to non-Hispanic White participants (38.2 vs. 39.2 weeks) and were more likely to report ever and more frequent use of hair products. In regression models, participants reporting daily use of hair oils at visit 4 had lower mean gestational age at delivery compared to non-users (β: -8.3 days; 95% confidence interval: -14.9, -1.6). We did not find evidence of associations at earlier visits or with other products. Conclusions Frequent use of hair oils during late pregnancy may be associated with shorter gestational duration. As hair oils are more commonly used by non-Hispanic Black women and represent potentially modifiable EDC exposure sources, this may have important implications for the known racial disparity in preterm birth.

scholarly journals Tumor-suppressive and tumor-promoting role of Tgf-Beta in Hepatocellular Carcinoma

2016 ◽  
Vol 9 (1) ◽  
pp. 41 ◽  
Author(s):  
Somyoth Sridurongrit
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Tumor Development ◽  
The Other ◽  
Tgf Beta ◽  
Hepatic Cells ◽  
Proliferation And Apoptosis ◽  
Regulation Of Proliferation ◽  
Metastatic Process

Tgf-Beta is a pleiotropic cytokine with diverse functions on hepatic cells. The well-known function of Tgf-Beta in pathogenesis of liver disease is to stimulate liver fibrosis that often precedes the onset of liver cancer. While Tgf-Beta-mediated fibrosis seems to make liver more prone to the development of liver cancer, Tgf-Beta suppresses initial malignant transformation of hepatic cells thru regulation of proliferation and apoptosis. On the other hand, Tgf-Beta has shown to act as an inducer of tumor development thru enhancement of metastatic process. Additionally, it has been shown that Tgf-Beta signaling in hepatocytes promotes hepatocarcinogenesis caused by certain genetic conditions. This review highlights observations that have improved an understanding of how Tgf-Beta contributes to the development of hepatocellular carcinoma.

scholarly journals Study of pathological lesions in rats after the experimental administration of Lindane

2018 ◽  
Vol 49 (1) ◽  
pp. 39
Author(s):  
N. PAPAIOANNOU (Ν. ΠΑΠΑΪΩΑΝΝΟΥ) ◽  
G. KELLER-SAMOUILIDOU (ΓΚ. ΚΕΛΛΕΡ-ΣΑΜΟΥΗΛΙΔΟΥ) ◽  
S. LEKKAS (Σ. ΛΕΚΚΑΣ) ◽  
V. P. KOTSAKI-KOVATSI (Β. Π. ΚΩΤΣΑΚΗ-ΚΟΒΑΤΣΗ) ◽  
A. KOVATSI (Α. ΚΟΒΑΤΣΗΣ)
Keyword(s):  
Clinical Symptoms ◽  
Chemical Substance ◽  
The Other ◽  
Coagulative Necrosis ◽  
Cardiac Muscle Cells ◽  
Experimental Animals ◽  
Long Period ◽  
Hepatic Cells ◽  
Cross Striation ◽  
The Brain

In this experimental study, the lesions that are caused from the chemical substance Lindane were studied. Sixteen rats were used as experimental animals. The substance was orally administered, with food, to 10 rats (5 females and 5 males) in a dose of 8,2 mg/kg b.w./3 days during the first 10 days and in a dose of the 33 mg/kg b.w./ 2 days during the following 40 days. The remaining 6 rats (4 females and 2 males) were used as controls. The mainly clinical symptoms which were observed in the experimental animals, in the end of the experimentation, were anorexia, lethargy, hypothermia and muscular rigor. All the rats were sacrificed 5 days after the administration of the last dose of the substance and they were autopsied. In the macroscopical examination oedema and vascular hyperhaemia were observed in the brain. In the histological examination spongiosis of the white matter of the brain, interstitial pneumonia, oedema and loss of the cross striation of the cardiac muscle cells, coagulative necrosis of individual groups of hepatic cells and degeneration of the epithelial cells of the urinary tubules were detected. In conclusion, when Lindane is administered in subtoxical doses for a long period of time it is possible to cause damages to the organism of the experimental animals, which are located mainly in the brain and secondary in the liver, the kidneys and the other organs.

Novel Strategy for Antifouling Paints with Zero Endocrine Disrupting Chemical (EDC) Elution based on Interpenetrating Polymer Networks (IPNs)

2005 ◽  
Vol 873 ◽  
Author(s):  
Masanobu Naito ◽  
Takashi Nakai ◽  
Takuma Kawabe ◽  
Kenji Mori ◽  
Daisuke Furuta ◽  
...  
Keyword(s):  
Polymer Networks ◽  
Three Dimensional ◽  
Silica Matrix ◽  
Interpenetrating Polymer Networks ◽  
Repellent Activity ◽  
Antifouling Paints ◽  
Endocrine Disrupting Chemical ◽  
Endocrine Disrupting ◽  
Novel Strategy ◽  
Fouling Organisms

AbstractEnvironmentally friendly organic-inorganic hybrid materials with repellent activity against marine fouling organisms have been developed using interpenetrating polymer networks (IPNs), composed of a three-dimensional silica matrix of tetraethoxysilane (TEOS) and chain-like polymers, such as poly(methylmethacrylate) (PMMA) and poly(vinylacetate) (PVAc). The repellent activity of the IPNs reached a maximum of approximately 90% relative to that of tetrabutyl tin oxide (TBTO). Simple bioassays using blue mussels and algae were used to screen out the adequate proportions of those components.

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