TO ASSESS AND COMPARE THE EFFICACY OF TREATMENT OF ALLERGIC RHINITIS USING THREE DIFFERENT SALINE PREPARATIONS.

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Amit Kumar ◽  
Satyendra Sharma
Keyword(s):  
Allergic Rhinitis ◽  
Hypertonic Saline ◽  
Normal Saline ◽  
Post Treatment ◽  
Saline Irrigation ◽  
Nasal Irrigation ◽  
Medical College ◽  
Significant Difference ◽  
Prospective Comparative Study ◽  
Efficacy Of Treatment

Aim: to assess and compare the efficacy of 3% hypertonic saline irrigation with 0.9% normal saline and 0.5% diluted betadine saline irrigation. Materials and Methods: present prospective comparative study was conducted on 60 randomly selected patients confirmed of allergic rhinitis visited the department of ENT, Nalanda Medical College and Hospital, Patna, Bihar, India. Patients were divided into three groups. The outcome between pre and post treatment was compared. Results: Females outnumber males. Within each group pre and post treatment showed statistical significant difference but between three groups no statistically significant difference is seen in outcome. Conclusion: reports outcome following nasal irrigation in all the three treatments was found statistically significant but between the treatments no statistically significant difference observed. Keywords: nasal irrigation, rhinitis, 3% hypertonic saline, 0.9% normal saline, 0.5% diluted betadine saline

Efficacy of Hypertonic Saline Irrigation for Nasal Symptoms in Children with Perennial Allergic Rhinitis: A Randomized Double-Blind Study

2021 ◽  
Vol 104 (10) ◽  
pp. 1570-1577
Keyword(s):  
Allergic Rhinitis ◽  
Side Effects ◽  
Hypertonic Saline ◽  
Symptom Score ◽  
Nasal Congestion ◽  
Nasal Symptom ◽  
Perennial Allergic Rhinitis ◽  
Saline Irrigation ◽  
Nasal Irrigation ◽  
Nasal Cytology

Background: Nasal saline irrigation was an adjunctive therapy of allergic rhinitis (AR). It has been suggested that the use of hypertonic saline (HS) is better than normal saline (NSS) in treatment of AR. Reduction of mucosal edema by hypertonicity induced water transport through nasal mucosa, nasal congestion reduction and mucociliary clearance improvement. Objective: To compare total nasal symptom score (TNSS) between 3% HS and NSS irrigation in perennial allergic rhinitis children. Materials and Methods: The present study was conducted at the Allergy Center of Bhumibol Adulyadej Hospital (BAH), Royal Thai Airforce, Bangkok, Thailand between January and March 2021. Sixty-two perennial AR children were enrolled and categorized in severity level, namely mild, moderate or severe. Subjects were randomized into two groups. Each participant was blind-randomized to nasal irrigation of either 3% HS or NSS twice-daily for 4 weeks by the same investigator. The primary outcome was TNSS improvement between both groups. Secondary outcomes were quality of life, nasal congestion severity improvement, nasal cytology change and side effects. Results: TNSS improvement of 3% HS was more than NSS group (4.03±2.36 versus 2.73±3.06, p=0.034). Nasal congestion was the only symptom that differed significantly between the two groups (1.32±1.01 in 3% HS versus 0.70±1.24 in NSS, p=0.024). Reduction of congestion severity by physical examination, nasal cytology changes and side effects were comparable. Conclusion: Nasal irrigation with 3% HS in children with perennial AR had more improvement than NSS in TNSS., especially nasal congestion. Keyword: Hypertonic saline; Nasal irrigation; Allergic rhinitis; Nasal symptom score

scholarly journals A Study on the Efficacy of Saline Nasal Irrigation in Chronic Rhinosinusitis

2021 ◽  
Vol 10 (30) ◽  
pp. 2266-2270
Author(s):  
Rachana Ramachandran ◽  
Santhi Thankappan Pillai
Keyword(s):  
Quality Of Life ◽  
Chronic Rhinosinusitis ◽  
Post Treatment ◽  
Oral Drug ◽  
P Value ◽  
Saline Irrigation ◽  
Nasal Irrigation ◽  
Significant Difference ◽  
Chronic Rhino Sinusitis

BACKGROUND The objective of this study was to test as to whether daily saline nasal irrigation improved sinus symptoms in adult subjects with chronic rhino sinusitis, and also study the safety of saline irrigation, incidence of any complication and improvement in quality of life in these patients. METHODS This was a prospective observational study conducted between two groups of patients at Government TD Medical College, Alappuzha. Patients who satisfied the criteria for diagnosing chronic rhino sinusitis were included in the study. The first group was given saline nasal irrigation with oral drug therapy while the second group was put on oral drugs alone. Each subject was given a pretested, structured questionnaire. Along with socio-demographic information, the questionnaire also contained queries of quality of life measure, compliance of nasal irrigation and adverse effects following its use. RESULTS The pre-treatment scores and post treatment scores were analysed and the results were statistically significant with P values of < 0.001 in all. 77 % of the patients in the saline irrigation group were strictly using saline nasal irrigation which meant a satisfactory compliance and the improvement in post treatment scores was statistically highly significant with a P value of < 0.001. Also there was a statistically significant difference between the mean pre-test and post test scores of the two groups with P value of < 0.001 and t value of 51.942 using the paired t test. CONCLUSIONS Chronic rhinosinusitis has a major negative impact on the healthcare and economy of not only the patients but also of the society. Saline nasal irrigation is an effective yet easy method of therapy in alleviating the symptoms of chronic rhinosinusitis and improving the quality of life in these chronic sufferers. KEY WORDS Chronic Rhinosinusitis, Saline Nasal Irrigation, Quality of Life, Economic Burden

TO COMPARE THE EFFECTIVENESS OF NEBULISATION WITH ADRENALINE, 3% HYPERTONIC SALINE AND NORMAL SALINE IN BRONCHIOLITIS IN CHILDREN OF 2 TO 24 MONTHS OF AGE BASED ON CLINICAL SEVERITY SCORE AND NEBULISATION FREQUENCY.

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Priyanka Jain ◽  
Rakesh Jain
Keyword(s):  
Hypertonic Saline ◽  
Normal Saline ◽  
Mean Difference ◽  
Clinical Severity ◽  
Research Centre ◽  
P Value ◽  
College Hospital ◽  
Mean Values ◽  
Significant Difference ◽  
The Mean

Background & Method: We conducted a double blinded study at Index Medical College Hospital & Research Centre, Indore. The sample size was determined to be minimum of 120 cases as based upon previous years admission due to acute bronchiolitis. Initially, 146 cases were included in the study out of which 23 cases dropped out of the study after giving consent by guardian for participation in the study as they left against medical advice from the hospital. Result: The mean difference of CSS between 0 minutes to 60 minutes of nebulisation between groups in all cases was 0.4 ± 0.6, between 60 minutes and 4 hours was 0.8 ± 0.6, between 4 to 8 hours was 0.7 ± 0.6, between 8-12 hours was 0.6 ± 0.4, between 12-24 hours was 1.6 ± 0.9 and between 24-48 hours was 1.9 ± 0.9.The mean values and resultant p-value of ANOVA of various nebulising agents used for improvement in CSS shows significant association between various nebulising agents used along with improvement in CSS at the end of assessment at 48 hours of treatment. Conclusion: This study was conducted to establish the efficacy of each nebulisation agent (i.e.  adrenaline, 3% hypertonic saline and normal saline) currently used and compare the outcomes as there is not enough evidence amongst Indian population on level of efficacy of each drug in causing improvement in symptoms and signs in various severities of bronchiolitis in early childhood. Comparison of significant improvement in mean difference in CSS at various intervals in all cases compared between groups by post hoc test revealed non-significant difference (p-value 0.700) between 3% hypertonic saline and normal saline. Keywords: nebulisation, adrenaline, bronchiolitis & clinical.

scholarly journals Comparative Study of Efficiency between Povidone Iodine and Normal Saline Lavage in the Treatment of Acute Peritonitis

2018 ◽  
Vol 4 (1) ◽  
pp. 15-20
Author(s):  
Haridas Saha ◽  
Mohammad Ibrahim Khalil ◽  
Aminul Islam ◽  
Abdullah Al Mamun ◽  
Md Margub Hossain
Keyword(s):  
Hospital Stay ◽  
Wound Infection ◽  
Normal Saline ◽  
Povidone Iodine ◽  
Medical College ◽  
Acute Peritonitis ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Saline Lavage

Background: Control of the primary site of sepsis is the main determinant of good surgical outcome. Objective: The purpose of the present study was to compare the efficiency between povidone iodine and normal saline lavage in the treatment of acute peritonitis. Methodology: This was a randomized clinical trial conducted in the Department of Surgery at Dhaka Medical College & Hospital, Dhaka, Bangladesh. Patients with acute peritonitis due to gastrointestinal causes who were admitted in the different units of Dhaka Medical College Hospital during the study period were selected as study population. Among them patients who were treated with povidone iodine were enrolled in the present study in group A and patients who were treated with conventional normal saline were in group B. Results: A total number of 1050 patients were recruited for this study. Among them 100 patients were enrolled in the present study of which group A (50 patients) for povidone iodine and group B (50 patients) for conventional normal saline. On 7th POD wound infection was found in Group A and Group B were 11(22.4%) and 21(44.7%) respectively. Statistically significant difference in post operative complication of wound infection was observed on 7th POD between the groups (p<0.05). Post operative hospital stay in Group A and Group B were 11.50 ± 4.48 and 13.46 ± 5.13 days respectively. There is statistically significant difference in post operative hospital stay between the groups (p<0.05). Conclusion: Statistically significant difference observed in post operative complication of wound infection and burst abdomen on 7th POD between the groups. The present study there is statistically significant difference in post operative hospital stay between the groups also observed. Bangladesh Journal of Infectious Diseases 2017;4(1):15-20

Impact of isotonic and hypertonic saline solutions on mucociliary activity in various nasal pathologies: clinical study

2008 ◽  
Vol 123 (5) ◽  
pp. 517-521 ◽  
Author(s):  
A Ural ◽  
T Kocak Oktemer ◽  
Y Kizil ◽  
F Ileri ◽  
S Uslu
Keyword(s):  
Allergic Rhinitis ◽  
Hypertonic Saline ◽  
Mucociliary Clearance ◽  
Chronic Sinusitis ◽  
Acute Sinusitis ◽  
Clearance Time ◽  
Nasal Irrigation ◽  
Before And After ◽  
Saline Solutions ◽  
The Impact

AbstractObjective:To investigate the impact of nasal irrigation with isotonic or hypertonic sodium chloride solution on mucociliary clearance time in patients with allergic rhinitis, acute sinusitis and chronic sinusitis.Patients and methods:Mucociliary clearance time was measured using the saccharine clearance test on 132 adults before and after 10 days' application of intranasal isotonic or hypertonic saline. Patient numbers were as follows: controls, 45; allergic rhinitis, 21; acute sinusitis, 24; and chronic sinusitis, 42. The results before and after irrigation were compared using the Wilcoxon t-test.Results:Before application of saline solutions, mucociliary clearance times in the three patient treatment groups were found to be significantly delayed, compared with the control group. Irrigation with hypertonic saline restored impaired mucociliary clearance in chronic sinusitis patients (p < 0.05), while isotonic saline improved mucociliary clearance times significantly in allergic rhinitis and acute sinusitis patients (p < 0.05).Conclusion:Nasal irrigation with isotonic or hypertonic saline can improve mucociliary clearance time in various nasal pathologies. However, these solutions should be selectively prescribed rather than used based on anecdotal evidence. Further studies should be conducted to develop a protocol for standardised use of saline solution irrigation in various nasal pathologies.

scholarly journals The Effect of Nebulized Magnesium Sulphate on the Incidence of Postoperative Sorethroat

2020 ◽  
Vol 5 (1) ◽  
pp. 185-190
Author(s):  
T. Padma ◽  
Raju B ◽  
Raviraj GS
Keyword(s):  
Clinical Study ◽  
Sore Throat ◽  
Normal Saline ◽  
Magnesium Sulphate ◽  
Age Group ◽  
Postoperative Sore Throat ◽  
Medical College ◽  
Randomized Clinical Study ◽  
Significant Difference ◽  
Definition Of

Background: Postoperative sore throat (POST) is a well-recognized complication that remains unresolved in patients undergoing endotracheal intubation for general anaesthesia. The wide variation in these figures is presumably due to different skills and techniques among anesthetists and to differences between patients in the definition of sore throat. The main aim is to study the attenuating effect of Magnesium sulphate nebulization on the incidence of post-operative sore throat. Subjects and Methods: This is a prospective randomized clinical study. A total number of 100 patients of ASA grade 1 & 2, in the age group of 18 - 60 years. The study has been carried out at Sri Venkateswara Ram Narayana Ruia Government General Hospital, Sri Venkateswara Medical College, Tirupati, over a period of 12 months. Results: There was no significant difference among the groups in terms of age, gender and weight. Whereas Magnesium sulphate significantly lessens the POST during swallowing at 4th hour as compared to Normal saline (p< 0.05) and this statement can be attributed to any population. Conclusion:  Post-operative sore throat is one of the most common undesirable anesthesia-associated problems in the patients undergoing GA with an endotracheal tube for routine surgical cases for up to 24 h. Magnesium sulphate was significantly reduces the incidence of POST compared to Normal saline , and it is safe, simple and effective in reducing postoperative sore throat.

Budesonide vs Saline Nasal Irrigation in Allergic Rhinitis: A Randomized Placebo-Controlled Trial

2020 ◽  
Vol 162 (6) ◽  
pp. 979-984
Author(s):  
Nikitha Periasamy ◽  
Kailesh Pujary ◽  
Ajay M. Bhandarkar ◽  
Naveen D. Bhandarkar ◽  
Balakrishnan Ramaswamy
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Response ◽  
Hypertonic Saline ◽  
Controlled Trial ◽  
Tertiary Care ◽  
Sinus Surgery ◽  
Care Hospital ◽  
Double Blind ◽  
Nasal Irrigation ◽  
Snot 22

Objectives Budesonide nasal irrigation is currently widely used in the treatment of chronic sinusitis typically following endoscopic sinus surgery to improve inflammatory control. Its application in treatment of allergic rhinitis has not been previously studied. This study assesses the subjective and clinical response to budesonide buffered hypertonic saline nasal irrigation and hypertonic saline nasal irrigation in patients with allergic rhinitis. Study Design This is a prospective, single-center, double-blind, randomized placebo-controlled trial. Setting Tertiary care hospital. Subjects and Methods Fifty-two patients diagnosed with allergic rhinitis were randomized into 2 groups to receive either buffered hypertonic saline nasal irrigation with a placebo respule or buffered hypertonic saline nasal irrigation with a budesonide respule. Patients were assessed at baseline and 4 weeks subjectively using the Sino-Nasal Outcome Test–22 (SNOT-22) questionnaire and visual analog scale (VAS). Clinical assessment was done using the modified Lund-Kennedy score. Results The average SNOT-22, VAS, and modified Lund-Kennedy scores improved in both groups ( P < .001). The budesonide irrigation group was found to have significantly better improvement than the saline nasal irrigation group with the SNOT-22 scores ( P = .012) and VAS scores ( P = .007). However, the difference in the clinical response between the 2 groups was not significant ( P = .268). Conclusion This study adds evidence to the use of saline nasal irrigation in allergic rhinitis but also demonstrates efficacy of the addition of budesonide to irrigations. Budesonide nasal irrigation thus appears to be a viable treatment option for allergic rhinitis.

Hypertonic Saline Versus Isotonic Saline Nasal Irrigation: Systematic Review and Meta-analysis

2018 ◽  
Vol 32 (4) ◽  
pp. 269-279 ◽  
Author(s):  
Dichapong Kanjanawasee ◽  
Kachorn Seresirikachorn ◽  
Wirach Chitsuthipakorn ◽  
Kornkiat Snidvongs
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Hypertonic Saline ◽  
Meta Analysis ◽  
Isotonic Saline ◽  
High Volume ◽  
Mean Difference ◽  
Saline Irrigation ◽  
Nasal Irrigation ◽  
Subgroup Analyses

Background Saline nasal lavage is one of the treatments of sinonasal diseases. Evidence from basic research favors hypertonic saline (HS) over isotonic saline (IS) for mucociliary clearance, but evidence from clinical studies is controversial. Conversely, HS may carry greater side effects. Objective To compare the effects of HS and IS nasal irrigation in treating sinonasal diseases. Methods Systematic search with Ovid MEDLINE, Scopus, PubMed, Google Scholar, and Manual additional sources was conducted. Randomized controlled trials comparing HS with IS nasal irrigation in treating any sinonasal diseases, including rhinitis and rhinosinusitis, were included. Data were pooled for meta-analyses. Outcomes were symptom scores, sinonasal outcome test (SNOT), and adverse events. Heterogeneity was explored by subgroup analyses. Results Nine studies (740 patients) were included. HS nasal irrigation brought greater benefits over IS in symptom reduction (standardized mean difference (SMD) −0.58; 95% confidence interval [CI]: −0.76, −0.40); however, no difference was shown in SNOT-20 improvement (mean difference 1.81; 95% CI: −0.68, 4.30). In subgroup analyses, effects favoring HS on symptoms were larger in 4 subgroups. These were (1) patients with rhinitis (SMD −1.09; 95% CI: −1.42, −0.76) compared with rhinosinusitis (SMD −0.37; 95% CI: −0.58, −0.15), P < .01; (2) patients under the age of 18 years (SMD −1.22; 95% CI: −1.53, −0.91) compared with patients over the age of 18 years (SMD −0.26; 95% CI: −0.49, −0.04), P < .01; (3) saline irrigation using high volume (SMD −0.89; 95% CI: −1.18, −0.60) compared with low volume (SMD −0.39; 95% CI: −0.62, −0.16), P < .01; and (4) saline irrigation with hypertonicity of <3% (SMD −1.09; 95% CI: −1.42, −0.76) and hypertonicity of 3%–5% (SMD −1.20; 95% CI: −1.61, −0.78) compared with hypertonicity of >5% (SMD 0.20; 95% CI: −0.15, 0.55), P < .01. Buffered saline and operative status did not have impact. HS brought greater minor adverse effects. No major adverse effects were reported. Conclusion HS improves symptoms over IS nasal irrigation in treating sinonasal diseases. There is no difference in disease-specific quality of life. However, HS brings greater minor side effects than IS.

scholarly journals Comorbid Asthma in Allergic Rhinitis Patients in Kashmir

2015 ◽  
Vol 8 (3) ◽  
pp. 107-109
Author(s):  
Shahid Rasool Biloo ◽  
Farooq Ahmad Dar ◽  
Rauf Ahmad
Keyword(s):  
Allergic Rhinitis ◽  
Neck Surgery ◽  
Forced Expiratory Volume ◽  
Post Treatment ◽  
P Value ◽  
Jammu And Kashmir ◽  
Score System ◽  
Prick Test ◽  
Medical College ◽  
Inhalant Allergens

ABSTRACT The study was conducted in the department of otorhinolaryngology, head and neck surgery, Government Medical College, Srinagar and Associated Hospitals, Jammu and Kashmir for the period of 2 years from May 2011 to June 2013 with the aim to determine the prevalence of asthma in allergic rhinitis (AR) patients and the effect of medical management of allergic rhinitis on asthma it is a hospital based prospective study. A total of 576 patients who presented with features of AR were enrolled in the study after proper written consent was taken. All cases were evaluated for AR and for the comorbid asthma. Detailed history and clinical examination was done. Skin prick test (SPT) and spirometry was used to confirm the allergy and to detect comorbid asthma respectively. Wilsons scoring system and spirometeric parameters forced expiratory volume and forced vital capacity (FEV1/FEV25-75 and FVC) were used for pre- and post-treatment symptom comparison. Results Out of 576 patients, 117 patients were positive for SPT for various inhalant allergens, with prevalence of comorbid asthma being 41.08%. There was significant improvement in symptomology of asthma following the use of nasal inhalational steroids for AR. Wilsons score system and spirometric parameters showed marked improvement in post-treatment results, with p-value of 0.00 which is statistically highly significant. How to cite this article Biloo SR, Dar FA, Ahmad R. Comorbid Asthma in Allergic Rhinitis Patients in Kashmir. Clin Rhinol An Int J 2015;8(3):107-109.

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