scholarly journals METAPLASTIC CARCINOMA OF BREAST

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Lalit Aseri ◽  
Vanita Kumar ◽  
Sharda Dhawa ◽  
Qadir Fatima ◽  
Neelu Gupta
Keyword(s):  
Ductal Carcinoma ◽  
World Health ◽  
Metaplastic Carcinoma ◽  
Adjuvant Radiation ◽  
Carcinoma Of The Breast ◽  
Squamous Cells ◽  
Spindle Cells ◽  
Health Organization ◽  
Neoplastic Epithelium ◽  
Metaplastic Breast Carcinoma

Metaplastic carcinoma of the breast is a rare but aggressive type of breast cancer that has been recognized as a unique pathologic entity by the World Health Organization. Morphologically, it is characterized by the differentiation of neoplastic epithelium into squamous cells and/or mesenchymal-looking elements (spindle cells, cartilage or bone, etc). It shares many similarities with invasive ductal carcinoma and benign lesions on mammography, which further complicates the diagnosis. Treatment for metaplastic breast carcinoma is relatively unknown because of the rarity of the disease, but studies suggest that removal of the tumor and adjuvant radiation therapy has the greatest benefit.

Metaplastic Carcinoma of the Breast

2015 ◽  
Vol 139 (6) ◽  
pp. 819-822 ◽  
Author(s):  
Elizabeth McKinnon ◽  
Philip Xiao
Keyword(s):  
Ductal Carcinoma ◽  
World Health ◽  
Metaplastic Carcinoma ◽  
Adjuvant Radiation ◽  
Carcinoma Of The Breast ◽  
Squamous Cells ◽  
Spindle Cells ◽  
Health Organization ◽  
Neoplastic Epithelium ◽  
Metaplastic Breast Carcinoma

Metaplastic carcinoma of the breast is a rare but aggressive type of breast cancer that has been recognized as a unique pathologic entity by the World Health Organization. Morphologically, it is characterized by the differentiation of neoplastic epithelium into squamous cells and/or mesenchymal-looking elements (squamous cells, spindle cells, cartilage or bone, etc). It shares many similarities with invasive ductal carcinoma and benign lesions on mammography, which further complicates the diagnosis. Treatment for metaplastic breast carcinoma is relatively unknown because of the rarity of the disease, but studies suggest that removal of the tumor and adjuvant radiation therapy has the greatest benefit.

scholarly journals Metaplastic Carcinoma of the Breast with Squamous Differentiation: A Case Report from the University Teaching Hospital of Kigali (CHUK), Rwanda

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Delphine Uwamariya ◽  
Carine Nyampinga ◽  
Anne Yvette Nsenguwera ◽  
Belson Rugwizangoga
Keyword(s):  
Triple Negative ◽  
Large Mass ◽  
University Teaching ◽  
Metaplastic Carcinoma ◽  
Squamous Cells ◽  
Spindle Cells ◽  
The University ◽  
Neoplastic Epithelium ◽  
Metaplastic Breast Carcinoma ◽  
Breast Malignancies

Metaplastic breast carcinoma is a rare and aggressive condition, accounting less than 1% of breast malignancies. It presents with large mass and frequently with distant metastasis at time of diagnosis. Morphologically, it is characterized by the differentiation of neoplastic epithelium into epithelial or mesenchymal-looking elements like squamous cells, spindle cells, cartilage, or bone and has poor prognosis with its triple negative status.

scholarly journals Metaplastic Breast Carcinoma: Update on Histopathology and Molecular Alterations

2019 ◽  
Vol 143 (12) ◽  
pp. 1492-1496 ◽  
Author(s):  
Emily R. McMullen ◽  
Nicholas A. Zoumberos ◽  
Celina G. Kleer
Keyword(s):  
Differential Diagnosis ◽  
Breast Carcinoma ◽  
Gene Mutations ◽  
World Health ◽  
Metaplastic Carcinoma ◽  
Molecular Alterations ◽  
New Genes ◽  
Pathway Gene ◽  
Health Organization ◽  
Metaplastic Breast Carcinoma

Context— Metaplastic carcinoma is a rare, triple-negative carcinoma of the breast that exhibits transformation of part or all of its glandular carcinomatous component into a nonglandular, or metaplastic, component. The World Health Organization currently recognizes 5 variants of metaplastic carcinoma based on their histologic appearance. Objective— To review the histologic classifications, differential diagnosis, prognosis, and recent laboratory studies of metaplastic breast carcinoma. Data Sources.— We reviewed recently published studies that collectively examine metaplastic carcinomas, including results from our own research. Conclusions.— Metaplastic breast carcinoma has a broad spectrum of histologic patterns, often leading to a broad differential diagnosis. Diagnosis can typically be rendered by a combination of morphology and immunohistochemical staining for high-molecular-weight cytokeratins and p63. Recent studies elucidate new genes and pathways involved in the pathogenesis of metaplastic carcinoma, including the downregulation of CCN6 and WNT pathway gene mutations, and provide a novel MMTV-Cre;Ccn6fl/fl knockout disease-relevant mouse model to test new therapies.

scholarly journals Metaplastic Carcinoma of the Breast with Neuroectodermal Stromal Component

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Tibor Tot ◽  
Juan José Badani De La Parra ◽  
Leif Bergkvist
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Brain Metastases ◽  
Lymph Node Metastases ◽  
Metaplastic Carcinoma ◽  
Unique Case ◽  
Carcinoma Of The Breast ◽  
Stromal Component ◽  
Node Metastases ◽  
Metaplastic Breast Carcinoma

A unique case of metaplastic breast carcinoma with an epithelial component showing tumoral necrosis and neuroectodermal stromal component is described. The tumor grew rapidly and measured 9 cm at the time of diagnosis. No lymph node metastases were present. The disease progressed rapidly and the patient died two years after the diagnosis from a hemorrhage caused by brain metastases. The morphology and phenotype of the tumor are described in detail and the differential diagnostic options are discussed.

scholarly journals Right Breast Metaplastic Carcinoma with Chondroid Diff erentiation (Chondrosarcoma)

2018 ◽  
Vol 22 (4) ◽  
pp. 45-51
Author(s):  
Alya S. Binmahfouz
Keyword(s):  
Breast Cancer ◽  
Metaplastic Carcinoma ◽  
Adjuvant Radiation ◽  
Resonance Imaging ◽  
Metaplastic Breast Cancer ◽  
Diagnostic Features ◽  
Palpable Mass ◽  
Adjuvant Radiation Therapy ◽  
The Right ◽  
Metaplastic Breast Carcinoma

Metaplastic breast cancer is rare, representing < 5% of breast cancer (only eight cases have been reported so far). We present here a 42-year-old female complaining of a painless lump in the right breast for the previous two months. Physical examination revealed a palpable mass. Lumpectomy was performed and histopathologic examination revealed metaplastic breast carcinoma with foci of chondrosarcoma. The patient received adjuvant radiation therapy and chemotherapy and is currently following up as an outpatient. We also discuss diff erentimaging diagnostic features of this specifi c type of breast cancer using mammography, ultrasonography, and magnetic resonance imaging.

scholarly journals Primary Neuroendocrine Neoplasms of the Breast: Case Series and Literature Review

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 733 ◽  
Author(s):  
Burcin Özdirik ◽  
Antonin Kayser ◽  
Andrea Ullrich ◽  
Lynn J. Savic ◽  
Markus Reiss ◽  
...  
Keyword(s):  
Ductal Carcinoma ◽  
Wide Spectrum ◽  
Correct Diagnosis ◽  
Case Series ◽  
Neuroendocrine Differentiation ◽  
Interdisciplinary Approach ◽  
World Health ◽  
Neuroendocrine Neoplasms ◽  
Carcinoma Of The Breast ◽  
Outpatient Unit

Primary neuroendocrine carcinoma of the breast (NECB) as defined by the World Health Organization (WHO) in 2012 is a rare, but possibly under-diagnosed entity. It is heterogeneous as it entails a wide spectrum of diseases comprising both well-differentiated neuroendocrine tumors of the breast as well as highly aggressive small cell carcinomas. Retrospective screening of hospital charts of 612 patients (2008–2019) from our specialized outpatient unit for neuroendocrine neoplasia revealed five patients diagnosed with NECB. Given the low prevalence of these malignancies, correct diagnosis remains a challenge that requires an interdisciplinary approach. Specifically, NECB may be misclassified as carcinoma of the breast with neuroendocrine differentiation, carcinomas of the breast of no special type/invasive ductal carcinoma, or a metastasis to the breast. Therefore, this study presents multifaceted characteristics as well as the clinical course of these patients and discusses the five cases from our institution in the context of available literature.

scholarly journals Neuroendocrine carcinoma of the breast: a case report

2021 ◽  
pp. 306-311
Author(s):  
Iulia Gîvan ◽  
George Ciulei ◽  
Angela Cozma ◽  
Mădălina Indre ◽  
Vlad Țâru ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Manifestations ◽  
World Health ◽  
Neuroendocrine Neoplasms ◽  
Breast Carcinomas ◽  
Hormone Production ◽  
Carcinoma Of The Breast ◽  
Clinical Syndromes ◽  
Health Organization

Neuroendocrine breast carcinomas represent a rare subtype of breast cancer. Their definition, prevalence and prognosis remain controversial in the literature. Regarding the presentation, there are no differences from other breast carcinomas and clinical syndromes related to hormone production are extremely rare. Refinement of the classification of neuroendocrine neoplasms of the breast is needed in order to improve the reproducibility of their diagnostic criteria and to define their clinical significance. This article presents the case of a 44-year-old female patient diagnosed with invasive breast carcinoma with neuroendocrine features, according to the 2012 World Health Organization (WHO) definition, with focus on presentation, clinical manifestations, diagnostic approach and differential diagnosis.

scholarly journals Imaging features of adenosquamous carcinoma of the breast – A rare variant of metaplastic breast carcinoma

2021 ◽  
pp. 20210108
Author(s):  
Tiffany Marian Sae-Kho ◽  
Asha Bhatt ◽  
Malvika H. Solanki ◽  
Elizabeth B. Jeans ◽  
Kimberly S. Corbin ◽  
...  
Keyword(s):  
Adenosquamous Carcinoma ◽  
Ductal Carcinoma ◽  
Case Series ◽  
Screening Mammography ◽  
Metaplastic Carcinoma ◽  
Whole Body ◽  
Low Grade ◽  
Imaging Features ◽  
High Grade ◽  
Carcinoma Of The Breast

Adenosquamous carcinoma of the breast is a rare subtype of metaplastic carcinoma, which accounts for <1% of invasive breast malignancy. Metaplastic carcinoma is usually high grade and aggressive with typically reported benign imaging features when compared to invasive ductal carcinoma. However, the adenosquamous variant is a subtype with a more favorable prognosis. Within the literature, there is limited imaging description with case studies focusing on metaplastic carcinoma. Herein, we report seven cases of the adenosquamous subtype describing the imaging findings with correlation to clinical history and pathology. The majority of patients (n = 6) presented with palpable breast masses. One patient was identified through screening mammography. Mammographically (n = 6), tumors appeared as irregular masses. Sonographically (n = 7), tumors appeared as irregular masses ranging from solid to mixed solid/cystic masses. On MRI (n = 1), one tumor appeared as an irregular rim enhancing mass. FDG PET/CT (n = 2) and whole-body bone scan (n = 1) were also available for review. The majority of tumors were low-grade (n = 6) with only one high-grade tumor. This case series of seven patients demonstrated predominantly suspicious imaging features despite the majority being low-grade tumors.

Sebaceous Carcinoma of the Breast: Fact or Fiction? A Case Report and a Review of the Literature

2020 ◽  
pp. 106689692093778
Author(s):  
Ludovica De Vincentiis ◽  
Maria Paola Mariani ◽  
Anna Maria Cesinaro ◽  
Anna Maria Dalena ◽  
Gerardo Ferrara
Keyword(s):  
Breast Carcinoma ◽  
Needle Aspiration ◽  
Sebaceous Carcinoma ◽  
World Health ◽  
Positive Staining ◽  
Carcinoma Of The Breast ◽  
Aspiration Cytology ◽  
Clear Cut ◽  
Needle Aspiration Cytology ◽  
Health Organization

Introduction. Previously considered an exceedingly rare entity, sebaceous carcinoma of the breast is now regarded in the World Health Organization 2019 classification as a “special histopathological pattern” of invasive breast carcinoma of no special type. Case Description. In this article, we report the case of a fine needle aspiration cytology and the histopathological features of a breast carcinoma with clear-cut morphological features suggesting sebaceous differentiation, but showing no positive staining with the anti-adipophilin antibody. Conclusions. A morphologically clear-cut sebaceous differentiation is not invariably associated with adipophilin positivity; moreover, in breast carcinoma, adipophilin positivity does not automatically imply sebaceous differentiation. At present, immunomorphological evidence for the recognition of sebaceous carcinoma as a “special type” breast carcinoma subtype is too weak.

Simpson Grade I-III Resection of Spinal Atypical (World Health Organization Grade II) Meningiomas is Associated With Symptom Resolution and Low Recurrence

Neurosurgery ◽  
2015 ◽  
Vol 76 (6) ◽  
pp. 739-746 ◽  
Author(s):  
Sam Q. Sun ◽  
Chunyu Cai ◽  
Vijay M. Ravindra ◽  
Paul Gamble ◽  
Chester K. Yarbrough ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Confidence Interval ◽  
World Health ◽  
Gross Total Resection ◽  
Adjuvant Radiation ◽  
Total Resection ◽  
Adjuvant Radiation Therapy ◽  
Symptom Resolution ◽  
Simpson Grade ◽  
Health Organization

Abstract BACKGROUND: Because of their rarity, outcomes regarding spinal atypical meningiomas (AMs) remain unclear. OBJECTIVE: To describe the recurrence rate and postoperative outcomes after resection of spinal AMs, and to discuss an appropriate resection strategy and adjuvant therapy for spinal AMs. METHODS: Data from all patients who presented with spinal AMs to 2 tertiary referral centers between 1998 and 2013 were obtained by chart review. RESULTS: From 102 patients with spinal meningioma, 20 AM tumors (7 cervical, 11 thoracic, 2 thoracolumbar) were identified in 18 patients (median age, 50 years [range, 19-75] at time of resection; 11% male; median follow-up, 32 months [range, 1-179] after resection). Before resection, patients had sensory deficits (70%), pain (70%), weakness (60%), ataxia (50%), spasticity (65%), and incontinence (35%). One tumor presented asymptomatically. Simpson grade I, II, III, and IV resection were achieved in 3 (15%), 13 (65%), 2 (10%), and 2 (10%) tumors, respectively. One patient that underwent Simpson grade III resection received adjuvant radiation therapy. After Simpson grade I-III or gross total resection, no tumors recurred (0%; confidence interval, 0%-17.6%). After Simpson grade IV resection, 1 tumor recurred (50%; confidence interval, 1.3%-98.7%). With the exception of 1 patient who had bilateral paraplegia perioperatively, all other patients experienced improvement of preoperative symptoms after surgery (median time, 3.6 months [range, 1-13] after resection). CONCLUSION: Despite published cases suggesting an aggressive clinical course for spinal AMs, this series of spinal AMs reports that gross total resection without adjuvant radiation therapy resulted in symptom resolution and low recurrence.

Sign in / Sign up

Export Citation Format

Share Document