A Death Case Report in an Adult Woman With COVID-19 after Septoplasty

The mortality rate of Coronavirus Decease 2019 (COVID-19) is very high, but specific situations can increase the rate including severe hypoxemia, multiple organ injury, and thromboembolic events in various organs. Another factor is the stress caused after surgery that require general anesthesia. This study aims to report a case of death in an adult woman with COVID-19 infection who had underwent septoplasty and admitted to hospital after worsening of her general condition and treated when diagnosed with COVID-19. One day after admission, she was intubated due to progressive respiratory failure and deceased following bradycardia and cardiac arrest. It seems that the elective surgery should be avoided in patients infected with COVID-19 and should be postponed until complete recovery. Moreover, the possibility of this infection should be considered in all candidates for surgery with subtle respiratory symptoms.

Download Full-text

The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of Gram-positive and Gram-negative shock

Critical Care Medicine ◽

10.1097/00003246-200108000-00017 ◽

2001 ◽

Vol 29 (8) ◽

pp. 1599-1608 ◽

Cited By ~ 17

Author(s):

Kai Zacharowski ◽

Reinhard Berkels ◽

Antje Olbrich ◽

Prabal K. Chatterjee ◽

Salvatore Cuzzocrea ◽

...

Keyword(s):

Guanylate Cyclase ◽

Multiple Organ ◽

Organ Injury ◽

Rodent Models ◽

Gram Positive ◽

Gram Negative ◽

Multiple Organ Injury ◽

Negative Shock

Download Full-text

Effect Measure Modification and Confounding of Severe Head Injury Mortality by Age and Multiple Organ Injury Severity

Annals of Epidemiology ◽

10.1016/j.annepidem.2006.08.004 ◽

2007 ◽

Vol 17 (2) ◽

pp. 142-147 ◽

Cited By ~ 10

Author(s):

Shai Linn ◽

Leon Levi ◽

Peter D. Grunau ◽

Itzhak Zaidise ◽

Salman Zarka

Keyword(s):

Head Injury ◽

Severe Head Injury ◽

Injury Severity ◽

Multiple Organ ◽

Organ Injury ◽

Injury Mortality ◽

Effect Measure ◽

Effect Measure Modification ◽

Multiple Organ Injury

Download Full-text

Ubiquitin-Specific Protease 25 Aggravates Acute Pancreatitis and Acute Pancreatitis-Related Multiple Organ Injury by Destroying Tight Junctions Through Activation of The STAT3 Pathway

Frontiers in Cell and Developmental Biology ◽

10.3389/fcell.2021.806850 ◽

2022 ◽

Vol 9 ◽

Author(s):

Zhengru Liu ◽

Mingming Qi ◽

Shan Tian ◽

Qian Yang ◽

Jian Liu ◽

...

Keyword(s):

Acute Pancreatitis ◽

Tight Junctions ◽

Multiple Organ ◽

Organ Injury ◽

Pancreatic Acinar Cells ◽

Stat3 Pathway ◽

Specific Protease ◽

Ubiquitin Specific Protease ◽

Multiple Organ Injury

Ubiquitin-specific protease 25 (USP25) plays an important role in inflammation and immunity. However, the role of USP25 in acute pancreatitis (AP) is still unclear. To evaluate the role of USP25 in AP, we conducted research on clinical AP patients, USP25wild-type(WT)/USP25 knockout (USP25−/−) mice, and pancreatic acinar cells. Our results showed that serum USP25 concentration was higher in AP patients than in healthy controls and was positively correlated with disease severity. AP patients’ serum USP25 levels after treatment were significantly lower than that at the onset of AP. Moreover, USP25 expression was upregulated in cerulein-induced AP in mice, while USP25 deficiency attenuates AP and AP-related multiple organ injury. In vivo and in vitro studies showed that USP25 exacerbates AP by promoting the release of pro-inflammatory factors and destroying tight junctions of the pancreas. We showed that USP25 aggravates AP and AP-related multiple organ injury by activating the signal transducer and activator of transcription 3 (STAT3) pathway. Targeting the action of USP25 may present a potential therapeutic option for treating AP.

Download Full-text