Mucinous Carcinoma, Gastric Type of The Cervix

Introduction: Mucinous carcinoma, gastric type is an uncommon variant of cervical adenocarcinoma. This variant is different with most of cervical cancers due to gastric differentiation and unrelated with HPV infection. Well differentiated form of mucinous carcinoma, gastric type sometimes is called minimal deviation adenocarcinoma or adenoma malignum. The incidence is found in almost all groups of age (25- 72 years old) with mean 42 years old. Objective: To present a new and uncommon variant case in Indonesia primarily in Medan. Case description: We reported a case of 47-year- old woman, Mrs. M, who was clinically diagnosed with suspected carcinoma of cervix. A whitish, poorly demarcated mass in cervix was found in hysterectomy specimens. Microscopic examination showed that the cervix was lined by atypical and pleomorphic columnar cells, partially forming papillary pattern. The glands were proliferated with variable sized, some of which dilated and filled with mucin, and also the glands formed back to back appearance. In some foci were found disorganized glands. Glandular epithelium lining consisted of atypical and pleomorphic columnar cells with coarse chromatin and partially prominent nucleoli. Abnormal mitoses were easily found. In some foci, tumor cells also formed solid pattern. Discussion and Conclusion: According to these histological features, a diagnosis of mucinous carcinoma, gastric type of cervix was made (ICD-0 8482/3). Despite well differentiated form of mucinous carcinoma, gastric type, this variant has aggressive behavior and worse prognosis than other cervical carcinoma variants (usual type endocervical adenocarcinoma). Mucinous carcinoma, gastric type is an uncommon variant of cervical adenocarcinoma. This type is different from most of cervical cancers due to gastric differentiation and unrelated with HPV infection. Well differentiated form of mucinous carcinoma, gastric type sometimes is called minimal deviation adenocarcinoma or adenoma malignum. The incidence was found in almost all groups of age (25-72 years old). The average age was around 42 years old. This study objective is to present a new and uncommon variant case in Indonesia primarily in Medan. This study reported a case of 47-year- old woman, Mrs. M, who was clinically diagnosed with suspected carcinoma of cervix. A whitish, poorly demarcated mass in cervix was found in hysterectomy specimens. Microscopic examination revealed that the cervix was lined by atypical and pleomorphic columnar cells, partially forming papillary pattern. The glands were proliferated with variable sized, some of which dilated and covered with mucin, and also the glands formed back to back appearance. Disorganized glands were found in some foci. Glandular epithelium lining consisted of atypical and pleomorphic columnar cells with coarse chromatin and partially prominent nucleoli. Abnormal mitoses were easily found. In some foci, tumor cells also formed solid pattern. According to these histological features, a diagnosis of mucinous carcinoma, gastric type of cervix was made (ICD-0 8482/3). Despite well differentiated form of mucinous carcinoma, gastric type, this variant had aggressive behavior and worse prognosis than other cervical carcinoma variants (usual type endocervical adenocarcinoma).

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Magnetic resonance imaging findings and prognosis of gastric-type mucinous adenocarcinoma (minimal deviation adenocarcinoma or adenoma malignum) of the uterine corpus: Two case reports

Molecular and Clinical Oncology ◽

10.3892/mco.2016.789 ◽

2016 ◽

Vol 4 (5) ◽

pp. 699-704 ◽

Cited By ~ 3

Author(s):

MAYO HINO ◽

KEN YAMAGUCHI ◽

KAORU ABIKO ◽

YUMIKO YOSHIOKA ◽

JUNZO HAMANISHI ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Mucinous Adenocarcinoma ◽

Case Reports ◽

Imaging Findings ◽

Resonance Imaging ◽

Uterine Corpus ◽

Gastric Type ◽

Minimal Deviation ◽

Adenoma Malignum

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Retrospective analysis of Ca cervix postoperative: An institutional study

10.1055/s-0039-1685282 ◽

2016 ◽

Author(s):

Chandra Prakash

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Treatment Time ◽

Residual Disease ◽

Early Stage ◽

Treatment Length ◽

Recommended Treatment ◽

Carcinoma Of Cervix ◽

Well Differentiated

Introduction: Carcinoma of cervix is one of the leading causes of death worldwide and in developing countries like India. Cervical cancer is third most common cancer among women however there is a good chance of curability if diagnosed in early stage. Materials and Methods: We had analysed 78 patient of carcinoma of cervix post op who were registered from 2012 to 2015 at Dr. Ram Manohar Lohia Institute of Medical Sciences. Results: We analysed 78 patients between age of 32-70 years and median age is 50 year. Among all patients squamous cell carcinoma is most common (65 patient), adenocarcinoma were 12 and lieomyosarcoma was 1 patient. Among all patient 12 were of adenocarcinoma, 1 of lieomyosarcoma and 65 patient of squamous cell carcinoma. On examination 55 patients were NAD and 23 were residual. Among squamous cell carcinoma 35 were moderate differentiated, 18 were well differentiated and 12 were of poorly differentiated. On examination 55 patients were NAD rest were having disease. Gap between EBRT and SORBO ranging from 3 to 99 days and median is 27 days and median is 29 days. Treatment length varies from 4 cm to 8 cm and median is 6 cm. Ovoide size ranges from 2.5 cm to 3.5 cm and median is 2.5 cm. Dose per fraction ranges from 5 Gy to 9 Gy and median was 9 Gy. Median fraction of session were 2. Out of 78 patients 2 were developed metastasis and 6 having residual disease. 28 patients were NAD and rest were referral and send back to parent hospital. Conclusion: Due to lack of resources and awareness of disease maximum number of patient presented with advanced stage. The recommended treatment time could not be achieved due to scarcity of cancer centres, treatment time is prolonged. We have not found any relation between treatment length and outcome. We are still investigating to conclude to found out relation among these variables.

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Minimal-deviation adenocarcinoma (adenoma malignum) of the uterine cervix; four case reports

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/0028-2243(90)90022-s ◽

1990 ◽

Vol 34 (1-2) ◽

pp. 179-188 ◽

Cited By ~ 7

Author(s):

Ryuichi Kudo ◽

Satoru Sagae ◽

Tetsuya Kusanagi ◽

Hidemitsu Mizuuchi ◽

Osamu Hayakawa ◽

...

Keyword(s):

Uterine Cervix ◽

Case Reports ◽

Minimal Deviation ◽

Adenoma Malignum

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Immunophenotypic alteration of the stromal component in minimal deviation adenocarcinoma ('adenoma malignum') and endocervical glandular hyperplasia: a study using oestrogen receptor and alpha-smooth muscle actin double immunostaining

Histopathology ◽

10.1111/j.1365-2559.2005.02057.x ◽

2005 ◽

Vol 46 (2) ◽

pp. 130-136 ◽

Cited By ~ 30

Author(s):

Y Mikami ◽

T Kiyokawa ◽

T Moriya ◽

H Sasano

Keyword(s):

Smooth Muscle ◽

Oestrogen Receptor ◽

Smooth Muscle Actin ◽

Muscle Actin ◽

Double Immunostaining ◽

Alpha Smooth Muscle Actin ◽

Stromal Component ◽

Minimal Deviation ◽

Adenoma Malignum

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Gastric-type mucinous adenocarcinoma of the cervix in a woman with Peutz-Jeghers syndrome

10.21203/rs.3.rs-150876/v2 ◽

2021 ◽

Author(s):

Tong Tong ◽

Qiong Fan ◽

Shu Shi ◽

Yuhong Li ◽

Yudong Wang

Keyword(s):

Human Papilloma Virus ◽

Mucinous Adenocarcinoma ◽

Clinical Stage ◽

Young Patients ◽

Hpv Infection ◽

Sexual Life ◽

Autosomal Dominant Disorder ◽

Papilloma Virus ◽

Gastric Type ◽

Peutz Jeghers Syndrome

Abstract Background: Peutz-Jeghers syndrome(PJS) is a very rare autosomal dominant disorder with predisposition to multiple neoplasms. Gastric-type adenocarcinoma (GAS) is a less common carcinoma of the cervix than squamous cell carcinoma, which is more aggressive and has lower 5 year survival rate than usual type endocervical adenocarcinoma (ECA), and unrelated to human papilloma virus(HPV) infection as well. We present a 32 year-old patient with Peutz-Jeghers syndrome who was found to have gastric-type adenocarcinoma of the cervix.Case presentation: A 32-year-old woman without sexual life ever who was diagnosed Peutz-Jeghers syndrome when she was two years old presented with watery discharge for more than 6 months. A tumor around 6cm was found on the cervix and she was diagnosed gastric-type mucinous adenocarcinoma of the cervix clinical stage IB3. She was treated with artery intervention chemotherapy for one course followed by radical surgery and then systematic chemotherapy.Conclusions: The case suggests more thorough cancer screening for patients with PJS as the disorder is rare and has high risk of malignancies. Young patients with Peutz-Jeghers syndrome, including those without sexual life, who have watery discharge or bleeding should be screened for cervical carcinoma even if cytologic results or human papilloma virus (HPV) is negative.

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Adenoma Malignum(Minimal deviation adenocarcinoma) Resembling Benign Lesions of the Uterine Cervix: A Clinicopathological Analysis of six cases

Korean Journal of Gynecologic Oncology and Colposcopy ◽

10.3802/kjgoc.1994.5.1.45 ◽

1994 ◽

Vol 5 (1) ◽

pp. 45

Author(s):

Tae Jin Kim ◽

Kyung Taek Lim ◽

Hee Soo Baek ◽

Jae Uk Shim ◽

Chong Taek Park ◽

...

Keyword(s):

Uterine Cervix ◽

Benign Lesions ◽

Clinicopathological Analysis ◽

Minimal Deviation ◽

Adenoma Malignum

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Expression and Clinical Significance of Pepsinogen C in Resectable Pancreatic Cancer

The International Journal of Biological Markers ◽

10.1177/172460080101600104 ◽

2001 ◽

Vol 16 (1) ◽

pp. 31-36 ◽

Cited By ~ 9

Author(s):

N. Truan ◽

F. Vizoso ◽

M.F. Fresno ◽

R. Fernández ◽

I. Quintela ◽

...

Keyword(s):

Pancreatic Cancer ◽

Clinical Significance ◽

Breast Cancer Cells ◽

Biological Marker ◽

Resectable Pancreatic Cancer ◽

Pepsinogen C ◽

Gastric Type ◽

Poorly Differentiated ◽

Inducible Protein ◽

Well Differentiated

Pepsinogen C is an aspartyl-proteinase usually involved in the digestion of proteins in the stomach, and an androgen- inducible protein in breast cancer cells. In this study we evaluated its expression and clinical significance in patients with resectable pancreatic cancer. Pepsinogen C expression was examined by immunohistochemical methods in a series of 73 pancreatic carcinomas. The prognostic value of pepsinogen C was retrospectively evaluated by multivariate analysis. A total of 21 (28.8%) pancreatic carcinomas stained positively for pepsinogen C. The percentage of pepsinogen C-positive tumors was significantly higher in well-differentiated tumors (38.3%) than in moderately differentiated (15.8%) and poorly differentiated (0%) tumors (p<0.05). In addition, statistical analysis revealed that pepsinogen C expression was associated with clinical outcome. Thus, patients with pepsinogen C-negative tumors have a poorer overall survival than those with pepsinogen C-positive tumors. Our results led us to consider that the expression of pepsinogen C may represent a useful biological marker in pancreatic cancer. Expression of this protein may be a marker of gastric-type differentiation of the tumors and it might also reflect the existence of a complete hormone receptor pathway in a subset of pancreatic carcinomas.

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