scholarly journals Correlations between initial human-beta-defensin-1 level and quality of life of patients during anti-tuberculosis therapy

2021 ◽  
pp. 32-32
Author(s):  
O.S. Shevchenko ◽  
O.O. Pohorielova
Keyword(s):  
Quality Of Life ◽  
Pulmonary Tuberculosis ◽  
Physical Functioning ◽  
Initial Level ◽  
Bodily Pain ◽  
Role Functioning ◽  
Emotional Role ◽  
Treatment Onset ◽  
Tuberculosis Therapy

Background. The quality of life of patients with tuberculosis is an important component of the treatment effectiveness. Objective. To find the correlations between initial human-beta-defensin-1 (HBD-1) level and quality of life of patients during anti-tuberculosis therapy. Materials and methods. 100 patients with pulmonary tuberculosis were included in the study. The patients were diagnosed, treated and monitored according to current state protocols and World Health Organization guidelines. Additionally, the level if HBD-1 was measured in blood plasma by ELISA at the treatment onset. The patients were interviewed using SF-25 scale at the treatment inset, after 30 days and after 60 days. The parameters of physical functioning, role-physical functioning, bodily pain, general health, vitality, social functioning, emotional-role functioning, and mental health were assessed. Results. We found correlations between the initial level of HBD-1 and quality of life parameters: physical functioning (-0.43), role-physical functioning (-0.34), bodily pain (-0.23), general health (-0.42), social functioning (-0.42), emotional-role functioning (-0.36); p<0.05. The obtained negative correlations indicate that a high initial level of HBD-1 is a predictor of lower quality of life during treatment. Conclusions. An increase in the level of HBD-1 at the treatment onset can be considered a predictor of a decrease in the quality of life during treatment in patients with pulmonary tuberculosis.

scholarly journals Correlation between Seizure Characteristics and Quality of Life in Epilepsy Patients

2018 ◽  
Vol 9 (6) ◽  
pp. 1-6
Author(s):  
Rizaldy Taslim Pinzon ◽  
Rosa De Lima Renita Sanyasi ◽  
Jesisca Tandora ◽  
Andre Dharmawan Wijono ◽  
Fransiscus Buwana
Keyword(s):  
Quality Of Life ◽  
Social Role ◽  
Bodily Pain ◽  
Case Series ◽  
Health Perception ◽  
Role Functioning ◽  
Case Series Study ◽  
Pain Subscale ◽  
Emotional Role

Background: Epilepsy is one of the most common neurological disorder and characterized by recurrent seizures caused by abnormal electrical activity in the brain. Epilepsy is both a medical diagnosis and a social label that can negatively impact quality of life (QoL).Aims and Objective: This study aimed to evaluate the correlation between characteristics of seizure and QoL among epilepsy patients.Materials and Methods: This is a case series study conducted at Bethesda Hospital, Yogyakarta. Subjects answer 8 questions in the SF-8 questionnaire by choosing one from several alternative answers. Sub-scale assessed in this questionnaire including general health perception (GH), physical functioning (PF), physical role functioning (RP), bodily pain (BP), vitality (VT), social role function (SF), mental health (MH), and emotional role functioning (RE). Each answer will be score and processed in a program from Optum™. The final results will be summarized into physical component (PCS) and mental component (MCS).Results: Total of the subjects were 27. Subjects were dominated by male, age< 60 years. The highest score is on the bodily pain subscale (mean: 50.00 ± 8.0739), wherease the lowest score is on global health perception (mean: 43.95 ± 7.1970). Overall, subjects in this study have a better mental status than physical status (47.14 ± 10.2093 vs 46.90 ± 7.9418). Type of seizure (PCS p: 0.794; MCS p:0.093), duration of epilepsy(PCS p: 0.832; MCS p: 0.856), history of epileptic status (PCS p: 0.141; MCS p: 0.951), the presence of neurological deficit (PCS p: 0.140; MCS p: 0.283), frequency of seizure before treatment (PCS p: 0.648; MCS p: 0.213), frequency of seizure after treatment (PCS p: 0.249; MCS p: 0.407), and frequency of seizure within the last 1 year were not significant to influence the QoL (PCS p:0.978; MCS p: 0.513).Conclusion: There is no significant characteristics of seizure that influence the QoL.Asian Journal of Medical Sciences Vol.9(6) 2018 1-6

scholarly journals Alexithymia and Quality of Life in Adult Patients with Juvenile Idiopathic Arthritis

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Marta Dzhus
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Juvenile Idiopathic Arthritis ◽  
Physical Functioning ◽  
Psychological Functioning ◽  
Bodily Pain ◽  
Adult Patients ◽  
Role Functioning ◽  
Age And Sex

Patients with chronic pain disturb not only quality of life (QL) but also develop difficulties in describing their feelings. Prolonged pain, stress, pathological conditions and related emotions can alter the perceived sensation of pain. The aim of our study was to study the QL and the level of alexithymia in adult patients with different types of juvenile idiopathic arthritis (JIA).Materials and methods. 173 young people aged 18-40 years old were examined: 118 adult patients with different ILAR variants of JIA, 30 patients with ankylosing spondylitis (AS) and 25 healthy young people. The QL was assessed using the Short-Form-36 questionnaire (SF36) with further assessing the level of alexithymia by Toronto alexithymia scale (TAS-20).Results. The analysis of QL shows that PCS (44.8±9.9) was significantly lower (p=0.001) in patients with JIA than in healthy subjects (55.7±6.9) of the corresponding age and sex, but did not differ from patients with AS (42.3±7.5). Patients with JIA had lower physical (p=0.001), role functioning (p=0.001) and bodily pain (p=0.001) compared with healthy, with no difference from patients with AS. In the distribution of patients with JIA in groups by the level of alexithymia, differences in QL were not revealed by MCS or PCS and scales related with them. The relationship analysis between the alexithymia and QL in patients with JIA shows, that elevated and high levels of alexithymia were related with low levels of MCS (p<0.05), role functioning (p<0.05), mental health (p<0.05). PCS and physical functioning did not affect the level of alexithymia in adult patients with JIA. PCS, role functioning, bodily pain, and general health were the lowest in patients with poly-articular JIA. However patients with oligo-, poly-articular, enthesyte-related JIA had no differences on scales related to PCS. Patients with poly-JIA with elevated and high levels of alexithymia revealed significantly lower social (p<0.05) and role (p<0.05) functioning, mental health (p<0.05) compared to patients without alexithymia. The presence of low bodily pain in alexithymic patients was found. Signs of alexithymia were found in 90% and 85% of adult patients with the oligo-arthritis and enthesyte-related JIA, respectively. The comparison of the QL in patients with oligo-arthritis and enthesitis-related JIA with different levels of the alexithymia shows no significant differences.Conclusions. 85.2% of adult patients with different variants of JIA have elevated and high levels of alexithymia. Adult patients with JIA have lower physical functioning than healthy individuals of the same age and sex, although they do not differ from the control group and AS group on psychological functioning and related vitality, social and role functioning, and mental health. The presence of alexithymia is related with a low level of psychological functioning, role functioning, mental health. However, physical functioning did not affect the level of alexithymia in adult patients with JIA. Patients with poly-JIA have the lowest physical, role function, bodily pain and general health, but according to the psychological functioning there were no differences between different variants of JIA in adulthood. Patients with poly-JIA with elevated and high levels of alexithymia have significantly lower social (p<0.05), role (p<0.05) functioning and mental health (p<0.05) compared to patients without signs of alexithymia. 

scholarly journals Quality of Life and Self-care Activities in Diabetic Ulcer Patients, Grade 3: Gender Differences

2021 ◽  
Vol 10 (4) ◽  
pp. 184-190
Author(s):  
Maria Polikandrioti ◽  
Georgios Vasilopoulos ◽  
Evangelos Dousis ◽  
Georgia Gerogianni ◽  
Georgios Panoutsopoulos ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Gender Differences ◽  
Social Functioning ◽  
Physical Functioning ◽  
Bodily Pain ◽  
Self Care ◽  
Well Being ◽  
Physical Role ◽  
Emotional Role

Introduction: Diabetic foot ulcer (DFU) is a common complication of diabetes mellitus associated with increased morbidity and mortality and diminished quality of life (QoL). This study aimed to explore the effect of gender differences on QoL and adherence to self-care activities. Methods: In this cross-sectional study, we enrolled 135 male and 135 female patients with DFU. Data was collected using the Short Form Health Survey (SF-36) and a questionnaire that measured self-care activities (Diet, Exercise, Blood Examination, and Foot Check). Data analysis was performed using SPSS version 20. Results: In terms of QoL, male participants had moderate to high levels in the categories of energy/fatigue, emotional well-being, social functioning, and bodily pain, whereas they had low levels in physical functioning, physical role, and emotional role. Female patients had moderate QoL in the categories of energy/fatigue and social functioning, whereas they had low QoL in physical functioning, physical role, emotional role, emotional well-being, and bodily pain. Finally, regarding general health, male participants had moderate QoL and females had moderate to low QoL. Both males and females had low adherence to exercise and high in blood-examinations. For both genders, adherence to exercise had a statistically significant association with all sub-categories of QoL apart from those of role (physical and emotional). Conclusion: It is essential for health care professionals to provide gender-specific approaches in treatment of ulceration.

Relationship between aspects of health status and quality of life among widow elderly women

2020 ◽  
Vol 11 (01) ◽  
Author(s):  
Reena . ◽  
Bimla Dhanda
Keyword(s):  
Quality Of Life ◽  
Health Status ◽  
Physical Functioning ◽  
General Health ◽  
Elderly Women ◽  
Role Functioning ◽  
Physical Role ◽  
Body Pain ◽  
Emotional Role

The study was conducted in five cultural zones of Haryana state. For the rural sample 400 widow elderly women of age group 60-75 years were selected. Quality of life scale developed by World Health Organization (1997) was accessed to quality of life of widow elderly women. The questionnaire short form-36 health survey by Mchorney (1993) was used to assess the health status of widow elderly women. Clearly shows that relationship between aspects of perceived health status and quality of life among widow elderly women. Physical aspects of quality of life was positively significantly correlated with vitality (r =0.13**, p 0.01), body pain (r =0.39**, p 0.01), physical role functioning (r= 0.23**, p 0.01) , mental health ((r =0.10*, p 0.01) negatively significantly correlated with general health perception (r = -0.17**, p 0.01) and emotional role functioning (r = - 0.28**, p 0.01). Psychological aspects of quality of life was positively significantly correlated with physical functioning (r =0.13**, p 0.01) and body pain (r =0.10*, p 0.05). Another aspects social relationship of quality of life was negatively significantly correlated with physical functioning (r = -0.18**, p 0.01), body pain (r = -0.12**, p 0.01) and social role functioning (r = -0.11**, p 0.01), Physical role functioning, Emotional role function was negatively correlated with (r = 0.28**, p 0.01). Further aspects of environment was positively significantly correlated with vitality (r = 0.09*, p 0.05), Physical Functioning (r = 0.46**, p 0.01), body pain (r = 0.14**, p 0.01), General health perception (r = 0.30**, p 0.01) and physical role functioning (r = - 0.09*, p 0.05).

scholarly journals A functional electric orthesis on the paretic leg improves quality of life of stroke patients

2006 ◽  
Vol 64 (1) ◽  
pp. 20-23 ◽  
Author(s):  
Mara Renata Fernandes ◽  
Luciane B.C. Carvalho ◽  
Gilmar F. Prado
Keyword(s):  
Quality Of Life ◽  
Social Functioning ◽  
Physical Functioning ◽  
Bodily Pain ◽  
Improve Quality ◽  
Stroke Patients ◽  
Normal Life ◽  
Sf 36 ◽  
Before And After

CONTEXT: Hemiparesia changes quality of life of patients with stroke making difficult a normal life. OBJECTIVE: To evaluate the effect of Functional Eletric Orthesis (FEO) applied over the paretic leg in the quality of life of stroke patients. METHOD: The quality of life of 50 stroke patients of Associacao de Assistencia a Crianca Deficiente (AACD) was evaluated with SF-36 questionnaire before and after the treatment with a FEO for rehabilitation of walking. We analyzed data according to gender and affected hemisphere. RESULTS: The average values from all domains of SF-36 improved significantly (p<0.001). Female patients improved more than male in Emotional Domain (p=0.04) and presented a trend to be better regarding Bodily Pain and Social Functioning. Patients with right hemiparesia improved more than those with left hemiparesia (p=0.02). CONCLUSION: FEO over a paretic leg is efficient to improve quality of life of stroke patients, mainly Physical Functioning.

Quality of life during the first 6 months of interferon-b treatment in patients with MS

2000 ◽  
Vol 6 (5) ◽  
pp. 338-342
Author(s):  
J HA Arnoldus ◽  
J Killestein ◽  
L EMA Pfennings ◽  
B Jelles ◽  
B MJ Uitdehaag ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Depressive Symptoms ◽  
Side Effects ◽  
Physical Functioning ◽  
Bodily Pain ◽  
Significant Linear Trend ◽  
Role Physical ◽  
Sf 36 ◽  
The Impact

Objectives: To determine the quality of life (QoL) of MS patients during the initial 6 months of treatment with interferon-b (IFN-b). Furthermore, to determine whether changes in QoL relate to disability, emotional state, therapeutic expectations or side effect profile. Background: IFN-b has been shown to have beneficial effects on the course of MS. Since the aim of IFN-b treatment is not to cure but to slow down the disease it is important to know how this treatment affects QoL. Surprisingly, the impact of treatment with IFN-b on QoL measures has not been extensively studied so far. Methods: Case report documentation, including EDSS, SF-36 and MADRAS scores, of 51 relapsing-remitting MS patients treated with IFN-b was obtained at baseline and at months 1, 3 and 6. Patients also filled in a form about their expectations of therapy and a questionnaire on side effects. Results: During treatment there was a significant linear trend indicating improvement in the role-physical functioning (RPF) scale of the SF-36 (F1,50=4.9, P=0.032). A transient decrease at month 1 was found in the scale for bodily pain, indicating more experienced pain (F1,50=19.8, P50.001). Subgroup analysis showed that patients with most depressive symptoms on the MADRAS at baseline contributed most to the increase in RPF scores over time (F1,24=5,6 P=0.026). Furthermore, we found associations between adverse event scores and several domains of QoL. Conclusions: Our findings suggest that IFN-b therapy has an impact on QoL of MS patients in that it improves role-physical functioning and transiently worsens experienced bodily pain. QoL during treatment with IFN-b is influenced by depressive symptoms at baseline as well as by treatment-associated side-effects.

scholarly journals Influence of painless one-eye blindness on depression, anxiety and quality of life in glaucoma patients with a normal fellow eye

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Gábor Holló ◽  
Nikolett Gabriella Sándor ◽  
Péter Kóthy ◽  
Anna Géczy
Keyword(s):  
Quality Of Life ◽  
Social Role ◽  
Bodily Pain ◽  
Control Group ◽  
Life Questionnaire ◽  
Ophthalmological Examination ◽  
Role Functioning ◽  
Everyday Functioning ◽  
Fellow Eye

Abstract Background For clinical practice it is important to evaluate and compare anxiety, depression and quality of life of glaucoma patients with painless one-eye blindness and a normal fellow eye to unaffected age-matched individuals from a similar environment. Methods Twenty-eight stable glaucoma patients (age, mean ± SD: 69.0 ± 13.3 years) with one normal and one painless blind eye, and 26 controls (age: 67.0 ± 14.0 years) completed the standard Hungarian adaptations of the Beck Depression Inventory, Beck Anxiety Inventory, Spielberger-Trait Anxiety Inventory, Hopelessness Scale, and Quality of Life Questionnaire SF-36 with the assistance of trained psychologist interviewers within 3 months after a detailed ophthalmological examination. Results The groups did not differ in age, gender distribution, number of children, grandchildren and people in their household (p ≥ 0.235). The best corrected visual acuity (BCVA) of the diseased eye was minimal (median: 0.00), while BCVA of their better eye (median: 1.0) did not differ from that of the control group (p ≥ 0.694). Compared to the control group, the patients’ scores were significantly higher for depression (p ≤ 0.01), cognitive and psychophysiological symptoms of anxiety (p ≤ 0.05) and hopelessness (p ≤ 0.013), and lower (worse) for physical function, vitality, general health and bodily pain (p ≤ 0.045). No difference was found between the groups for mental health, physical role functioning, emotional role functioning and social role functioning (p ≥ 0.117). Conclusion Our results show that patients with glaucoma-related one-eye blindness may require regular psychological support even when the visual performance of the fellow eye is fully maintained on the long run, and the patients’ everyday functioning is normal.

scholarly journals Impact of Comorbidities on Quality Of Life in Breast Cancer Patients

2016 ◽  
Vol 01 (04) ◽  
pp. 025-028
Author(s):  
Monica Irukulla ◽  
Rama Vaghmare ◽  
Deepa Joseph ◽  
Syed Ahmed ◽  
Jyothi Jonnadula ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Physical Functioning ◽  
Bodily Pain ◽  
Evidence Base ◽  
Breast Cancer Patients ◽  
Co Morbidity ◽  
The Impact

AbstractIntroduction: Comorbidities are common among cancer patients and with an aging population are becoming more prevalent. These can potentially affect the stage at diagnosis, treatment and outcomes of people with cancer. Despite the intimate relationship between comorbidity and cancer, there is limited consensus on how to record, interpret or manage comorbidities in the context of cancer. Addressing the impact of comorbid conditions in cancer patients warrants improvement in the evidence base from which to make treatment decisions for those with comorbidities.Methods: In this prospective study, 64 patients with breast cancer, underwent QOL assessment using FACT –B questionnaire at three time points- pre-radiation and three and six months post radiation.Results: 29(46%) patients had comorbidities of which 23 (35%) had cardiovascular comorbidities and 6 had other comorbidities. The co-morbidities were negatively associated with multiple domains of quality of life, including physical functioning, general health, bodily pain. Patients with diabetes and hypertension had significantly lower scores in physical functioning in comparison to patients without diabetes and hypertension, but improved after treatment. In majority of patients the overall scores were less in patients with co-morbidities compared to patients without any co-morbidity.Conclusion: Comorbidities can significantly affect the quality of life in patients with comorbidities. Hence greater research into the QOL issues for better patient care and symptom management especially during the transitioning phase from active care to follow up will help clinicians improve the quality of care and interdisciplinary co-ordination.

Taxane-induced peripheral neuropathy and quality of life in breast cancer patients

2020 ◽  
Vol 26 (6) ◽  
pp. 1421-1428
Author(s):  
Ebrahim Salehifar ◽  
Ghasem Janbabaei ◽  
Abbas Alipour ◽  
Nasim Tabrizi ◽  
Razieh Avan
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Health Status ◽  
Peripheral Neuropathy ◽  
Global Health ◽  
Cancer Patients ◽  
Physical Functioning ◽  
Role Functioning ◽  
Breast Cancer Patients

Purpose Taxane-induced peripheral neuropathy (TIPN) is a common and bothersome toxicity. This study aimed to determine the incidence and severity of TIPN in patients with breast cancer and to investigate the relationship between TIPN and quality of life. Methods A total of 82 breast cancer patients with TIPN symptoms were included in this study. The criteria of National Cancer Institute-Common Terminology Criteria for Adverse Events (NCI-CTCAE v4.03) and the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30, version 3.0) were used to evaluate grading of sensory neuropathy and quality of life, respectively. Analysis of the data was done by IBM SPSS statistics version 23. Results A total of 346 patients received taxane-based chemotherapy and 82 patients (23.7%) experience TIPN. The mean (SD) global health status/quality of life, physical functioning, role functioning, and pain subscales were 60.63 (5.26), 80.64 (9.05), 81.77 (10.41), and 43.88 (11.27), respectively. There were significant negative correlations between global health status/quality of life, physical functioning, and role functioning subscales with the grade of neuropathy (r = −0.33, −0.80, and −0.61, respectively) and positive correlation between pain subscale and the grade of neuropathy (r = 0.70). Conclusion This study shows a clear association between TIPN and worsened quality of life. These findings emphasize on detecting and management of TIPN in an effort to improve the quality of life of breast cancer patients.

The number of active trigger points is associated with sensory and emotional aspects of health-related quality of life in tension type headache

2017 ◽  
Vol 16 (1) ◽  
pp. 166-166
Author(s):  
M. Palacios-Ceña ◽  
K. Wang ◽  
M. Castaldo ◽  
S. Fuensalida-Novo ◽  
C. Ordás-Bandera ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bodily Pain ◽  
Trigger Points ◽  
Tension Type Headache ◽  
Health Related Quality ◽  
Emotional Role ◽  
Related Quality ◽  
Health Related ◽  
Type Headache

Abstract Aims Some evidence supports that referred pain elicited by active trigger points (TrPs) reproduces some features of tension type headache (TTH). Our aim was to investigate the association between the number of active TrPs and health-related quality of life TTH. Methods Patients with TTH diagnosed by experienced neurologists according to the last International Headache Classification (ICHD-III) were included. Exclusion criteria included other primary headaches, medication overuse headache, whiplash injury or fibromyalgia. TrPs were bilaterally explored within the masseter, temporalis, trapezius, sternocleidomastoid, splenius capitis, and suboccipital. Health-related quality of life was assessed with the SF-36 questionnaire including 8 domains: physical functioning, physical role, bodily pain, general health, vitality, social functioning, role-emotional, and mental health. Higher scores represent better quality of life. Spearman correlation coefficients were used to determine correlations between the active TrPs and SF-36. Results Two hundred and two patients (mean age: 45±12 years) with a headache frequency of 17±7 days/month participated. Each patient with TTH exhibited 4.7±2.9 active TrPs. The number of active TrPs showed moderate weak negative associations with bodily pain (rs: −0.216; P =0.002), emotional role (rs: -0.185; P = 0.008) and vitality (rs: –0.161; P = 0.02), but not with the remaining domains: the higher the number of active TrPs, the worse the emotional role and vitality and the higher the pain interference with daily life. These results were similar in both frequent episodic and chronic TTH. Conclusions The number of active TrPs was associated with sensory and emotional aspects of quality of life in a cohort of subjects with TTH.

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