scholarly journals A multi-center, signal-arm study on cancer patients’ perception of chemotherapy side effects, depression, and decision regret at the end of adjuvant treatment

2020 ◽  
pp. 1-7
Author(s):  
Caterina Calderon ◽  
Raquel Hernández ◽  
María del Mar Muñoz ◽  
Alba Rosa Díez
Keyword(s):  
Quality Of Life ◽  
Side Effects ◽  
Adjuvant Chemotherapy ◽  
Healthcare Professional ◽  
Metastatic Cancer ◽  
Decision Regret ◽  
Chemotherapy Side Effects ◽  
To Receive ◽  
The Relationship

Purpose The aim was to assess patients’ perception of chemotherapy side effects and analyze the relationship between these, depression, and treatment rejection. Methods A multi-center, signal-arm study in 456 patients with resected, non-metastatic cancer. Conducted upon completion of adjuvant chemotherapy. Participants answered questionnaires evaluating chemotherapy side effects (EORTC-QLC-C30), depression (BSI), and decision regret (DRS). Results The three most common symptoms reported by the patients were fatigue (57.5%), insomnia (56.7%), and pain (31%). Only 7.6% (n=35) expressed regret over having opted to receive adjuvant chemotherapy. Fatigue, insomnia, dyspnea, and pain were associated with more depression, while fatigue, pain, and age were associated with decision regret. Conclusion Healthcare professional should consider decreasing fatigue, insomnia, and pain a priority if quality of life is to be improved for patients receiving chemotherapy. The treatment of the side effects of chemotherapy for cancer is essential to improve the quality of life and compliance with the treatment.

scholarly journals Ozone therapy can be considered as an integrative therapy in oncology? [abstract]

2019 ◽  
Vol 3 (4) ◽  
Author(s):  
Paolo Tordiglione ◽  
Fabio Silvio Mario Araimo ◽  
Carmela Imperiale ◽  
S. Zancla
Keyword(s):  
Quality Of Life ◽  
Pilot Study ◽  
Side Effects ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
System Quality ◽  
Ozone Therapy ◽  
Integrative Therapy ◽  
Antioxidant Defence System

BACKGROUND: Our group in Policlinic Umberto I - University Hospital of Sapienza Rome - has decided to further investigate if Ozone therapy can be of support in oncology. In literature it has been reported that ozone applications in oncology or in cancer cells is associated with: high efficiency in preventing chemotherapy complications (nausea, vomiting, opportunistic infections, asthenia) as well as confining or restricting the expansion of tumours.(1-5) PURPOSE: The aim of our study in to evaluate and eventually confirm the validity of ozone treatments in order to consider such procedures as a possible and concrete support therapy for oncology patients undertaking chemotherapy. A statistical significance and clinical evaluation of our work would finally give a scientifically validation, still missing, to officially consider ozone therapy as one of the many possible integrative therapy in oncology. DESIGN: It is a pilot study designed and approved by the Ethical Committee of the University of Rome, La Sapienza (March 2017) to evaluate quality of life and reduction of side effects of adjuvant chemotherapy in 20 breast cancer patients. METHODS: The selected patients will be treated with systemic ozone treatment: Ozonated autohemotherapy will be performed according to the following method: 200 ml venous blood will be exposed an equal amount of O2 /O3 (200 ml) The ozone concentration will be gradually increased as follows: 20-30-40 mcrg/mL with a specific schedule until each patient will receive 15 applications overall. The sessions will be scheduled according to a specific timetable during the administration of adjuvant chemotherapy by means of Epirubicin and Cyclophsphamide (EC) every 3 weeks for 4 cycles followed by Paclitaxel for 12 consecutive weeks. Ozone therapy will not be applied on days of chemotherapy in order to avoid interaction between chemotherapeutics and ozonides. Biochemical blood analysis and stress oxidative blood test will be used as parameters for activity of antioxidant defence system. Quality of life will be evaluated with Fact G Test. It is the first study to have been evaluated and approved by an official university ethical committee and we will be glad to publish our result as soon as possible. On this behalf it would be great if any other centre could be interested in cooperating with us so to transform this pilot study into a multicentre study with larger numbers and therefore, with a greater impact on the international community. Our aim is to give cancer patients a better life quality in general and especially help them overcome all the side effects during the chemotherapy. This could open a new scenario in the alternative complementary treatments in oncology.

scholarly journals Adjuvant chemotherapy for breast cancer: side effects and quality of life.

BMJ ◽  
1980 ◽  
Vol 281 (6255) ◽  
pp. 1594-1597 ◽  
Author(s):  
B V Palmer ◽  
G A Walsh ◽  
J A McKinna ◽  
W P Greening
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Side Effects ◽  
Adjuvant Chemotherapy

Patients’ perception of chemotherapy side effects: Expectations, doctor-patient communication and impact on quality of life - An Italian survey

2016 ◽  
Vol 26 (2) ◽  
pp. e12618 ◽  
Author(s):  
Domenica Lorusso ◽  
Emilio Bria ◽  
Anna Costantini ◽  
Massimo Di Maio ◽  
Giovanni Rosti ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Side Effects ◽  
Patient Communication ◽  
Doctor Patient Communication ◽  
Italian Survey ◽  
Chemotherapy Side Effects

Towards a better understanding of the relationship between side effects of analgesia and quality of life in patients with multiple myeloma

2015 ◽  
Vol 24 (1) ◽  
pp. 9-10 ◽  
Author(s):  
Pasquale Niscola ◽  
Agostina Siniscalchi ◽  
Andrea Tendas ◽  
Paolo de Fabritiis ◽  
Tommaso Caravita ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Myeloma ◽  
Side Effects ◽  
The Relationship

Dexamethasone for the Prophylaxis of Radiation-Induced Emesis: A National Cancer Institute of Canada Clinical Trials Group Phase III Study

2000 ◽  
Vol 18 (9) ◽  
pp. 1960-1966 ◽  
Author(s):  
P. Kirkbride ◽  
A. Bezjak ◽  
J. Pater ◽  
B. Zee ◽  
M.J. Palmer ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Side Effects ◽  
Life Assessment ◽  
Phase Iii ◽  
Fractionated Radiotherapy ◽  
Global Quality ◽  
Global Quality Of Life ◽  
Upper Abdomen ◽  
To Receive

PURPOSE: To investigate the efficacy of dexamethasone as a prophylactic antiemetic for patients receiving fractionated radiotherapy to the upper abdomen in a randomized controlled trial. PATIENTS AND METHODS: One hundred fifty-four patients planned to receive fractionated radiotherapy to fields involving the upper abdomen (minimum total dose, 20 Gy; minimum number of fractions, five) were randomized to receive prophylactic dexamethasone (2 mg orally three times a day [tid], starting in the morning of first treatment and continuing until after their fifth treatment) or placebo. The primary end point of the study was the proportion of patients free from emesis during the study period. Secondary end points included a quality-of-life assessment using the core questionnaire of the European Organization for Research and Treatment of Cancer and side effects of dexamethasone therapy in this population of patients. RESULTS: Fifty-four (70%) out of 75 patients receiving dexamethasone had complete protection versus 37 (49%) out of 75 patients on placebo (P = .025). Most emetic episodes occurred during the initial phase of treatment. Although there was no difference in global quality of life between the two sets of patients, patients receiving dexamethasone had less nausea and vomiting and less loss of appetite but more insomnia. CONCLUSION: Dexamethasone 2 mg tid seems to be an effective prophylactic antiemetic in this situation. Side effects were acceptable, but there seemed to be no overall effect on global quality of life.

The relationship between optimism, personal control and quality of life of patients with COPD

2002 ◽  
Author(s):  
R. Arnold ◽  
A. V. Ranchor ◽  
N. H. T. ten Hacken ◽  
G. H. Koeter ◽  
V. Otten ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Personal Control ◽  
The Relationship

Management of Economics and State "Bottom"

2020 ◽  
Vol 17 (6) ◽  
pp. 76-91
Author(s):  
E. D. Solozhentsev
Keyword(s):  
Quality Of Life ◽  
Artificial Intelligence ◽  
Probabilistic Models ◽  
Human Life ◽  
Special Software ◽  
Human Quality ◽  
Relationship Of ◽  
The Relationship

The scientific problem of economics “Managing the quality of human life” is formulated on the basis of artificial intelligence, algebra of logic and logical-probabilistic calculus. Managing the quality of human life is represented by managing the processes of his treatment, training and decision making. Events in these processes and the corresponding logical variables relate to the behavior of a person, other persons and infrastructure. The processes of the quality of human life are modeled, analyzed and managed with the participation of the person himself. Scenarios and structural, logical and probabilistic models of managing the quality of human life are given. Special software for quality management is described. The relationship of human quality of life and the digital economy is examined. We consider the role of public opinion in the management of the “bottom” based on the synthesis of many studies on the management of the economics and the state. The bottom management is also feedback from the top management.

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