Correlative Connections between Chronostructures of Water-Mineral Homeostasis and Weather Indices in Cardiovascular Pathology

Currently, and over the past decade, intensive research is being conducted in the field of organizational, preventive and therapeutic work with weather-sensitive and weather-dependent patients suffering from cardiovascular pathology. One of the most discussed issues in practical medicine is the application of climate conditions, with a fixed frequency and time of exposure. Conditions of influence of climatic factors, in some cases, can exceed the limits of the norm and, accordingly, have a pathological effect on the functional state of a person. Thus, we used data from statistically reliable results of 928 questionnaires processed and analyzed, reflecting the medical and social characteristics of patients with cardiovascular pathology. Direct results were evaluated by analyzing changes in the dynamics of indicators. According to a questionnaire survey, 62% of patients who have chronic diseases and seek medical help for diseases of the cardiovascular system believe that weather factors have a significant impact on their health. of the patients who do not have chronic diseases, 38% gave positive answers to the question about the weather sensitivity of their health. As part of the pilot project to create a system of long-term care for elderly and disabled citizens in the Voronezh region, patients are informed about the sources of obtaining specialized medical weather forecasts in the region; interaction between the parties is organized to conduct sanitary and educational work; medical examinations are organized and conducted; training sessions are organized for relatives of citizens who have lost the ability to self-service. Further organizational, preventive and therapeutic work with weather-sensitive and weather-dependent patients in the Voronezh region is characterized by an increase in the quality of medical care for patients with cardiovascular diseases.

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RESPIRATORY TUBERCULOSIS AND CHRONIC OBSTRUCTIVE LUNG DISEASE - FEATURES OF THE COMORBIDE STATE

Chronos Journal ◽

10.31618/2658-7556-2019-39-12-8 ◽

2019 ◽

Author(s):

Anna Viktorovna Katicheva ◽

Nikolai Andreyevich Brazhenko ◽

Olga Nikolaevna Brazhenko ◽

Anna Georgievna Chuikova

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Rapid Development ◽

Chronic Obstructive Lung Disease ◽

Chronic Obstructive ◽

Bronchial Obstruction ◽

Obstructive Pulmonary Disease ◽

Diffusion Capacity ◽

Cardiovascular Pathology ◽

Systemic Arterial Hypertension

In modern conditions, chronic tobacco intoxication and chronic obstructive pulmonary disease are widespread and affect the health and life expectancy of patients. Among patients with tuberculosis, chronic tobacco intoxication and COPD are also widespread. Against the background of smoking and chronic obstructive pulmonary disease in patients with tuberculosis of the respiratory system, bronchial obstruction, hypoxemia, impaired capillary pulmonary blood flow, and a decrease in the diffusion capacity of the lungs are determined. A comorbid state is accompanied by the development of oxidative stress, systemic inflammation, endothelial dysfunction. Such changes in combination with dyslipidemia contribute to the development of multifocal atherogenesis, systemic arterial hypertension and the rapid development of cardiovascular pathology

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Cardiovascular Pathology.

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1966.tb19754.x ◽

1966 ◽

Vol 1 (8) ◽

pp. 306-307

Keyword(s):

Cardiovascular Pathology

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miR-208b Reduces the Expression of Kcnj5 in a Cardiomyocyte Cell Line

Biomedicines ◽

10.3390/biomedicines9070719 ◽

2021 ◽

Vol 9 (7) ◽

pp. 719

Author(s):

Julia Hupfeld ◽

Maximilian Ernst ◽

Maria Knyrim ◽

Stephanie Binas ◽

Udo Kloeckner ◽

...

Keyword(s):

Untranslated Region ◽

Electrical Remodeling ◽

Sequencing Data ◽

Western Blots ◽

Cardiovascular Pathology ◽

Hypertrophic Response ◽

Channel Dependent ◽

Cardiac Excitation ◽

The Impact ◽

Generation Sequencing

MicroRNAs (miRs) contribute to different aspects of cardiovascular pathology, among them cardiac hypertrophy and atrial fibrillation. Cardiac miR expression was analyzed in a mouse model with structural and electrical remodeling. Next-generation sequencing revealed that miR-208b-3p was ~25-fold upregulated. Therefore, the aim of our study was to evaluate the impact of miR-208b on cardiac protein expression. First, an undirected approach comparing whole RNA sequencing data to miR-walk 2.0 miR-208b 3′-UTR targets revealed 58 potential targets of miR-208b being regulated. We were able to show that miR-208b mimics bind to the 3′ untranslated region (UTR) of voltage-gated calcium channel subunit alpha1 C and Kcnj5, two predicted targets of miR-208b. Additionally, we demonstrated that miR-208b mimics reduce GIRK1/4 channel-dependent thallium ion flux in HL-1 cells. In a second undirected approach we performed mass spectrometry to identify the potential targets of miR-208b. We identified 40 potential targets by comparison to miR-walk 2.0 3′-UTR, 5′-UTR and CDS targets. Among those targets, Rock2 and Ran were upregulated in Western blots of HL-1 cells by miR-208b mimics. In summary, miR-208b targets the mRNAs of proteins involved in the generation of cardiac excitation and propagation, as well as of proteins involved in RNA translocation (Ran) and cardiac hypertrophic response (Rock2).

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