scholarly journals Rapid Identification of Drug Resistant Candida Species Causing Recurrent Vulvovaginal Candidiasis

2012 ◽  
Vol 53 (3) ◽  
pp. 193-198 ◽  
Author(s):  
Kambiz Diba ◽  
Atefeh Namaki ◽  
Haleh Ayatolahi ◽  
Haleh Hanifian
Keyword(s):  
Candida Species ◽  
Rapid Identification ◽  
Vulvovaginal Candidiasis ◽  
Drug Resistant ◽  
Recurrent Vulvovaginal Candidiasis

Value of antifungal susceptibility testing in recurrent vulvovaginal Candidiasis by Non -Albicans Candida

2021 ◽  
Vol 30 (1) ◽  
pp. 161-167
Author(s):  
Ghada A. Mokhtar ◽  
Mohamed Sh. Ramadan ◽  
Shymaa Yahia
Keyword(s):  
Amphotericin B ◽  
Candida Species ◽  
Antifungal Susceptibility ◽  
High Sensitivity ◽  
Common Species ◽  
Vulvovaginal Candidiasis ◽  
Recurrent Vulvovaginal Candidiasis ◽  
Sensitivity Pattern ◽  
Vaginal Swabs ◽  
Vitek 2

Background: Vulvovaginal candidiasis (VVC) is regarded as a prevalent vaginal infection and mainly results from Candida albicans. Nevertheless, there has recently been a prominent shift in candidiasis etiology regarding non-albicans Candida (NAC) species with achieving importance. For women with more than three episodes annually are described as recurrent vulvovaginal candidiasis (RVVC). Objectives: To isolate, speciate, and determine the value of antifungal sensitivity pattern of candida species isolated from patients developed (RVVC). Methodology: High vaginal swabs (HVS) were taken from patients with RVVC and cultured on ordinary mycological media. Any significant candida growth was identified and speciated by VITEK 2 system. Their antifungal sensitivity was done by disc diffusion approach governed by CLSI guidelines. Results: A total of 110 Candida species from 250 high vaginal swabs were isolated. Among all candida species isolated from patients with RVCC, C.albicanis accounts for 44% while NAC accounts for 56% with C.glabrata most common species isolated. Voriconazole, amphotericin B, and nystatin showed high sensitivity rates (92 %, 89%, and 84% respectively) on all candida species (C.albicans and NAC) isolated from patients with RVVC. Conclusion: In RVCC there is increase in NAC (56%) with C.glabrata most common species isolated. Voriconazole, Nystatin, and amphotericin B have the best antifungal activity against all spp.

Vulvovaginal candidiasis in female sex workers

1998 ◽  
Vol 9 (9) ◽  
pp. 526-530 ◽  
Author(s):  
L Otero ◽  
V Palacio ◽  
F Carreno ◽  
F J Mendez ◽  
F Vazquez
Keyword(s):  
Prospective Study ◽  
Sex Workers ◽  
Candida Species ◽  
Female Sex Workers ◽  
Clinical Findings ◽  
Vulvovaginal Candidiasis ◽  
Recurrent Vulvovaginal Candidiasis ◽  
Female Sex ◽  
Related Risk ◽  
A Prospective Study

Vulvovaginal candidiasis is a frequent inflammatory process in women but it has not been widely studied in female sex workers FSWs . To estimate the frequency of Candida species infection in FSWs and to identify related risk factors and clinical findings, we carried out a retrospective study of 1923 FSWs over 11 years. We also performed a prospective study of 163 consecutive FSWs with a history of candidiasis during a 4 year period. Candida species were isolated in 1967 samples 18.5 of the total . Candida albicans 89.3 was the most frequent species, followed by Candida glabrata 2.7 , Candida parapsilosis 1.2 and Saccharomyces cerevisiae 0.4 . In the prospective study of 163 patients, we found vaginal discharge in 76.1 of cases, soreness in 52.1 and vulval pruritus in 32.5 . We identified 12 patients 7.4 with recurrent vulvovaginal candidiasis. No statistical difference was found between recurrent vulvovaginitis and the use of oral contraceptives, oral sex, tight fitting clothing and synthetic underwear. FSWs have the same prevalence of candidiasis as other groups of women described in published literature. The proportion of albicans and non albicans species does not differ between women with recurrent and non recurrent vulvovaginal candidiasis VVC .

scholarly journals Treating (Recurrent) Vulvovaginal Candidiasis with Medical-Grade Honey—Concepts and Practical Considerations

2021 ◽  
Vol 7 (8) ◽  
pp. 664
Author(s):  
Senna J. J. M. van Riel ◽  
Celine M. J. G. Lardenoije ◽  
Guy J. Oudhuis ◽  
Niels A. J. Cremers
Keyword(s):  
Candida Species ◽  
Treatment Options ◽  
Standard Of Care ◽  
Vulvovaginal Candidiasis ◽  
Controlled Clinical Trial ◽  
Immunomodulatory Activity ◽  
Current Standard ◽  
Vaginal Infections ◽  
Recurrent Vulvovaginal Candidiasis ◽  
Medical Grade

Recurrent vulvovaginal candidiasis (RVVC) is a relapsing vaginal fungal infection caused by Candida species. The prevalence varies among age populations and can be as high as 9%. Treatment options are limited, and in 57% of the cases, relapses occur within six months after fluconazole maintenance therapy, which is the current standard of care. The pathogenesis of RVVC is multifactorial, and recent studies have demonstrated that the vaginal microenvironment and activity of the immune system have a strong influence on the disease. Medical-grade honey (MGH) has protective, antimicrobial, and immunomodulatory activity and forms a putative alternative treatment. Clinical trials have demonstrated that honey can benefit the treatment of bacterial and Candida-mediated vaginal infections. We postulate that MGH will actively fight ongoing infections; eradicate biofilms; and modulate the vaginal microenvironment by its anti-inflammatory, antioxidative, and immunomodulatory properties, and subsequently may decrease the number of relapses when compared to fluconazole. The MGH formulation L-Mesitran Soft has stronger antimicrobial activity against various Candida species than its raw honey. In advance of a planned randomized controlled clinical trial, we present the setup of a study comparing L-Mesitran Soft with fluconazole and its practical considerations.

scholarly journals Susceptibility of Candida species isolated from recurrent vulvovaginal candidiasis to antifungal agents among women at Institut Pasteur of Cte dIvoire

2018 ◽  
Vol 9 (3) ◽  
pp. 21-26
Author(s):  
Etienne Angora Kpongbo ◽  
Djohan Vincent ◽  
A. Ira-Bonouman Valérie ◽  
A. Vanga-Bosson Henriette ◽  
Fulgence Kassi Kondo ◽  
...  
Keyword(s):  
Candida Species ◽  
Antifungal Agents ◽  
Vulvovaginal Candidiasis ◽  
Recurrent Vulvovaginal Candidiasis

scholarly journals Rapid identification of health care–associated infections with an integrated fluorescence anisotropy system

2016 ◽  
Vol 2 (5) ◽  
pp. e1600300 ◽  
Author(s):  
Ki Soo Park ◽  
Chen-Han Huang ◽  
Kyungheon Lee ◽  
Yeong-Eun Yoo ◽  
Cesar M. Castro ◽  
...  
Keyword(s):  
Health Care ◽  
Fluorescence Anisotropy ◽  
Bacterial Species ◽  
Rapid Identification ◽  
Integrated System ◽  
Clinical Samples ◽  
Drug Resistant ◽  
Polarization Anisotropy ◽  
Major Health ◽  
Health Care Associated Infections

Health care–associated infections (HAIs) and drug-resistant pathogens have become a major health care issue with millions of reported cases every year. Advanced diagnostics would allow clinicians to more quickly determine the most effective treatment, reduce the nonspecific use of broad-spectrum antimicrobials, and facilitate enrollment in new antibiotic treatments. We present a new integrated system, polarization anisotropy diagnostics (PAD), for rapid detection of HAI pathogens. The PAD uses changes of fluorescence anisotropy when detection probes recognize target bacterial nucleic acids. The technology is inherently robust against environmental noise and economically scalable for parallel measurements. The assay is fast (2 hours) and performed on-site in a single-tube format. When applied to clinical samples obtained from interventional procedures, the PAD determined the overall bacterial burden, differentiated HAI bacterial species, and identified drug resistance and virulence status. The PAD system holds promise as a powerful tool for near-patient, rapid HAI testing.

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