scholarly journals Effects of Histobulin (Immunoglobulin/Histamine Complex) on Depression and Anxiety in Chronic Urticaria: Psychiatric Manifestations or Psychiatric Comorbidities of Chronic Urticaria?: A Case Report

2021 ◽  
Vol 6 (6) ◽  
Keyword(s):  
Case Report ◽  
Chronic Urticaria ◽  
Clinical Manifestations ◽  
Severe Depression ◽  
Depression And Anxiety ◽  
Psychiatric Comorbidities ◽  
Case Presentation ◽  
Clinical Changes ◽  
Psychiatric Manifestations ◽  
Allergic Manifestations

Background: Psychiatric comorbidities of chronic urticaria (CU) have been reported and examined recently. The prevalence of mental disorders and emotional distress is high in patients with CU. This is a case report in which Histobulin was found to be effective for psychiatric manifestations in chronic spontaneous urticaria (CSU). Case Presentation: Three cases of CSU accompanying psychiatric manifestations (PMs) were treated with Histobulin. One patient with CSU with severe depression showed clinical changes in depressive symptoms in parallel to changes in allergic symptoms during treatment. Histobulin clearly improved not only CSU but also the accompanying PMs in one patient and slightly improved them in another patient. The PMs were not improved by an antihistamine (H1 blocker) in any case. Histobulin is effective not only for allergic manifestations (AMs) but also for PMs of CSU. Conclusions: PMs as well as AMs of CSU were improved by Histobulin therapy. PMs were suspected to be a part of the clinical manifestations in CSU, possibly through histamine-mediated mechanisms. These conditions were suggested to be ‘allergic psychiatric manifestations (APMs)’ or ‘histamine-mediated psychiatric manifestations (HPMs)’. Further study of PMs based on histamine-mediated mechanisms, including allergies, may be necessary. Accordingly, it should be clarified whether the PMs of CSU are a part of the clinical manifestations of CSU or are psychiatric comorbidities of CSU.

scholarly journals Effects of Histobulin on Depression and Anxiety in Chronic Urticaria: Psychiatric Manifestations or Psychiatric Comorbidities of Chronic Urticaria?: A Case Report

2020 ◽  
Author(s):  
G Noh ◽  
Sungjin Cho
Keyword(s):  
Case Report ◽  
Chronic Urticaria ◽  
Clinical Manifestations ◽  
Severe Depression ◽  
Depression And Anxiety ◽  
Psychiatric Comorbidities ◽  
Case Presentation ◽  
Clinical Changes ◽  
Psychiatric Manifestations ◽  
Allergic Manifestations

Abstract Background: Psychiatric comorbidities of chronic urticaria (CU) have been reported and examined recently. The prevalence of mental disorders and emotional distress is high in patients with chronic urticaria. Histobulin is well known to be effective in chronic urticaria. Case Presentation: Three cases of CU accompanying psychiatric manifestations (PMs) were treated with Histobulin. One patient with CU with severe depression showed clinical changes in depressive symptoms in parallel to changes in allergic symptoms. Histobulin improved not only chronic urticaria but also the accompanying PMs in two other patients with CU. The PMs were not improved by an antihistamine (H1 blocker) in all 3 cases. Histobulin is effective not only for allergic manifestations (AMs) but also for PMs of chronic urticaria. Conclusions: PMs seem to be clinical manifestations of chronic urticaria through histamine-mediated mechanisms. PMs as well as AMs of chronic urticaria were effectively and causatively treated with Histobulin. These conditions were suggested to be ‘allergic psychiatric manifestations (APM)’ or ‘histamine-mediated psychiatric manifestations (HmPM). Further study of PMs based on histamine-mediated mechanisms, including allergies, is necessary. Accordingly, it should be clarified whether the PMs of CU are actual PMs of CU or are psychiatric comorbidities of CU.

scholarly journals Left Renal Vein Thrombus and Pulmonary Thromboembolism Caused by Nutcracker Syndrome: a Case Report

2021 ◽  
Author(s):  
Kanta Hori ◽  
Shota Yamamoto ◽  
Maki Kosukegawa ◽  
Noboru Yamashita ◽  
Yuichiro Shinno
Keyword(s):  
Case Report ◽  
Renal Vein ◽  
Pulmonary Thromboembolism ◽  
Case Reports ◽  
Left Renal Vein ◽  
Clinical Manifestations ◽  
Venous Hypertension ◽  
Nutcracker Syndrome ◽  
Case Presentation ◽  
Renal Venous Hypertension

Abstract Background: Nutcracker syndrome (NCS) refers to compression of the left renal vein (LRV) between the aorta and superior mesenteric artery (SMA), which results in renal venous hypertension and its resultant clinical manifestations. Left renal vein thrombus (LRVT) complicating NCS is relatively rare. To the best of our knowledge, there are only four case reports of LRVT complicating NCS. Furthermore, there are no reports of pulmonary thromboembolism (PTE) caused by NCS. Herein, we describe a rare case of NCS causing LRVT and PTE and its clinical management. Case Presentation: A 40-year-old man was admitted to our hospital with acute left flank pain. Computed tomography angiography (CTA) revealed compression of the LRV between the aorta and the SMA with an LRVT. Furthermore, CTA revealed bilateral PTE. Rivaroxaban was administered as an anticoagulant. Twenty days after initiation, CTA revealed complete resolution of PTE and LRVT, and repeat CTA at 3 and 6 months showed no recurrence. Conclusions: This case report demonstrates that NSC may be a possible cause of LRVT and PTE. We review the reported cases of NCS complicated by LRVT and discuss the imaging modalities for NCS.

scholarly journals Palmo-plantar hyperkeratosis associated with HTLV-1 infection: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Elías Quintero-Muñoz ◽  
Daniel Martin Arsanios ◽  
María Fernanda Estupiñán Beltrán ◽  
Juan David Vera ◽  
Catalina Palacio Giraldo ◽  
...  
Keyword(s):  
Case Report ◽  
Clinical Manifestation ◽  
Seborrheic Dermatitis ◽  
Clinical Manifestations ◽  
Strongyloides Stercoralis ◽  
Palmoplantar Keratoderma ◽  
Case Presentation ◽  
Skin Manifestation ◽  
Human T Cell ◽  
Palmoplantar Hyperkeratosis

Abstract Background Palmoplantar hyperkeratosis is a cutaneous manifestation that had not been clearly associated with infection by the human T-cell lymphotropic virus, which is a retrovirus that in most cases does not develop clinical pathologies and its symptoms may be undetected. The skin is one of the most affected organs, however until now only seborrheic dermatitis, xerosis/ichthyosis and infective dermatitis associated with HTLV-1 have been described as cutaneous clinical manifestations of this disease. Case presentation We present the case of a 36-year-old male patient with serologically documented HTLV-1 infection, who presented symptoms of diarrhea, malabsorption due to Strongyloides stercoralis, and in whom a physical examination revealed an association with generalized xerosis and palmoplantar keratoderma confirmed by skin biopsy. Other infectious etiologies and malignancy were ruled out. This clinical manifestation was managed with dermal hydration, and skin care which improved the thickened skin and make it less noticeable. Conclusions According to our experience, this is the first reported case of palmoplantar keratoderma associated with a human lymphotropic virus infection. This is a skin manifestation that has not been confirmed in conjunction with HTLV-I before. This implies that palmoplantar keratoderma is a new clinical manifestation of this infection, that should be considered in the initial approach of patients in endemic areas with these dermatological characteristics.

scholarly journals First description of immune complex vasculitis after COVID-19 vaccination with BNT162b2: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Victoria Therese Mücke ◽  
Viola Knop ◽  
Marcus Maximilian Mücke ◽  
Falk Ochsendorf ◽  
Stefan Zeuzem
Keyword(s):  
Case Report ◽  
Immune Complex ◽  
Clinical Manifestations ◽  
Lower Abdomen ◽  
Short Treatment ◽  
Laboratory Findings ◽  
Case Presentation ◽  
Immune Complex Vasculitis ◽  
Oral Steroids ◽  
Hands And Feet

Abstract Background Cases of immune complex vasculitis have been reported following COVID-19 infections; so far none in association with novel mRNA-based COVID-19 vaccination. This case report describes a cutaneous immune complex vasculitis after vaccination with BNT162b2. Case presentation A 76-year old male with liver cirrhosis developed an immune complex vasculitis 12 days after the second injection of BNT162b2. On physical examination, the patient presented with pruritic purpuric macules on hands and feet, flexor and extensor parts of both legs and thighs and lower abdomen, and bloody diarrhoea. Laboratory testing showed elevated inflammatory markers. After short treatment with oral steroids all clinical manifestations and laboratory findings resolved. Conclusions An increasing number of clinical manifestations have been attributed to COVID-19 infection and vaccination. This is the first written report of immune complex vasculitis after vaccination with BNT162b2. We present our case report and a discussion in the light of type three hypersensitivity reaction.

scholarly journals COVID-19 Infected Woman with Tuberculous Meningitis: A Case Report

2020 ◽  
Author(s):  
Mahshid Nadershahbaz ◽  
Reza Bidaki ◽  
Saeid Azimi ◽  
fatemeh saghafi
Keyword(s):  
Case Report ◽  
Postpartum Depression ◽  
Tuberculous Meningitis ◽  
Psychological Disorders ◽  
Conversion Disorder ◽  
Depression And Anxiety ◽  
Infected Woman ◽  
Case Presentation ◽  
Panic Disorders ◽  
Afghan Woman

Abstract Background: Several factors have been reported for COVID-19 disease. In addition, patients with COVID-19 are also susceptible to suffer from other problems. In this study, a case suffering from TB meningitis is reported to have developed COVID-19 disease, eventually showing symptoms of psychological disorders.Case presentation: A young Afghan woman was hospitalized with TB meningitis who did not respond to treatment. After a while, she was hospitalized again with diagnosis of COVID-19. The patient showed symptoms of postpartum depression and anxiety. She also had pseudoseizure attacks several times, so antidepressants and anti-anxiety medications were started for the patient In order to treat conversion disorder and panic disorders.Conclusion: Tuberculous meningitis, postpartum depression and other factors can increase the risk of COVID-19 infection leading to psychological disorders like conversion disorder in susceptible.

scholarly journals Acute Hypertensive Retinochoroidopathy Secondary to an Anti-cancer Drug (apatinib): The First Case Report

2021 ◽  
Vol 8 ◽  
Author(s):  
Bangtao Yao ◽  
Gang Liu ◽  
Bei Wang ◽  
Qian Cao
Keyword(s):  
Case Report ◽  
Clinical Manifestations ◽  
Chinese Woman ◽  
Cancer Drug ◽  
Fundus Fluorescein Angiography ◽  
Ovarian Adenocarcinoma ◽  
Case Presentation ◽  
First Case ◽  
Anti Cancer ◽  
Sudden Decrease

Background: Acute hypertensive retinochoroidopathy is a rare, severe ocular disease, characterized by retinal and choroidal ischaemia. Untreated cases are associated with high mortality and poor visual outcomes. Patients subjected to treatment with the anti-neoplasic drug apatinib may trigger this disease. The purpose of this article is to describe in detail an acute hypertensive retinochoroidopathy in a young Chinese woman treated with apatinib.Case Presentation: A 40-year-old young Chinese woman presented a sudden but painless reduction of visual acuity in both eyes. She was previously diagnosed with gastric cancer and metastatic ovarian adenocarcinoma. The treatment consisted radical gastrectomy, transabdominal hysterectomy, bilateral adnexectomy, and 250 mg oral apatinib per day. After 58 days of apatinib administration, the patient immediately sought consult for a sudden decrease in vision. Her blood pressure was 208/136 mmHg and, based on the clinical manifestations, the patient was diagnosed with acute hypertensive retinochoroidopathy.Conclusions: This is the first case report of an apatinib-related acute hypertensive retinochoroidopathy diagnosed using fundal photograph, fundus fluorescein angiography, and spectral-domain optical coherence tomography simultaneously. It is crucial to develop a suitable strategy for management and prevention of this adverse event.

scholarly journals Abdominal cocoon with bilateral cryptorchidism and seminoma in the right testis: a case report and review of literature

BMC Surgery ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Bingqing Yue ◽  
Zilian Cui ◽  
Weiting Kang ◽  
Hanbo Wang ◽  
Yuzhu Xiang ◽  
...  
Keyword(s):  
Case Report ◽  
Clinical Manifestations ◽  
Pathological Examination ◽  
Review Of Literature ◽  
Abdominal Cocoon ◽  
Case Presentation ◽  
Bilateral Cryptorchidism ◽  
Effective Diagnosis ◽  
The Right ◽  
Fibrous Tissues

Abstract Background Abdominal cocoon is a rare peritoneal lesion and is difficult to diagnose because of its lack of special clinical manifestations. Until now, there is no case report of abdominal cocoon combined with cryptorchidism and seminoma. Case presentation A case of abdominal cocoon with cryptorchidism and seminoma was diagnosed and treated in our hospital. The patient had no symptoms except occasional abdominal pain. He underwent laparoscopy because of bilateral cryptorchidism and seminoma in the right testis. During the surgery, he was diagnosed with abdominal cocoon due to the thick fibrous tissues which was tightly adhered and encased part of intestine like a cocoon. Enterolysis and bilateral cryptochiectomy were performed after the diagnosis and nutritional and symptomatic support was provided after the surgery. The patient recovered well and was discharged soon. The postoperative pathological examination confirmed the presence of bilateral cryptorchidism and seminoma in the patient’s right testis. Conclusion There are only a handful of cases where a patient has both abdominal cocoon and cryptorchidism. Since the etiologies of both diseases remain unknown, further research is required to investigate effective diagnosis and treatment for the diseases and explore the potential connection between the two diseases.

scholarly journals Case report: a camouflaged parathyroid carcinoma with initial misdiagnosis

BMC Surgery ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Hongtao Cao ◽  
Weibin Wang
Keyword(s):  
Case Report ◽  
Preoperative Diagnosis ◽  
Poor Prognosis ◽  
Parathyroid Carcinoma ◽  
Clinical Manifestations ◽  
Rare Condition ◽  
Optimal Management ◽  
Case Presentation ◽  
Preoperative Ultrasonography ◽  
Rare Malignancy

Abstract Background Parathyroid carcinoma is a rare malignancy with an increasing incidence. Most patients are characterized by the presence of severe primary hyperparathyroidism, especially hypercalcemia, while patients with normal level of serum calcium are extremely rare. Unfortunately, patients free of hypercalcemia are usually diagnosed at a later stage and suffer from a rather poor prognosis. Case presentation We describe a patient diagnosed with intrathyroidal normocalcemic parathyroid carcinoma, whose preoperative ultrasonography suggests that the tumor is located inside the thyroid gland and present without obvious clinical manifestations, which makes it more challenging for diagnosis. Conclusions Preoperative suspicion of malignancy is of great importance for advanced management while preoperative diagnosis is rather challenging with the limited contribution of imaging examinations. Any abnormality in serum level of calcium or parathormone may help to make an initial diagnosis especially when the level is extremely high. We introduce this case of initial misdiagnosis of an intrathyroidal parathyroid carcinoma, mimicking a suspicious thyroid nodule, to focus on the possible anomalous presentations of this rare condition and on its optimal management.

scholarly journals Intellectual Decline in a Patient with Migraine and APT1A2 Mutation: A Case Report

2021 ◽  
Author(s):  
Pian Wang ◽  
Yan-Rong Yang ◽  
Hong-Bo Zhang ◽  
Jiang-Hong Wang ◽  
Yan Wang
Keyword(s):  
Case Report ◽  
Intellectual Disabilities ◽  
Intelligence Quotient ◽  
Three Dimensional ◽  
Clinical Manifestations ◽  
Specific Area ◽  
Hemiplegic Migraine ◽  
Rare Type ◽  
Case Presentation ◽  
The Impact

Abstract Background: Hemiplegic migraine (HM) is a rare type of migraine with aura. Some reports have described the clinical manifestations in HM patients with the ATP1A2 mutation. But the impact of the ATP1A2 mutation on intelligence in HM patients has not been evaluated in detail. Here we report a patient with intellectual decline in specific area.Case presentation: A 15-year-old boy with an aura that included disturbances in consciousness, associated with fever, vomiting, hemiplegia, and aphasia. He was diagnosed HM with the ATP1A2 mutation before. He had trouble in mathematics and depicting three-dimensional things.Conclusions: The HM with ATP1A2 patient could develop permanent intellectual disabilities. Therefore, the intelligence quotient should be carefully and comprehensively evaluated.

scholarly journals Conjunctival granulomatous capillary haemangioma in children: case report and review of the literature

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Caiping Shi ◽  
Yanhong Ren ◽  
Jia Feng ◽  
Weizhong Guo ◽  
Xiaoyu Zheng
Keyword(s):  
Case Report ◽  
Relevant Literature ◽  
Clinical Manifestations ◽  
Diagnosis And Treatment ◽  
Vascular Tumour ◽  
Review Of The Literature ◽  
Case Presentation ◽  
Capillary Haemangioma ◽  
Pathological Characteristics ◽  
Main Basis

Abstract Background Granulomatous capillary haemangioma refers to a benign vascular tumour that commonly affects the skin, with occasional involvement of the mucosa. Reports of conjunctival granulomatous capillary haemangioma in children are uncommon. In this article, we present a case of granulomatous capillary haemangioma and a brief review of the relevant literature. Case presentation An 11-year-old girl presented with a conjunctival mass. An excision of the entire lesion was performed. Histopathology showed a granulomatous capillary haemangioma. Conclusions The clinical manifestations of granulomatous capillary haemangioma lack specificity; pathological characteristics and immunohistochemistry are the main basis for diagnosis. We retrospectively analysed the diagnosis and treatment of a patient with conjunctival granulomatous capillary haemangioma to deepen the understanding and facilitate the diagnosis and treatment of this disease.

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