scholarly journals The potential benefit of omega-3 fatty acid capsule on Mean platelet volume and Platelet count in type-2 Diabetes Mellitu

2020 ◽  
Vol 8 (1) ◽  
pp. 37-40
Author(s):  
Tamanna Binte Habib ◽  
Qazi Shamima Akhter ◽  
Hasan Imam ◽  
Nahid Yeasmin ◽  
Sharmin Nahar ◽  
...  
Keyword(s):  
Platelet Count ◽  
Fatty Acid ◽  
Control Group ◽  
Diabetic Patients ◽  
Omega 3 ◽  
Glycemic Status ◽  
Type 2 Diabetic Patients ◽  
Omega 3 Fatty Acid ◽  
Type 2 Diabetic

Background: Diabetes Mellitus (DM) is a major non-communicable health problem that has effects on glycemic status. Hyperglycemia that is an inherent finding of diabetes causes platelet dysfunction. Oral omega-3 fatty acid supplementation may improve glycemic status in diabetic patient and reduce micro and macrovascular complications. Objective: To observe the effect of supplementation of omega-3 fatty acid on Mean Platelet Volume (MPV) and Platelet count in type 2 DM. Methods: A prospective interventional study was conducted from January 2017 to December 2017. A total numbers of 52 diagnosed type 2 diabetic patients of both sexes were selected within age 40 to 50 years. Among them, 27 type 2 diabetic patients with supplementation of omega 3 fatty acid (2g/day) for 12 weeks were considered as study group and another 25 type 2 diabetic patients without supplementation of omega 3 fatty acid were considered as control group. The study subjects were selected from Outpatient Department of Endocrinology, Dhaka Medical College Hospital, Dhaka and personal contact from Dhaka city. MPV and platelet count were measured by hematology analyzer. The study parameters were measured at base line and after 12 weeks of study period in both groups. Results: In this study MPV and platelet count levels were significantly lower (p<.001) in diabetic patients after supplementation with omega-3 fatty acid in comparison to that of their baseline value. Again, after 12 weeks, MPV and platelet count were significantly lower (p<.001) in diabetic patients after supplementation with omega-3 fatty acid in comparison to control group. In control group, MPV and Platelet count were almost similar both at baseline and after 3 months of follow-up. Conclusion: After analyzing the results of the study it can be concluded that omega-3 fatty acid may improve MPV and Platelet count levels in type 2 diabetic patients and may be helpful to minimize the complications of type-2 DM. Bangladesh Crit Care J March 2020; 8(1): 37-40

scholarly journals The effect of fish oil capsule on serum total cholesterol and triglycride levels in type-2 diabetic patient

2018 ◽  
Vol 13 (2) ◽  
pp. 73-77
Author(s):  
Tamanna Binte Habib ◽  
Qazi Shamima Akhter
Keyword(s):  
Fatty Acid ◽  
Diabetic Patient ◽  
Control Group ◽  
Diabetic Patients ◽  
Omega 3 ◽  
Type 2 Diabetic Patients ◽  
Omega 3 Fatty Acid ◽  
Type 2 Dm ◽  
Type 2 Diabetic

Background: Diabetes Mellitus (DM) is one of the common metabolic disorders that have effects on lipid metabolism. Fish oil supplementation may improve lipid abnormalities in diabetic patient.Objective: To observe the effect of supplementation of omega-3 fatty acid on total cholesterol (TC) and triglyceride(TG) level in type 2 DM. Methods: A prospective interventional study was conducted from January 2017 to December 2017. A total numbers of 52 diagnosed type 2 diabetic patients of both sexes were selected with age 40 to 50 years. Among them, 27 type 2 diabetic patient with supplementation of omega 3 fatty acid (2g/ day) for 12 weeks was considered as study group. Another 25 type 2 diabetic patients without supplementation of omega 3 fatty acid was considered as control group. The study subjects were selected from Outpatient Department of Endocrinology, Dhaka Medical College Hospital, Dhaka and personal contact from Dhaka city.Serum TC and TG were estimated by enzymatic endpoint method in autoanalyzer. The study parameters were measured at base line and after 12 weeks of study period in both groups. For statistical analysis, Paired Student’s‘t’ test and Unpaired Student’s ‘t’ test were performed as applicable using SPSS for windows version 16.0. Results: In this study serumTC and TG levels were significantly lower (p<.001) in diabetic patients after supplementation with omega- 3 fatty acid in comparison to that of their baseline value.Again, after 12 weeks, serum TC and TG levels were significantly lower (p<.001) in diabetic patients after supplementation with omega-3 fatty acid in comparison to control group. In control group, serum TC and TG levels were almost similar both at baseline and after 3 months of follow-up. Conclusion: After analyzing the results of the study, it can be concluded that omega-3 fatty acid may improve serum TC and TG levels in type 2 diabetic patient and may be helpful to minimize the complications of type-2 DM. J Bangladesh Soc Physiol. 2018, December; 13(2): 73-77

scholarly journals Effects of ɷ - 3 Fatty Acids on Liver Function Tests in Patients with Diabetes Mellitus

2020 ◽  
Vol 32 (2) ◽  
pp. 91-94
Author(s):  
Tamanna Binte Habib ◽  
Qazi Shamima Akhter ◽  
Hasan Imam ◽  
Nahid Yeasmin
Keyword(s):  
Fatty Acid ◽  
Total Protein ◽  
Liver Function Tests ◽  
Control Group ◽  
Diabetic Patients ◽  
Omega 3 ◽  
Type 2 Diabetic Patients ◽  
Omega 3 Fatty Acid ◽  
Type 2 Diabetic

Introduction: Patients with type-2 Diabetes are augmented the risk of non alchoholic fatty liver disease that rises liver enzymes and total protein.To observe the favourable effects of fish oil capsule on liver function tests in patients with type 2 DM. Materials and Methods: A prospective interventional study was conducted from January 2017 to December 2017. A total numbers of 52 diagnosed type 2 diabetic patients of both sexes were scrutinized with age ranging from 40 to 50 years. Among them, 27 type 2 diabetic patients those who taken oral fish oil gel (2g/day) for 12 weeks were preferred as study group. Another 25 type 2 diabetic patients without supplementation of omega 3 fatty acid were nominated as control group for comparison. The study subjects were selected from Dhaka Medical College Hospital, Dhaka and personal contact from Dhaka city on the basis of criteria. The research work was administrated with ethical clearance from concerned authority. Results: In this study ALP, LDH, total protein were reduced in diabetic patients after supplementation with omega-3 fatty acid in comparison to that of their baseline value. Again, after 12 weeks, ALP (Alkaline Phosphatase) LDH (Lctate dehydrogenase) and total protein were decreased in diabetic patients after supplementation with omega-3 fatty acid in comparison to control group. Conclusion: After analyzing the results of the study, it can be concluded that omega-3 fatty acid can reduce ALP, LDH and total protein levels in diabetic patients may be helpful to minimize the risk of fatty liver in type-2 diabetes mellitus. Medicine Today 2020 Vol.32(2): 91-94

scholarly journals Effect of omega-3 fatty acid supplementation on serum fasting glucose and HbA1c levels in type-2 Diabetes Mellitus

2019 ◽  
Vol 14 (1) ◽  
pp. 33-37
Author(s):  
Tamanna Binte Habib ◽  
Qazi Shamima Akhter
Keyword(s):  
Fatty Acid ◽  
Diabetic Patient ◽  
Control Group ◽  
Diabetic Patients ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Type 2 Dm ◽  
Type 2 Diabetic ◽  
Hba1c Levels

Background: Diabetes Mellitus (DM) is a major non-communicable health problem that have effects on glycemic status. Oral omega-3 fatty acid supplementation may improve glycemic status in diabetic patient. Objective: To observe the effect of supplementation of omega-3 fatty acid on fasting serum glucose (FSG) and glycosylated hemoglobin (HbA1c) levels in type 2 DM. Methods: This prospective interventional study was conducted from January 2017 to December 2017. A total numbers of 52 diagnosed type 2 diabetic patients(type-2 DM) of both sexes were selected with age 40 to 50 years. Among them, 27 type 2 diabetic patient with supplementation of omega 3 fatty acid (2g/day) for 12 weeks was considered as study group. Another 25 type 2 diabetic patients without supplementation of omega 3 fatty acid was considered as control group. The study subjects were selected from Outpatient Department of Endocrinology, Dhaka Medical College Hospital, Dhaka and personal contact from Dhaka city. FSG was estimated by enzymatic colorimetric method and HbA1c was estimated by turbidimetric inhibition immunoassay method. The study parameters were measured at base line and after 12 weeks of study period in both groups. For statistical analysis, Student’s paired ‘t’ test and Student’s unpaired ‘t’ test were performed as applicable using SPSS for windows version 16.0. Results: In this study serum FSG and HbA1c levels were significantly lower (p<.001) in diabetic patients after supplementation with omega-3 fatty acid in comparison to that of their baseline value. Again, after 12 weeks, FSG and HbA1c levels significantly decreased (p<.001) in omega-3 fatty acid supplemented diabetic patients compared to control group. In control group, there was no significant change in FSG and HbA1c levels between baseline and after 3 months of follow-up. Conclusion: From the results of the study, it can be concluded that omega-3 fatty acid may improve serum FSG and HbA1c levels in type 2 diabetic patient and may be helpful to minimize the complications of type-2 DM. J Bangladesh Soc Physiol. 2019, June; 14(1): 33-37

The influence of interleukin-6 gene polymorphism on omega-3 fatty acid effect in type 2 diabetic patients

2016 ◽  
Vol 42 (4) ◽  
pp. 300
Author(s):  
Y. Karachentsev ◽  
M. Gorshunska ◽  
N. Krasova ◽  
E. Jansen ◽  
T. Tyzhnenko ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Gene Polymorphism ◽  
Interleukin 6 ◽  
Diabetic Patients ◽  
Omega 3 ◽  
Type 2 Diabetic Patients ◽  
Omega 3 Fatty Acid ◽  
Acid Effect ◽  
Type 2 Diabetic

scholarly journals Effects of supplementation with omega-3 on insulin sensitivity and non-esterified free fatty acid (NEFA) in type 2 diabetic patients

2014 ◽  
Vol 58 (4) ◽  
pp. 335-340 ◽  
Author(s):  
Payam Farahbakhsh Farsi ◽  
Abolghassem Djazayery ◽  
Mohammad Reza Eshraghian ◽  
Fariba Koohdani ◽  
Ali Akbar Saboor-Yaraghi ◽  
...  
Keyword(s):  
Placebo Group ◽  
Fatty Acid ◽  
Insulin Sensitivity ◽  
Intervention Group ◽  
Diabetic Patients ◽  
Omega 3 ◽  
Type 2 Diabetic Patients ◽  
Study Results ◽  
Type 2 Diabetic

Objective: The aim of this study was to determine the role of omega-3 supplementation on NEFA concentration, insulin sensitivity and resistance, and glucose and lipid metabolism in type 2 diabetic patients. Subjects and methods: Forty-four type 2 diabetic patients were randomly recruited into two groups. Group A received 4 g/day omega-3 soft gels, and group B received a placebo for 10 wks. Blood samples were collected after 12-h fast. Physical activity records, three-day food records, and anthropometric measurements were obtained from all participants at the beginning and end of the study. Results: Omega-3 supplementation caused a significant reduction in NEFA in the intervention group compared with the placebo group (P = 0.009). Additionally, the administration of omega-3 resulted in significantly greater changes (Diff) for the intervention group in various parameters, such as insulin and Quicki indices compared with the placebo group (P < 0.05). Conclusions: Omega-3 fatty acid supplementation in type 2 diabetic patients improved insulin sensitivity, probably due to the decrease in NEFA concentrations. Arq Bras Endocrinol Metab. 2014;58(4):335-40

Association of fatty acid profile in plasma lipid fractions with HbA1c in type 2 diabetic patients

2015 ◽  
Vol 36 (1) ◽  
pp. 23-33 ◽  
Author(s):  
Tomáš Čermák ◽  
Petr Laštovička ◽  
Vladimíra Mužáková ◽  
Martina Líbalová ◽  
Lucie Koukalová ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Profile ◽  
Plasma Lipid ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Lipid Fractions ◽  
Type 2 Diabetic

Fatty Acid Composition of Serum Lipid Fractions in Type 2 Diabetic Patients With Microalbuminuria

Diabetes Care ◽  
2003 ◽  
Vol 26 (3) ◽  
pp. 613-618 ◽  
Author(s):  
M. S. Perassolo ◽  
J. C. Almeida ◽  
R. L. Pra ◽  
V. D. Mello ◽  
A. L. Maia ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Serum Lipid ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Lipid Fractions ◽  
Type 2 Diabetic

Platelet count is independently associated with insulin resistance in non-obese Japanese type 2 diabetic patients

Metabolism ◽  
2003 ◽  
Vol 52 (10) ◽  
pp. 1246-1249 ◽  
Author(s):  
Ataru Taniguchi ◽  
Mitsuo Fukushima ◽  
Yutaka Seino ◽  
Masahiko Sakai ◽  
Satoru Yoshii ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Platelet Count ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Plasma Fatty Acid-Binding Protein 4 Increases with Renal Dysfunction in Type 2 Diabetic Patients without Microalbuminuria

2008 ◽  
Vol 54 (1) ◽  
pp. 181-187 ◽  
Author(s):  
Anna Cabré ◽  
Iolanda Lázaro ◽  
Josefa Girona ◽  
Josep M Manzanares ◽  
Francesc Marimón ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acid ◽  
Renal Dysfunction ◽  
Fatty Acid Binding Protein ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Type 2 Diabetic

Abstract Background: Fatty acid–binding protein 4 (FABP4) has been linked to metabolic syndrome development, diabetes, and arteriosclerosis, but the role of FABP4 in target organ damage has not been assessed. We evaluated whether plasma FABP4 is associated with renal dysfunction in type 2 diabetic patients. Methods: In 263 individuals (161 type 2 diabetic patients and 102 healthy nondiabetic controls), we analyzed the correlation between FABP4 and creatinine or glomerular filtration index (MDRD-GFR) regarding the presence or absence of microalbuminuria. Patients with severe chronic kidney disease (MDRD-GFR &lt;30 mL/min/1.73 m2) or albuminuria were not included. Results: FABP4 concentrations were higher in diabetic patients with MDRD-GFR &lt;60 mL/min/1.73 m2 (P &lt;0.001). We observed a significant, direct correlation between FABP4 and creatinine (r = 0.446, P &lt;0.001) and an inverse correlation between FABP4 and MDRD-GFR (r = −0.511, P &lt;0.001) in type 2 diabetic patients, but not in nondiabetic individuals. These correlations were sustained when only those patients without microalbuminuria were analyzed (r = 0.414, P &lt;0.001 and r = −0.510, P &lt;0.001, respectively). Type 2 diabetic patients with FABP4 in the highest tertile compared with those in the lower tertiles had increased adjusted odds ratios for moderate renal dysfunction [7.5 (95%CI 1.8–30.7), P = 0.005 and 15.3 (3.1–76.4), P = 0.001; respectively], independent of microalbuminuria. Conclusions: High FABP4 plasma concentrations are associated with high plasma creatinine and low MDRD-GFR in patients with type 2 diabetes even in the absence of microalbuminuria or clinically relevant alterations of creatinine and MDRD-GFR values. FABP4 concentrations should be taken into consideration as an early marker of kidney damage in patients with type 2 diabetes.

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