scholarly journals The effect of fish oil capsule on serum total cholesterol and triglycride levels in type-2 diabetic patient

2018 ◽  
Vol 13 (2) ◽  
pp. 73-77
Author(s):  
Tamanna Binte Habib ◽  
Qazi Shamima Akhter
Keyword(s):  
Fatty Acid ◽  
Diabetic Patient ◽  
Control Group ◽  
Diabetic Patients ◽  
Omega 3 ◽  
Type 2 Diabetic Patients ◽  
Omega 3 Fatty Acid ◽  
Type 2 Dm ◽  
Type 2 Diabetic

Background: Diabetes Mellitus (DM) is one of the common metabolic disorders that have effects on lipid metabolism. Fish oil supplementation may improve lipid abnormalities in diabetic patient.Objective: To observe the effect of supplementation of omega-3 fatty acid on total cholesterol (TC) and triglyceride(TG) level in type 2 DM. Methods: A prospective interventional study was conducted from January 2017 to December 2017. A total numbers of 52 diagnosed type 2 diabetic patients of both sexes were selected with age 40 to 50 years. Among them, 27 type 2 diabetic patient with supplementation of omega 3 fatty acid (2g/ day) for 12 weeks was considered as study group. Another 25 type 2 diabetic patients without supplementation of omega 3 fatty acid was considered as control group. The study subjects were selected from Outpatient Department of Endocrinology, Dhaka Medical College Hospital, Dhaka and personal contact from Dhaka city.Serum TC and TG were estimated by enzymatic endpoint method in autoanalyzer. The study parameters were measured at base line and after 12 weeks of study period in both groups. For statistical analysis, Paired Student’s‘t’ test and Unpaired Student’s ‘t’ test were performed as applicable using SPSS for windows version 16.0. Results: In this study serumTC and TG levels were significantly lower (p<.001) in diabetic patients after supplementation with omega- 3 fatty acid in comparison to that of their baseline value.Again, after 12 weeks, serum TC and TG levels were significantly lower (p<.001) in diabetic patients after supplementation with omega-3 fatty acid in comparison to control group. In control group, serum TC and TG levels were almost similar both at baseline and after 3 months of follow-up. Conclusion: After analyzing the results of the study, it can be concluded that omega-3 fatty acid may improve serum TC and TG levels in type 2 diabetic patient and may be helpful to minimize the complications of type-2 DM. J Bangladesh Soc Physiol. 2018, December; 13(2): 73-77

scholarly journals Effect of omega-3 fatty acid supplementation on serum fasting glucose and HbA1c levels in type-2 Diabetes Mellitus

2019 ◽  
Vol 14 (1) ◽  
pp. 33-37
Author(s):  
Tamanna Binte Habib ◽  
Qazi Shamima Akhter
Keyword(s):  
Fatty Acid ◽  
Diabetic Patient ◽  
Control Group ◽  
Diabetic Patients ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Type 2 Dm ◽  
Type 2 Diabetic ◽  
Hba1c Levels

Background: Diabetes Mellitus (DM) is a major non-communicable health problem that have effects on glycemic status. Oral omega-3 fatty acid supplementation may improve glycemic status in diabetic patient. Objective: To observe the effect of supplementation of omega-3 fatty acid on fasting serum glucose (FSG) and glycosylated hemoglobin (HbA1c) levels in type 2 DM. Methods: This prospective interventional study was conducted from January 2017 to December 2017. A total numbers of 52 diagnosed type 2 diabetic patients(type-2 DM) of both sexes were selected with age 40 to 50 years. Among them, 27 type 2 diabetic patient with supplementation of omega 3 fatty acid (2g/day) for 12 weeks was considered as study group. Another 25 type 2 diabetic patients without supplementation of omega 3 fatty acid was considered as control group. The study subjects were selected from Outpatient Department of Endocrinology, Dhaka Medical College Hospital, Dhaka and personal contact from Dhaka city. FSG was estimated by enzymatic colorimetric method and HbA1c was estimated by turbidimetric inhibition immunoassay method. The study parameters were measured at base line and after 12 weeks of study period in both groups. For statistical analysis, Student’s paired ‘t’ test and Student’s unpaired ‘t’ test were performed as applicable using SPSS for windows version 16.0. Results: In this study serum FSG and HbA1c levels were significantly lower (p<.001) in diabetic patients after supplementation with omega-3 fatty acid in comparison to that of their baseline value. Again, after 12 weeks, FSG and HbA1c levels significantly decreased (p<.001) in omega-3 fatty acid supplemented diabetic patients compared to control group. In control group, there was no significant change in FSG and HbA1c levels between baseline and after 3 months of follow-up. Conclusion: From the results of the study, it can be concluded that omega-3 fatty acid may improve serum FSG and HbA1c levels in type 2 diabetic patient and may be helpful to minimize the complications of type-2 DM. J Bangladesh Soc Physiol. 2019, June; 14(1): 33-37

scholarly journals Effects of ɷ - 3 Fatty Acids on Liver Function Tests in Patients with Diabetes Mellitus

2020 ◽  
Vol 32 (2) ◽  
pp. 91-94
Author(s):  
Tamanna Binte Habib ◽  
Qazi Shamima Akhter ◽  
Hasan Imam ◽  
Nahid Yeasmin
Keyword(s):  
Fatty Acid ◽  
Total Protein ◽  
Liver Function Tests ◽  
Control Group ◽  
Diabetic Patients ◽  
Omega 3 ◽  
Type 2 Diabetic Patients ◽  
Omega 3 Fatty Acid ◽  
Type 2 Diabetic

Introduction: Patients with type-2 Diabetes are augmented the risk of non alchoholic fatty liver disease that rises liver enzymes and total protein.To observe the favourable effects of fish oil capsule on liver function tests in patients with type 2 DM. Materials and Methods: A prospective interventional study was conducted from January 2017 to December 2017. A total numbers of 52 diagnosed type 2 diabetic patients of both sexes were scrutinized with age ranging from 40 to 50 years. Among them, 27 type 2 diabetic patients those who taken oral fish oil gel (2g/day) for 12 weeks were preferred as study group. Another 25 type 2 diabetic patients without supplementation of omega 3 fatty acid were nominated as control group for comparison. The study subjects were selected from Dhaka Medical College Hospital, Dhaka and personal contact from Dhaka city on the basis of criteria. The research work was administrated with ethical clearance from concerned authority. Results: In this study ALP, LDH, total protein were reduced in diabetic patients after supplementation with omega-3 fatty acid in comparison to that of their baseline value. Again, after 12 weeks, ALP (Alkaline Phosphatase) LDH (Lctate dehydrogenase) and total protein were decreased in diabetic patients after supplementation with omega-3 fatty acid in comparison to control group. Conclusion: After analyzing the results of the study, it can be concluded that omega-3 fatty acid can reduce ALP, LDH and total protein levels in diabetic patients may be helpful to minimize the risk of fatty liver in type-2 diabetes mellitus. Medicine Today 2020 Vol.32(2): 91-94

scholarly journals The potential benefit of omega-3 fatty acid capsule on Mean platelet volume and Platelet count in type-2 Diabetes Mellitu

2020 ◽  
Vol 8 (1) ◽  
pp. 37-40
Author(s):  
Tamanna Binte Habib ◽  
Qazi Shamima Akhter ◽  
Hasan Imam ◽  
Nahid Yeasmin ◽  
Sharmin Nahar ◽  
...  
Keyword(s):  
Platelet Count ◽  
Fatty Acid ◽  
Control Group ◽  
Diabetic Patients ◽  
Omega 3 ◽  
Glycemic Status ◽  
Type 2 Diabetic Patients ◽  
Omega 3 Fatty Acid ◽  
Type 2 Diabetic

Background: Diabetes Mellitus (DM) is a major non-communicable health problem that has effects on glycemic status. Hyperglycemia that is an inherent finding of diabetes causes platelet dysfunction. Oral omega-3 fatty acid supplementation may improve glycemic status in diabetic patient and reduce micro and macrovascular complications. Objective: To observe the effect of supplementation of omega-3 fatty acid on Mean Platelet Volume (MPV) and Platelet count in type 2 DM. Methods: A prospective interventional study was conducted from January 2017 to December 2017. A total numbers of 52 diagnosed type 2 diabetic patients of both sexes were selected within age 40 to 50 years. Among them, 27 type 2 diabetic patients with supplementation of omega 3 fatty acid (2g/day) for 12 weeks were considered as study group and another 25 type 2 diabetic patients without supplementation of omega 3 fatty acid were considered as control group. The study subjects were selected from Outpatient Department of Endocrinology, Dhaka Medical College Hospital, Dhaka and personal contact from Dhaka city. MPV and platelet count were measured by hematology analyzer. The study parameters were measured at base line and after 12 weeks of study period in both groups. Results: In this study MPV and platelet count levels were significantly lower (p<.001) in diabetic patients after supplementation with omega-3 fatty acid in comparison to that of their baseline value. Again, after 12 weeks, MPV and platelet count were significantly lower (p<.001) in diabetic patients after supplementation with omega-3 fatty acid in comparison to control group. In control group, MPV and Platelet count were almost similar both at baseline and after 3 months of follow-up. Conclusion: After analyzing the results of the study it can be concluded that omega-3 fatty acid may improve MPV and Platelet count levels in type 2 diabetic patients and may be helpful to minimize the complications of type-2 DM. Bangladesh Crit Care J March 2020; 8(1): 37-40

The influence of interleukin-6 gene polymorphism on omega-3 fatty acid effect in type 2 diabetic patients

2016 ◽  
Vol 42 (4) ◽  
pp. 300
Author(s):  
Y. Karachentsev ◽  
M. Gorshunska ◽  
N. Krasova ◽  
E. Jansen ◽  
T. Tyzhnenko ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Gene Polymorphism ◽  
Interleukin 6 ◽  
Diabetic Patients ◽  
Omega 3 ◽  
Type 2 Diabetic Patients ◽  
Omega 3 Fatty Acid ◽  
Acid Effect ◽  
Type 2 Diabetic

scholarly journals Effects of supplementation with omega-3 on insulin sensitivity and non-esterified free fatty acid (NEFA) in type 2 diabetic patients

2014 ◽  
Vol 58 (4) ◽  
pp. 335-340 ◽  
Author(s):  
Payam Farahbakhsh Farsi ◽  
Abolghassem Djazayery ◽  
Mohammad Reza Eshraghian ◽  
Fariba Koohdani ◽  
Ali Akbar Saboor-Yaraghi ◽  
...  
Keyword(s):  
Placebo Group ◽  
Fatty Acid ◽  
Insulin Sensitivity ◽  
Intervention Group ◽  
Diabetic Patients ◽  
Omega 3 ◽  
Type 2 Diabetic Patients ◽  
Study Results ◽  
Type 2 Diabetic

Objective: The aim of this study was to determine the role of omega-3 supplementation on NEFA concentration, insulin sensitivity and resistance, and glucose and lipid metabolism in type 2 diabetic patients. Subjects and methods: Forty-four type 2 diabetic patients were randomly recruited into two groups. Group A received 4 g/day omega-3 soft gels, and group B received a placebo for 10 wks. Blood samples were collected after 12-h fast. Physical activity records, three-day food records, and anthropometric measurements were obtained from all participants at the beginning and end of the study. Results: Omega-3 supplementation caused a significant reduction in NEFA in the intervention group compared with the placebo group (P = 0.009). Additionally, the administration of omega-3 resulted in significantly greater changes (Diff) for the intervention group in various parameters, such as insulin and Quicki indices compared with the placebo group (P < 0.05). Conclusions: Omega-3 fatty acid supplementation in type 2 diabetic patients improved insulin sensitivity, probably due to the decrease in NEFA concentrations. Arq Bras Endocrinol Metab. 2014;58(4):335-40

scholarly journals Lipid Profile of Type 2 Diabetic and Hypertensive Patients in the Jamaican Population

2010 ◽  
Vol 2 (01) ◽  
pp. 025-030 ◽  
Author(s):  
Lorenzo Gordon ◽  
Dalip Ragoobirsingh ◽  
Errol Y St A Morrison ◽  
Eric Choo-Kang ◽  
Donovan McGrowder ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Type 2 Diabetic Patients ◽  
Type 2 Dm ◽  
Type 2 Diabetic

ABSTRACT Aims: Previous studies have shown that diabetes mellitus (DM) increases the risk of cardiovascular diseases in females to a greater extent than in males. In this cross-sectional study, we evaluated the lipid profiles of type 2 diabetic males and females. Materials and Methods: The study included 107 type 2 diabetic patients (41 males and 66 females), and 122 hypertensive type 2 diabetic patients (39 males and 83 females), aged 15 years and older. Total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C) and high density lipoprotein-cholesterol (HDL-C) concentrations were assayed for each group using standard biochemical methods. Results: The mean TC, TG, VLDL-C, HDL-C and LDL-C concentrations, TG/HDL and LDL/HDL ratios were higher in type 2 diabetic and hypertensive type 2 diabetic patients compared with non-diabetic, and hypertensive non-diabetic control subjects, although these were not significant (P > 0.05). Hypertensive type 2 diabetic females had significantly higher serum TC (7.42 ± 1.63 mmol/L) than hypertensive non-diabetic males (5.76±1.57 mmol/L; P < 0.05). All the other lipid and lipoprotein parameters except HDL-C were non-significantly higher in females with type 2 DM and those with hypertension and type 2 DM, compared with type 2 diabetic and hypertensive type 2 diabetic males, respectively (P > 0.05). Conclusion: This study demonstrated that dyslipidemia exists in our type 2 diabetic population with greater TC in hypertensive type 2 diabetic females compared with hypertensive type 2 diabetic males. This suggests that hypertensive type 2 diabetic females are exposed more profoundly to risk factors including atherogenic dyslipidemia compared with males.

Association of fatty acid profile in plasma lipid fractions with HbA1c in type 2 diabetic patients

2015 ◽  
Vol 36 (1) ◽  
pp. 23-33 ◽  
Author(s):  
Tomáš Čermák ◽  
Petr Laštovička ◽  
Vladimíra Mužáková ◽  
Martina Líbalová ◽  
Lucie Koukalová ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Profile ◽  
Plasma Lipid ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Lipid Fractions ◽  
Type 2 Diabetic

scholarly journals Reduced Serum Adiponectin Levels in Type 2 Diabetic Patients in Zaria

2018 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Serum Adiponectin ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Mean Values ◽  
Control Subjects ◽  
Type 2 Dm ◽  
And Control ◽  
Biochemical Assessment ◽  
Type 2 Diabetic

Background: Adiponectin is a collagen-like plasma protein secreted by adipocytes that has been suggested to play a causal role in the development of insulin resistance. Even though hypoadiponectinaemia is reported to be closely associated with obesity-related diseases such as ACVD, type 2 DM, dyslipidaemia, report from our environment is lacking. Materials and Methods: Serum adiponectin, insulin and glucose were measured in 90 type 2 diabetic and control subjects respectively. The patients were known diabetics attending the diabetic clinic at the ABUTH, Zaria. The control subjects were apparently healthy individuals within the hospital and Zaria environs. Results: Mean serum adiponectin levels were significantly lower (P<0.05) in the diabetic patients than in the control subjects. On the other hand, the mean values of insulin and glucose were significantly higher (P<0.05) in the diabetic patients than in the controls. Conclusion: Measurement of serum adiponectin as an adjunct in the biochemical assessment of type 2 DM is suggested.

scholarly journals Expression of Apoptotic Proteins Bax and Bcl-2 in Blood Cells of Type 2 Diabetic Patients

Proceedings ◽  
2018 ◽  
Vol 2 (25) ◽  
pp. 1563
Author(s):  
Ebru Gokalp-Ozkorkmaz ◽  
Günsel Kirman ◽  
Zafer Pekkolay ◽  
Firat Asir ◽  
Engin Deveci
Keyword(s):  
Complex Disease ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Homeostatic Process ◽  
Production Type ◽  
Type 2 Dm ◽  
Resistance To Insulin ◽  
Apoptotic Proteins ◽  
Type 2 Diabetic

Diabetes mellitus (DM) is a complex disease characterized by absolute insulin deficiency or resistance leading to hyperglycemia. Type 2 DM is caused by development of cellular resistance to insulin combined with insufficient insulin production. Type 2 DM is a common disorder causing hyperglycemia, impaired homeostatic process, inhibition of inflammatory response, generation of reactive oxygen species. Apoptosis is a crucial process that influence normal development and tissue homeostasis. Apoptosis is known to be reduced in diabetics. Apoptotic proteins such as bcl-2 and Bax proteins regulate apoptosis. Bcl-2 serves as anti-apoptotic protein while Bax is pro-apoptotic. The balance between these apoptotic proteins determine the apoptotic process. The aim of this study was to examine the expression of apoptotic proteins Bax and Bcl-2 with immunohistochemical methods in the blood samples of type 2 diabetic patients.

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