Effects of supplementation with omega-3 on insulin sensitivity and non-esterified free fatty acid (NEFA) in type 2 diabetic patients

Objective: The aim of this study was to determine the role of omega-3 supplementation on NEFA concentration, insulin sensitivity and resistance, and glucose and lipid metabolism in type 2 diabetic patients. Subjects and methods: Forty-four type 2 diabetic patients were randomly recruited into two groups. Group A received 4 g/day omega-3 soft gels, and group B received a placebo for 10 wks. Blood samples were collected after 12-h fast. Physical activity records, three-day food records, and anthropometric measurements were obtained from all participants at the beginning and end of the study. Results: Omega-3 supplementation caused a significant reduction in NEFA in the intervention group compared with the placebo group (P = 0.009). Additionally, the administration of omega-3 resulted in significantly greater changes (Diff) for the intervention group in various parameters, such as insulin and Quicki indices compared with the placebo group (P < 0.05). Conclusions: Omega-3 fatty acid supplementation in type 2 diabetic patients improved insulin sensitivity, probably due to the decrease in NEFA concentrations. Arq Bras Endocrinol Metab. 2014;58(4):335-40

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Erythrocyte fatty acid composition and insulin sensitivity in daughters of Type 2 diabetic patients and women with no family history of diabetes

Journal of Endocrinological Investigation ◽

10.1007/bf03346591 ◽

2010 ◽

Vol 33 (5) ◽

pp. 306-312 ◽

Cited By ~ 1

Author(s):

G. Ntali ◽

C. Koutsari ◽

K. Karakike ◽

P. Makras ◽

F. Skopouli ◽

...

Keyword(s):

Fatty Acid Composition ◽

Fatty Acid ◽

Insulin Sensitivity ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Family History Of Diabetes ◽

History Of ◽

Erythrocyte Fatty Acid ◽

Type 2 Diabetic

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The effect of fish oil capsule on serum total cholesterol and triglycride levels in type-2 diabetic patient

Journal of Bangladesh Society of Physiologist ◽

10.3329/jbsp.v13i2.39481 ◽

2018 ◽

Vol 13 (2) ◽

pp. 73-77

Author(s):

Tamanna Binte Habib ◽

Qazi Shamima Akhter

Keyword(s):

Fatty Acid ◽

Diabetic Patient ◽

Control Group ◽

Diabetic Patients ◽

Omega 3 ◽

Type 2 Diabetic Patients ◽

Omega 3 Fatty Acid ◽

Type 2 Dm ◽

Type 2 Diabetic

Background: Diabetes Mellitus (DM) is one of the common metabolic disorders that have effects on lipid metabolism. Fish oil supplementation may improve lipid abnormalities in diabetic patient.Objective: To observe the effect of supplementation of omega-3 fatty acid on total cholesterol (TC) and triglyceride(TG) level in type 2 DM. Methods: A prospective interventional study was conducted from January 2017 to December 2017. A total numbers of 52 diagnosed type 2 diabetic patients of both sexes were selected with age 40 to 50 years. Among them, 27 type 2 diabetic patient with supplementation of omega 3 fatty acid (2g/ day) for 12 weeks was considered as study group. Another 25 type 2 diabetic patients without supplementation of omega 3 fatty acid was considered as control group. The study subjects were selected from Outpatient Department of Endocrinology, Dhaka Medical College Hospital, Dhaka and personal contact from Dhaka city.Serum TC and TG were estimated by enzymatic endpoint method in autoanalyzer. The study parameters were measured at base line and after 12 weeks of study period in both groups. For statistical analysis, Paired Student’s‘t’ test and Unpaired Student’s ‘t’ test were performed as applicable using SPSS for windows version 16.0. Results: In this study serumTC and TG levels were significantly lower (p<.001) in diabetic patients after supplementation with omega- 3 fatty acid in comparison to that of their baseline value.Again, after 12 weeks, serum TC and TG levels were significantly lower (p<.001) in diabetic patients after supplementation with omega-3 fatty acid in comparison to control group. In control group, serum TC and TG levels were almost similar both at baseline and after 3 months of follow-up. Conclusion: After analyzing the results of the study, it can be concluded that omega-3 fatty acid may improve serum TC and TG levels in type 2 diabetic patient and may be helpful to minimize the complications of type-2 DM. J Bangladesh Soc Physiol. 2018, December; 13(2): 73-77

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The influence of interleukin-6 gene polymorphism on omega-3 fatty acid effect in type 2 diabetic patients

Diabetes & Metabolism ◽

10.1016/j.diabet.2016.07.021 ◽

2016 ◽

Vol 42 (4) ◽

pp. 300

Author(s):

Y. Karachentsev ◽

M. Gorshunska ◽

N. Krasova ◽

E. Jansen ◽

T. Tyzhnenko ◽

...

Keyword(s):

Fatty Acid ◽

Gene Polymorphism ◽

Interleukin 6 ◽

Diabetic Patients ◽

Omega 3 ◽

Type 2 Diabetic Patients ◽

Omega 3 Fatty Acid ◽

Acid Effect ◽

Type 2 Diabetic

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Effects of ɷ - 3 Fatty Acids on Liver Function Tests in Patients with Diabetes Mellitus

Medicine Today ◽

10.3329/medtoday.v32i2.48820 ◽

2020 ◽

Vol 32 (2) ◽

pp. 91-94

Author(s):

Tamanna Binte Habib ◽

Qazi Shamima Akhter ◽

Hasan Imam ◽

Nahid Yeasmin

Keyword(s):

Fatty Acid ◽

Total Protein ◽

Liver Function Tests ◽

Control Group ◽

Diabetic Patients ◽

Omega 3 ◽

Type 2 Diabetic Patients ◽

Omega 3 Fatty Acid ◽

Type 2 Diabetic

Introduction: Patients with type-2 Diabetes are augmented the risk of non alchoholic fatty liver disease that rises liver enzymes and total protein.To observe the favourable effects of fish oil capsule on liver function tests in patients with type 2 DM. Materials and Methods: A prospective interventional study was conducted from January 2017 to December 2017. A total numbers of 52 diagnosed type 2 diabetic patients of both sexes were scrutinized with age ranging from 40 to 50 years. Among them, 27 type 2 diabetic patients those who taken oral fish oil gel (2g/day) for 12 weeks were preferred as study group. Another 25 type 2 diabetic patients without supplementation of omega 3 fatty acid were nominated as control group for comparison. The study subjects were selected from Dhaka Medical College Hospital, Dhaka and personal contact from Dhaka city on the basis of criteria. The research work was administrated with ethical clearance from concerned authority. Results: In this study ALP, LDH, total protein were reduced in diabetic patients after supplementation with omega-3 fatty acid in comparison to that of their baseline value. Again, after 12 weeks, ALP (Alkaline Phosphatase) LDH (Lctate dehydrogenase) and total protein were decreased in diabetic patients after supplementation with omega-3 fatty acid in comparison to control group. Conclusion: After analyzing the results of the study, it can be concluded that omega-3 fatty acid can reduce ALP, LDH and total protein levels in diabetic patients may be helpful to minimize the risk of fatty liver in type-2 diabetes mellitus. Medicine Today 2020 Vol.32(2): 91-94

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The potential benefit of omega-3 fatty acid capsule on Mean platelet volume and Platelet count in type-2 Diabetes Mellitu

Bangladesh Critical Care Journal ◽

10.3329/bccj.v8i1.47707 ◽

2020 ◽

Vol 8 (1) ◽

pp. 37-40

Author(s):

Tamanna Binte Habib ◽

Qazi Shamima Akhter ◽

Hasan Imam ◽

Nahid Yeasmin ◽

Sharmin Nahar ◽

...

Keyword(s):

Platelet Count ◽

Fatty Acid ◽

Control Group ◽

Diabetic Patients ◽

Omega 3 ◽

Glycemic Status ◽

Type 2 Diabetic Patients ◽

Omega 3 Fatty Acid ◽

Type 2 Diabetic

Background: Diabetes Mellitus (DM) is a major non-communicable health problem that has effects on glycemic status. Hyperglycemia that is an inherent finding of diabetes causes platelet dysfunction. Oral omega-3 fatty acid supplementation may improve glycemic status in diabetic patient and reduce micro and macrovascular complications. Objective: To observe the effect of supplementation of omega-3 fatty acid on Mean Platelet Volume (MPV) and Platelet count in type 2 DM. Methods: A prospective interventional study was conducted from January 2017 to December 2017. A total numbers of 52 diagnosed type 2 diabetic patients of both sexes were selected within age 40 to 50 years. Among them, 27 type 2 diabetic patients with supplementation of omega 3 fatty acid (2g/day) for 12 weeks were considered as study group and another 25 type 2 diabetic patients without supplementation of omega 3 fatty acid were considered as control group. The study subjects were selected from Outpatient Department of Endocrinology, Dhaka Medical College Hospital, Dhaka and personal contact from Dhaka city. MPV and platelet count were measured by hematology analyzer. The study parameters were measured at base line and after 12 weeks of study period in both groups. Results: In this study MPV and platelet count levels were significantly lower (p<.001) in diabetic patients after supplementation with omega-3 fatty acid in comparison to that of their baseline value. Again, after 12 weeks, MPV and platelet count were significantly lower (p<.001) in diabetic patients after supplementation with omega-3 fatty acid in comparison to control group. In control group, MPV and Platelet count were almost similar both at baseline and after 3 months of follow-up. Conclusion: After analyzing the results of the study it can be concluded that omega-3 fatty acid may improve MPV and Platelet count levels in type 2 diabetic patients and may be helpful to minimize the complications of type-2 DM. Bangladesh Crit Care J March 2020; 8(1): 37-40

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