scholarly journals New Indications & Dosage Forms for Existing Drugs Vol 24(2)

2021 ◽  
Vol 24 (2) ◽  
pp. 200-201
Author(s):  
Md Akbar Hossain
Keyword(s):  
Pharmaceutical Journal ◽  
Dosage Forms

Abstract not available Bangladesh Pharmaceutical Journal 24(2): 200-201, 2021

scholarly journals New Indications & Dosage Forms For Existing Drugs Vol.23(2)

2020 ◽  
Vol 23 (2) ◽  
pp. 203-204
Author(s):  
Md Akbar Hossain
Keyword(s):  
Pharmaceutical Journal ◽  
Dosage Forms

Abstract Not Available Bangladesh Pharmaceutical Journal 23(2): 203-204, 2020

scholarly journals Formulation and Evaluation of Effects of Superdisintegrants on Immediate Release Tablet of Linagliptin, a DDP-4 Inhibitor

2021 ◽  
Vol 24 (2) ◽  
pp. 168-179
Author(s):  
Tanoy Saha ◽  
Md Mahbubul Alam ◽  
Dilshad Noor Lira ◽  
Abu Shara Shamsur Rouf
Keyword(s):  
Drug Release ◽  
Immediate Release ◽  
Pharmaceutical Journal ◽  
Dosage Forms ◽  
Angle Of Repose ◽  
Drug Dissolution ◽  
Disintegration Time ◽  
Weight Variation ◽  
Tablet Dosage ◽  
Release Tablet

The study aimed to develop and evaluate an immediate-release tablet dosage form of Linagliptin. Different concentrations (ranges 5-10%) of super-disintegrants, Croscarmellose sodium (CCS), and Sodium starch glycolate (SSG) were used to prepare nine tablet dosage forms (F1 to F9) through the direct compression method. The compatibility of the formulations was evaluated by FTIR to reveal any possible drug-excipient interactions and it was proved to be compatible with all formulations. Precompression (bulk density, tapped density, Carr’s index, Hausner’s ratio, and angle of repose) and post-compression parameters (weight variation, hardness, thickness, and friability) were analyzed for all tablets and the results were found satisfactory as well as within limits as per USP guidelines. All the formulated batches (F1 to F9) exhibited disintegration of tablets within 2 minutes, where formulation F9 represented the lowest disintegration time (51±3 sec) which was also found significantly better than the marketed product (310±5 sec). In terms of drug dissolution, 90% of drug release was observed for all nine formulations within 45 minutes and formulation F9 (5% CCS and 5% SSG) illustrated the rapid and highest dissolution rate compared to the marketed one’s, 100% drug release at 20 minutes and 91.77 % drug release at 30 minutes successively. The respective data sets of drug release were mathematically fitted to several kinetic models and for all formulations, drug release pattern obeyed first-order kinetics amongst those, formulation F2 (r2= 0.98), F4 (r2= 0.99), F5 (r2= 0.98), and F9 (r2= 0.97) were found to be best fitted in this kinetic norm. Based on disintegration time and dissolution data comparison to a brand leader market product, F9 was experienced as the best formulation. Furthermore, it was observed that if SSG and CCS were combined, then these two parameters were more improved compared to their separate uses. Thus, incorporation of the optimum amount of super-disintegrants in a formulation showed rapid swelling, faster disintegration as well as ease of dissolution of tablet dosage forms. Bangladesh Pharmaceutical Journal 24(2): 168-179, 2021

scholarly journals Development and Validation of a Simple RP-HPLC Method for Determination of Naproxen in Pharmaceutical Dosage Forms

2015 ◽  
Vol 16 (2) ◽  
pp. 137-141 ◽  
Author(s):  
Saleha Tanjin ◽  
Farhana Islam ◽  
Md Zakir Sultan ◽  
Asma Rahman ◽  
Sharmin Reza Chowdhury ◽  
...  
Keyword(s):  
High Performance ◽  
Pharmaceutical Formulations ◽  
Pharmaceutical Journal ◽  
Reversed Phase ◽  
Dosage Forms ◽  
Hplc Method ◽  
Uv Detector ◽  
Allowable Limit ◽  
Pharmaceutical Dosage Forms ◽  
Rp Hplc

A simple, sensitive and precise reversed phase high performance liquid chromatographic (RP-HPLC) method has been developed for the estimation of naproxen in pharmaceutical dosage forms. The method was developed using the mobile phase comprising of dibasic sodium phosphate buffer (Na2HPO4) at pH 7.80 (adjusted by sodium hydroxide) and acetonitrile in the ratio of 70:30 (v/v) over C-18 column (250 x 4.6 mm, 5?m, Phenomenex Inc.) at ambient temperature. The flow rate was at 0.7 ml/min and the column washing was monitored by UV detector at 225 nm. The retention time of naproxen was 4.8 ± 0.1 min. The recovery was found to be >97% which is demonstrative of accuracy of the protocol. Inter-day and intra-day precision of the newly developed method were less than the maximum allowable limit (RSD% ? 2.0) according to ICH, USP and FDA guidelines. The method showed linear response with correlation coefficient (r2) value of 0.9991. Therefore, the method was found to be accurate, reproducible, sensitive and less time consuming and can be successfully applied for routine analysis of naproxen in pharmaceutical formulations. DOI: http://dx.doi.org/10.3329/bpj.v16i2.22295 Bangladesh Pharmaceutical Journal 16(2): 137-141, 2013

scholarly journals Formulation and evaluation of potash alum as deodorant lotion and after shaving astringent as cream and gel

2014 ◽  
Vol 3 (2) ◽  
pp. 228-233 ◽  
Author(s):  
Abdulkarim K. Alzomor ◽  
Ahmad Safe Moharram ◽  
Nahlah Mansour Al Absi
Keyword(s):  
Dosage Form ◽  
Inhibitory Concentration ◽  
Pharmaceutical Journal ◽  
Dosage Forms ◽  
Stability Study ◽  
Dispersion Method ◽  
Mueller Hinton ◽  
Normal Microbiota ◽  
The Stability

Potash alum has different traditional application including deodorant and astringent. In order to wide advancement in development of pharmaceutical and cosmetic industries we preferred to work in this field as well as for improvement of safety and efficacy of traditionally used natural products. The aim of the present study was to formulate deodorant potash alum as lotion dosage form and astringent as cream and gel dosage forms. The activity of potash alum against axillaries normal microbiota was tested in vitro using wells diffusion agar method for different concentrations (0.1% to 9%) on Mueller Hinton (MH) agar and the minimum inhibitory concentration (MIC) was determined as 2% and also subculture was done to determine the activity of potash alum as bacteriostatic. Alum powder has wide traditional usage as astringent to prevent bleeding from minor cuts and for its accelerated healing. Therefore, a more appropriate dosage form was designed in a suitable concentration (2% gel) to elongate its astringent activity by its higher retention time due to highly viscous nature of gel. Using suitable excipients, 2% lotion and gel were prepared by dispersion method while emulsification was used for preparation of the potash alum cream of same strength. The above formulations were evaluated by comparing their pH, viscosity, spreadability, contents uniformity and in vitro diffusion. The stability study was carried out at 25°C for 3 months and at 40°C with 75±5% RH for one month. pH, viscosity, spreadability, extrudability and consistency of the products were evaluated at the end of the studies. The results indicated no change in the formulations demonstrating their stable nature as a dosage form and suitability as a commercial product line.DOI: http://dx.doi.org/10.3329/icpj.v3i2.17512 International Current Pharmaceutical Journal, January 2014, 3(2): 228-233

scholarly journals Validated stability indicating gradient RP-HPLC method for the estimation of antihypertensive drugs in bulk and pharmaceutical dosage forms

2012 ◽  
Vol 1 (11) ◽  
pp. 336-341 ◽  
Author(s):  
Napa Delhi Raj ◽  
Sockalingam Anbazhagan ◽  
Kunapareddy Anudeep Babu ◽  
Sunkara Narendra Babu ◽  
Chusena Narasimharaju Bhimanadhuni
Keyword(s):  
Antihypertensive Drugs ◽  
Degradation Products ◽  
Olmesartan Medoxomil ◽  
Pharmaceutical Journal ◽  
Dosage Forms ◽  
Hplc Method ◽  
Pharmaceutical Dosage Forms ◽  
Rp Hplc ◽  
Ich Guidelines

A rapid and precise RP-HPLC method for determination of Olmesartan medoxomil and Hydrochlorothiazide in bulk and pharmaceutical dosage forms. Olmesartan medoxomil & Hydrochlorothiazide are found to be degraded together under different set of conditions as followed according to ICH guidelines and the degradants so formed along with olmesartan & hydrochlorothiazide are separated by using INERTSIL ODS C18 3V (150 x 4.6, 5µ) using mobile phase 1ml triethanolamine in one litre water and the pH was adjusted to 2.5 with orthophosphoric acid and acetonitrile using a gradient program with a flow rate of 1ml/min, throughout the gradient program with a detection wavelength of 225nm for both the compounds with a injection volume of 10µl. The method was validated for selectivity, linearity, accuracy, robustness, precision and specificity. The results were indicating the method was selective in analysis of both olmesartan medoxomil and hydrochlorothiazide in the presence of degradation products formed under various stress conditions.DOI: http://dx.doi.org/10.3329/icpj.v1i11.12058 International Current Pharmaceutical Journal 2012, 1(11): 336-341

scholarly journals Spectrophotometric determination of chlorpheniramine maleate and phenylpropanolamine hydrochloride in dosage forms

2013 ◽  
Vol 2 (5) ◽  
pp. 97-100 ◽  
Author(s):  
Arun Kaura ◽  
Vikas Gupta ◽  
G S Roy ◽  
Monika Kaura
Keyword(s):  
Pharmaceutical Journal ◽  
Dosage Forms ◽  
Uv Spectrophotometry ◽  
Chlorpheniramine Maleate ◽  
Simple Method ◽  
Pharmaceutical Dosage Forms ◽  
First Derivative ◽  
Phenylpropanolamine Hydrochloride ◽  
Derivative Uv Spectrophotometry

A rapid and simple method for simultaneous determination of Chlorpheniramine Maleate (CPM) and Phenylpropanolamine Hydrochloride (PPM) by first derivative UV spectrophotometry has been developed in combined pharmaceutical dosage forms. The proposed method was successfully applied for the determination of drugs in physical mixture and commercial formulations and results showed good linearity, precision and reproducibility. DOI: http://dx.doi.org/10.3329/icpj.v2i5.14436 International Current Pharmaceutical Journal, April 2013, 2(5): 97-100 

scholarly journals New Indications & Dosage Forms For Existing Drugs

2020 ◽  
Vol 23 (1) ◽  
pp. 83-85
Author(s):  
Md Akbar Hossain
Keyword(s):  
Pharmaceutical Journal ◽  
Dosage Forms

Abstract not available Bangladesh Pharmaceutical Journal 23(1): 83-85, 2020

scholarly journals Influence of dependent variables on granule formulation using factorial design: microwave irradiation as one of the factor

2013 ◽  
Vol 2 (7) ◽  
pp. 115-118 ◽  
Author(s):  
Prameela Rani Avula ◽  
Hema Veesam
Keyword(s):  
Factorial Design ◽  
Pharmaceutical Journal ◽  
Flow Property ◽  
Dosage Forms ◽  
Regression Equations ◽  
Dependent Variables ◽  
Granule Formulation ◽  
Traditional Drug ◽  
Contour Plots ◽  
The Impact

As traditional drug delivery poses many disadvantages such as difficulty in consumption, the granules were opted to replace tablet dosage forms available in the market. A 23 full factorial design was employed for the formulation and characterization of the granule dosage form of oxcarbazepine. From regression equations we can assess the impact of each factor on the response further contour plots helped to pre-analyze the desired target factor values, in addition optimization process helped to analyze the values of dependent variables. Thus as of the results achieved a preferred response of flow property and drug release was obtained. In the current study, an attempt has been made to minimize possible number of experiments in the formulation of granule dosage forms. Polyvidone is a hydrophilic binder and primellose is a good disintegrate to obtain higher dissolution rate. A part, microwave assisted drying process plays a major role in achieving desired flow properties of granules.DOI: http://dx.doi.org/10.3329/icpj.v2i7.15153 International Current Pharmaceutical Journal, June 2013, 2(7): 115-118

scholarly journals Development and validation of RP-HPLC method for the estimation of omeprazole in bulk and capsule dosage forms

2012 ◽  
Vol 1 (11) ◽  
pp. 366-369 ◽  
Author(s):  
Kalakonda Sri Nataraj ◽  
Mohammad Badrud Duza ◽  
Kalyani Pragallapati ◽  
Dussa Kiran Kumar
Keyword(s):  
Mobile Phase ◽  
High Performance ◽  
Accurate Method ◽  
Pharmaceutical Journal ◽  
Dosage Forms ◽  
Hplc Method ◽  
Reverse Phase ◽  
Rp Hplc ◽  
Development And Validation

A method for the determination of omeprazole in bulk and capsule dosage form by reverse phase high performance liquid chromatography has been developed. This is a simple, rapid, precise and an accurate method. The method was developed on a Novapak C18, (250 x 4.6 mm, 5µ) column using phosphate buffer (pH 7.4) and acetonitrile in the ratio of 60:40, v/v as a mobile phase which was pumped at a flow rate of 1.0 ml/min and detection was done at 302 nm. The retention time of the drug was found to be 7.71 min. The method was validated for accuracy, precision, linearity, specificity, robustness. The linearity was observed in the range of 20-60 ppm. The results of recovery studies indicated that the method was accurate. Hence the developed method was found to be suitable for the estimation of omeprazole in bulk and capsule dosage forms.DOI: http://dx.doi.org/10.3329/icpj.v1i11.12062 International Current Pharmaceutical Journal 2012, 1(11): 366-369

scholarly journals Development and Validation of a UV-Spectrophotometric Method for Determination of Vildagliptin and Linagliptin in Bulk and Pharmaceutical Dosage Forms

2015 ◽  
Vol 18 (2) ◽  
pp. 163-168 ◽  
Author(s):  
Sujan Banik ◽  
Palash Karmakar ◽  
Md Anowar Hossain Miah
Keyword(s):  
Spectrophotometric Method ◽  
Limit Of Detection ◽  
Correlation Coefficients ◽  
Pharmaceutical Journal ◽  
Dosage Forms ◽  
Limit Of Quantification ◽  
Allowable Limit ◽  
Pharmaceutical Dosage Forms ◽  
Tablet Dosage

The present study was undertaken to develop a spectrophotometric method for determination of vildagliptin and Linagliptin in pharmaceutical dosage forms. This paper describes a simple, rapid, accurate and precise UVspectrophotometric method for the assay of vildagliptin and linagliptin in bulk and marketed tablet dosage forms. The validation of the developed method was carried out according to ICH guidelines with respect to linearity, precision, accuracy, specificity, limit of detection and limit of quantification. Calibration curves were obtained in the concentration range of 8-32 ?g/ml for vildagliptin and 5-25 ?g/ml for linagliptin with good correlation coefficients (r=0.999). The precisions of the new method for both drugs were less than the maximum allowable limit (%RSD < 2.0) specified by the USP, ICH and FDA. Therefore, the method was found to be an accurate, reproducible and sensitive for analysis of vildagliptin and linagliptin in pharmaceutical dosage forms.Bangladesh Pharmaceutical Journal 18(2): 163-168, 2015

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