scholarly journals Influence of dependent variables on granule formulation using factorial design: microwave irradiation as one of the factor

2013 ◽  
Vol 2 (7) ◽  
pp. 115-118 ◽  
Author(s):  
Prameela Rani Avula ◽  
Hema Veesam
Keyword(s):  
Factorial Design ◽  
Pharmaceutical Journal ◽  
Flow Property ◽  
Dosage Forms ◽  
Regression Equations ◽  
Dependent Variables ◽  
Granule Formulation ◽  
Traditional Drug ◽  
Contour Plots ◽  
The Impact

As traditional drug delivery poses many disadvantages such as difficulty in consumption, the granules were opted to replace tablet dosage forms available in the market. A 23 full factorial design was employed for the formulation and characterization of the granule dosage form of oxcarbazepine. From regression equations we can assess the impact of each factor on the response further contour plots helped to pre-analyze the desired target factor values, in addition optimization process helped to analyze the values of dependent variables. Thus as of the results achieved a preferred response of flow property and drug release was obtained. In the current study, an attempt has been made to minimize possible number of experiments in the formulation of granule dosage forms. Polyvidone is a hydrophilic binder and primellose is a good disintegrate to obtain higher dissolution rate. A part, microwave assisted drying process plays a major role in achieving desired flow properties of granules.DOI: http://dx.doi.org/10.3329/icpj.v2i7.15153 International Current Pharmaceutical Journal, June 2013, 2(7): 115-118

Impact on Simulated Jurors of Testimony as a Function of Non-Evidential Characteristics of Witness and Defendant

1980 ◽  
Vol 46 (2) ◽  
pp. 343-348 ◽  
Author(s):  
Victor M. Catano
Keyword(s):  
Decision Making ◽  
Factorial Design ◽  
Significant Interaction ◽  
Relevant Research ◽  
Dependent Variables ◽  
The Impact

The impact on jurors' decision making of the non-evidential characteristics of witnesses' and defendant's attractiveness and the agreement of their testimony was explored in a 2 × 2 × 2 between-subjects factorial design. 48 undergraduates read a summary of a courtroom trial in which an eyewitness, who was either a professional (High Attractive) or laborer (Low Attractive), either agreed or disagreed with the testimony of a defendant whose character had been assessed positively (High Attractive) or negatively (Low Attractive). Dependent variables were subjects' verdicts and confidence in the witnesses' and defendant's testimony. Conflict in testimony between the witness and defendant led to higher ratings of guilt but lowered the subject's confidence in the testimony of both. A significant interaction of witness × defendant × testimony showed that ratings of guilt decreased when a witness testified against a defendant who was dissimilar in attractiveness; an unattractive witness supporting an attractive defendant also reduced assessment of guilt but an attractive witness who testified for an unattractive defendant increased findings of guilt. Results were discussed in the context of relevant research involving simulated jurors.

scholarly journals Implementation of experimental design methodology in preparation and characterization of zolmitriptan loaded chitosan nanoparticles

2017 ◽  
Vol 6 (3) ◽  
pp. 16-22 ◽  
Author(s):  
Satish K. Mandlik ◽  
Nisharani S. Ranpise
Keyword(s):  
Statistical Analysis ◽  
Factorial Design ◽  
High Speed ◽  
Chitosan Nanoparticles ◽  
Spherical Shape ◽  
Entrapment Efficiency ◽  
Pharmaceutical Journal ◽  
Optimization Method ◽  
Fickian Diffusion ◽  
Contour Plots

The present study investigated the implementation of 32 factorial design of experiment and statistical analysis for the optimization of chitosan nanoparticles containing zolmitriptan an antimigraine drug. The influence of chitosan concentration (X1) and sodium tripoly phosphate (X2) on responses namely nanoparticle size (Y1), and entrapment efficiency (Y2), was studied. As per design, nine runs of nanoparticles were prepared by modified ionic gelation method using high speed vortex mixing. The particle size was found in the range of 151-880 nm and entrapment efficiency was 72.3-81.2%. A statistical analysis was performed using licensed design expert software V.8.0 with respect to ANOVA, regression analysis. The contour plots and response surface plots showed visual representation of relationship between the experimental responses and the set of independent variables. Regression model equations were validated by a numerical and graphical optimization method. Further, optimized drug loaded nanoparticles showed +23.7mV zeta potential indicating storage stability, electron micrograph reflects spherical shape and mixed type of drug release followed by Fickian diffusion (n=0.266) was observed. Thus, using systematic factorial design approach, desirable goals can be achieved in shortest possible time with lesser number of experiments which was proven to be an effective tool in quality by design.Mandlik and Ranpise, International Current Pharmaceutical Journal, February 2017, 6(3): 16-22http://www.icpjonline.com/documents/Vol6Issue3/01.pdf

scholarly journals Investigation on Motorcyclist Riding Behaviour at Curve Entry Using Instrumented Motorcycle

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Choon Wah Yuen ◽  
Mohamed Rehan Karim ◽  
Ahmad Saifizul
Keyword(s):  
Structural Equation ◽  
Equation Modeling ◽  
Regression Equations ◽  
Curve Section ◽  
Independent Variables ◽  
Data Loggers ◽  
Dependent Variables ◽  
Brake Force ◽  
The Impact ◽  
The Relationship

This paper details the study on the changes in riding behaviour, such as changes in speed as well as the brake force and throttle force applied, when motorcyclists ride over a curve section road using an instrumented motorcycle. In this study, an instrumented motorcycle equipped with various types of sensors, on-board cameras, and data loggers, was developed in order to collect the riding data on the study site. Results from the statistical analysis showed that riding characteristics, such as changes in speed, brake force, and throttle force applied, are influenced by the distance from the curve entry, riding experience, and travel mileage of the riders. A structural equation modeling was used to study the impact of these variables on the change of riding behaviour in curve entry section. Four regression equations are formed to study the relationship between four dependent variables, which are speed, throttle force, front brake force, and rear brake force applied with the independent variables.

Effect of Witnesses' Expertness and Manner of Delivery of Testimony on Verdicts of Simulated Jurors

1978 ◽  
Vol 42 (3) ◽  
pp. 955-961 ◽  
Author(s):  
Kurt Ludwig ◽  
Gary Fontaine
Keyword(s):  
Decision Making ◽  
Factorial Design ◽  
Police Officer ◽  
Expert Witness ◽  
Criminal Case ◽  
Criminal Charge ◽  
Dependent Variables ◽  
The Impact ◽  
Practical Implications ◽  
Second Degree

The impact on jurors' decision making of the type of expert witness and the manner of delivery of testimony was explored in a 3 × 2 between-subjects, factorial design. 68 undergraduate subjects read an edited, 26-page transcript of an actual criminal case in which the crucial testimony concerned the intoxication of the victim. A physician, police officer, or layperson as witness delivered that testimony against the defendant in either an opinionated or non-opinionated manner. Dependent variables were subjects' verdicts and recommended sentences. Results indicated that verdicts and sentences were most severe following testimony against the defendant by a physician and least severe following testimony against the defendant by a police officer. An interaction between the criminal charge and the manner of delivery of testimony showed that opinionated delivery was followed by more severe judgments of guilt on the relatively severe charges of first and second degree murder, whereas non-opinionated delivery was followed by more severe judgments of guilt on the charge of manslaughter. Discussion centered on both the theoretical and practical implications of the findings.

scholarly journals Strength Abilities: Modeling of Immediate and Delayed Training Effect of Strength Loads in Boys Aged 8 Years

2020 ◽  
Vol 20 (4) ◽  
pp. 248-255
Author(s):  
Oleg Khudolii ◽  
Sergii Iermakov ◽  
Olha Ivashchenko ◽  
Mykola Nosko
Keyword(s):  
Factorial Design ◽  
Regression Models ◽  
Training Effect ◽  
Regression Equations ◽  
Interval Duration ◽  
Rest Interval ◽  
Strength Exercises ◽  
Study Results ◽  
The Impact ◽  
Full Factorial

The purpose of the study was to obtain regression models of immediate and delayed training effect of strength loads in boys aged 8 years, based on a full factorial experiment. Materials and methods. The study participants were 48 boys aged 8 years. The experiment was performed using a 22 factorial design. The study materials were processed by the IBM SPSS 22 statistical analysis program. The study examined the impact of four variants of strength load on the immediate (ITE) and the delayed (DTE) training effect of orthogonal strength exercises modes and rest intervals in boys aged 8 years. Results. The study results show that in the proposed matrix of the 22 full factorial design, the chosen step of variation of factors is sufficient to study the influence of different modes of strength exercises on the dynamics of ITE in boys aged 8 years. Based on the data analysis, the study obtained regression models of load for calculating the ITE1, ITE2, and DTE. The obtained regression models make it possible to calculate the number of repetitions and rest interval to achieve the most rational load variant. Conclusions. The analysis of regression equations shows the interrelation between training effects: ITE1 —> ITE2 —> DTE. The value of ITE1, ITE2, and DTE at station I (exercises to strengthen arms and shoulders) and station II (exercises to strengthen abdominal muscles) depends on the increase in the number of repetitions in a set and the duration of the rest interval. The value of ITE1, ITE2 at station ІІІ (exercises to strengthen back muscles) depends on the increase in the number of repetitions in a set and the duration of the rest interval. The value of DTE – on the increase in the number of repetitions in a set and the reduction of the rest interval duration. The value of ITE1 at station IV (exercises to strengthen leg muscles) depends on the increase in the number of repetitions in a set and the reduction of the rest interval duration. To strengthen the DTE, it is necessary to reduce the number of repetitions in a set and the duration of the rest interval.

THE MODEL FOR MANAGING INVESTMENTS IN THE MOSCOW ENVIRONMENT BASED ON A POWER REGRESSION EQUATION

2020 ◽  
Vol 2 (7) ◽  
pp. 91-99
Author(s):  
E. V. KOSTYRIN ◽  
◽  
M. S. SINODSKAYA ◽  
Keyword(s):  
Solid Waste ◽  
Influencing Factors ◽  
Pair Correlation ◽  
Approximation Error ◽  
Regression Equation ◽  
Regression Equations ◽  
The Impact ◽  
The Relationship ◽  
Average Approximation ◽  
Average Approximation Error

The article analyzes the impact of certain factors on the volume of investments in the environment. Regression equations describing the relationship between the volume of investment in the environment and each of the influencing factors are constructed, the coefficients of the Pearson pair correlation between the dependent variable and the influencing factors, as well as pairwise between the influencing factors, are calculated. The average approximation error for each regression equation is determined. A correlation matrix is constructed and a conclusion is made. The developed econometric model is implemented in the program of separate collection of municipal solid waste (MSW) in Moscow. The efficiency of the model of investment management in the environment is evaluated on the example of the growth of planned investments in the activities of companies specializing in the export and processing of solid waste.

scholarly journals Evaluation of Climate Change Impact on Groundwater Recharge in Groundwater Regions in Taiwan

Water ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1153
Author(s):  
Shih-Jung Wang ◽  
Cheng-Haw Lee ◽  
Chen-Feng Yeh ◽  
Yong Fern Choo ◽  
Hung-Wei Tseng
Keyword(s):  
Climate Change ◽  
Groundwater Recharge ◽  
Climate Change Impact ◽  
Groundwater Resources ◽  
Regression Equations ◽  
Impact Of Climate Change ◽  
Groundwater Systems ◽  
Change Impact ◽  
The Impact ◽  
Assessment Results

Climate change can directly or indirectly influence groundwater resources. The mechanisms of this influence are complex and not easily quantified. Understanding the effect of climate change on groundwater systems can help governments adopt suitable strategies for water resources. The baseflow concept can be used to relate climate conditions to groundwater systems for assessing the climate change impact on groundwater resources. This study applies the stable baseflow concept to the estimation of the groundwater recharge in ten groundwater regions in Taiwan, under historical and climate scenario conditions. The recharge rates at the main river gauge stations in the groundwater regions were assessed using historical data. Regression equations between rainfall and groundwater recharge quantities were developed for the ten groundwater regions. The assessment results can be used for recharge evaluation in Taiwan. The climate change estimation results show that climate change would increase groundwater recharge by 32.6% or decrease it by 28.9% on average under the climate scenarios, with respect to the baseline quantity in Taiwan. The impact of climate change on groundwater systems may be positive. This study proposes a method for assessing the impact of climate change on groundwater systems. The assessment results provide important information for strategy development in groundwater resources management.

The Effect of Statistics on Enjoyment and Perceived Credibility in Sports Media

2021 ◽  
pp. 216747952199839
Author(s):  
Dustin Hahn
Keyword(s):  
New Media ◽  
Future Research ◽  
Media Industry ◽  
Sports Media ◽  
Perceived Credibility ◽  
Competitive Environments ◽  
Dependent Variables ◽  
Media Source ◽  
The Impact

Evolving media landscapes toward increasingly diverse and competitive environments in both traditional and new media requires producers regularly examine the quality of their productions. One growing line of research identifies the increasing presence and significance of statistics in sports media programming. This experiment measures the effect of statistics on enjoyment and perceived credibility by sport consumers while considering level of fanship, media source, and variations in placement within Instagram posts. Results uncover evidence that validates previous observations about statistics in media while contradicting others. Specifically, findings reveal that statistics enhance enjoyment and improve perceived credibility. Observations were consistent across fanship level. However, additional findings also suggest media source and placement of statistics influences both enjoyment and credibility as well. For both dependent variables, statistics in both the Instagram caption and image yielded significantly greater enjoyment and credibility than some other conditions including posts without statistics at all. The impact of these and other findings on sports media industry and scholarship, along with limitations and directions for future research, are discussed.

scholarly journals Changes in Incisor Third-Order Inclination Resulting from Vertical Variation in Lingual Bracket Placement

2009 ◽  
Vol 79 (4) ◽  
pp. 747-754 ◽  
Author(s):  
Michael Knösel ◽  
Klaus Jung ◽  
Liliam Gripp-Rudolph ◽  
Thomas Attin ◽  
Rengin Attin ◽  
...  
Keyword(s):  
Null Hypothesis ◽  
Interindividual Variation ◽  
Occlusal Plane ◽  
Third Order ◽  
Vertical Variation ◽  
Independent Variables ◽  
The Third ◽  
Dependent Variables ◽  
Incisor Inclination ◽  
The Impact

Abstract Objective: To test the null hypothesis that third-order measurements are not correlated to lingual incisor features seen on radiographs. Material and Methods: The lateral headfilms of 38 untreated, norm-occlusion subjects without incisor abrasions or restorations were used for third-order measurements of upper and lower central incisors and assessment of the inclination of four sites suitable for lingual bracket placement with reference to the occlusal plane perpendicular. Lingual sections were determined by the tangents at the incisal fossa (S1), at the transition plateau between incisal fossa and the cingulum (S2), by a constructed line reaching from the incisal tip to the cingulum (S3), and by a tangent at the cingulum convexity (S4). Third-order angles were also assessed on corresponding dental casts using an incisor inclination gauge. Regression analysis was performed using the third-order measurements of both methods as the dependent variables and the inclination of the lingual enamel sections (S1, S2, S3, S4) as the independent variables. Results: The null hypothesis was rejected. For the most common bracket application sites located on the lingual shovel (S1 and S2), third-order inclination changes of 0.4–0.7 degrees are expected for each degree of change in the inclination of the lingual surface. The impact of bracket placement errors on third-order angulation is similar between sections S1 and S2 and the cingulum convexity (S4). Section S3 proved to be least affected by interindividual variation. Conclusion: The third-order measurements are correlated to lingual incisor features. Accordingly, third-order changes resulting from variation in lingual bracket placement can be individually predicted from radiographic assessments.

Abstract W P302: Assessment of a New Method of Warfarin Management vs the New Oral Anticoagulants and Conventional Warfarin Management in Atrial Fibrillation

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Henry I Bussey ◽  
Edith Nutescu
Keyword(s):  
Atrial Fibrillation ◽  
Oral Anticoagulants ◽  
New Oral Anticoagulants ◽  
Target Range ◽  
Regression Equations ◽  
Major Event ◽  
Cost Avoidance ◽  
Study Results ◽  
Event Rates ◽  
The Impact

PURPOSE: To assess the impact of International Normalized Ratio (INR) self testing and online remote monitoring and management (STORM2) on clinical events and costs vs. traditional warfarin management and the new oral anticoagulants (NOACs) in atrial fibrillation (AF). METHODS: Seven STORM2 trials had a weighted mean INR time in the target range (TTR) of 77.2%. Thromboembolism (TE) and major bleeding (MB) rates at 30%, 45%, 55%, 65%, and 75% TTR were calculated using linear regression equations from a systematic review of 38 AF studies. MB = 10.104 - 0.120x[TTR], (p = 0.004) and TE = 8.313 - 0.098x[TTR], (p = 0.03). MB and TE rates were sub-divided based on the distribution in the NOAC trials. TTR-based mortality was calculated based on a 6%/yr rate multiplied by the adjusted relative risks from a data base analysis of approximately 38,000 AF patients. Projected event rates at 75% TTR, expressed as number per 1,000 patient-years, were compared to event rates at lower TTR ranges and to rates reported in the NOAC trials. Differences in major event rates were used to calculate cost avoidance. RESULTS: Projected event rates with STORM2 (TTR of 75%) when compared to “conventional ” TTR of 55% to 65% were 64% to 71% lower for MB, 47% to 64% lower for TE, and 47% to 57% lower for mortality. Compared to the NOAC study results, the projected rates were 48% to 70% lower for MB, 41% to 66% lower for TE, and 40% to 53% lower for mortality. Projected cost avoidance was $10.4 million vs. a TTR of < 30%, $2.2 million vs. a TTR of 65%; and from $1.4 to $3.1 million vs the NOACs. Costs of “other” MB and TE , drug costs, and monitoring costs were not included in the estimates. CONCLUSIONS: STORM2 management of warfarin is projected to produce a 50% or greater reduction in major event rates with a cost avoidance of $1.4 to $10.4 million per 1,000 patients per year. CLINICAL IMPLICATIONS: STORM2 management may transform the safety and efficacy of anticoagulation for the millions of people with AF while substantially reducing costs. These findings warrant randomized, prospective trials in AF and other indications for anticoagulation.

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