Fresh Bitter Melon Fruit (Momordica charantia) Attenuated Oxidative Stress, Fibrosis and Renal Injury in Carbon Tetrachloride Treated Rats

Chemical or drug-induced kidney damage is increasing every year and the end-stage renal disease is becoming a burden for health care system of many countries. Oxidative stress may be a crucial pathway for the development of end-stage renal disease. Thus, natural antioxidant or plant-based therapy would be a better alternative to protect renal function against chemical-induced renal damage. To determine these aspects we evaluated renoprotective effects of M. charantia in carbon tetrachloride administered rats. A 10% w/w mixture of fresh fruits of M. charantia was given with the chow food every day to CCl4 treated rats. After fourteen days, all animals were sacrificed and the kidneys were examined to observe the possible protective effects of M. charantia against CCl4 induced toxicity. The CCl4 treated rats showed increased oxidative stress parameters and decreased antioxidant enzymes activities. Supplementation of 10% w/w M. charantia fruits in CCl4 administered rats prevented the oxidative stress and restored the antioxidant enzymes activities. M. charantia fruits supplementation also prevented the rise of uric acid and creatinine concentration in plasma of CCl4 treated rats. Furthermore, histological studies showed that supplementation of 10% w/w M. charantia fruits prevented the collagen deposition, immune cell migration and iron deposition in kidney sections of CCl4 treated rats. The results of this study revealed that the fruits of M. charantia may protect oxidative stress-mediated damage in kidneys due to CCl4 administration, which is mediated probably via the restoration of anti-oxidant enzyme functions.Dhaka Univ. J. Pharm. Sci. 16(2): 205-214, 2017 (December)

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Could Antioxidant Supplementation Delay Progression of Cardiovascular Disease in End-Stage Renal Disease Patients?

Current Vascular Pharmacology ◽

10.2174/1570161118666200317151553 ◽

2020 ◽

Vol 19 (1) ◽

pp. 41-54 ◽

Cited By ~ 1

Author(s):

Stefanos Roumeliotis ◽

Athanasios Roumeliotis ◽

Xenia Gorny ◽

Peter R. Mertens

Keyword(s):

Oxidative Stress ◽

Renal Disease ◽

End Stage Renal Disease ◽

Close Association ◽

Omega 3 ◽

Endstage Renal Disease ◽

Increased Risk ◽

Underlying Mechanisms ◽

Stage Renal Disease ◽

End Stage

In end-stage renal disease patients, the leading causes of mortality are of cardiovascular (CV) origin. The underlying mechanisms are complex, given that sudden heart failure is more common than acute myocardial infarction. A contributing role of oxidative stress is postulated, which is increased even at early stages of chronic kidney disease, is gradually augmented in parallel to progression to endstage renal disease and is further accelerated by renal replacement therapy. Oxidative stress ensues when there is an imbalance between reactive pro-oxidants and physiologically occurring electron donating antioxidant defence systems. During the last decade, a close association of oxidative stress with accelerated atherosclerosis and increased risk for CV and all-cause mortality has been established. Lipid peroxidation has been identified as a trigger for endothelial dysfunction, the first step towards atherogenesis. In order to counteract the deleterious effects of free radicals and thereby ameliorate, or delay, CV disease, exogenous administration of antioxidants has been proposed. Here, we attempt to summarize existing data from studies that test antioxidants for CV protection, such as vitamins E and C, statins, omega-3 fatty acids and N-acetylcysteine.

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Cu/Zn superoxide dismutase plasma levels as a new useful clinical biomarker of oxidative stress in patients with end-stage renal disease

Clinical Biochemistry ◽

10.1016/j.clinbiochem.2005.02.009 ◽

2005 ◽

Vol 38 (8) ◽

pp. 700-705 ◽

Cited By ~ 40

Author(s):

Krystyna Pawlak ◽

Dariusz Pawlak ◽

Michal Mysliwiec

Keyword(s):

Oxidative Stress ◽

Superoxide Dismutase ◽

Renal Disease ◽

End Stage Renal Disease ◽

Plasma Levels ◽

Clinical Biomarker ◽

Stage Renal Disease ◽

End Stage

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Matrix metalloproteinase-9 and MMP-2 functional promoter polymorphisms and end-stage renal disease in dialysis patients: Correlation with oxidative stress marker

Annals of Tropical Medicine and Public Health ◽

10.4103/atmph.atmph_116_17 ◽

2017 ◽

Vol 10 (4) ◽

pp. 831

Author(s):

Lida Hagh-Nazari ◽

Hamid Nomani ◽

Hamed Abdi ◽

Asad Vaisi-Raygani ◽

Fariborz Bahremand ◽

...

Keyword(s):

Oxidative Stress ◽

Matrix Metalloproteinase ◽

Renal Disease ◽

End Stage Renal Disease ◽

Oxidative Stress Marker ◽

Dialysis Patients ◽

Promoter Polymorphisms ◽

Stage Renal Disease ◽

End Stage ◽

Metalloproteinase 9

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Role of vitamin D in oxidative stress modulation in end‐stage renal disease patients: A double‐blind randomized clinical trial

Hemodialysis International ◽

10.1111/hdi.12849 ◽

2020 ◽

Vol 24 (3) ◽

pp. 367-373

Author(s):

Leila Malekmakan ◽

Zeinab Karimi ◽

Afshin Mansourian ◽

Maryam Pakfetrat ◽

Jamshid Roozbeh ◽

...

Keyword(s):

Oxidative Stress ◽

Clinical Trial ◽

Vitamin D ◽

Renal Disease ◽

Randomized Clinical Trial ◽

End Stage Renal Disease ◽

Double Blind ◽

Stage Renal Disease ◽

End Stage

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Serum Prolidase Activity and Oxidative Stress in Diabetic Nephropathy and End Stage Renal Disease: A Correlative Study with Glucose and Creatinine

Biochemistry Research International ◽

10.1155/2014/291458 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 11

Author(s):

Akhilesh Kumar Verma ◽

Subhash Chandra ◽

Rana Gopal Singh ◽

Tej Bali Singh ◽

Shalabh Srivastava ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetic Nephropathy ◽

Blood Glucose ◽

Renal Disease ◽

Serum Creatinine ◽

End Stage Renal Disease ◽

Prolidase Activity ◽

Stage Renal Disease ◽

End Stage ◽

And Oxidative Stress

Association of oxidative stress and serum prolidase activity (SPA) has been reported in many chronic diseases. The study was aimed at evaluating the correlation of glucose and creatinine to SPA and oxidative stress in patients with diabetic nephropathy (DN) and end stage renal disease (ESRD) concerned with T2DM. 50 healthy volunteers, 50 patients with T2DM, 86 patients with DN, and 43 patients with ESRD were considered as control-1, control-2, case-1, and case-2, respectively. Blood glucose, creatinine, SPA, total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) were measured by colorimetric tests. SPA, TOS, and OSI were significantly increased in case-1 and case-2 than control-1 and control-2, while TAS was significantly decreased(P<0.001). Blood glucose was linearly correlated to SPA, TOS, TAS, and OSI in control-2, case-1 and case-2(P<0.001). Serum creatinine was linearly correlated with SPA, TOS, TAS and OSI in control-2 and case-1(P<0.001). In case-2, serum creatinine was significantly correlated with SPA only(P<0.001). Thus, the study concluded that SPA and oxidative stress significantly correlated with blood glucose and creatinine. SPA, TOS, TAS, and OSI can be used as biomarkers for diagnosis of kidney damage.

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Oxidative stress in end-stage renal disease: an emerging threat to patient outcome

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfg074 ◽

2003 ◽

Vol 18 (7) ◽

pp. 1272-1280 ◽

Cited By ~ 425

Author(s):

F. Locatelli ◽

B. Canaud ◽

K.-U. Eckardt ◽

P. Stenvinkel ◽

C. Wanner ◽

...

Keyword(s):

Oxidative Stress ◽

Patient Outcome ◽

Renal Disease ◽

End Stage Renal Disease ◽

Stage Renal Disease ◽

End Stage

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Contribution of monoamine oxidases to vascular oxidative stress in patients with end-stage renal disease requiring hemodialysis

Canadian Journal of Physiology and Pharmacology ◽

10.1139/cjpp-2017-0067 ◽

2017 ◽

Vol 95 (11) ◽

pp. 1383-1388 ◽

Cited By ~ 3

Author(s):

Diana Uțu ◽

Stelian Pantea ◽

Oana M. Duicu ◽

Danina M. Muntean ◽

Adrian Sturza

Keyword(s):

Oxidative Stress ◽

Endothelial Dysfunction ◽

Renal Disease ◽

Vascular Access ◽

End Stage Renal Disease ◽

Mao Inhibitors ◽

Monoamine Oxidases ◽

Stage Renal Disease ◽

End Stage ◽

Vascular Oxidative Stress

Arteriovenous fistula (AVF) is the “lifeline” for patients with end-stage renal disease (ESRD) undergoing hemodialysis. AVF maturation failure is a poorly understood process, one of the contributors being endothelial dysfunction due to oxidative stress. Monoamine oxidases (MAOs) A and B were recently identified as novel sources of vascular oxidative stress. The aim of the present study was to assess the contribution of MAOs to the endothelial dysfunction in patients with ESDR with indication of hemodialysis. Fragments of brachial artery collaterals were harvested from ESRD patients during the surgical procedure aimed at creating the vascular access in the cubital fossa. The effect of increasing concentrations (10, 30, 100 μmol/L) of the irreversible MAO-A inhibitor, clorgyline, and MAO-B inhibitor, selegiline, on endothelial-dependent relaxation (EDR) in response to cumulative doses of acetylcholine was studied in isolated phenylephrine-preconstricted vascular rings. Hydrogen peroxide (H2O2) production was assessed using ferrous oxidation xylenol orange assay. We showed that incubation of brachial rings with MAO inhibitors significantly improved EDR and attenuated H2O2 generation in patients with ESRD. MAO-related oxidative stress might contribute to the primary dysfunction/non-maturation of the AVF and MAO inhibitors could improve maturation and long-term patency of the vascular access in dialysis patients.

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