scholarly journals Impaired Cardiac Vagal Tone in Patients with Major Depressive Disorder

2016 ◽  
Vol 10 (2) ◽  
pp. 41-45
Author(s):  
Choudhury Rifat Jahan ◽  
Shelina Begum ◽  
Sultana Ferousi ◽  
Md Moyeen Uddin
Keyword(s):  
Heart Rate ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Vagal Tone ◽  
Cross Sectional Study ◽  
Autonomic Nerve ◽  
Nerve Function ◽  
Major Depressive ◽  
Cross Sectional ◽  
Autonomic Nerve Function

Background: Altered cardiovascular autonomic nerve function with impaired autonomicl balance is found in Major Depressive Disorder(MDD).Objective: To assess some time domain measures of Heart Rate Variability (HRV) in MDD patients to observe their autonomic nerve function status.Methods: This cross sectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, during 2011on 60 patients of both sexes with Major Depressive disorder (MDD) aged 20-50 years. They were further subdivided into 30 drug naïve and 30 patients treated with anti depressive drug. Age, sex and BMI matched 30 apparently healthy subjects were control. The HRV parameters were recorded by 4 active channels, Polyrite-D. For statistical analysis ANOVA, independent sample t-test, were performed.Result: Mean R-R interval, SDNN,RMSSD ,PNN50%, NN50% were found significanty lower but heart rate was significantly higher in all MDD patients of both group compared to control.No significant differences were found in these parameters between treated and recently diagnosed patient.Conclusion: Cardiac autonomic nerve function was impaired in MDD patient which was characterized by reduced vagal tone. Antidepressive medication may not have any effect on impaired autonomic function in MDD.Bangladesh Soc Physiol. 2015, December; 10(2): 41-45

scholarly journals Parasympathetic Nerve Function Status in Major Depressive Disorder Patients and Its Correlation with Duration of Disease

2020 ◽  
Vol 32 (2) ◽  
pp. 76-80
Author(s):  
Choudhury Rifat Jahan ◽  
Md Moyeen Uddin ◽  
Md Samir Uddin ◽  
Misbah Ul Hoq Chowdury ◽  
Wajeunnesa ◽  
...  
Keyword(s):  
Heart Rate ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Autonomic Nerve ◽  
Nerve Function ◽  
Major Depressive ◽  
Parasympathetic Nerve ◽  
Autonomic Nerve Function ◽  
Duration Of Disease ◽  
Drug Naïve

Introduction:Cardiovascular (CV) morbidity is a major problem in patients suffering from depression. Greater CV mortality is found in cardiac patients with depression than without depression. Depressive disorder can cause altered autonomic nerve function. This study design to assess autonomic nerve function activity by heart rate variability analysis in patients with major depressive disorder and its correlation with duration of disease. Materials and Methods: This case study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka in 2011. 60 patients of both sexes with major depressive disorder (MDD) aged from 20-50 years were included in the study group (Group B). The patients were selected from out and inpatient Department of Psychiatry in Bangabandhu Sheik Mujib Medical University (BSMMU). Group B were divided into B-1 consisting of 30 drug naive MDD patients & B-2 consisting of 30 medicated MDD patients. For comparison age and sex matched 30 apparently healthy subjects (Group A) were also studied. The HRV parameters were recorded by 4 active channels, Polyrite-D machine. For statistical analysis ANOVA, independent sample t-test, chi-square test and Pearson’s correlation coefficient test were performed by using SPSS for windows version-16 as applicable. Results: Mean resting pulse rate, mean heart rate, systolic blood pressure were significantly higher in drug naive and medicated MDD patients in comparison with that of healthy control. Mean R-R interval, Max/Min R-R interval, SDNN, RMSSD, PNN50%, NN50% were significantly lower in this groups of patients. Correlation analysis showed negative correlations of SDNN, RMSSD, PNN50%, NN50% with disease duration which was statistically significant only for SDNN. Conclusion: Sympathovagal imbalance may occur in both drug naive and medicated MDD patients which is associated with higher sympathetic and lower vagal modulation of the heart rate. In addition, parasympathetic nerve function parameters show negative relationship with the duration of disease. Medicine Today 2020 Vol.32(2): 76-80

scholarly journals Heart Rate Variability in Patients with Rheumatoid Arthritis

2013 ◽  
Vol 7 (2) ◽  
pp. 78-82 ◽  
Author(s):  
Kawser Jahan ◽  
Noorzahan Begum ◽  
Sultana Ferdousi
Keyword(s):  
Rheumatoid Arthritis ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Time Domain ◽  
Cross Sectional Study ◽  
Autonomic Nerve ◽  
Nerve Function ◽  
Activity Data ◽  
Cross Sectional ◽  
Autonomic Nerve Function

Background: Altered cardiovascular autonomic nerve function with impaired sympathovagal balance is found in rheumatoid arthritis (RA). Heart Rate Variability (HRV) analysis is an important tool for assessment of autonomic nerve activity. Objective: To assess cardiac autonomic nerve function status in patients with Rheumatoid arthritis (RA) by time domain measures of HRV. Methods: This cross sectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from January to December 2010. Sixty female RA patients, age range 18-50 years were constituted study group enrolled from the Out- patient Rheumatology Wing, Department of Medicine, BSMMU. Age matched thirty apparently healthy females were studied as control. Time domain measures of Heart Rate Variability (HRV) such as Mean RR intervals, Mean HR, SDNN, RMSSD, NN50% and PNN 50% were recorded for 5 minutes by a Polygraph machine to observe cardiac autonomic nerve function activity. Data were analyzed by independent sample t test. Results: Mean R-R interval, SDNN, RMSSD, PNN50%, NN50% were significantly lower (p<0.001) but heart rate was significantly (P<0.001) higher in rheumatoid arthritis patients. Conclusion: Cardiac autonomic nerve function is impaired and characterized by reduced resting parasympathetic activity in female Rheumatoid Arthritis patients. DOI: http://dx.doi.org/10.3329/jbsp.v7i2.14455 J Bangladesh Soc Physiol. 2012, December; 7(2): 78-82

scholarly journals Music therapy on non linear assessment of cardiac autonomic function in patients with major depressive disorder

2019 ◽  
Vol 14 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Shams Ruhani Islam ◽  
Sultana Ferdousi
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Music Therapy ◽  
Autonomic Nerve ◽  
Nerve Function ◽  
Newly Diagnosed ◽  
Major Depressive ◽  
Autonomic Nerve Function ◽  
Non Linear ◽  
Healthy Control

Background :Non linear measure of heart rate variability (HRV) is an emerging method to detect changes in cardiac autonomic nerve function in major depressive disorder (MDD). Objective: To observe the effect of music therapy on non linear measures of HRV in newly diagnosed MDD patients. Methods: This prospective interventional study was done in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka in 2018 on 60 newly diagnosed MDD patients aged 20-40 years, both male and female. They were further subdivided into 30 patients with only antidepressant medication (Mirtazapine) and 30 patients received music therapy with Raga kafi (Rabindrasangeet) along with the same medication for 3 months. Age, sex and BMI matched healthy control were also enrolled. HRV non linear parameters were recorded by Power Lab 8/35. For statistical analysis paired sample ‘t’ test and independent sample ‘t’ test were done. Result: SD1, SD2 and SD1/SD2 were found significantly lower in MDD patients compared to healthy control at baseline. After 3 months of music therapy, significant increment of these parameters occurred with trend of improvement in cardiac autonomic nerve function (CANF) in these patients. Conclusion: This study concluded that music therapy can improve CANF by increasing parasympathetic and reducing sympathetic activity in MDD patients. J Bangladesh Soc Physiol. 2019, June; 14(1): 7-13

P.2.a.035 Quality of life in major depressive disorder: a cross-sectional study

2007 ◽  
Vol 17 ◽  
pp. S332 ◽  
Author(s):  
O. Aydemir ◽  
H. Ergun ◽  
S. Kesebir ◽  
H. Soygur
Keyword(s):  
Quality Of Life ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Major Depressive ◽  
Cross Sectional

scholarly journals Major depression subtypes are differentially associated with migraine subtype, prevalence and severity

Cephalalgia ◽  
2019 ◽  
Vol 40 (4) ◽  
pp. 347-356 ◽  
Author(s):  
Claudia Pisanu ◽  
Emma Lundin ◽  
Martin Preisig ◽  
Mehdi Gholam-Rezaee ◽  
Enrique Castelao ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Migraine With Aura ◽  
Migraine Without Aura ◽  
Population Based ◽  
Cross Sectional Study ◽  
High Rate ◽  
Major Depressive ◽  
Cross Sectional ◽  
Depression Subtypes

Objective Migraine and major depressive disorder show a high rate of comorbidity, but little is known about the associations between the subtypes of major depressive disorder and migraine. In this cross-sectional study we aimed at investigating a) the lifetime associations between the atypical, melancholic, combined and unspecified subtype of major depressive disorder and migraine with and without aura and b) the associations between major depressive disorder and its subtypes and the severity of migraine. Methods A total of 446 subjects with migraine (migraine without aura: n = 294; migraine with aura: n = 152) and 2511 controls from the population-based CoLaus/PsyCoLaus study, Switzerland, were included. Associations between major depressive disorder subtypes and migraine characteristics were tested using binary logistic or linear regression. Results Melancholic, combined and unspecified major depressive disorder were associated with increased frequency of migraine with aura, whereas only melancholic major depressive disorder was associated with increased frequency of migraine without aura. Lifetime and unspecified major depressive disorder were associated with severe migraine intensity among subjects with migraine with aura but not migraine without aura, while combined major depressive disorder was associated with higher migraine frequency independently from migraine subtype. Conclusion This study suggests that melancholic but not atypical major depressive disorder is associated with migraine and migraine subtypes. Future studies exploring pathophysiological mechanisms shared between melancholic depression and migraine are warranted.

Investigation of associations between recurrence of major depressive disorder and spinal posture alignment: A quantitative cross-sectional study

2017 ◽  
Vol 52 ◽  
pp. 258-264 ◽  
Author(s):  
Janette Z. Canales ◽  
Juliana T. Fiquer ◽  
Rodolfo N. Campos ◽  
Márcio Gerhardt Soeiro-de-Souza ◽  
Ricardo Alberto Moreno
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Major Depressive ◽  
Cross Sectional ◽  
Spinal Posture

White matter fiber microstructure is associated with prior hospitalizations rather than acute symptomatology in major depressive disorder

2020 ◽  
pp. 1-9
Author(s):  
Susanne Meinert ◽  
Elisabeth J. Leehr ◽  
Dominik Grotegerd ◽  
Jonathan Repple ◽  
Katharina Förster ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Cross Sectional Study ◽  
Disease State ◽  
Major Depressive ◽  
Cross Sectional ◽  
Course Of Illness ◽  
The Right

Abstract Background Eighty percent of all patients suffering from major depressive disorder (MDD) relapse at least once in their lifetime. Thus, understanding the neurobiological underpinnings of the course of MDD is of utmost importance. A detrimental course of illness in MDD was most consistently associated with superior longitudinal fasciculus (SLF) fiber integrity. As similar associations were, however, found between SLF fiber integrity and acute symptomatology, this study attempts to disentangle associations attributed to current depression from long-term course of illness. Methods A total of 531 patients suffering from acute (N = 250) or remitted (N = 281) MDD from the FOR2107-cohort were analyzed in this cross-sectional study using tract-based spatial statistics for diffusion tensor imaging. First, the effects of disease state (acute v. remitted), current symptom severity (BDI-score) and course of illness (number of hospitalizations) on fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity were analyzed separately. Second, disease state and BDI-scores were analyzed in conjunction with the number of hospitalizations to disentangle their effects. Results Disease state (pFWE < 0.042) and number of hospitalizations (pFWE< 0.032) were associated with decreased FA and increased MD and RD in the bilateral SLF. A trend was found for the BDI-score (pFWE > 0.067). When analyzed simultaneously only the effect of course of illness remained significant (pFWE < 0.040) mapping to the right SLF. Conclusions Decreased FA and increased MD and RD values in the SLF are associated with more hospitalizations when controlling for current psychopathology. SLF fiber integrity could reflect cumulative illness burden at a neurobiological level and should be targeted in future longitudinal analyses.

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