scholarly journals Pattern of Primary Thyroid Malignancy in a Tertiary Care Hospital

2020 ◽  
Vol 27 (2) ◽  
pp. 161-174
Author(s):  
Mohammad Asraful Islam ◽  
Rashedul Islam ◽  
Debnath Talukder ◽  
AHM Noor E As Sayeed ◽  
SK Nurul Fattah Rumi ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Carcinoma ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Follicular Carcinoma ◽  
Medullary Carcinoma ◽  
Anaplastic Carcinoma ◽  
Care Hospital ◽  
Thyroid Malignancy ◽  
Follicular Variant

Background: Among the endocrine malignancies thyroid cancer is the most common. It constitutes a heterogeneous group of malignancies ranking it as the fifth most common cancer worldwide. On health as well as health system it has severe implication. Thyroid cancer incidence is rising most rapidly worldwide. Different thyroid malignancy requires different management strategy. Proper addressing and prompt management of different thyroid malignancies can lessen the suffering. Objective: The study aimed to evaluate the pattern of primary thyroid malignancy in a tertiary care hospital. Methods: The study was a hospital based descriptive cross sectional study and was conducted in Dhaka Medical College Hospital, Dhaka for one-year period following approval of this protocol. Patients suffering from primary thyroid carcinoma admitted in or attending the outpatient department (OPD) in the department of Otolaryngology and Head-Neck Surgery was approached for inclusion in the study. Written informed consent was taken from the subject and ethical issues were ensured. A total of 50 individual suffering from primary thyroid carcinoma calculated by sample size formula was selected by inclusion and exclusion criteria and data was collected by interview using a semi-structured questionnaire and by personal document analysis. Collected data was analyzed by the SPSS 20 for windows. This study reflects the pattern of primary thyroid malignancy in a tertiary care hospital in Bangladesh. Results: Mean age of the participants was 32.7 years with SD ± 13.8 years, Minimum age was 17 years and maximum age was 70 years. Majority of the patients (46%) were in the age group of 31- 40 years. Among the participants, 70% were female and 30% were male. The majority of the patients belong to Dhaka and Rangpur divisions (26% & 22% respectively) of which maximum patients were from rural area (70%). By occupation, maximum (22%) of the study subjects were businessman, maximum study subjects were below SSC (24%) and maximum patients (42%) had relatively low income per month. Half of the participants had habit of tobacco. All patients (100%) had presented with palpable thyroid swelling. Among the total participants 54% had lymphadenopathy, 10% had dysphagia, 4% had hoarseness of voice and 4% had lumpiness in throat. Only 2% of patients had the symptom of dyspnoea. No palpable lymph nodes were found in 46% followed by Single node lymphadenopathy 26%, multiple nodules in one side in 18%, bilateral lymphadenopathy 8% and 20% participants had Central compartment lymphadenopathy. USG findings of thyroid revealed Single solid nodule in 22.0%, Single cystic nodule in 16.0%, multiple mixed (solid + cystic) nodules in 62.0% cases. FNAC findings revealed Anaplastic carcinoma in 2.0%, Follicular neoplasm in 16.0% and Follicular variant of papillary carcinoma in 8.0%. Papillary carcinoma found in maximum 70.0% cases. No lymphoma found whereas medullary carcinoma found in 4.0% cases. Histopathological findings confirmed Anaplastic carcinoma in 4.0%, Follicular carcinoma in 16.0%, Follicular variant of papillary carcinoma in 8.0% and Papillary carcinoma 68.0% cases. By histopathological examination no lymphoma found whereas medullary carcinoma found in 4.0% cases. Only 24% participants had hypertension and 76% had DM as co-morbid diseases. Distant metastasis of carcinoma was not present in any of the participants. Conclusion: In this study, middle age group and female sex prevalent thyroid cancer. Geographical distribution also has an important role. Business, low educational level, low socioeconomic status and tobacco smoking are found the most important risk factors. Histopathologically papillary carcinoma was predominant followed by follicular carcinoma, follicular variant of papillary carcinoma, anaplastic carcinoma and medullary carcinoma. No lymphoma found. J Dhaka Medical College, Vol. 27, No.2, October, 2018, Page 161-174

scholarly journals Morphological Spectrum of Lesions Seen in Thyroidectomy Specimens At A Tertiary Care Institute

Esculapio ◽  
2020 ◽  
Vol 16 (03, july 2020-Septmber 2020) ◽  
Author(s):  
Iram Nadeem ◽  
Samra Sameen ◽  
Sahar Iqbal ◽  
Tazeen Anis
Keyword(s):  
Papillary Carcinoma ◽  
Tertiary Care ◽  
Follicular Adenoma ◽  
Follicular Carcinoma ◽  
Medullary Carcinoma ◽  
Anaplastic Carcinoma ◽  
Cell Adenoma ◽  
Care Institute ◽  
Hyalinizing Trabecular Tumor ◽  
Neoplastic Lesions

Objective: To determine the morphological spectrum of thyroid lesions encountered in thyroidectomy specimens at a tertiary care institute. Methods: It was a retrospective study conducted in Pathology Department, Allama Iqbal Medical College, Lahore. A retrospective manual collection of data was done from record registers, for the years 2012 & 2013. Results: A total of 307 cases were retrieved with age range of 16-70 years. Amongst them, 47 were males and 260 were females. Non neoplastic conditions outnumbered the neoplastic lesions as 229(75%) cases were of colloid goiter. Hashimoto thyroiditis was present in 12(3.9%) specimens and associated hyperplastic changes were seen in 15(4.9%) cases. There were 19(6.2%) cases of papillary carcinoma, 3(0.9%) cases of follicular carcinoma, 3(0.9%) cases of medullary carcinoma, 1(0.3 %) case of insular carcinoma and 2(0.6%) anaplastic carcinoma. Papillary microcarcinoma was seen in 4(1.3 %) cases and medullary microcarcinoma in 1(0.3%) case. Follicular adenoma comprised 29(9.4%) cases and Hurthle cell adenoma 3(0.9%) cases. Study data also showed 1(0.3%) rare case of hyalinizing trabecular tumor. Conclusion: Non neoplastic thyroid diseases are more common as compared to neoplastic lesions. Papillary carcinoma is most common thyroid malignancy encountered in our setting. Key Words: Thyroidectomy, Colloid goiter, papillary carcinoma

scholarly journals Clinico-histopathological Assessment of Patients Undergoing Thyroidectomy

2020 ◽  
pp. 96-101
Author(s):  
Rasool Bux Behan ◽  
Agha Taj Mohammed ◽  
Bilal Rasool ◽  
Mujeeb-Ur-Rehman Laghari
Keyword(s):  
Papillary Carcinoma ◽  
Tertiary Care ◽  
Histological Finding ◽  
Follicular Carcinoma ◽  
Anaplastic Carcinoma ◽  
Care Hospital ◽  
Thyroid Disorder ◽  
Diagnostic Laboratory ◽  
Cross Sectional ◽  
Adenomatous Goiter

Objective: To determine the clinical presentation and histopathological evaluation of patients undergoing thyroidectomies at tertiary care Hospital. Methodology: This cross-sectional study was done at department of general surgery of LUMHS/Jamshoro. Duration of the study was 1 year from October 2017 to September 2018. All the cases with a diagnosis of thyroid disorder and underwent thyroidectomy were selected and above 25 years of the age were included. All the surgeries were carried out by senior surgeons along with the cooperation of the ENT surgeons. After surgeries specimens of all the cases were sent to the diagnostic laboratory for the histological assessment. Data was collected via self-made proforma. Results: Of 58 patients majority i.e. 43.10% were found with age group of 35-44 years. Females found in the majority 63.80%. The swelling was noted among all of the cases, followed by pain, difficulty in swallowing, difficulty in breathing and others 8.62%, 10.34%, 20.68% and 25.68% respectively. Adenomatous goiter was the most common histopathological finding in 82.75% cases, papillary carcinoma was found 8.62%, follicular carcinoma was only in one case and anaplastic carcinoma was also in 1 case. Conclusion: Swelling, difficulty in swallowing and difficulty in breathing were the most common clinical features. Adenomatous goiter was the most common histological finding and papillary carcinoma was the commonest malignancy.

scholarly journals Association of Obesity and Thyroid Cancer at a Tertiary Care Hospital in Pakistan

Cureus ◽  
2018 ◽  
Author(s):  
Adnan Ali ◽  
Yumna Mirza ◽  
Urooj Faizan ◽  
Nida Zahid ◽  
Muhammad S Awan
Keyword(s):  
Thyroid Cancer ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital

scholarly journals Incidence of Thyroid Cancer in Thyroid Swelling, Study of 200 Cases

2021 ◽  
Vol 27 (1) ◽  
pp. 12-16
Author(s):  
MA Matin ◽  
Mohammad Saiful Islam ◽  
Md Abdur Razzak ◽  
Mohosana Khanam ◽  
Md Abdullah Al Harun ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Surgery ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Developed Countries ◽  
The United States ◽  
Care Hospital ◽  
Thyroid Malignancy ◽  
True Incidence ◽  
Thyroid Swelling

Objective: The incidence of thyroid cancer has rapidly increased in the United States (US) and other developed countries over the past 30 years but there is no study to find out the true incidence of thyroid cancer in Bangladesh. The aim of this study is to compare FNAC with histopathology reports and to find out the true incidence of thyroid malignancy in thyroidectomy patients presenting with thyroid swelling. Methods: This is a prospective study of 200 thyroid swelling patients underwent thyroid surgery done at Shaheed Suhrawardy Medical College Hospital, a tertiary Care Hospital in Dhaka from July 2017 to December 2020. FNAC and histopathology reports were studied to find out the incidence of benign and thyroid malignancy among the thyroid swelling. Results: The age of the patients ranged from 8 to 75 years. The mean age was 37.2 years. There were 156 female and 44 male patients with female male ratio 3.54:1. Diagnostic categorization of 200 thyroid swelling underwent surgery, FNAC based on Bathesda classification showed that 163 (81.5%) cases were cytologically benign, 37 (18.5%) cases were malignant category. Out of 200 cases histopathology showed134 cases(67.0%) are benign and 66(33.0%) are malignant thyroid swelling. Among the benign lesions96.31% are colloid goiter and among the malignant lesions 93.4% are papillary thyroid carcinoma. Conclusion: Although FNAC is an essential diagnostic test to rule out thyroid malignancy but histopathological examination is the only way to give true incidence of thyroid malignancy among the thyroid swelling and it is observed that there is high incidence of thyroid malignancy(33.0%) among the thyroid swelling patient underwent thyroid surgery. Bangladesh J Otorhinolaryngol; April 2021; 27(1): 12-16

scholarly journals Comparative study on association between serum TSH concentration and Thyroid cancer

2017 ◽  
Vol 4 (8) ◽  
pp. 2800
Author(s):  
Prasad C. ◽  
Supreet Kumar ◽  
Tej Tej Y.
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Nodules ◽  
Tertiary Care ◽  
Follicular Carcinoma ◽  
Thyroid Stimulating Hormone ◽  
P Value ◽  
Thyroid Malignancy ◽  
Tertiary Care Centre ◽  
Serum Tsh ◽  
Tsh Levels

Background: In India, thyroid cancer accounts for less than 1% of all malignancies (2% of women and 0.5% of men). Thyroid cancer is responsible for 6 deaths per 1 million persons annually. Serum TSH is a well-established growth factor for thyroid nodules, however its role in thyroid malignancy is inconclusive hence this study was conducted with the objective to determine the association between serum Thyroid stimulating hormone (TSH) concentrations with thyroid carcinoma.Methods: Case control study was conducted in a tertiary care centre. 120 Benign and malignant thyroid subjects respectively were included in the study. Newly diagnosed and record based data collection was done. Measurements of serum TSH concentrations were performed by automated immune chemiluminescent assay. Data was analyzed using SPSS 22 version software, Chi-square test was used as test of significance for qualitative data, p value of <0.05 was considered as statistically significant.Results: Majority of them were females in the age group 26 to 40 years in both the groups and were diagnosed to have solitary thyroid nodule. In malignant thyroid nodules 51.7% were diagnosed to have follicular carcinoma, 46.7% had papillary carcinoma and 1.7% were diagnosed to have Hurthle cell carcinoma. Significant association was observed between TSH levels and diagnosis of thyroid lesions. TSH was raised (>4mIU/L) in 46.6% of malignant nodules and in 15% of benign nodules. Raised TSH had an odds ratio of 4.958 for Thyroid malignancy compared to benign nodulesConclusions: Higher TSH levels were associated with Thyroid malignancy and the risk of malignancy rises in parallel with serum TSH within normal range, and high levels of serum TSH concentrations was associated with advanced stage of thyroid cancer. 

scholarly journals Malignant Thyroid Lesions: A Histopathological Perspective

2019 ◽  
pp. 1-10
Author(s):  
Innocent Emmanuel ◽  
Mansur Aliyu Ramalan ◽  
Adam Ochigbo ◽  
Philip Akpa ◽  
Daniel Yakubu ◽  
...  
Keyword(s):  
Papillary Carcinoma ◽  
Follicular Carcinoma ◽  
Female Gender ◽  
Medullary Carcinoma ◽  
Anaplastic Carcinoma ◽  
Diagnostic Methods ◽  
University Teaching ◽  
Female Ratio ◽  
Thyroid Cancers ◽  
Age Range

Introduction: Thyroid cancer incidence is increasing globally. This increase has been attributed to improvement in diagnostic methods. This study has as its aim the analysis of the pattern of thyroid gland malignancies seen at the Jos University Teaching Hospital, Jos, Nigeria, between January 2008 and December 2018. Methodology: A descriptive retrospective study of consecutive cases of thyroid specimens analyzed at our center was done. Data was obtained from the Histopathology Department Records. The diagnosis of each case was confirmed by reviewing archival slides. Results: There were 70 cases of thyroid carcinomas during the period of the study. The histological types of thyroid cancers seen were: follicular carcinoma, papillary carcinoma, medullary carcinoma and anaplastic carcinoma, respectively accounting for 36(51.4%), 23(32.9%), 4(5.7%) and 7(8.6%) cases. There was only 1 case of follicular carcinoma in 2012, and non between 2013 and 2018. The male to female ratio was 1: 3.1. The mean age of thyroid carcinoma was 42.7 years, with an age range of 13-80 years. Conclusion: The histological pattern of thyroid cancers has changed over the last two decades in our environment with the erstwhile predominant follicular carcinoma receding to near disappearance. The papillary carcinoma histotype is currently overwhelmingly the commonest type diagnosed. The former is relatively commonly seen in the older age group, in a sharp contrast with the later. The female gender remains the most afflicted group.

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