scholarly journals Multiple Bone Hemangiomas Presenting As Bony Metastasis of Unknown Primary

1970 ◽  
Vol 11 (2) ◽  
pp. 196-199 ◽  
Author(s):  
Ehab Daoud
Keyword(s):  
Unknown Primary ◽  
Benign Tumors ◽  
Primary Malignancy ◽  
Sclerosing Hemangioma ◽  
Bony Metastasis ◽  
Extensive Search ◽  
Vascular Origin

Bone hemangiomas are rare benign tumors of the bones of vascular origin. A patient with bony pains and abnormalradiological findings is described. Following an unsuccessful extensive search for primary malignancy the patient wasdiagnosed as multiple bone hemangioma. This case serves as a reminder for considering benign causes of bonelesion while investigating cases with such presentation.Keywords: Hemangioma; multiple; sclerosing hemangioma; back painDOI: 10.3329/jom.v11i2.5473J MEDICINE 2010; 11 : 196-199

Multiple Pulmonary Pleomorphic Adenomas of Unknown Primary

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S38-S39
Author(s):  
X Liu ◽  
W Miller
Keyword(s):  
Ct Scan ◽  
Salivary Glands ◽  
Lower Lobe ◽  
Unknown Primary ◽  
Benign Tumors ◽  
Low Grade ◽  
Eosinophilic Cytoplasm ◽  
Pleomorphic Adenomas ◽  
Multiple Primary ◽  
History Of

Abstract Introduction/Objective The most common site of pleomorphic adenomas (PAs) is salivary glands, which behave as benign tumors and rarely metastasize. Primary PAs in lungs are exceedingly rare. We report a case of multiple PAs in lungs with an inconclusive origin. Methods A 65-year-old woman had a two-year history of numerous scattered bilateral well-circumscribed pulmonary nodules measuring up to 2.1 cm. She had no prior history of smoking, asbestos exposure and salivary gland diseases, and denied any symptoms. The latest chest computed tomography (CT) scan showed the two largest lower lobe nodules had mildly increased in size compared to two years before. The patient then underwent wedge resections. Results Grossly, the wedge resection specimens showed multiple well-circumscribed, pale tan, firm nodules. Microscopically, the nodules comprised cytologically bland nests of polygonal to plasmacytoid cells with eosinophilic cytoplasm, variably set in a myxoid matrix. Immunohistochemical stains demonstrated that the cells were positive for AE-1/AE-3, S-100, bcl-2 and SOX-10, and negative for chromogranin, smooth muscle actin, p63, calponin, PAX-8, CD34, CD31, HMB-45, melan-A, HHF-35, GATA-3, GFAP and RCC marker; TTF-1 highlighted entrapped pulmonary epithelium but the tumor cells were negative. These findings might suggest metastatic low grade PA from salivary glands. However, the patient’s follow-up examination by an otolaryngologist was normal; the CT scan of her chest and abdomen did not show any remarkable findings other than her lung nodules. Conclusion To our knowledge, this is the first reported case of multiple pulmonary PAs without a preceding primary. It has raised questions about the pathogenesis of multiple PAs in lungs. Could PA present as multiple primary nodules in lungs? Could one primary pulmonary PA generate multiple satellite nodules in lungs? Do multiple primary pulmonary PAs have a different IHC profile than that of a single primary pulmonary PA? More research is needed.

IMRT‐based treatment of unknown primary malignancy of the head and neck: Outcomes and improved toxicity with decreased mucosal dose and larynx sparing

Head & Neck ◽  
2019 ◽  
Vol 41 (4) ◽  
pp. 959-966
Author(s):  
Anna W. LaVigne ◽  
Danielle N. Margalit ◽  
Bhupendra Rawal ◽  
Maria Puzanov ◽  
Donald J. Annino ◽  
...  
Keyword(s):  
Head And Neck ◽  
Unknown Primary ◽  
Primary Malignancy

Fibrous Histiocytoma of the Trachea

1978 ◽  
Vol 87 (5_suppl) ◽  
pp. 2-4 ◽  
Author(s):  
Seymour R. Cohen ◽  
Benjamin H. Landing ◽  
Hart Isaacs
Keyword(s):  
Fibrous Histiocytoma ◽  
Female Child ◽  
Middle Lobe ◽  
Benign Tumors ◽  
Endoscopic Removal ◽  
Respiratory Obstruction ◽  
Sclerosing Hemangioma ◽  
Fibrous Histiocytomas ◽  
Right Middle Lobe

Intratracheal tumors are rare in children. A case is reported of a two-year-old female child with a fibrous histiocytoma of the trachea which caused severe respiratory obstruction and persistent right middle lobe pneumonia. Fibrous histiocytomas are basically benign tumors of histiocytes and have been mistaken for other tumors such as fibroma, sclerosing hemangioma, neurilemoma, fibromatosis, hemangiopericytoma, fibrosarcoma, and some primitive sarcomas. Fibrous histiocytomas have not been reported in the trachea or bronchi. The patient was treated with endoscopic removal of the tumor, and has remained free of disease to this date.

The added value of18F-fluorodeoxyglucose positron emission tomography computed tomography in patients with neck lymph node metastases from an unknown primary malignancy

2013 ◽  
Vol 127 (8) ◽  
pp. 780-787 ◽  
Author(s):  
S J B Prowse ◽  
R Shaw ◽  
D Ganeshan ◽  
P M Prowse ◽  
R Hanlon ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Lymph Node ◽  
Cervical Lymph Node ◽  
Detection Rate ◽  
Primary Tumour ◽  
Emission Tomography ◽  
Unknown Primary ◽  
Primary Malignancy ◽  
Positron Emission

AbstractBackground:The search for a primary malignancy in patients with a metastatic cervical lymph node is challenging yet ultimately of utmost clinical importance. This study evaluated the efficacy of positron emission tomography computed tomography in detecting the occult primary, within the context of a tertiary referral centre head and neck cancer multidisciplinary team tumour board meeting.Methods:Thirty-two patients (23 men and 9 women; mean and median age, 61 years) with a metastatic cervical lymph node of unknown primary origin, after clinical examination and magnetic resonance imaging, underwent positron emission tomography computed tomography.Results:The primary tumour detection rate was 50 per cent (16/32). Positron emission tomography computed tomography had a sensitivity of 94 per cent (16/17) and a specificity of 67 per cent (10/15). Combining these results with those of 10 earlier studies of similar patients gave an overall detection rate of 37 per cent.Conclusion:Positron emission tomography computed tomography has become an important imaging modality. To date, it has the highest primary tumour detection rate, for head and neck cancer patients presenting with cervical lymph node metastases from an unknown primary.

scholarly journals Presumed Melanoma of Unknown Primary Origin Metastatic to the Choroid Mimics Primary Uveal Melanoma

2021 ◽  
pp. 987-993
Author(s):  
John M. Rieth ◽  
Randy Chris Bowen ◽  
Mohammed M. Milhem ◽  
H. Culver Boldt ◽  
Elaine M. Binkley
Keyword(s):  
Genetic Analysis ◽  
Uveal Melanoma ◽  
Primary Tumor ◽  
Tumor Tissue ◽  
Treatment Options ◽  
Unknown Primary ◽  
Primary Malignancy ◽  
Rare Presentation ◽  
Primary Origin ◽  
Unknown Primary Origin

We describe the case of a 69-year-old woman who presented with a decline in vision in the left eye and was found to have a choroidal lesion with clinical and echographic features concerning for primary uveal melanoma. Systemic imaging identified numerous metastases to the liver, kidneys, paratracheal lymph nodes, lung, and brain. The hepatic lesion was biopsied, and genetic analysis identified a Val600Glu (c.1799T&#x3e;A) <i>BRAF</i> mutation, consistent with a cutaneous primary malignancy, although no primary tumor was identified. This case highlights that metastasis to the choroid is a rare presentation of nonuveal melanoma that can mimic primary uveal melanoma. Genetic analysis of tumor tissue can identify the origin of the melanoma and guide treatment options. Systemic imaging should be performed prior to intervention for choroidal neoplasms.

scholarly journals A rare case of Sister Mary Joseph nodule as the only sign of unknown primary malignancy

2016 ◽  
pp. 1682-1684
Author(s):  
Sunil Lanjewar ◽  
Vishal Nandagawali ◽  
Dhiraj Sagrule ◽  
Pratik Lavankar ◽  
Kuntal Surana ◽  
...  
Keyword(s):  
Rare Case ◽  
Unknown Primary ◽  
Primary Malignancy ◽  
Sister Mary Joseph

The validity of the Mirels score for predicting impending pathological fractures of the lower limb

2018 ◽  
Vol 100-B (8) ◽  
pp. 1100-1105 ◽  
Author(s):  
E. L. Howard ◽  
K. L. Shepherd ◽  
G. Cribb ◽  
P. Cool
Keyword(s):  
Metastatic Disease ◽  
Lower Limb ◽  
Metastatic Carcinoma ◽  
Unknown Primary ◽  
Anatomical Site ◽  
Pathological Fractures ◽  
Primary Malignancy ◽  
Radiographic Appearance ◽  
Kappa Test ◽  
The Individual

Aims The aim of this study was to validate the Mirels score in predicting pathological fractures in metastatic disease of the lower limb. Patients and Methods A total of 62 patients with confirmed metastatic disease met the inclusion criteria. Of the 62 patients, 32 were female and 30 were male. The mean age of patients was 65 years (35 to 89). The primary malignancy originated from the breast in 27 (44%) patients, prostate in 15 (24%) patients, kidney in seven (11%), and lung in four (6%) of patients. One patient (2%) had metastatic carcinoma from the lacrimal gland, two patients (3%) had multiple myeloma, one patient (2%) had lymphoma of bone, and five patients (8%) had metastatic carcinoma of unknown primary. Plain radiographs at the time of initial presentation were scored using Mirels system by the four authors. The radiographic components of the score (anatomical site, size, and radiographic appearance) were scored two weeks apart. Inter- and intraobserver reliability were calculated with Fleiss’ kappa test. Bland-Altman plots were created to compare the variances of the individual components of the score and the total Mirels score. Results Kappa values for the interobserver variability of the components of the Mirels score were k = 0.554 (95% CI 0.483 to 0.626) for site, k = 0.342 (95% CI 0.285 to 0.400) for size, k = 0.443 (95% CI 0.387 to 0.499) for radiographic appearance, and k = 0.294 (95% CI 0.258 to 0.331)for the total score. Kappa values for the intra-observer reliability were k = 0.608 (95% CI 0.506 to 0.710) for site, k = 0.579 (95% CI 0.487 to 0.670) for size, k = 0.614 (95% CI 0.522 to 0.703) for radiographic appearance, and k = 0.323 (95% CI 0.266 to 0.379) for total score. Conclusion Our study showed fair to moderate agreement between authors when using the Mirels score, and moderate to substantial agreement when authors rescored radiographs. The Mirels score is subjective and lacks reproducibility in predicting the risk of pathological fracture. Cite this article: Bone Joint J 2018;100-B:1100–5.

26 Adrenal metastases of unknown primary malignancy - what is the diagnostic way?

2004 ◽  
Vol 3 (2) ◽  
pp. 9
Author(s):  
H. Wunderlich ◽  
O. Reichelt ◽  
W. Hindermann ◽  
H. Kosmehl ◽  
J. Schubert
Keyword(s):  
Unknown Primary ◽  
Adrenal Metastases ◽  
Primary Malignancy

Breast MR Imaging in Patients with Axillary Node Metastases and Unknown Primary Malignancy

Radiology ◽  
1999 ◽  
Vol 212 (2) ◽  
pp. 543-549 ◽  
Author(s):  
Susan G. Orel ◽  
Susan P. Weinstein ◽  
Mitchell D. Schnall ◽  
Carol A. Reynolds ◽  
Lynn M. Schuchter ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Axillary Node ◽  
Unknown Primary ◽  
Primary Malignancy ◽  
Breast Mr ◽  
Node Metastases

scholarly journals Synovial Hemangioma in the Knee: MRI Findings

2015 ◽  
Vol 5 ◽  
pp. 23 ◽  
Author(s):  
Harun Arslan ◽  
Necat İslamoğlu ◽  
Zülküf Akdemir ◽  
Cihan Adanaş
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Knee Pain ◽  
Benign Tumors ◽  
Resonance Imaging ◽  
Mri Findings ◽  
Synovial Hemangioma ◽  
Biopsy Tissue ◽  
Vascular Origin ◽  
Histopathologic Findings

Synovial hemangiomas are rare benign tumors of vascular origin. A 23-year-old boy presented with knee pain and swelling. The boy had developed symptoms 18-months earlier. He was diagnosed with synovial hemangioma based on magnetic resonnance imaging examination and histopathologic findings of the arthroscopic biopsy tissue. We present the magnetic resonance imaging and histopathologic findings of synovial hemangioma of the knee.

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