scholarly journals Association between High Serum Homocystine and Preeclampsia

2013 ◽  
Vol 5 (1) ◽  
pp. 21-25
Author(s):  
Munira Ferdausi ◽  
Mahmuda Khatun ◽  
Md Abdullah Yusuf ◽  
Aurin Rahman ◽  
Zara Rahman
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Fluorescence Polarization ◽  
High Serum ◽  
Chronic Hypertension ◽  
Fluorescence Polarization Immunoassay ◽  
Fasting Serum ◽  
Homocysteine Concentration ◽  
Serum Homocysteine ◽  
Total Homocysteine

Background: Hyperhomocysteinemia is an important biological marker for adverse outcome of pregnancy. Objective: The aim of the present study was to see the association of high serum homocysteine with preeclampsia (PE). Methodology: This cross sectional study was carried out in the Department of Obstetrics and Gynaecology at Sir Salimullah Medical College & Mitford Hospital, Dhaka. All pregnant women with or without eclampsia admitted at the hospital were included in this study. Pregnant women with diabetes mellitus, chronic hypertension, multiple pregnancies, chronic renal disease and patients taking anti-folate drugs were excluded from this study. Fasting serum total homocysteine (tHomocysteine) concentration was estimated by Fluorescence Polarization Immunoassay (FPIA) method. Result: A total number of 50 PE patient [Severe PE (23) & Mild PE (27)] and 50 pregnant women without PE were selected purposively. Fasting serum total homocysteine (tHomocysteine) concentration was estimated by fluorescence polarization immunoassay (FPIA) method. Mean serum homocysteine concentration in severe PE, mild PE and pregnant women without PE were 11.5 4.58 mol/L, 10.43 5.12 and 5.70 1.30 respectively. Serum homocysteine was significantly increased in severe PE and mild PE in comparison to without PE group . Howere severe PE and mild PE group cases did not differ with respect to serum homocysteine. Conclusion: Significant positive correlation was found between serum homocysteine concentration and urinary total protein, uric acid level, systolic blood pressure and diastolic blood pressure. DOI: http://dx.doi.org/10.3329/jssmc.v5i1.16200 J Shaheed Suhrawardy Med Coll, 2013;5(1):21-25

Does genetically-defined ancestry predict booking blood pressure in pregnant women with chronic hypertension?

2019 ◽  
Vol 17 ◽  
pp. S11
Author(s):  
Frances Conti-Ramsden ◽  
Raquel Iniesta ◽  
Phil Chowienczyk ◽  
Lucy C. Chappell
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Chronic Hypertension

Specific measurement of cyclosporine concentrations in whole blood: radioimmunoassay and fluorescence polarization immunoassay compared

1991 ◽  
Vol 37 (12) ◽  
pp. 2150-2152 ◽  
Author(s):  
Kathleen A Fuller ◽  
Wayne S Brown ◽  
John W Koenig ◽  
Barbara J Eveland ◽  
Mitchell G Scott
Keyword(s):  
Thyroid Hormone ◽  
Whole Blood ◽  
Fluorescence Polarization ◽  
Hashimoto Thyroiditis ◽  
High Serum ◽  
Fluorescence Polarization Immunoassay ◽  
Normal Range ◽  
Normal Value ◽  
Serum T3 ◽  
History Of

Letters A 39-year-old woman with a 20-year history of hypothyroidism caused by Hashimoto thyroiditis had been managed adequately with oral thyroxun (T4), 200 mg/day, until a few months before referral, at which time she developed symptoms of hyperthyroidism. Her thyroid hormone proffle at the time of referral is shown in Table 1 (Sample 1). Her normal value for serum thyrotropin (TSH) concentration indicates that she was euthyreid but, because of the high serum triiodothyronune (T3) value, the daily oral doseof T4 was decreased to 100 mg. The serum thyroid tests were repeated four weeks later (Table 1, Sample 2): The decreased T4 and increased TSH show that the patient had become hypothyroid at this dosagé of T4 but the serum T3 concentration was still in the high normal range.

Serum homocysteine concentration, blood pressure and risk of stroke

1995 ◽  
Vol 13 (12) ◽  
pp. 1503
Author(s):  
I. J. Perry ◽  
H. Refsum ◽  
R. W Morris ◽  
S. B. Ebrahim ◽  
P. M Ueland ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Homocysteine Concentration ◽  
Serum Homocysteine

scholarly journals Pregnant women’s experiences with the management of hypertensive disorders of pregnancy: a qualitative study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Amyna Helou ◽  
Kay Stewart ◽  
Kath Ryan ◽  
Johnson George
Keyword(s):  
Blood Pressure ◽  
Qualitative Study ◽  
Pregnant Women ◽  
Clinical Management ◽  
Blood Pressure Monitoring ◽  
Chronic Hypertension ◽  
Hypertensive Disorders Of Pregnancy ◽  
Pressure Monitoring ◽  
Hypertensive Disorders ◽  
Management Of Complications

Abstract Background Hypertensive disorders are a leading cause of mortality and morbidity during pregnancy. Despite multiple national and international clinical guidelines and a plethora of research in the field of optimising management, there has been limited research describing the perspectives and experiences of pregnant women with the management of hypertensive disorders of pregnancy (HDP). Understanding these perceptions and experiences is imperative to the optimisation of HDP management. Methods A qualitative study involving face-to-face, in-depth interviews were undertaken with 27 pregnant women diagnosed with and being treated for HDP to explore their perspectives of and experiences with clinical management. Written consent was obtained individually from each participant, and the interviews ranged from 16 to 54 min. Inductive codes were generated systematically for the entire data set. Line-by-line analysis was then performed and nodes were created within NVivo, a qualitative data management software. Data collection was continued until thematic saturation was reached. Thematic analysis was employed to interpret the data. Results Three major descriptive themes were discerned regarding the women’s perspectives on and experiences with the management of HDP: attitudes towards monitoring of HDP, attitudes and perceptions towards development and management of complications, and perceptions of pregnant women with chronic hypertension. Trust in the hospital system, positive attitudes towards close blood pressure monitoring as well as self-monitoring of blood pressure, and a realistic approach to emergency antenatal hospital admissions contributed to a positive attitude towards monitoring of HDP. Women with prior experiences of HDP complications, including pre-eclampsia, were more confident in their clinical management and knew what to expect. Those without prior experience were often in shock when they developed pre-eclampsia. Some women with chronic hypertension displayed limited understanding of the potential risks that they may experience during pregnancy and thus lacked comprehension of the seriousness of the condition. Conclusions The clinical management experiences of pregnant women with HDP were varied. Many women did not feel that they were well informed of management decisions and had a desire to be more informed and involved in decision-making. Clear, concise information about various facets of HDP management including blood pressure monitoring, prescription of the appropriate antihypertensive agent, and planning for potential early delivery are required.

scholarly journals Socioeconomic, demographic and obstetric profile of pregnant women with Hypertensive Syndrome in a public maternity

2020 ◽  
Vol 41 ◽  
Author(s):  
Lia Maristela da Silva Jacob ◽  
Artur Paiva Santos ◽  
Maria Helena Baena de Moraes Lopes ◽  
Antonieta Keiko Kakuda Shimo
Keyword(s):  
High School ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Pregnant Women ◽  
Body Mass ◽  
Gestational Age ◽  
Skin Color ◽  
High School Education ◽  
Chronic Hypertension ◽  
Elevated Blood

ABSTRACT Objective: To describe the socioeconomic, demographic and obstetric profile of pregnant women with Gestational Hypertensive Syndrome. Methods: A descriptive and correlational study, conducted in Maternity School Assis Chateaubriand, with 120 pregnant women, through a questionnaire analyzed by descriptive and analytical statistics. Results: most women had chronic hypertension (60.83%). Regarding the socioeconomic and demographic profile, most pregnant women had a mean age of 30.9 ± 6.9 years, were Catholic, brown skin color, employed, in stable unions, complete high school education, and income of up to R$ 954.00. Regarding the obstetric profile, their Body Mass Index was up to 66, slightly elevated blood pressure, an average of five prenatal consultations, two pregnancies, one delivery and no abortions. Women with chronic hypertension were older (p = 0.0024), had lower gestational age (p = 0.0219) and a higher number of abortions (p = 0.0140). Conclusions: Pregnant women are overweight/obese, with a mean age of 30.9 years and are socially vulnerable. Pregnant women with chronic hypertension are older and have a higher number of abortions.

scholarly journals Correlation Between Divided Doses of Chronic Antihypertensive Drugs and Pregnancy Outcomes

2017 ◽  
Vol 8 (3) ◽  
pp. 328-332
Author(s):  
Safura Hatamipour Dehno ◽  
Simin Taghavi ◽  
Nayyereh Ayati
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Antihypertensive Drugs ◽  
Gestational Hypertension ◽  
Blood Pressure Monitoring ◽  
Perinatal Outcomes ◽  
Chronic Hypertension ◽  
Pressure Monitoring ◽  
Fetal Complications

Objectives: Hypertension, as a common problem during pregnancy, is a major cause of maternal and fetal morbidity and mortality. Anti-hypertensive drugs are used to prolong the pregnancy or modify perinatal outcomes in pregnant women with hypertensive disorders. Severe monitoring of blood pressure is subsequently essential in these mothers. The aim of this study was to evaluate the correlation between divided doses of chronic hypertensive drugs and the end of pregnancy in mothers with gestational hypertension. Materials and Methods: In this prospective research, 99 pregnant women with chronic hypertension, who were treated with antihypertensive medicines, were studied during pregnancy. During routine follow-up of these mothers, the number of the drug and the divided doses were recorded. The incidence of maternal and fetal outcomes were evaluated according to the number of less or more than 5 divided doses. Results: Maternal and fetal-baby complications were observed in 5.50 and 5.53% cases, respectively. The incidence of maternal and fetal complications were significantly enhanced by increasing the number of up-taken anti-hypertensive drugs. The maternal and fetal-baby complications were higher in mothers who received more than five divided doses compared to those who received less than five doses. Conclusion: Based on our results, chronic hypertension was associated with maternal and fetal-baby complications in half of the cases. It is clarified that precise blood pressure monitoring and regularly taking of anti-hypertensive medicine may decrease the hypertension side effects. The awareness about this field in the pre-pregnancy consulting is considered as the patients’ rights and should be respected.

scholarly journals Lipoprotein (a) level in pre-eclampsia patients

1970 ◽  
Vol 36 (3) ◽  
pp. 97-99 ◽  
Author(s):  
Saila Parvin ◽  
Latifa Samsuddin ◽  
Ahammed Ali ◽  
Safiqul Alam Chowdhury ◽  
Ibrahim Siddique
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
High Serum ◽  
Serum Lipoprotein ◽  
Control Group ◽  
High Serum Level ◽  
Lipoprotein A ◽  
Control Serum ◽  
The Mean ◽  
And Control

This study was carried in BSMMU from July 2001 to June 2003. During the study period, 60 pregnant women were studied. Thirty patients were preeclamptic and thirty were normal healthy pregnant women served as control. Serum lipoprotein(a) was found significantly higher in preeclamptic women 56.63±22.6 mg/dl and found within limit in normal healthy pregnant women, 12.89±4.59mg/dl. Result is statistically highly significant (P<0.001). Mean Systolic Blood Pressure was 163.33±29.63 mmHg and 117.00±11.19mmHg in case and control and Diastolic Blood Pressure was 108.53±14.54 mmHg and 76.00±6.87mmHg respectively in case and control group. Result was highly significant as P <0.001. The mean (±SD) serum lipoprotein(a) concentration in normal pregnancies and preeclampsia were found to be 12.91±4.94 and 56.65±22.62. Moderate Proteinuria was found in 77.5% and severe proteinuria in 22.2% cases of preeclampsia respectively. Regardless of mechanism and pathophysiology of preeclampsia, we found high serum level of lipoprotein (a) in preeclampsia patients. These high levels of lipoprotein (a) significantly correlated with blood pressure and proteinuria. DOI: 10.3329/bmrcb.v36i3.7289Bangladesh Med Res Counc Bull 2010; 36: 97-99

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