Formation of Docetaxel-related Substances in the Polymer Particles During Storage and Gamma-treatment

Introduction. Docetaxel is widely used for cancer treatment. Actual issue for newly developed polymer-based Docetaxel formulations is applicability of current quality requirements. The technology of polymeric forms, including gamma-sterilization, are differ from actual Docetaxel injections technology. In this study were used PLGA-based particles with Docetaxel. The main attention was directed to studying qualitative and quantitative content of related impurities in polymeric forms during long-term storage and gamma-sterilization in comparison with pharmacopoeial requirements for Docetaxel injections.Aim. Studying of possible patterns of Docetaxel-related impurities formation between intact and gamma-irradiated batches.Materials and methods. Objects of study – lyophilizates of Docetaxel polymeric forms was previously obtained by the authors. Qualitative and quantitative analysis was performed by high pressure liquid chromatography.Results and discussion. Docetaxel-related impurities was determined and evaluated in the intact and gamma-treated batches. It was cleared, that related substances in the gamma-treated batches was different in comparison with non-treated but after vary storage periods.Conclusion. Docetaxel-loaded polymeric drugs shown proper stability during long term storage. The influence of gamma-treatment to Docetaxelrelated impurities content was found. Gamma sterilization can be promising method for novel drugs, but it needs individual study in the each case.

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In vitro evaluation of metabolic changes and residual platelet responsiveness in photochemical treated and gamma-irradiated single-donor platelet concentrates during long-term storage

Transfusion ◽

10.1111/j.1537-2995.2007.01167.x ◽

2007 ◽

Vol 47 (4) ◽

pp. 653-665 ◽

Cited By ~ 59

Author(s):

Torunn O. Apelseth ◽

Øystein Bruserud ◽

Tore Wentzel-Larsen ◽

Anne M. Bakken ◽

Solfrid Bjørsvik ◽

...

Keyword(s):

Metabolic Changes ◽

Platelet Concentrates ◽

In Vitro Evaluation ◽

Long Term Storage ◽

Single Donor ◽

Gamma Irradiated ◽

Term Storage

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The effect of long-term storage on the microleakage of composite resin restorations: qualitative and quantitative evaluation

Pesquisa Odontológica Brasileira ◽

10.1590/s1517-74912003000300011 ◽

2003 ◽

Vol 17 (3) ◽

pp. 261-266

Author(s):

Fernanda Tranchesi Sadek ◽

Sandra Kiss Moura ◽

Rafael Yagüe Ballester ◽

Antonio Muench ◽

Paulo Eduardo Capel Cardoso

Keyword(s):

Composite Resin ◽

Class Ii ◽

Adhesive Systems ◽

Qualitative And Quantitative ◽

Long Term Storage ◽

Significant Difference ◽

Blue Solution ◽

Composite Resin Restorations ◽

Term Storage

The aim of this study was to evaluate the influence of storage periods of 24 hours and 3 months on the microleakage of class II cavities. Two methods of assessing microleakage were also compared. Class II cavities were prepared in sound human molars. MO cavities were restored using ABF experimental (Kuraray Medical Inc.) + Z250 composite resin (3M ESPE), and DO cavities were restored using Single Bond (3M ESPE) + Z250. After different storage periods, specimens were thermocycled, immersed in a dye (0.5% methylene blue solution for 4 h) and longitudinally sectioned. Dye penetration was scored according to a 0-4 scale. The extent of microleakage was measured using the ImageLab 2000 program. A statistically significant correlation was verified between both evaluation methods (r = 0.978, p < 0.001). ANOVA revealed a statistically significant difference between the tested adhesive systems regarding microleakage (p < 0.001), although it was not influenced by the different storage periods.

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Comparison of Anti-Oxidative Activities of Gamma-Irradiated Aralia continentalis Extracts for Long-Term Storage of Oriental Medicine

Journal of the Korean Society of Food Science and Nutrition ◽

10.3746/jkfn.2017.46.1.046 ◽

2017 ◽

Vol 46 (1) ◽

pp. 46-55

Author(s):

Hye-Jin Park ◽

Eun-Jin Hong ◽

Shin-Hyub Hong ◽

Young-Je Cho

Keyword(s):

Oriental Medicine ◽

Aralia Continentalis ◽

Long Term Storage ◽

Gamma Irradiated ◽

Term Storage

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Detection of Gamma-irradiated Spices after Long-term Storage by ESR, PSL and TL Methods

Nippon Shokuhin Kagaku Kogaku Kaishi ◽

10.3136/nskkk.62.382 ◽

2015 ◽

Vol 62 (8) ◽

pp. 382-393 ◽

Cited By ~ 2

Author(s):

Hiromi Kameya ◽

Kimie Saito ◽

Shoji Hagiwara ◽

Setsuko Todoriki

Keyword(s):

Long Term Storage ◽

Gamma Irradiated ◽

Term Storage

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The influence of high temperatures on the growth and survival of Rhizobium spp. in peat inoculants during preparation, storage, and distribution

Canadian Journal of Microbiology ◽

10.1139/m84-004 ◽

1984 ◽

Vol 30 (1) ◽

pp. 23-30 ◽

Cited By ~ 20

Author(s):

P. Somasegaran ◽

V. G. Reyes ◽

H. J. Hoben

Keyword(s):

Laboratory Data ◽

Cell Multiplication ◽

Growth And Survival ◽

Long Term Storage ◽

Tropical Legumes ◽

Special Instruction ◽

Rhizobium Spp ◽

Gamma Irradiated ◽

Term Storage

Gamma-irradiated peat was used to prepare inoculants for 10 different species of tropical legumes. These inoculants were sent to cooperators in 14 cities in 13 tropical countries. Each cooperator received a package containing a maximum recording thermometer, plating-media components, special instruction sheets, and inoculants. Control experiments were pursued in the laboratory by exposing the various inoculants to 28, 37, and 46 °C. Temperatures reached in the inoculants during their transportation varied from 26 (Mexico) to 45 °C (Kenya). Arrival time of the inoculants ranged from 6 days (Hissar, India) to 54 days (St. Augustine, West Indies). Although a total loss of viability was reported for the chick-pea inoculant (Saudia Arabia) and a severe decrease in two others (bean and lentil inoculants in Kenya and Saudi Arabia, respectively), over 90% of the inoculants received had viable counts in excess of 1 × 108 cells per gram of moist peat. Laboratory data indicated that 28 °C was optimal for multiplication to maximal numbers in excess of 1 × 1010 cells per gram of moist peat. Six inoculants studied for long-term storage showed excellent quality for 24 weeks at 28 °C. At 37 °C the cell multiplication was comparable with that at 28 °C with 8 of the 10 strains only during the 1st week. For all strains, 46 °C was lethal. Large reductions in viable counts were observed during inoculant preparation when broth cultures were added to peat.

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Modelling of Moisture Movement in Wood during Outdoor Storage

Nonlinear Analysis Modelling and Control ◽

10.15388/na.2001.6.1.15210 ◽

2001 ◽

Vol 6 (2) ◽

pp. 3-14 ◽

Cited By ~ 23

Author(s):

R. Baronas ◽

F. Ivanauskas ◽

I. Juodeikienė ◽

A. Kajalavičius

Keyword(s):

Experimental Data ◽

Finite Difference ◽

Climatic Conditions ◽

Two Dimensional ◽

Moisture Movement ◽

Finite Difference Technique ◽

Long Term Storage ◽

Space Formulation ◽

Term Storage

A model of moisture movement in wood is presented in this paper in a two-dimensional-in-space formulation. The finite-difference technique has been used in order to obtain the solution of the problem. The model was applied to predict the moisture content in sawn boards from pine during long term storage under outdoor climatic conditions. The satisfactory agreement between the numerical solution and experimental data was obtained.

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