scholarly journals Optimization of the Composition of the Ointment with Phytoecdysteroids Serpisten

2021 ◽  
Vol 10 (4) ◽  
pp. 89-95
Author(s):  
E. I. Molokhova ◽  
Yu. V. Sorokina ◽  
D. E. Lipin
Keyword(s):  
Thermal Stability ◽  
Raw Materials ◽  
Tween 80 ◽  
Physiological Effect ◽  
Acid Number ◽  
Agar Gel ◽  
Ointment Base ◽  
Rotary Viscometer ◽  
Stability Of Structure ◽  
Thermal Stability Of

Introduction. Phytoecdysteroids are a group of natural compounds related in structure and physiological effect to ecdysone - the hormone of insect molting. Phytoecdisteroids have been found to have an antiflammatory effect, which suggests that they have regenerative properties. The development of a soft dosage form containing phytoecdysteroids is of interest.Aim. Improvement of ointment compositions with phytoecdysteroids by optimizing the composition of base adjuvants.Materials and methods. As an active substance was used Serpisten, containing the sum of phytoecdysteroids, the main of which is 20-hydroxyecdysone and obtained from the leaves of Serratulaecoronatae. Raw materials "Serpukhi crowned leaves" were registered by the Federal Service Rospotrebnadzor (Moscow) for the production of dietary supplements (Gr. No. 77.99.23.3.U.1922.3.08), substance Serpisten (Gr. No. 77.99.23.3.U.1923.3.08. TU 9369-002-15092611-2008). In work were used the excipients allowed for medical use: the monoglycerides distilled, T-2 emulsifier, tween 80, sodium - carboxymethylcellulose, polyvinyl alcohol, hydroxide of aluminum, aero forces, vaseline, oil vaseline, sunflower oil. Optimization of ointment auxiliary substances composition was carried out according to the Greco-Latin 4 x 4 square plan with repeated observations. The concentration of hydrogen ions from aqueous ointments was evaluated as process parameters; acid number; release of serpistene from ointment into agar gel, thermal stability of structure. The structural and mechanical properties of the optimal composition ointment composition were determined on a RV type REOTEST 2.1 rotary viscometer (RHEOTEST Medingen GmbH, Germany). Ointment Bepanten (GP Grenzach Produktions GmbH, Germany) was used as a comparison preparation.Results and discussion. During optimization of the composition of the diphilic ointment with serpistene, was found that the ratio of hydrophobic and hydrophilic phases should be 1 : 1, it is advisable to introduce into the ointment base an emulsifier T-2, aerosil and a mixture of vaseline and vaseline oil in the proportion of 1 : 1. As a result of the carried out studies on the optimization of ointment compositions, the following serpisten ointment composition is proposed: serpisten - 0.02; emulsifier T-2 - 3.0; aerosil - 3.0; vaseline - 23.0; vaseline oil - 23.0; ethyl alcohol 40 % - 1 ml; purified water to 100.0. Comparative analysis of effective viscosity showed that the proposed composition is as close as possible to the Bepanten ointment.Conclusion. A set of technological studies was carried out to optimize the composition of the Serpisten, 0.02 °% ointment on a diphilic basis. The developed composition and technology made it possible to obtain a composition with thermal stability, bring the hydrogen index of the ointment closer to the pH of human skin and achieve the parameters included in the rheological optimum for dermatological ointments (0.34-108 Pa • s).

scholarly journals Fire Suppression and Thermal Behavior of Biobased Rigid Polyurethane Foam Filled with Biomass Incineration Waste Ash

Polymers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 683 ◽  
Author(s):  
Agnė Kairytė ◽  
Arūnas Kremensas ◽  
Saulius Vaitkus ◽  
Sylwia Członka ◽  
Anna Strąkowska
Keyword(s):  
Thermal Stability ◽  
Building Materials ◽  
Raw Materials ◽  
Fire Suppression ◽  
Waste Incineration ◽  
Supply Chain System ◽  
Smoke Suppressant ◽  
Foam Filled ◽  
Pu Foams ◽  
Thermal Stability Of

Currently, there is great demand to implement circular economy principles and motivate producers of building materials to integrate into a closed loop supply chain system and improve sustainability of their end-product. Therefore, it is of great interest to replace conventional raw materials with inorganic or organic waste-based and filler-type additives to promote sustainability and the close loop chain. This article investigates the possibility of bottom waste incineration ash (WA) particles to be used as a flame retardant replacement to increase fire safety and thermal stability under higher temperatures. From 10 wt.% to 50 wt.% WA particles do not significantly deteriorate performance characteristics, such as compressive strength, thermal conductivity, and water absorption after 28 days of immersion, and at 32 °C WA particles improve the thermal stability of resultant PU foams. Furthermore, 50 wt.% WA particles reduce average heat release by 69% and CO2 and CO yields during fire by 76% and 77%, respectively. Unfortunately, WA particles do not act as a smoke suppressant and do not reduce smoke release rate.

Structure and Thermal Stability of Cu after Severe Plastic Deformation

2010 ◽  
Vol 297-301 ◽  
pp. 1312-1321 ◽  
Author(s):  
Vladimir V. Popov ◽  
A.V. Stolbovkiy ◽  
E.N. Popova ◽  
V.P. Pilyugin
Keyword(s):  
Thermal Stability ◽  
Plastic Deformation ◽  
Severe Plastic Deformation ◽  
High Pressure Torsion ◽  
Pure Copper ◽  
Nanocrystalline Structure ◽  
Transmission Electron ◽  
Evolution Of Structure ◽  
Stability Of Structure ◽  
Thermal Stability Of

Evolution of structure of high-purity and commercially pure copper at severe plastic deformation (SPD) by high pressure torsion (HPT) at room temperature and in liquid nitrogen has been studied by transmission electron microscopy (TEM) and measurements of microhardness. Thermal stability of structure obtained by HPT has been investigated. Factors preventing from obtaining nanocrystalline structure in Cu are analyzed and possible ways of their overcoming are discussed.

Crystallization Characteristics and Thermal Stability of Fluor-Hydroxyapatite Composites with Zirconia

2012 ◽  
Vol 182-183 ◽  
pp. 122-125
Author(s):  
Li Li Wang ◽  
Xiu Feng Wang ◽  
Cheng Long Yu ◽  
Hong Tao Jiang
Keyword(s):  
Thermal Stability ◽  
High Temperature ◽  
Solid State ◽  
Low Temperature ◽  
Solid Solutions ◽  
Tricalcium Phosphate ◽  
Solid State Reaction ◽  
Calcium Fluoride ◽  
Raw Materials ◽  
Thermal Stability Of

Hydroxyapatite (HA) was synthesized in presence of 20wt% m-ZrO2by solid state reaction between tricalcium phosphate(TCP) and Ca(OH)2at 1000 °C for 2h. Similarily, Fluorine hydroxyapatite(FA) was synthesized using tricalcium phosphate and calcium fluoride as raw materials at 1000 °Cfor 3h. The as-prepared HA was mixed with 10%,25%,45%,55%,70wt% FA and the mixture was sintered at 1000°C-1400°C for 2h. The main phase and bulk density was measured. The results show that when the relative amount of FA to HA increased, the decomposition of the composite is decreased gradually because of the formation of thermally stable FHA solid solutions. Low temperature would effect the exchange of ionic between FA and HA,while high temperature would impact synthesis of composites, because high temperature would lead to dissolution of HA ,which has to react with FA. Increase the content of HA would be advantage for synthesis FHA-ZrO2composite.

scholarly journals Thermal Stability of Structure and Mechanical Properties of a Nano-Quasi-Crystalline Al$_{94}$Fe$_{3}$Cr$_{3}$ Alloy

2016 ◽  
Vol 38 (11) ◽  
pp. 1463-1477
Author(s):  
O. I. Yurkova ◽  
◽  
O. I. Kravchenko ◽  
O. V. Byakova ◽  
A. O. Vlasov ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Thermal Stability ◽  
Stability Of Structure ◽  
Thermal Stability Of

The Research on the Disperse Form of PEO Fiber by Electrostatic Spinning Method

2012 ◽  
Vol 601 ◽  
pp. 110-114
Author(s):  
Ting Lou ◽  
Yan Bo Wu ◽  
Tie Ben Song
Keyword(s):  
Thermal Stability ◽  
Electrical Conductivity ◽  
Solution Viscosity ◽  
Electrostatic Spinning ◽  
Nano Fiber ◽  
Disperse Form ◽  
Rotary Viscometer ◽  
Derivative Thermogravimetry ◽  
Thermal Stability Of ◽  
Better Than

We prepared PEO nano fiber with different concentration of PEO acid solution by electrostatic spinning in different technology conditions. Then we studied the property of solution by rotary viscometer instrument and electrical conductivity spectrometer, the disperse form of the fiber by SEM scattered forms, the thermal property of the composite was studied by thermogravimetry and derivative thermogravimetry (TG-DTA). The conclusion is the disperse form of fiber is controlled by the concentration of solution, the voltage of spinning, the distance of solidification. The important factor is about the solution. To increase the solution viscosity and the solidification distance, reduce the spinning voltage would decrease the diameter of the fiber. Thermal stability of fiber was significantly better than powder.

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