Serum selenium levels in patients with Graves’ disease: associations with clinical activity and severity in a retrospective case-control study

Background: Febrile seizures are the most common form of childhood seizures. Children are at particular risk for selenium deficiency. There was various hypothesis about the co-relation between selenium levels and febrile seizures. The aim of the present study was to determine whether there were any changes in serum selenium levels in children with febrile seizures when compared to children with febrile illness without seizures.Methods: This was a hospital based prospective case control study, consisting of 40 children (20 cases and 20 controls) aged between 6 months to 60 months. The serum selenium level was measured in each of them by atomic absorption spectrophotometer. Data was analysed by using frequency percentage and pearson’s chi square test.Results: Out of the 40 children included in the study, serum selenium level was lower in febrile seizure group (80%) when compared to controls (20%) which was statistically significant (P value: 0.003). Also, there was no statistically significant difference between males and females.Conclusions: In the present study, we found significantly low serum selenium levels in children with febrile seizures as compared to the children with febrile illness with no seizures. Decreased levels of selenium in children with febrile seizures may be the result of oxidative damage, occurring in the neuronal cells. In our study, a significant co-relation between low levels of selenium and febrile seizures have been observed in children. However, since the numbers are small, further studies with larger sample size are recommended.

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Serum Cholinesterases, a Novel Marker of Clinical Activity in Inflammatory Bowel Disease: A Retrospective Case-Control Study

Mediators of Inflammation ◽

10.1155/2020/4694090 ◽

2020 ◽

Vol 2020 ◽

pp. 1-7

Author(s):

Xiaona Shao ◽

Lei Yang ◽

Keyue Hu ◽

Ruiwei Shen ◽

Qunqun Ye ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Case Control Study ◽

Activity Index ◽

Case Control ◽

Clinical Activity ◽

Retrospective Case ◽

Lower Serum ◽

Inflammatory Bowel ◽

Control Study

Background. The aim of our study was to investigate whether serum cholinesterase (ChE) levels were associated with inflammatory bowel disease (IBD). Materials and Methods. We conducted a retrospective case-control study to clarify the relationship between serum ChE levels and IBD that included 142 patients with ulcerative colitis (UC), 60 patients with Crohn’s disease (CD), and 264 healthy controls (HCs). We used ROC curves to evaluate the diagnostic value of serum ChE levels for IBD. Results. Substantially lower serum ChE levels were detected in patients with UC than in HCs (6376 U/L versus 8418 U/L, P<0.001) and in patients with CD than in HCs (5181 U/L versus 8418 U/L, P<0.001). Additionally, patients with CD displayed significantly lower serum ChE levels than patients with UC (5181 U/L versus 6376 U/L, P<0.01). We also found that there was a negative association between serum ChE levels and the Crohn’s Disease Activity Index (CDAI) score of patients with CD (P=0.011) and the Simple Clinical Colitis Activity Index (SCCAI) score of patients with UC (P=0.018). The area under the curve (AUC) for serum ChE for the diagnosis of IBD was 0.826, and the AUCs of serum ChE for the diagnosis of CD and UC were 0.890 and 0.800, respectively. Conclusions. Serum ChE levels have important clinical significance in the diagnosis and assessment of clinical activity in patients with IBD, and the cholinergic anti-inflammatory pathway may provide new ideas for targeted treatment of IBD.

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Gender Differences with Dose–Response Relationship between Serum Selenium Levels and Metabolic Syndrome—A Case-Control Study

Nutrients ◽

10.3390/nu11020477 ◽

2019 ◽

Vol 11 (2) ◽

pp. 477 ◽

Cited By ~ 5

Author(s):

Chia-Wen Lu ◽

Hao-Hsiang Chang ◽

Kuen-Cheh Yang ◽

Chien-Hsieh Chiang ◽

Chien-An Yao ◽

...

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Dose Response ◽

Case Control Study ◽

Fasting Glucose ◽

Selenium Concentration ◽

Case Control ◽

Serum Selenium ◽

Serum Selenium Levels ◽

Control Study

Few studies have investigated the association between selenium and metabolic syndrome. This study aimed to explore the associations between the serum selenium level and metabolic syndrome as well as examining each metabolic factor. In this case-control study, the participants were 1165 adults aged ≥40 (65.8 ± 10.0) years. Serum selenium was measured by inductively coupled plasma-mass spectrometry. The associations between serum selenium and metabolic syndrome were examined by multivariate logistic regression analyses. The least square means were computed by general linear models to compare the serum selenium levels in relation to the number of metabolic factors. The mean serum selenium concentration was 96.34 ± 25.90 μg/L, and it was positively correlated with waist circumference, systolic blood pressure, triglycerides, fasting glucose, and homeostatic model assessment insulin resistance (HOMA-IR) in women, but it was only correlated with fasting glucose and HOMA-IR in men. After adjustment, the odds ratios (ORs) of having metabolic syndrome increased with the selenium quartile groups (p for trend: <0.05), especially in women. The study demonstrated that the serum selenium levels were positively associated with metabolic syndrome following a non-linear dose–response trend. Selenium concentration was positively associated with insulin resistance in men and women, but it was associated with adiposity and lipid metabolism in women. The mechanism behind this warrants further confirmation.

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