Risk Factors of Advanced Adenoma in Small and Diminutive Colorectal Polyp

Background: The frequency of delayed bleeding after colorectal polypectomy has been reported as 0.6–2.8%. With the increasing performance of polypectomy under continuous use of antithrombotic agents, care is required regarding delayed post-polypectomy bleeding (DPPB). Better instruction to educate endoscopists is therefore needed. We aimed to evaluate the effect of instruction and factors associated with delayed bleeding after endoscopic colorectal polyp resection. Methods: This single-center, retrospective study was performed to assess instruction in checking complete hemostasis and risk factors for onset of DPPB. The incidence of delayed bleeding, comorbidities, and medications were evaluated from medical records. Characteristics of historical control patients and patients after instruction were compared. Results: A total of 3318 polyps in 1002 patients were evaluated. The control group comprised 1479 polyps in 458 patients and the after-instruction group comprised 1839 polyps in 544 patients. DPPB occurred in 1.1% of polyps in control, and 0.4% in after-instruction. Instruction significantly decreased delayed bleeding, particularly in cases with antithrombotic agents. Hot polypectomy, clip placement, and use of antithrombotic agents were significant independent risk factors for DPPB even after instruction. Conclusion: The rate of delayed bleeding significantly decreased after instruction to check for complete hemostasis. Even after instruction, delayed bleeding can still occur in cases with antithrombotic agents or hot polypectomy.

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Characteristics and Risk Factors of Interval Colorectal Advanced Adenomas after Negative Index Colonoscopy

10.21203/rs.3.rs-118174/v1 ◽

2020 ◽

Author(s):

Haibin Dong ◽

Yutang Ren ◽

Bo Jiang

Keyword(s):

Risk Factors ◽

Family History ◽

Alcohol Intake ◽

Proximal Colon ◽

Smoking History ◽

Advanced Adenoma ◽

Pathological Grade ◽

Adenoma Detection ◽

History Of ◽

Advanced Adenomas

Abstract Objectives Interval colorectal advanced adenoma (I-CRAA) carries insidious risk of interval colorectal cancer (I-CRC). The study aims to determine the frequency of I-CRAA after negative colonoscopy and discover the characteristics and the risk factors.Methods We retrospectively analyzed the information of the patients undergoing colonoscopy in the endoscopic center (2015-2019). Frequency of I-CRAA was calculated. The clinical features of I-CRAA were compared with sporadic colorectal advanced adenoma (Sp-CRAA). Results The frequency of I-CRAA was 0.71% (112/15759) per colonoscopy. I-CRAA was more likely to be located in the proximal colon (65.2% vs 34.8%, p<0.05) and has high pathological grade (5.4% vs 1.6%, p<0.05). Diabetes, family history of CRC, smoking, alcohol intake and diverticulosis are risk factors for I-CRAA（p<0.05）. Excellent bowel preparation (OR 3.727; 95% CI 2.425–5.73, p<0.001) and higher adenoma detection rate (OR 1.924; 95% CI 1.153–3.21, p = 0.012) are helpful for the detection of I-CRAA. I-CRAA found within 1 year other than 2 or 3 years after the initial colonoscopy were usually found by an endoscopist with higher ADR.Conclusions I-CRAA is usually located in the proximal colon and has high pathological grade. Diabetes, diverticulosis, smoking history, alcohol intake, and family history of CRC are the risk factors. Its occurrence is more related to low-quality colonoscopy, especially within one year.

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Su1732 RISK FACTORS FOR METACHRONOUS ADVANCED ADENOMA AFTER SCREENING OR DIAGNOSTIC COLONOSCOPY: EIGHT YEARS’ FOLLOW-UP STUDY USING ASIAN POPULATION

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2019.03.604 ◽

2019 ◽

Vol 89 (6) ◽

pp. AB399

Author(s):

Fumio Omata ◽

Yasuhisa Kumakura ◽

Naoki Ishii ◽

Katsuyuki Fukuda ◽

Yoshiyuki Fujita ◽

...

Keyword(s):

Risk Factors ◽

Asian Population ◽

Advanced Adenoma ◽

Diagnostic Colonoscopy ◽

Follow Up Study

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Modifiable lifestyle factors associated with risk of sessile serrated polyps, conventional adenomas and hyperplastic polyps

Gut ◽

10.1136/gutjnl-2016-312893 ◽

2016 ◽

Vol 67 (3) ◽

pp. 456-465 ◽

Cited By ~ 30

Author(s):

James R Davenport ◽

Timothy Su ◽

Zhiguo Zhao ◽

Helen G Coleman ◽

Walter E Smalley ◽

...

Keyword(s):

Risk Factors ◽

Colorectal Polyp ◽

Folate Intake ◽

Hyperplastic Polyps ◽

Meat Intake ◽

Serrated Polyps ◽

Factors Associated ◽

Increased Risk ◽

Modifiable Factors ◽

Inflammatory Drugs

ObjectiveTo identify modifiable factors associated with sessile serrated polyps (SSPs) and compare the association of these factors with conventional adenomas (ADs) and hyperplastic polyps (HPs).DesignWe used data from the Tennessee Colorectal Polyp Study, a colonoscopy-based case–control study. Included were 214 SSP cases, 1779 AD cases, 560 HP cases and 3851 polyp-free controls.ResultsCigarette smoking was associated with increased risk for all polyps and was stronger for SSPs than for ADs (OR 1.74, 95% CI 1.16 to 2.62, for current vs never, ptrend=0.008). Current regular use of non-steroidal anti-inflammatory drugs was associated with a 40% reduction in SSP risk in comparison with never users (OR 0.68, 95% CI 0.48 to 0.96, ptrend=0.03), similar to the association with AD. Red meat intake was strongly associated with SSP risk (OR 2.59, 95% CI 1.41 to 4.74 for highest vs lowest intake, ptrend<0.001) and the association with SSP was stronger than with AD (ptrend=0.003). Obesity, folate intake, fibre intake and fat intake were not associated with SSP risk after adjustment for other factors. Exercise, alcohol use and calcium intake were not associated with risk for SSPs.ConclusionsSSPs share some modifiable risk factors for ADs, some of which are more strongly associated with SSPs than ADs. Thus, preventive efforts to reduce risk for ADs may also be applicable to SSPs. Additionally, SSPs have some distinctive risk factors. Future studies should evaluate the preventive strategies for these factors. The findings from this study also contribute to an understanding of the aetiology and biology of SSPs.

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Colorectal cancer risk factors in the detection of advanced adenoma and colorectal cancer

Cancer Epidemiology ◽

10.1016/j.canep.2013.02.004 ◽

2013 ◽

Vol 37 (3) ◽

pp. 278-283 ◽

Cited By ~ 28

Author(s):

Inge Stegeman ◽

Thomas R. de Wijkerslooth ◽

Esther M. Stoop ◽

Monique E. van Leerdam ◽

Evelien Dekker ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Cancer Risk ◽

Colorectal Cancer Risk ◽

Advanced Adenoma ◽

Cancer Risk Factors

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T2035 The Prevalence and Risk Factors of Overall Colorectal Adenoma and Advanced Adenoma in Asymptomatic Average-Risk Individuals Aged 40 to 49 Years

Gastroenterology ◽

10.1016/s0016-5085(09)62881-x ◽

2009 ◽

Vol 136 (5) ◽

pp. A-625

Author(s):

Sung Noh Hong ◽

In Kyung Sung ◽

So Young Kwon ◽

Jeong Hwan Kim ◽

Sun-Young Lee ◽

...

Keyword(s):

Risk Factors ◽

Colorectal Adenoma ◽

Advanced Adenoma ◽

Average Risk

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Risk Factors for the Colorectal Polyp: Relation Between Obesity and Colorectal Adenoma

Health Evaluation and Promotion ◽

10.7143/jhep.33.502 ◽

2006 ◽

Vol 33 (5) ◽

pp. 502-505 ◽

Cited By ~ 1

Author(s):

Yumi SATO ◽

Ryoichi NOZAKI ◽

Kazutaka YAMADA ◽

Masahiro TAKANO

Keyword(s):

Risk Factors ◽

Colorectal Adenoma ◽

Colorectal Polyp

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Meat and fish consumption and risk of colorectal adenomas in Korea.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.4_suppl.559 ◽

2017 ◽

Vol 35 (4_suppl) ◽

pp. 559-559

Author(s):

Sun Young Yang ◽

Eun Young Doo ◽

Young Sun Kim ◽

Jung Eun Lee ◽

Jiyoung Youn ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Colorectal Adenoma ◽

Red Meat ◽

Fish Intake ◽

Colorectal Adenomas ◽

Advanced Adenoma ◽

Processed Meat ◽

Meat Intake ◽

High Fish

559 Background: Consumption of red meat and alcohol are known risk factors for colorectal cancer. Colorectal adenomas are considered precursors to colorectal cancer through adenoma-carcinoma sequence. The identification of modifiable risk factors for colorectal adenoma contributes to prevent colorectal cancer from progressing. Many studies have suggested that high red meat or processed meat intake is associated with an increased risk of colorectal adenoma. However, the effect of high fish intake on colorectal adenoma has been insufficient in epidemiological studies. The aim of this study is examine the relationship between meat and fish intake and the risk of colorectal adenoma. Methods: The study enrolled participants who visited Seoul National University Hospital Healthcare System Gangnam Center from May to December, 2011. All participants underwent screening colonoscopy and completed validated food frequency questionnaire. The study sample included 414 adenoma patients, 142 advanced adenoma patients and 1160 polyp-free controls. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between meat and fish and colorectal adenoma using multivariate logistic regression. Results: The intake of total meat, red meat, poultry or processed meat showed no clear association with risk of colorectal adenoma or advanced adenoma. A significant negative association between fish intake and risk of advanced adenoma (OR = 0.51, 95% CI = 0.27 – 0.95, p for trend = 0.0281) after adjusting for confounders such as age, BMI, family history of colorectal cancer, alcohol consumption, smoking status, diabetes, total energy intake, fiber, vegetable/fruit and red meat intake. Conclusions: In conclusion, this study showed no clear relationship between the incidence of colorectal adenoma/advanced adenoma and meat intake. Although, high fish intake and incidence of advanced adenoma showed a significant inverse association in Korean.

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