T2035 The Prevalence and Risk Factors of Overall Colorectal Adenoma and Advanced Adenoma in Asymptomatic Average-Risk Individuals Aged 40 to 49 Years

559 Background: Consumption of red meat and alcohol are known risk factors for colorectal cancer. Colorectal adenomas are considered precursors to colorectal cancer through adenoma-carcinoma sequence. The identification of modifiable risk factors for colorectal adenoma contributes to prevent colorectal cancer from progressing. Many studies have suggested that high red meat or processed meat intake is associated with an increased risk of colorectal adenoma. However, the effect of high fish intake on colorectal adenoma has been insufficient in epidemiological studies. The aim of this study is examine the relationship between meat and fish intake and the risk of colorectal adenoma. Methods: The study enrolled participants who visited Seoul National University Hospital Healthcare System Gangnam Center from May to December, 2011. All participants underwent screening colonoscopy and completed validated food frequency questionnaire. The study sample included 414 adenoma patients, 142 advanced adenoma patients and 1160 polyp-free controls. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) for associations between meat and fish and colorectal adenoma using multivariate logistic regression. Results: The intake of total meat, red meat, poultry or processed meat showed no clear association with risk of colorectal adenoma or advanced adenoma. A significant negative association between fish intake and risk of advanced adenoma (OR = 0.51, 95% CI = 0.27 – 0.95, p for trend = 0.0281) after adjusting for confounders such as age, BMI, family history of colorectal cancer, alcohol consumption, smoking status, diabetes, total energy intake, fiber, vegetable/fruit and red meat intake. Conclusions: In conclusion, this study showed no clear relationship between the incidence of colorectal adenoma/advanced adenoma and meat intake. Although, high fish intake and incidence of advanced adenoma showed a significant inverse association in Korean.

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Comparative risk assessment for the development of cardiovascular diseases in the Hungarian general and Roma population

Scientific Reports ◽

10.1038/s41598-021-82689-0 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Peter Piko ◽

Zsigmond Kosa ◽

Janos Sandor ◽

Roza Adany

Keyword(s):

Risk Factors ◽

Risk Assessment ◽

Cardiovascular Risk ◽

Cardiovascular Diseases ◽

High Risk ◽

Risk Group ◽

High Risk Group ◽

Average Risk ◽

Cvd Risk ◽

Roma Population

AbstractCardiovascular diseases (CVDs) are the number one cause of death globally, and the early identification of high risk is crucial to prevent the disease and to reduce healthcare costs. Short life expectancy and increased mortality among the Roma are generally accepted (although not indeed proven by mortality analyses) which can be partially explained by the high prevalence of cardiovascular risk factors (CVRF) among them. This study aims to elaborate on the prevalence of the most important CVD risk factors, assess the estimation of a 10-year risk of development of fatal and nonfatal CVDs based on the most used risk assessment scoring models, and to compare the Hungarian general (HG) and Roma (HR) populations. In 2018 a complex health survey was accomplished on the HG (n = 380) and HR (n = 347) populations. The prevalence of CVRS was defined and 10-year cardiovascular risk was estimated for both study populations using the following systems: Framingham Risk Score for hard coronary heart disease (FRSCHD) and for cardiovascular disease (FRSCVD), Systematic COronary Risk Evaluation (SCORE), ACC/AHA Pooled Cohort Equations (PCE) and Revised Pooled Cohort Equations (RPCE). After the risk scores had been calculated, the populations were divided into risk categories and all subjects were classified. For all CVD risk estimation scores, the average of the estimated risk was higher among Roma compared to the HG independently of the gender. The proportion of high-risk group in the Hungarian Roma males population was on average 1.5–3 times higher than in the general one. Among Roma females, the average risk value was higher than in the HG one. The proportion of high-risk group in the Hungarian Roma females population was on average 2–3 times higher compared to the distribution of females in the general population. Our results show that both genders in the Hungarian Roma population have a significantly higher risk for a 10-year development of cardiovascular diseases and dying from them compared to the HG one. Therefore, cardiovascular interventions should be focusing not only on reducing smoking among Roma but on improving health literacy and service provision regarding prevention, early recognition, and treatment of lipid disorders and diabetes among them.

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Vegetarianism as a Protective Factor for Colorectal Adenoma and Advanced Adenoma in Asians

Digestive Diseases and Sciences ◽

10.1007/s10620-013-2974-5 ◽

2013 ◽

Vol 59 (5) ◽

pp. 1025-1035 ◽

Cited By ~ 6

Author(s):

Chang Geun Lee ◽

Suk Jae Hahn ◽

Min Keun Song ◽

Jun Kyu Lee ◽

Jae Hak Kim ◽

...

Keyword(s):

Colorectal Adenoma ◽

Protective Factor ◽

Advanced Adenoma

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Left-Sided Colectomy: One of the Important Risk Factors of Metachronous Colorectal Adenoma After Colectomy for Colon Cancer

Digestive Diseases and Sciences ◽

10.1007/s10620-018-4958-y ◽

2018 ◽

Vol 63 (4) ◽

pp. 1052-1061

Author(s):

Gee Young Yun ◽

Hee Seok Moon ◽

In Sun Kwon ◽

Ju Seok Kim ◽

Sun Hyung Kang ◽

...

Keyword(s):

Risk Factors ◽

Colon Cancer ◽

Colorectal Adenoma

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Mo2009 – Association Between Colorectal Adenoma and Nonalcoholic Fatty Liver Disease: Sharing Common Risk Factors with Obesity and Metabolic Syndrome

Gastroenterology ◽

10.1016/s0016-5085(19)39272-8 ◽

2019 ◽

Vol 156 (6) ◽

pp. S-924

Author(s):

Yu Sasaki ◽

Yasuhiko Abe ◽

Takao Yaoita ◽

Makoto Yagi ◽

Naoko Mizumoto ◽

...

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Colorectal Adenoma ◽

Fatty Liver Disease ◽

Nonalcoholic Fatty Liver ◽

Common Risk Factors

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Systematic Review of Prevalence, Risk Factors, and Risk for Metachronous Advanced Neoplasia in Patients With Young-Onset Colorectal Adenoma

Clinical Gastroenterology and Hepatology ◽

10.1016/j.cgh.2020.04.092 ◽

2020 ◽

Cited By ~ 1

Author(s):

Ngozi Enwerem ◽

Moo Y. Cho ◽

Joshua Demb ◽

Ashley Earles ◽

Karen M. Heskett ◽

...

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Colorectal Adenoma ◽

Young Onset ◽

Advanced Neoplasia

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Alcohol and Tobacco Use: Risk Factors for Colorectal Adenoma and Carcinoma?

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/87.4.239 ◽

1995 ◽

Vol 87 (4) ◽

pp. 239-240 ◽

Cited By ~ 10

Author(s):

A. H. Wu ◽

B. E. Henderson

Keyword(s):

Risk Factors ◽

Tobacco Use ◽

Colorectal Adenoma

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Colorectal Adenoma Risk Is Increased among Recently Diagnosed Adult Celiac Disease Patients

Gastroenterology Research and Practice ◽

10.1155/2018/6150145 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5

Author(s):

Juan Lasa ◽

Astrid Rausch ◽

Luis Florez Bracho ◽

Josefina Altamirano ◽

Daniela Speisky ◽

...

Keyword(s):

Celiac Disease ◽

Colorectal Adenoma ◽

Colorectal Neoplasia ◽

Adult Patients ◽

Colorectal Adenomas ◽

Screening Colonoscopy ◽

Advanced Adenoma ◽

Adenoma Detection ◽

Adult Celiac Disease ◽

Recent Diagnosis

Background. The association between celiac disease and colorectal neoplasia has been previously studied, but the question whether recently diagnosed celiac patients show an increased colorectal adenoma prevalence remains unanswered. Aims. To compare the prevalence of colorectal adenomas between adult patients with a recent diagnosis of celiac disease versus healthy controls. Materials and Methods. A retrospective case-control study was undertaken. Patients with a diagnosis of celiac disease at an age of 45 years or more who undertook colonoscopy six months before or six months after the initiation of a gluten-free diet were enrolled as cases. Asymptomatic subjects undertaking screening colonoscopy were recruited as controls in a 2 : 1 fashion. The prevalence of colorectal adenomas and the prevalence of advanced adenomas were compared between groups. Results. 57 celiac disease patients and 118 controls were enrolled. There was a greater prevalence of female patients among the celiac group, with no significant differences in terms of age. There were more obese patients among controls and a higher proportion of tabaquism among celiac patients. Adenoma prevalence was significantly higher among celiac patients (47.37% versus 27.97%, p=0.01). Advanced adenoma detection was not different between groups. Conclusion. Adult patients with a recent diagnosis of celiac disease have an increased prevalence of colorectal adenomas.

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Risk factors of colorectal adenoma recurrence among individuals under 50 years of age compared to those 50 years of age or older.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.1554 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. 1554-1554

Author(s):

Christine Louise Sardo Molmenti ◽

Jingyan Yang ◽

Cynthia A Thomson ◽

Elizabeth A Hibler ◽

Gloria Ho ◽

...

Keyword(s):

Risk Factors ◽

Colorectal Adenoma ◽

Colorectal Adenomas ◽

Age Group ◽

Current Smoking ◽

Adenoma Recurrence ◽

Younger Age ◽

History Of ◽

Colorectal Adenoma Recurrence

1554 Background: Colorectal cancer incidence and mortality are increasing among individuals < 50 years of age. Data are limited regarding the epidemiology of colorectal adenomas in this younger age group. This study investigated and compared risk factors associated with recurrence of adenomas in individuals under and over 50 years of age. Methods: Pooled analyses from the Wheat Bran Fiber and Ursodeoxycholic Acid phase III, randomized, controlled clinical trials included 1,623 participants, aged 40-80 years. Each completed baseline questionnaires related to family history and lifestyle habits, had one or more colorectal adenomas removed at baseline, and had a follow-up colonoscopy during the trial (mean follow up 36 months). Univariate and multivariate logistic regression modeling estimated the association between age and colorectal adenoma recurrence, and evaluate multiple risk factors, while controlling for confounding factors. Results: A statistically significant increased trend was found for colorectal adenoma recurrence with increasing age ( Ptrend= < 0.001). Multivariate logistic regression revealed that risk factors significantly associated with adenoma recurrence in the ≥50 age group (n = 1,523) included history of previous polyps, characteristics of adenomas removed at baseline (multiple adenomas and villous feature), current smoking, and an increased waist circumference. Although risk profile in the < 50 age group (n = 95) shared similarities with that in the ≥50 age group (e.g., current smoking), there were a few notable differences: history of previous polyps was a more prominent predictor for recurrence for the < 50 (OR< 50 = 4.76 and OR≥50 = 1.33, Pinteraction = 0.042), whereas baseline characteristics of adenomas were more important for the ≥50 (multiple adenomas: OR< 50 = 0.40 and OR≥50 = 2.28, Pinteraction = 0.043). Conclusions: Predisposition to colorectal adenoma is a more important risk factor for recurrence in the < 50 as compared to the ≥50. Future studies need to identify susceptibility factors contributing to the increasing incidence of colorectal cancer in this younger age group.

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