US Characterization of Soft Tissue Hemangiomas of Extremities: Correlation with MR Signal Intensity

1995 ◽  
Vol 33 (1) ◽  
pp. 131
Author(s):  
Kyung Sub Shinn ◽  
Sung Su Hwang ◽  
Mi Sook Sung ◽  
Hye Suk Jang ◽  
Jung Ik Yim
Keyword(s):  
Soft Tissue ◽  
Signal Intensity

Imaging of rare appendicular non-acral soft-tissue chondromas in adults with histopathologic correlation

2017 ◽  
Vol 59 (6) ◽  
pp. 700-708
Author(s):  
Mohamed Ragab Nouh ◽  
Hanan Abd El-Aziz Amr ◽  
Rola H Ali
Keyword(s):  
Soft Tissue ◽  
Signal Intensity ◽  
Tissue Reaction ◽  
High Signal ◽  
Diagnostic Challenge ◽  
Post Contrast ◽  
Intensity Matrix ◽  
Tissue Edema ◽  
Magnetic Resonance Imaging Mri

Background Soft-tissue chondroma (STC) is a rare benign soft tissue tumor that arises primarily in acral extra-skeletal locations. Occasionally, STCs may arise in more proximal non-acral locations, accompanied by non-classic features that label them as indeterminate lesions and pose diagnostic challenge for both radiologists and pathologists alike. Purpose To explicate the potential of diagnostic imaging in the identification and characterization of appendicular non-acral STCs with emphasis on their morphologic magnetic resonance imaging (MRI) enhancement. Material and Methods Our clinical database records were searched for patients with histologically proven primary soft-tissue chondroid lesions over a five-year period. Two musculoskeletal (MSK) trained radiologists evaluated the imaging studies and an MSK pathologist revised the pathological findings. Results The study included six cases of appendicular non-acral STCs (mean age = 40.5 years). The mean size of the tumors was 5.6 cm, with four localized to the knee region, one in the thigh, and one in the sternoclavicular region. All cases showed high signal intensity matrix with low-signal intensity septa on T2-weighted MRI and post-contrast marginal/septal enhancement. The lesions were lobulated and lacked host tissue reaction except for one showing subjacent mild soft-tissue edema. Histologically, the cases lacked overt features of malignancy although one was originally misdiagnosed as chondrosarcoma. Conclusion Non-acral STCs are benign cartilaginous tumors that may pose a diagnostic challenge, both radiologically and pathologically. Collaborative imaging and pathologic workup is needed for better characterization of non-aggression of these lesions, and to avoid diagnostic pitfalls and unnecessary radical resections.

scholarly journals US Characterization of Soft Tissue Hemangiomas of Extremities: Correlation with MR Signal Intensity

1995 ◽  
Vol 33 (1) ◽  
pp. 133
Author(s):  
Hye Suk Jang ◽  
Mi Sook Sung ◽  
Sung Su Hwang ◽  
Jung Ik Yim ◽  
Kyung Sub Shinn
Keyword(s):  
Soft Tissue ◽  
Signal Intensity

scholarly journals Intravoxel incoherent motion MRI for the initial characterization of non-fatty non-vascular soft tissue tumors

2020 ◽  
Vol 101 (4) ◽  
pp. 245-255 ◽  
Author(s):  
P.A. Gondim Teixeira ◽  
L. Simon ◽  
F. Sirveaux ◽  
B. Marie ◽  
M. Louis ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Tumors ◽  
Intravoxel Incoherent Motion ◽  
Initial Characterization ◽  
Motion Mri

Viscoelastic characterization of soft tissue from dynamic finite element models

2008 ◽  
Vol 53 (22) ◽  
pp. 6569-6590 ◽  
Author(s):  
Hani Eskandari ◽  
Septimiu E Salcudean ◽  
Robert Rohling ◽  
Jacques Ohayon
Keyword(s):  
Finite Element ◽  
Soft Tissue ◽  
Finite Element Models ◽  
Dynamic Finite Element

scholarly journals Molecular Determinants of Soft Tissue Sarcoma Immunity: Targets for Immune Intervention

2021 ◽  
Vol 22 (14) ◽  
pp. 7518
Author(s):  
Marcella Tazzari ◽  
Laura Bergamaschi ◽  
Alessandro De Vita ◽  
Paola Collini ◽  
Marta Barisella ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Malignant Tumors ◽  
Soft Tissue Sarcomas ◽  
Point Of View ◽  
Molecular Features ◽  
Molecular Determinants ◽  
Genetic Landscape ◽  
Current Therapies ◽  
Cumulative Evidence

Soft tissue sarcomas (STSs) are a family of rare malignant tumors encompassing more than 80 histologies. Current therapies for metastatic STS, a condition that affects roughly half of patients, have limited efficacy, making innovative therapeutic strategies urgently needed. From a molecular point of view, STSs can be classified as translocation-related and those with a heavily rearranged genotype. Although only the latter display an increased mutational burden, molecular profiles suggestive of an “immune hot” tumor microenvironment are observed across STS histologies, and response to immunotherapy has been reported in both translocation-related and genetic complex STSs. These data reinforce the notion that immunity in STSs is multifaceted and influenced by both genetic and epigenetic determinants. Cumulative evidence indicates that a fine characterization of STSs at different levels is required to identify biomarkers predictive of immunotherapy response and to discover targetable pathways to switch on the immune sensitivity of “immune cold” tumors. In this review, we will summarize recent findings on the interplay between genetic landscape, molecular profiling and immunity in STSs. Immunological and molecular features will be discussed for their prognostic value in selected STS histologies. Finally, the local and systemic immunomodulatory effects of the targeted drugs imatinib and sunitinib will be discussed.

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