Periarticular lesions as actual problem of general practice: modern possibilities of diagnosis and boosting effectiveness of treatment

2021 ◽  
pp. 7-14
Author(s):  
A. R. Babaeva ◽  
A. A. Ansarova ◽  
E. V. Kalinina ◽  
I. V. Kostryukova

Background. Lesions of extra-articular soft tissues occupy a leading place in the structure of diseases of the musculoskeletal system in primary health care. At the same time, insuffcient attention is paid to this pathology, which leads to a decrease in the quality of care for patients with extra-articular pathology.Objective. Increasing the awareness of general practitioners about the clinical forms of extra-articular soft tissue diseases, current approaches to diagnosis and treatment.Basic provisions. The article presents the characteristics of the main forms of periarticular lesions: periarthritis, incl. painful shoulder, tendonitis, tenosynovitis, capsulitis, bursitis. The leading mechanisms of periarticular disorders are presented, the clinical picture and diagnostic signs of particular forms are described. The role of modern methods of visualization of periarticular lesions using ultrasound and MRI is noted. The main approaches to the drug therapy of periarticular disorders are presented, including use of slow-acting symptom-modifying drugs (SYSADOA). The authors present their own data demonstrating the connective tissue metabolism disturbance in periarticular disorders as well as the effectiveness of the drug Alflutop in the treatment of periarticular lesions of a ‘mechanical’ nature.Conclusions. Primary forms of periarticular disorders are a consequence of microtraumatization and can be attributed to ‘mechanical’ types of damage. The ultrasound is pivotal in the diagnosis and evaluation the severity of the lesion and its origin. Biomarkers of connective tissue damage can be detected in the blood of patients with periarticular disorders. The treatment results can be improved with drugs from the SYSADOA group.

Author(s):  
Oleksandr Topchiyev ◽  
Vitalii Sych ◽  
Viktoriya Yavorska ◽  
Katerina Kolomiyets

The article defines the directions that it is recommended to assess the role of the population in the formation of recreation and tourism activities (RTA). It is proved the need to investigate the role of the population in the RTA in two main directions: 1) as a subject of recreational and tourist systems in its relation to their media (objects); 2) combined - as a subject and component of the object of recreational and tourist systems. The population forms the flows of recreation and tourists, developing relevant structures and mechanisms for their recreational and tourist service, organizes directions and fields of economic and non-economic activities that ensure the recreational needs of the population, creates a specialized recreation infrastructure, develops and implements a variety of functional and territorial organization of recreation and tourism, forms at the national and international level of territorial division of labor. In order to evaluate the recreational potential of a separate plot or object usually consider not the entire nomenclature of conditions and resources, but only a characteristic or typical combination. Each territory, each object of recreation and tourism has its own set (complex) of resource characteristics. And this circumstance greatly facilitates the procedure for a comprehensive assessment of recreational potential due to elimination (allocation) of a characteristic complex of terms and resources of RTA. A similar situation arises for a functional assessment of recreational potential. The valuation of conditions and resources are not developed for a general list of species and forms of RTA, but for those that are distributed in this area in this locality. It is determined that among the numerous characteristics and indicators of recreational potential, the concept of recreational and tourist attractiveness is one of the objective indicators of resource potential. Estimation of recreational potential for quantitative indicators of recreation and tourists and their numerical and spatial distributions creates an objective basis for all other characteristics and indicators of RTD. Another important characteristic of the recreational potential, which forms the population as a factor of RTA is a recreation capacity of territories and objects of RTA. The concept of "recreational capacity" is related to "recreational attractiveness". Attractiveness characterizes recreational territories and objects for their attraction, according to real flows of recreation and tourists. Recreational capacity is intended to set the upper limits of such attractiveness. Attractiveness represents the actual use of a recreational resource, and the capacity indicates its critical level of recreation, which does not lead to degradation of this resource. In recreational geography, tourism and planning of territories, this direction is well known and extremely designed. The indicators of recreational capacities for certain types and recreation forms and recreations - beach baths, short-term rest in green zones, anthropogenic load of resort zones and areas of the natural reserve fund, maximum population density in various functional zones of the big city, etc. At the same time, the zonal principles of assessing the recreational capacity of objects and areas of recreation and tourism have not yet been developed, and this actual problem is waiting for its researchers. The population forms a so-called anthropogenic load on the territory, and its economic activity is man-made load. Anthropogenic-technogenic load is considered as a factor of recreational and tourist activities, in turn, indicators of anthropogenic-technogenic load are the original characteristics of "anti-resource" of recreation potential. The article has proven that in the context of the study of the prerequisites for the development of recreation and tourist activities of the region also need to analyze both the quality of life of the population, in addition to the assessment of this indicator have a high contrast and diversity in the country. Key words: population, recreational and tourist potential, attractiveness of recreational territories, anthropogenic-technogenic load, quality of life of the population.


Author(s):  
Liisa Voutila ◽  
Anne Maria Mullen ◽  
Paul Allen ◽  
Declan Troy ◽  
Eero Puolanne

Loose structure and PSE like zones on the lateral surface of porcine semimembranosus muscle have beenobserved by other researchers. However the role of connective tissue in this abnormally loose structure insemimembranosus muscle has not yet been clarified. We collected about 100g samples from 7 loosestructured and 7 normal structured Irish commercial porcine semimembranosus muscles in order tocompare the onset and peak of thermal transition temperature of intramuscular connective tissue betweenthe samples from the two groups. Meat quality parameters, ultimate pH, rough estimate for drip loss,lightness (L), redness (a) yellowness (b) and as well as electrical conductivity and reflectance were alsomeasured on the samples. Four of the samples characterized as normal by visual assessment showed DFDcharacteristic so the statistical analysis was carried out both including and excluding those samples. Inboth cases the onset (p<0.001; 56.94ºC vs. 59.82ºC) and peak (p<0.001; 62.59ºC vs. 64.06ºC) of thermaltransition temperature were significantly lower in loose structured meat than in normal structured meat.Also reflectance% was lower (p<0.01; 45.18% vs. 69.17%) and the colour lighter (higher L value; p<0.01;55.05 vs. 45.52) and more yellow (higher b value; p<0.001; 18.27 vs. 14.78) in loose structured meat thanin normal structured meat when the DFD like samples were excluded. These results indicate that loosestructure in porcine semimembranosus muscle could be attributed in part to connective tissue propertiespossibly in conjunction with PSE effects.


2019 ◽  
Vol 101 (5) ◽  
pp. 916-927 ◽  
Author(s):  
Ali Borazjani ◽  
Bruna M Couri ◽  
Mei Kuang ◽  
Brian M Balog ◽  
Margot S Damaser

Abstract Pelvic organ prolapse (POP) in lysyl oxidase like-1 knockout (Loxl1 KO) mice occurs primarily in parous mice and is rare in nulliparous mice. We determined the effect of Loxl1 deficiency on postpartum regulation of connective tissue metabolism genes and degradative enzyme activity in the vagina at 20 days gestation or 4 h, 48 h, 7 days, 15 days, 25 days, 7 weeks, or 12 weeks postpartum. Nulliparous Loxl1 KO and wildtype (WT) mice aged 11, 18, or 23 weeks were controls. Gene expression and enzyme activity were assessed using real-time quantitative reverse transcription PCR and fluorescein conjugated gelatin zymography, respectively. Parity, but not aging, had a significant influence on gene expression both with time postpartum and between KO and WT mice. Mmp2, Timp1, Timp2, Timp3, Timp4, Col1a1, Col3a1, Acta2, and Bmp1 were differentially expressed between KO and WT mice. Correlational analysis of gene-gene pairs revealed 10 significant differences between parous KO and WT groups, 5 of which were due to lack of co-expression of Bmp1 in KO mice. The overall enzyme activity that could be attributed to MMPs was significantly higher in WT compared to KO mice both 25 days and 12 weeks postpartum, and MMP activity was significantly lower 15 days and 25 days postpartum compared to KO nulliparous controls, but not WT. These findings suggest that Loxl1 deficiency combined with parity has a significant impact on postpartum regulation of connective tissue metabolism, particularly as it relates to co-expression of Bmp1 and altered proteolytic activity.


Author(s):  
D.J. Etherington ◽  
R.A. Maciewicz ◽  
M.A.J. Taylor ◽  
R.J. Wardale ◽  
I.A. Silver ◽  
...  

Infolib ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 68-71
Author(s):  
Nargiza Pazilova ◽  

The article examines the importance of using information resources in scientific and educational activities and their impact on improving the quality of scientific research and dissertations. The role of information and library institutions in organizing online access to scientific information, completing the collection based on the analysis of user needs is shown. The author also touches upon the actual problem of plagiarism in science and provides information on the Russian system for detecting text borrowings Antiplagiat, which most closely meets the needs of scientific and educational institutions of Uzbekistan


2021 ◽  
Vol 1 (4) ◽  
pp. 16-22
Author(s):  
D. A. Stuzhuk ◽  
◽  
V. I. Izdepsky ◽  
P. A. Rudenko ◽  
◽  
...  

The article presents data on the role of indicators of connective tissue metabolism in morphobiochemical screening of purulent-inflammatory processes in cats. It was found that the acute purulent-inflammatory process in cats proceeds with significant shifts in clinical, morphological and biochemical blood parameters. With inflammation in cats, the level of sialic acids, the content of hexoses associated with proteins and the redistribution of their fractions in the blood serum at the late stages of the pathological process increases in the direction of increasing the hexoses of glycoproteins. It is shown that the determination of indicators of connective tissue metabolism during morpho-biochemical screening of purulent-inflammatory processes of surgical profile in cats will improve the diagnosis, determination of the severity of the course, prediction of the outcome and existing methods of their treatment.


2013 ◽  
Vol 21 (1) ◽  
pp. 24-33 ◽  
Author(s):  
Anne Eschen ◽  
Franzisca Zehnder ◽  
Mike Martin

This article introduces Cognitive Health Counseling 40+ (CH.CO40+), an individualized intervention that is conceptually based on the orchestration model of quality-of-life management ( Martin & Kliegel, 2010 ) and aims at improving satisfaction with cognitive health in adults aged 40 years and older. We describe the theoretically deduced characteristics of CH.CO40+, its target group, its multifactorial nature, its individualization, the application of subjective and objective measures, the role of participants as agents of change, and the rationale for choosing participants’ satisfaction with their cognitive health as main outcome variable. A pilot phase with 15 middle-aged and six older adults suggests that CH.CO40+ attracts, and may be particularly suitable for, subjective memory complainers. Implications of the pilot data for the further development of the intervention are discussed.


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